HIV molecular immunology database

 

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Found 14 matching records:

Displaying record number 828

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MAb ID LA9 (121-134)
HXB2 Location gp160(728-745)
DNA(8406..8459)
gp160 Epitope Map
Author Location gp41(735-752 IIIB)
Epitope DRPEGIEEEGGERDRDRS Epitope Alignment
DRPEGIEEEGGERDRDRS epitope logo
Ab Type  
Neutralizing  
Species (Isotype) mouse(IgM)
Patient  
Immunogen  
Keywords  

References

Showing 1 of 1 references.

Evans1989 D. J. Evans, J. McKeating, J. M. Meredith, K. L. Burke, K. Katrak, A. John, M. Ferguson, P. D. Minor, R. A. Weiss, and J. W. Almond. An Engineered Poliovirus Chimera Elicits Broadly Reactive HIV-1 Neutralizing Antibodies. Nature, 339:385-388, 1989. PubMed ID: 2542797. Show all entries for this paper.


Displaying record number 829

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MAb ID ED6
HXB2 Location gp160(728-745)
DNA(8406..8459)
gp160 Epitope Map
Author Location gp41(735-752 IIIB)
Epitope DRPEGIEEEGGERDRDRS Epitope Alignment
DRPEGIEEEGGERDRDRS epitope logo
Ab Type  
Neutralizing  
Species (Isotype) mouse(IgM)
Patient  
Immunogen  
Keywords  

References

Showing 1 of 1 references.

Evans1989 D. J. Evans, J. McKeating, J. M. Meredith, K. L. Burke, K. Katrak, A. John, M. Ferguson, P. D. Minor, R. A. Weiss, and J. W. Almond. An Engineered Poliovirus Chimera Elicits Broadly Reactive HIV-1 Neutralizing Antibodies. Nature, 339:385-388, 1989. PubMed ID: 2542797. Show all entries for this paper.


Displaying record number 830

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MAb ID 1575
HXB2 Location gp160(728-745)
DNA(8406..8459)
gp160 Epitope Map
Author Location gp41(735-752 IIIB)
Research Contact C. Vella, NIBSC, Potters Bar UK
Epitope DRPEGIEEEGGERDRDRS Epitope Alignment
DRPEGIEEEGGERDRDRS epitope logo
Ab Type C-term
Neutralizing  
Species (Isotype) mouse
Patient  
Immunogen vaccine
Keywords review

Vaccine Details

Vaccine type poliovirus
Vaccine strain B clade IIIB
Vaccine component gp41

Notes

Showing 6 of 6 notes.

References

Showing 6 of 6 references.

Evans1989 D. J. Evans, J. McKeating, J. M. Meredith, K. L. Burke, K. Katrak, A. John, M. Ferguson, P. D. Minor, R. A. Weiss, and J. W. Almond. An Engineered Poliovirus Chimera Elicits Broadly Reactive HIV-1 Neutralizing Antibodies. Nature, 339:385-388, 1989. PubMed ID: 2542797. Show all entries for this paper.

Vella1993 C. Vella, M. Ferguson, G. Dunn, R. Meloen, H. Langedijk, D. Evans, and P. D. Minor. Characterization and Primary Structure of a Human Immunodeficiency Virus Type 1 (HIV-1) Neutralization Domain as Presented by a Poliovirus Type 1/HIV-1 Chimera. J. Gen. Virol., 7:15-21, 1993. This study elaborated on a set of antibodies first reported in Evans et al., 1989. Not all of the neutralization results are congruent between the studies. The antibodies in this study were raised to a region including the cytoplasmic domain of gp41 inserted into a poliovirus type 1/HIV-1 chimera. PubMed ID: 7506299. Show all entries for this paper.

Buratti1997 E. Buratti, S. G. Tisminetzky, P. D'Agaro, and F. E. Baralle. A neutralizing monoclonal antibody previously mapped exclusively on human immunodeficiency virus type 1 gp41 recognizes an epitope in p17 sharing the core sequence. J. Virol., 71:2457-62, 1997. PubMed ID: 9032383. Show all entries for this paper.

Cleveland2000b S. M. Cleveland, E. Buratti, T. D. Jones, P. North, F. Baralle, L. McLain, T. McInerney, Z. Durrani, and N. J. Dimmock. Immunogenic and antigenic dominance of a nonneutralizing epitope over a highly conserved neutralizing epitope in the gp41 envelope glycoprotein of human immunodeficiency virus type 1: its deletion leads to a strong neutralizing response. Virology, 266:66-78, 2000. PubMed ID: 10612661. Show all entries for this paper.

Dimmock2005 Nigel J. Dimmock. The Complex Antigenicity of a Small External Region of the C-Terminal Tail of the HIV-1 gp41 Envelope Protein: A Lesson in Epitope Analysis. Rev. Med. Virol., 15(6):365-381, Nov-Dec 2005. PubMed ID: 16106492. Show all entries for this paper.

Heap2005a Caroline J. Heap, Steven A. Reading, and Nigel J. Dimmock. An Antibody Specific for the C-Terminal Tail of the gp41 Transmembrane Protein of Human Immunodeficiency Virus Type 1 Mediates Post-Attachment Neutralization, Probably Through Inhibition of Virus-Cell Fusion. J. Gen. Virol., 86(5):1499-1507, May 2005. PubMed ID: 15831963. Show all entries for this paper.


Displaying record number 831

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MAb ID 1576
HXB2 Location gp160(728-745)
DNA(8406..8459)
gp160 Epitope Map
Author Location gp41(735-752 IIIB)
Epitope DRPEGIEEEGGERDRDRS Epitope Alignment
DRPEGIEEEGGERDRDRS epitope logo
Ab Type  
Neutralizing  
Species (Isotype) mouse
Patient  
Immunogen vaccine
Keywords  

Vaccine Details

Vaccine type poliovirus
Vaccine strain B clade IIIB
Vaccine component gp41

Notes

Showing 1 of 1 note.

References

Showing 1 of 1 reference.

Vella1993 C. Vella, M. Ferguson, G. Dunn, R. Meloen, H. Langedijk, D. Evans, and P. D. Minor. Characterization and Primary Structure of a Human Immunodeficiency Virus Type 1 (HIV-1) Neutralization Domain as Presented by a Poliovirus Type 1/HIV-1 Chimera. J. Gen. Virol., 7:15-21, 1993. This study elaborated on a set of antibodies first reported in Evans et al., 1989. Not all of the neutralization results are congruent between the studies. The antibodies in this study were raised to a region including the cytoplasmic domain of gp41 inserted into a poliovirus type 1/HIV-1 chimera. PubMed ID: 7506299. Show all entries for this paper.


Displaying record number 836

Download this epitope record as JSON.

MAb ID 1578
HXB2 Location gp160(728-745)
DNA(8406..8459)
gp160 Epitope Map
Author Location gp41(735-752 IIIB)
Epitope DRPEGIEEEGGERDRDRS Epitope Alignment
DRPEGIEEEGGERDRDRS epitope logo
Ab Type  
Neutralizing  
Species (Isotype) mouse
Patient  
Immunogen vaccine
Keywords  

Vaccine Details

Vaccine type poliovirus
Vaccine strain B clade IIIB
Vaccine component gp41

Notes

Showing 2 of 2 notes.

References

Showing 2 of 2 references.

Evans1989 D. J. Evans, J. McKeating, J. M. Meredith, K. L. Burke, K. Katrak, A. John, M. Ferguson, P. D. Minor, R. A. Weiss, and J. W. Almond. An Engineered Poliovirus Chimera Elicits Broadly Reactive HIV-1 Neutralizing Antibodies. Nature, 339:385-388, 1989. PubMed ID: 2542797. Show all entries for this paper.

Vella1993 C. Vella, M. Ferguson, G. Dunn, R. Meloen, H. Langedijk, D. Evans, and P. D. Minor. Characterization and Primary Structure of a Human Immunodeficiency Virus Type 1 (HIV-1) Neutralization Domain as Presented by a Poliovirus Type 1/HIV-1 Chimera. J. Gen. Virol., 7:15-21, 1993. This study elaborated on a set of antibodies first reported in Evans et al., 1989. Not all of the neutralization results are congruent between the studies. The antibodies in this study were raised to a region including the cytoplasmic domain of gp41 inserted into a poliovirus type 1/HIV-1 chimera. PubMed ID: 7506299. Show all entries for this paper.


Displaying record number 837

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MAb ID 1899
HXB2 Location gp160(728-745)
DNA(8406..8459)
gp160 Epitope Map
Author Location gp41(735-752 IIIB)
Epitope DRPEGIEEEGGERDRDRS Epitope Alignment
DRPEGIEEEGGERDRDRS epitope logo
Ab Type  
Neutralizing  
Species (Isotype) mouse
Patient  
Immunogen vaccine
Keywords  

Vaccine Details

Vaccine type poliovirus
Vaccine strain B clade IIIB
Vaccine component gp41

Notes

Showing 1 of 1 note.

References

Showing 1 of 1 reference.

Vella1993 C. Vella, M. Ferguson, G. Dunn, R. Meloen, H. Langedijk, D. Evans, and P. D. Minor. Characterization and Primary Structure of a Human Immunodeficiency Virus Type 1 (HIV-1) Neutralization Domain as Presented by a Poliovirus Type 1/HIV-1 Chimera. J. Gen. Virol., 7:15-21, 1993. This study elaborated on a set of antibodies first reported in Evans et al., 1989. Not all of the neutralization results are congruent between the studies. The antibodies in this study were raised to a region including the cytoplasmic domain of gp41 inserted into a poliovirus type 1/HIV-1 chimera. PubMed ID: 7506299. Show all entries for this paper.


Displaying record number 838

Download this epitope record as JSON.

MAb ID 1579
HXB2 Location gp160(728-745)
DNA(8406..8459)
gp160 Epitope Map
Author Location gp41(735-752 IIIB)
Epitope DRPEGIEEEGGERDRDRS Epitope Alignment
DRPEGIEEEGGERDRDRS epitope logo
Ab Type  
Neutralizing  
Species (Isotype) mouse
Patient  
Immunogen vaccine
Keywords  

Vaccine Details

Vaccine type poliovirus
Vaccine strain B clade IIIB
Vaccine component gp41

Notes

Showing 1 of 1 note.

References

Showing 1 of 1 reference.

Vella1993 C. Vella, M. Ferguson, G. Dunn, R. Meloen, H. Langedijk, D. Evans, and P. D. Minor. Characterization and Primary Structure of a Human Immunodeficiency Virus Type 1 (HIV-1) Neutralization Domain as Presented by a Poliovirus Type 1/HIV-1 Chimera. J. Gen. Virol., 7:15-21, 1993. This study elaborated on a set of antibodies first reported in Evans et al., 1989. Not all of the neutralization results are congruent between the studies. The antibodies in this study were raised to a region including the cytoplasmic domain of gp41 inserted into a poliovirus type 1/HIV-1 chimera. PubMed ID: 7506299. Show all entries for this paper.


Displaying record number 839

Download this epitope record as JSON.

MAb ID 1583
HXB2 Location gp160(728-745)
DNA(8406..8459)
gp160 Epitope Map
Author Location gp41(735-752 IIIB)
Epitope DRPEGIEEEGGERDRDRS Epitope Alignment
DRPEGIEEEGGERDRDRS epitope logo
Ab Type  
Neutralizing  
Species (Isotype) mouse
Patient  
Immunogen vaccine
Keywords review

Vaccine Details

Vaccine type poliovirus
Vaccine strain B clade IIIB
Vaccine component gp41

Notes

Showing 5 of 5 notes.

References

Showing 5 of 5 references.

Evans1989 D. J. Evans, J. McKeating, J. M. Meredith, K. L. Burke, K. Katrak, A. John, M. Ferguson, P. D. Minor, R. A. Weiss, and J. W. Almond. An Engineered Poliovirus Chimera Elicits Broadly Reactive HIV-1 Neutralizing Antibodies. Nature, 339:385-388, 1989. PubMed ID: 2542797. Show all entries for this paper.

Vella1993 C. Vella, M. Ferguson, G. Dunn, R. Meloen, H. Langedijk, D. Evans, and P. D. Minor. Characterization and Primary Structure of a Human Immunodeficiency Virus Type 1 (HIV-1) Neutralization Domain as Presented by a Poliovirus Type 1/HIV-1 Chimera. J. Gen. Virol., 7:15-21, 1993. This study elaborated on a set of antibodies first reported in Evans et al., 1989. Not all of the neutralization results are congruent between the studies. The antibodies in this study were raised to a region including the cytoplasmic domain of gp41 inserted into a poliovirus type 1/HIV-1 chimera. PubMed ID: 7506299. Show all entries for this paper.

Sattentau1995 Q. J. Sattentau, S. Zolla-Pazner, and P. Poignard. Epitope Exposure on Functional, Oligomeric HIV-1 gp41 Molecules. Virology, 206:713-717, 1995. Most gp41 epitopes are masked when associated with gp120 on the cell surface. Weak binding of anti-gp41 MAbs can be enhanced by treatment with sCD4. MAb 2F5 binds to a membrane proximal epitope which binds in the presence of gp120 without sCD4. PubMed ID: 7530400. Show all entries for this paper.

Dimmock2005 Nigel J. Dimmock. The Complex Antigenicity of a Small External Region of the C-Terminal Tail of the HIV-1 gp41 Envelope Protein: A Lesson in Epitope Analysis. Rev. Med. Virol., 15(6):365-381, Nov-Dec 2005. PubMed ID: 16106492. Show all entries for this paper.

Heap2005a Caroline J. Heap, Steven A. Reading, and Nigel J. Dimmock. An Antibody Specific for the C-Terminal Tail of the gp41 Transmembrane Protein of Human Immunodeficiency Virus Type 1 Mediates Post-Attachment Neutralization, Probably Through Inhibition of Virus-Cell Fusion. J. Gen. Virol., 86(5):1499-1507, May 2005. PubMed ID: 15831963. Show all entries for this paper.


Displaying record number 840

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MAb ID 1907
HXB2 Location gp160(728-745)
DNA(8406..8459)
gp160 Epitope Map
Author Location gp41(735-752 IIIB)
Epitope DRPEGIEEEGGERDRDRS Epitope Alignment
DRPEGIEEEGGERDRDRS epitope logo
Ab Type  
Neutralizing  
Species (Isotype) mouse
Patient  
Immunogen vaccine
Keywords  

Vaccine Details

Vaccine type poliovirus
Vaccine strain B clade IIIB
Vaccine component gp41

Notes

Showing 1 of 1 note.

References

Showing 1 of 1 reference.

Vella1993 C. Vella, M. Ferguson, G. Dunn, R. Meloen, H. Langedijk, D. Evans, and P. D. Minor. Characterization and Primary Structure of a Human Immunodeficiency Virus Type 1 (HIV-1) Neutralization Domain as Presented by a Poliovirus Type 1/HIV-1 Chimera. J. Gen. Virol., 7:15-21, 1993. This study elaborated on a set of antibodies first reported in Evans et al., 1989. Not all of the neutralization results are congruent between the studies. The antibodies in this study were raised to a region including the cytoplasmic domain of gp41 inserted into a poliovirus type 1/HIV-1 chimera. PubMed ID: 7506299. Show all entries for this paper.


Displaying record number 841

Download this epitope record as JSON.

MAb ID 1908
HXB2 Location gp160(728-745)
DNA(8406..8459)
gp160 Epitope Map
Author Location gp41(735-752 IIIB)
Epitope DRPEGIEEEGGERDRDRS Epitope Alignment
DRPEGIEEEGGERDRDRS epitope logo
Ab Type  
Neutralizing  
Species (Isotype) mouse
Patient  
Immunogen vaccine
Keywords  

Vaccine Details

Vaccine type poliovirus
Vaccine strain B clade IIIB
Vaccine component gp41

Notes

Showing 2 of 2 notes.

References

Showing 3 of 3 references.

Evans1989 D. J. Evans, J. McKeating, J. M. Meredith, K. L. Burke, K. Katrak, A. John, M. Ferguson, P. D. Minor, R. A. Weiss, and J. W. Almond. An Engineered Poliovirus Chimera Elicits Broadly Reactive HIV-1 Neutralizing Antibodies. Nature, 339:385-388, 1989. PubMed ID: 2542797. Show all entries for this paper.

Vella1993 C. Vella, M. Ferguson, G. Dunn, R. Meloen, H. Langedijk, D. Evans, and P. D. Minor. Characterization and Primary Structure of a Human Immunodeficiency Virus Type 1 (HIV-1) Neutralization Domain as Presented by a Poliovirus Type 1/HIV-1 Chimera. J. Gen. Virol., 7:15-21, 1993. This study elaborated on a set of antibodies first reported in Evans et al., 1989. Not all of the neutralization results are congruent between the studies. The antibodies in this study were raised to a region including the cytoplasmic domain of gp41 inserted into a poliovirus type 1/HIV-1 chimera. PubMed ID: 7506299. Show all entries for this paper.

Sattentau1995 Q. J. Sattentau, S. Zolla-Pazner, and P. Poignard. Epitope Exposure on Functional, Oligomeric HIV-1 gp41 Molecules. Virology, 206:713-717, 1995. Most gp41 epitopes are masked when associated with gp120 on the cell surface. Weak binding of anti-gp41 MAbs can be enhanced by treatment with sCD4. MAb 2F5 binds to a membrane proximal epitope which binds in the presence of gp120 without sCD4. PubMed ID: 7530400. Show all entries for this paper.


Displaying record number 842

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MAb ID 1909
HXB2 Location gp160(728-745)
DNA(8406..8459)
gp160 Epitope Map
Author Location gp41(735-752 IIIB)
Epitope DRPEGIEEEGGERDRDRS Epitope Alignment
DRPEGIEEEGGERDRDRS epitope logo
Ab Type  
Neutralizing  
Species (Isotype) mouse
Patient  
Immunogen vaccine
Keywords  

Vaccine Details

Vaccine type poliovirus
Vaccine strain B clade IIIB
Vaccine component gp41

Notes

Showing 1 of 1 note.

References

Showing 1 of 1 reference.

Vella1993 C. Vella, M. Ferguson, G. Dunn, R. Meloen, H. Langedijk, D. Evans, and P. D. Minor. Characterization and Primary Structure of a Human Immunodeficiency Virus Type 1 (HIV-1) Neutralization Domain as Presented by a Poliovirus Type 1/HIV-1 Chimera. J. Gen. Virol., 7:15-21, 1993. This study elaborated on a set of antibodies first reported in Evans et al., 1989. Not all of the neutralization results are congruent between the studies. The antibodies in this study were raised to a region including the cytoplasmic domain of gp41 inserted into a poliovirus type 1/HIV-1 chimera. PubMed ID: 7506299. Show all entries for this paper.


Displaying record number 843

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MAb ID 41-1
HXB2 Location gp160(728-745)
DNA(8406..8459)
gp160 Epitope Map
Author Location gp41(735-752 IIIB)
Epitope DRPEGIEEEGGERDRDRS Epitope Alignment
DRPEGIEEEGGERDRDRS epitope logo
Ab Type  
Neutralizing  
Species (Isotype) mouse(IgMκ)
Patient  
Immunogen vaccine
Keywords antibody generation

Vaccine Details

Vaccine type peptide
Vaccine strain B clade IIIB
Vaccine component gp41

Notes

Showing 2 of 2 notes.

References

Showing 2 of 2 references.

Isolation Paper
Dalgleish1988 A. G. Dalgleish, T. C. Chanh, R. C. Kennedy, P. Kanda, P. R. Clapham, and R. A. Weiss. Neutralization of Diverse HIV-1 Strains by Monoclonal Antibodies Raised against a gp41 Synthetic Peptide. Virology, 165:209-215, 1988. PubMed ID: 2838959. Show all entries for this paper.

Kennedy1986 R. C. Kennedy, R. D. Henkel, D. Pauletti, J. S. Allan, T. H. Lee, M. Essex, and G. R. Dreesman. Antiserum to a Synthetic Peptide Recognizes the HTLV-III Envelope Glycoprotein. Science, 231(4745):1556-1559, 28 Mar 1986. PubMed ID: 3006246. Show all entries for this paper.


Displaying record number 844

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MAb ID 41-2
HXB2 Location gp160(728-745)
DNA(8406..8459)
gp160 Epitope Map
Author Location gp41(735-752 IIIB)
Epitope DRPEGIEEEGGERDRDRS Epitope Alignment
DRPEGIEEEGGERDRDRS epitope logo
Ab Type  
Neutralizing  
Species (Isotype) mouse(IgMκ)
Patient  
Immunogen vaccine
Keywords antibody generation

Vaccine Details

Vaccine type peptide
Vaccine strain B clade IIIB
Vaccine component gp41

Notes

Showing 1 of 1 note.

References

Showing 2 of 2 reference.

Isolation Paper
Dalgleish1988 A. G. Dalgleish, T. C. Chanh, R. C. Kennedy, P. Kanda, P. R. Clapham, and R. A. Weiss. Neutralization of Diverse HIV-1 Strains by Monoclonal Antibodies Raised against a gp41 Synthetic Peptide. Virology, 165:209-215, 1988. PubMed ID: 2838959. Show all entries for this paper.

Kennedy1986 R. C. Kennedy, R. D. Henkel, D. Pauletti, J. S. Allan, T. H. Lee, M. Essex, and G. R. Dreesman. Antiserum to a Synthetic Peptide Recognizes the HTLV-III Envelope Glycoprotein. Science, 231(4745):1556-1559, 28 Mar 1986. PubMed ID: 3006246. Show all entries for this paper.


Displaying record number 845

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MAb ID 41-3
HXB2 Location gp160(728-745)
DNA(8406..8459)
gp160 Epitope Map
Author Location gp41(735-752 IIIB)
Epitope DRPEGIEEEGGERDRDRS Epitope Alignment
DRPEGIEEEGGERDRDRS epitope logo
Ab Type  
Neutralizing  
Species (Isotype) mouse(IgMκ)
Patient  
Immunogen vaccine
Keywords  

Vaccine Details

Vaccine type peptide
Vaccine strain B clade IIIB
Vaccine component gp41

Notes

Showing 1 of 1 note.

References

Showing 2 of 2 reference.

Isolation Paper
Dalgleish1988 A. G. Dalgleish, T. C. Chanh, R. C. Kennedy, P. Kanda, P. R. Clapham, and R. A. Weiss. Neutralization of Diverse HIV-1 Strains by Monoclonal Antibodies Raised against a gp41 Synthetic Peptide. Virology, 165:209-215, 1988. PubMed ID: 2838959. Show all entries for this paper.

Kennedy1986 R. C. Kennedy, R. D. Henkel, D. Pauletti, J. S. Allan, T. H. Lee, M. Essex, and G. R. Dreesman. Antiserum to a Synthetic Peptide Recognizes the HTLV-III Envelope Glycoprotein. Science, 231(4745):1556-1559, 28 Mar 1986. PubMed ID: 3006246. Show all entries for this paper.


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