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Displaying record number 394

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MAb ID	polyclonal
HXB2 Location	gp160(303-319) DNA(7131..7181)	gp160 Epitope Map
Author Location	gp120( subtype C)
Epitope	`CKRKIHIGPGQAFYT`	Epitope Alignment
Subtype	C
Ab Type	gp120 V3 // V3 glycan (V3g)
Neutralizing
Species (Isotype)	mouse(IgG2a, IgG2b)
Patient
Immunogen	vaccine
Keywords

Vaccine Details

Vaccine type	peptide in ISCOM, peptide in liposome
Vaccine component	Env V3
Adjuvant	Immune stimulating complexes (ISCOM)

Notes

Showing 1 of 1 note.

A V3 loop peptide modified to resemble an Indian form (GPGQ) was incorporated into ISCOMS (immune stimulating complexes) or liposomes, and used to immunize mice -- the IgG2a/IgG2b antibody response was enhanced by the presentation in the ISCOM suggestive of a Th1 response. Ahluwalia1997

References

Showing 1 of 1 reference.

Ahluwalia1997 A. Ahluwalia, K. Gokulan, I. Nath, and D. N. Rao. Modification of delivery system enhances MHC nonrestricted immunogenicity of V3 loop region of HIV-1 gp120. Microbiol. Immunol., 41:779-84, 1997. PubMed ID: 9403501. Show all entries for this paper.