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HIV Molecular Immunology Database

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Found 22 matching records:

Displaying record number 3656

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MAb ID DH511.2 (DH512, Ab510049)
HXB2 Location Env Env Epitope Map
Author Location gp120
Epitope
Subtype C
Ab Type gp41 MPER (membrane proximal external region)
Neutralizing P (tier 2)  View neutralization details
Contacts and Features View contacts and features
Species (Isotype) human(IgG)
Patient CH0210
Immunogen HIV-1 infection
Country South Africa
Keywords acute/early infection, antibody binding site, antibody generation, antibody lineage, antibody polyreactivity, antibody sequence, broad neutralizer, computational prediction, contact residues, germline, mother-to-infant transmission, neutralization, structure, transmission pair, vaccine antigen design

Notes

Showing 6 of 6 notes.

References

Showing 6 of 6 references.

Isolation Paper
Williams2017 LaTonya D. Williams, Gilad Ofek, Sebastian Schätzle, Jonathan R. McDaniel, Xiaozhi Lu, Nathan I. Nicely, Liming Wu, Caleb S. Lougheed, Todd Bradley, Mark K. Louder, Krisha McKee, Robert T. Bailer, Sijy O'Dell, Ivelin S. Georgiev, Michael S. Seaman, Robert J. Parks, Dawn J. Marshall, Kara Anasti, Guang Yang, Xiaoyan Nie, Nancy L. Tumba, Kevin Wiehe, Kshitij Wagh, Bette Korber, Thomas B. Kepler, S. Munir Alam, Lynn Morris, Gift Kamanga, Myron S. Cohen, Mattia Bonsignori, Shi-Mao Xia, David C. Montefiori, Garnett Kelsoe, Feng Gao, John R. Mascola, M. Anthony Moody, Kevin O. Saunders, Hua-Xin Liao, Georgia D. Tomaras, George Georgiou, and Barton F. Haynes. Potent and Broad HIV-Neutralizing Antibodies in Memory B Cells and Plasma. Sci. Immunol., 2(7), 27 Jan 2017. PubMed ID: 28783671. Show all entries for this paper.

Bricault2019 Christine A. Bricault, Karina Yusim, Michael S. Seaman, Hyejin Yoon, James Theiler, Elena E. Giorgi, Kshitij Wagh, Maxwell Theiler, Peter Hraber, Jennifer P. Macke, Edward F. Kreider, Gerald H. Learn, Beatrice H. Hahn, Johannes F. Scheid, James M. Kovacs, Jennifer L. Shields, Christy L. Lavine, Fadi Ghantous, Michael Rist, Madeleine G. Bayne, George H. Neubauer, Katherine McMahan, Hanqin Peng, Coraline Chéneau, Jennifer J. Jones, Jie Zeng, Christina Ochsenbauer, Joseph P. Nkolola, Kathryn E. Stephenson, Bing Chen, S. Gnanakaran, Mattia Bonsignori, LaTonya D. Williams, Barton F. Haynes, Nicole Doria-Rose, John R. Mascola, David C. Montefiori, Dan H. Barouch, and Bette Korber. HIV-1 Neutralizing Antibody Signatures and Application to Epitope-Targeted Vaccine Design. Cell Host Microbe, 25(1):59-72.e8, 9 Jan 2019. PubMed ID: 30629920. Show all entries for this paper.

Haynes2016a B. F. Haynes, H. X. Liao, M. A. Moody, L. Williams, K. J. Wiehe, and G. A. Ofek. HIV-1 Neutralizing Antibodies and Uses Thereof. WIPO patent application, Sep 2016. URL: https://patentscope.wipo.int/search/en/detail.jsf?docId=WO2016149710. Application number PCT/US2016/023488. Show all entries for this paper.

Kumar2018 Amit Kumar, Claire E. P. Smith, Elena E. Giorgi, Joshua Eudailey, David R. Martinez, Karina Yusim, Ayooluwa O. Douglas, Lisa Stamper, Erin McGuire, Celia C. LaBranche, David C. Montefiori, Genevieve G. Fouda, Feng Gao, and Sallie R. Permar. Infant Transmitted/Founder HIV-1 Viruses from Peripartum Transmission Are Neutralization Resistant to Paired Maternal Plasma. PLoS Pathog., 14(4):e1006944, Apr 2018. PubMed ID: 29672607. Show all entries for this paper.

Wiehe2018 Kevin Wiehe, Todd Bradley, R. Ryan Meyerhoff, Connor Hart, Wilton B. Williams, David Easterhoff, William J. Faison, Thomas B. Kepler, Kevin O. Saunders, S. Munir Alam, Mattia Bonsignori, and Barton F. Haynes. Functional Relevance of Improbable Antibody Mutations for HIV Broadly Neutralizing Antibody Development. Cell Host Microbe, 23(6):759-765.e6, 13 Jun 2018. PubMed ID: 29861171. Show all entries for this paper.

Zhang2019a Lei Zhang, Adriana Irimia, Lingling He, Elise Landais, Kimmo Rantalainen, Daniel P. Leaman, Thomas Vollbrecht, Armando Stano, Daniel I. Sands, Arthur S. Kim, IAVI Protocol G Investigators, Pascal Poignard, Dennis R. Burton, Ben Murrell, Andrew B. Ward, Jiang Zhu, Ian A. Wilson, and Michael B. Zwick. An MPER Antibody Neutralizes HIV-1 Using Germline Features Shared Among Donors. Nat. Commun., 10(1):5389, 26 Nov 2019. PubMed ID: 31772165. Show all entries for this paper.


Displaying record number 3657

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MAb ID DH511.2_K3 (DH511.2 K3, DH511 K3)
HXB2 Location Env Env Epitope Map
Author Location gp120
Epitope
Subtype C
Ab Type gp41 MPER (membrane proximal external region)
Neutralizing P (tier 2)  View neutralization details
Contacts and Features View contacts and features
Species (Isotype) human(IgG)
Patient CH0210
Immunogen HIV-1 infection
Country South Africa
Keywords antibody binding site, antibody generation, antibody lineage, antibody polyreactivity, antibody sequence, binding affinity, broad neutralizer, chimeric antibody, computational prediction, effector function, neutralization, structure, vaccine antigen design, vaccine-induced immune responses

Notes

Showing 6 of 6 notes.

References

Showing 6 of 6 references.

Isolation Paper
Williams2017 LaTonya D. Williams, Gilad Ofek, Sebastian Schätzle, Jonathan R. McDaniel, Xiaozhi Lu, Nathan I. Nicely, Liming Wu, Caleb S. Lougheed, Todd Bradley, Mark K. Louder, Krisha McKee, Robert T. Bailer, Sijy O'Dell, Ivelin S. Georgiev, Michael S. Seaman, Robert J. Parks, Dawn J. Marshall, Kara Anasti, Guang Yang, Xiaoyan Nie, Nancy L. Tumba, Kevin Wiehe, Kshitij Wagh, Bette Korber, Thomas B. Kepler, S. Munir Alam, Lynn Morris, Gift Kamanga, Myron S. Cohen, Mattia Bonsignori, Shi-Mao Xia, David C. Montefiori, Garnett Kelsoe, Feng Gao, John R. Mascola, M. Anthony Moody, Kevin O. Saunders, Hua-Xin Liao, Georgia D. Tomaras, George Georgiou, and Barton F. Haynes. Potent and Broad HIV-Neutralizing Antibodies in Memory B Cells and Plasma. Sci. Immunol., 2(7), 27 Jan 2017. PubMed ID: 28783671. Show all entries for this paper.

Bricault2019 Christine A. Bricault, Karina Yusim, Michael S. Seaman, Hyejin Yoon, James Theiler, Elena E. Giorgi, Kshitij Wagh, Maxwell Theiler, Peter Hraber, Jennifer P. Macke, Edward F. Kreider, Gerald H. Learn, Beatrice H. Hahn, Johannes F. Scheid, James M. Kovacs, Jennifer L. Shields, Christy L. Lavine, Fadi Ghantous, Michael Rist, Madeleine G. Bayne, George H. Neubauer, Katherine McMahan, Hanqin Peng, Coraline Chéneau, Jennifer J. Jones, Jie Zeng, Christina Ochsenbauer, Joseph P. Nkolola, Kathryn E. Stephenson, Bing Chen, S. Gnanakaran, Mattia Bonsignori, LaTonya D. Williams, Barton F. Haynes, Nicole Doria-Rose, John R. Mascola, David C. Montefiori, Dan H. Barouch, and Bette Korber. HIV-1 Neutralizing Antibody Signatures and Application to Epitope-Targeted Vaccine Design. Cell Host Microbe, 25(1):59-72.e8, 9 Jan 2019. PubMed ID: 30629920. Show all entries for this paper.

Haynes2016a B. F. Haynes, H. X. Liao, M. A. Moody, L. Williams, K. J. Wiehe, and G. A. Ofek. HIV-1 Neutralizing Antibodies and Uses Thereof. WIPO patent application, Sep 2016. URL: https://patentscope.wipo.int/search/en/detail.jsf?docId=WO2016149710. Application number PCT/US2016/023488. Show all entries for this paper.

Schorcht2020 Anna Schorcht, Tom L. G. M. van den Kerkhof, Christopher A. Cottrell, Joel D. Allen, Jonathan L. Torres, Anna-Janina Behrens, Edith E. Schermer, Judith A. Burger, Steven W. de Taeye, Alba Torrents de la Peña, Ilja Bontjer, Stephanie Gumbs, Gabriel Ozorowski, Celia C. LaBranche, Natalia de Val, Anila Yasmeen, Per Johan Klasse, David C. Montefiori, John P. Moore, Hanneke Schuitemaker, Max Crispin, Marit J. van Gils, Andrew B. Ward, and Rogier W. Sanders. Neutralizing Antibody Responses Induced by HIV-1 Envelope Glycoprotein SOSIP Trimers Derived from Elite Neutralizers. J. Virol., 94(24), 23 Nov 2020. PubMed ID: 32999024. Show all entries for this paper.

Berendam2021 Stella J. Berendam, Tiffany M. Styles, Papa K.. Morgan-Asiedu, DeAnna Tenney, Amit Kumar, Veronica Obregon-Perko, Katharine J. Bar, Kevin O. Saunders, Sampa Santra, Kristina De Paris, Georgia D. Tomaras, Ann Chahroudi, Sallie R. Permar, Rama R. Amara, and Genevieve G. Fouda. Systematic Assessment of Antiviral Potency, Breadth, and Synergy of Triple Broadly Neutralizing Antibody Combinations against Simian-Human Immunodeficiency Viruses. J. Virol., 95(3), 13 Jan 2021. PubMed ID: 33177194. Show all entries for this paper.

Sliepen2019 Kwinten Sliepen, Byung Woo Han, Ilja Bontjer, Petra Mooij, Fernando Garces, Anna-Janina Behrens, Kimmo Rantalainen, Sonu Kumar, Anita Sarkar, Philip J. M. Brouwer, Yuanzi Hua, Monica Tolazzi, Edith Schermer, Jonathan L. Torres, Gabriel Ozorowski, Patricia van der Woude, Alba Torrents de la Pena, Marielle J. van Breemen, Juan Miguel Camacho-Sanchez, Judith A. Burger, Max Medina-Ramirez, Nuria Gonzalez, Jose Alcami, Celia LaBranche, Gabriella Scarlatti, Marit J. van Gils, Max Crispin, David C. Montefiori, Andrew B. Ward, Gerrit Koopman, John P. Moore, Robin J. Shattock, Willy M. Bogers, Ian A. Wilson, and Rogier W. Sanders. Structure and immunogenicity of a stabilized HIV-1 envelope trimer based on a group-M consensus sequence. Nat Commun, 10(1):2355 doi, May 2019. PubMed ID: 31142746 Show all entries for this paper.


Displaying record number 3665

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MAb ID DH517 (Ab510053)
HXB2 Location Env Env Epitope Map
Author Location gp41
Epitope
Ab Type gp41 MPER (membrane proximal external region)
Neutralizing P (tier 2)  View neutralization details
Species (Isotype) human(IgG)
Patient CH0210
Immunogen HIV-1 infection
Keywords antibody generation, antibody lineage, contact residues, germline, neutralization, structure

Notes

Showing 3 of 3 notes.

References

Showing 3 of 3 references.

Isolation Paper
Williams2017 LaTonya D. Williams, Gilad Ofek, Sebastian Schätzle, Jonathan R. McDaniel, Xiaozhi Lu, Nathan I. Nicely, Liming Wu, Caleb S. Lougheed, Todd Bradley, Mark K. Louder, Krisha McKee, Robert T. Bailer, Sijy O'Dell, Ivelin S. Georgiev, Michael S. Seaman, Robert J. Parks, Dawn J. Marshall, Kara Anasti, Guang Yang, Xiaoyan Nie, Nancy L. Tumba, Kevin Wiehe, Kshitij Wagh, Bette Korber, Thomas B. Kepler, S. Munir Alam, Lynn Morris, Gift Kamanga, Myron S. Cohen, Mattia Bonsignori, Shi-Mao Xia, David C. Montefiori, Garnett Kelsoe, Feng Gao, John R. Mascola, M. Anthony Moody, Kevin O. Saunders, Hua-Xin Liao, Georgia D. Tomaras, George Georgiou, and Barton F. Haynes. Potent and Broad HIV-Neutralizing Antibodies in Memory B Cells and Plasma. Sci. Immunol., 2(7), 27 Jan 2017. PubMed ID: 28783671. Show all entries for this paper.

Haynes2016a B. F. Haynes, H. X. Liao, M. A. Moody, L. Williams, K. J. Wiehe, and G. A. Ofek. HIV-1 Neutralizing Antibodies and Uses Thereof. WIPO patent application, Sep 2016. URL: https://patentscope.wipo.int/search/en/detail.jsf?docId=WO2016149710. Application number PCT/US2016/023488. Show all entries for this paper.

Zhang2019a Lei Zhang, Adriana Irimia, Lingling He, Elise Landais, Kimmo Rantalainen, Daniel P. Leaman, Thomas Vollbrecht, Armando Stano, Daniel I. Sands, Arthur S. Kim, IAVI Protocol G Investigators, Pascal Poignard, Dennis R. Burton, Ben Murrell, Andrew B. Ward, Jiang Zhu, Ian A. Wilson, and Michael B. Zwick. An MPER Antibody Neutralizes HIV-1 Using Germline Features Shared Among Donors. Nat. Commun., 10(1):5389, 26 Nov 2019. PubMed ID: 31772165. Show all entries for this paper.


Displaying record number 3847

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MAb ID DH511.1 (DH511)
HXB2 Location Env Env Epitope Map
Author Location gp120
Epitope
Subtype C
Ab Type gp41 MPER (membrane proximal external region)
Neutralizing P (tier 2)  View neutralization details
Species (Isotype) human(IgG)
Patient CH0210
Immunogen HIV-1 infection
Country South Africa
Keywords antibody binding site, antibody generation, antibody lineage, antibody polyreactivity, antibody sequence, broad neutralizer, neutralization, structure

Notes

Showing 5 of 5 notes.

References

Showing 5 of 5 references.

Isolation Paper
Williams2017 LaTonya D. Williams, Gilad Ofek, Sebastian Schätzle, Jonathan R. McDaniel, Xiaozhi Lu, Nathan I. Nicely, Liming Wu, Caleb S. Lougheed, Todd Bradley, Mark K. Louder, Krisha McKee, Robert T. Bailer, Sijy O'Dell, Ivelin S. Georgiev, Michael S. Seaman, Robert J. Parks, Dawn J. Marshall, Kara Anasti, Guang Yang, Xiaoyan Nie, Nancy L. Tumba, Kevin Wiehe, Kshitij Wagh, Bette Korber, Thomas B. Kepler, S. Munir Alam, Lynn Morris, Gift Kamanga, Myron S. Cohen, Mattia Bonsignori, Shi-Mao Xia, David C. Montefiori, Garnett Kelsoe, Feng Gao, John R. Mascola, M. Anthony Moody, Kevin O. Saunders, Hua-Xin Liao, Georgia D. Tomaras, George Georgiou, and Barton F. Haynes. Potent and Broad HIV-Neutralizing Antibodies in Memory B Cells and Plasma. Sci. Immunol., 2(7), 27 Jan 2017. PubMed ID: 28783671. Show all entries for this paper.

Henderson2019 Rory Henderson, Brian E. Watts, Hieu N. Ergin, Kara Anasti, Robert Parks, Shi-Mao Xia, Ashley Trama, Hua-Xin Liao, Kevin O. Saunders, Mattia Bonsignori, Kevin Wiehe, Barton F. Haynes, and S. Munir Alam. Selection of Immunoglobulin Elbow Region Mutations Impacts Interdomain Conformational Flexibility in HIV-1 Broadly Neutralizing Antibodies. Nat. Commun., 10(1):654, 8 Feb 2019. PubMed ID: 30737386. Show all entries for this paper.

Krebs2019 Shelly J. Krebs, Young D. Kwon, Chaim A. Schramm, William H. Law, Gina Donofrio, Kenneth H. Zhou, Syna Gift, Vincent Dussupt, Ivelin S. Georgiev, Sebastian Schätzle, Jonathan R. McDaniel, Yen-Ting Lai, Mallika Sastry, Baoshan Zhang, Marissa C. Jarosinski, Amy Ransier, Agnes L. Chenine, Mangaiarkarasi Asokan, Robert T. Bailer, Meera Bose, Alberto Cagigi, Evan M. Cale, Gwo-Yu Chuang, Samuel Darko, Jefferson I. Driscoll, Aliaksandr Druz, Jason Gorman, Farida Laboune, Mark K. Louder, Krisha McKee, Letzibeth Mendez, M. Anthony Moody, Anne Marie O'Sullivan, Christopher Owen, Dongjun Peng, Reda Rawi, Eric Sanders-Buell, Chen-Hsiang Shen, Andrea R. Shiakolas, Tyler Stephens, Yaroslav Tsybovsky, Courtney Tucker, Raffaello Verardi, Keyun Wang, Jing Zhou, Tongqing Zhou, George Georgiou, S Munir Alam, Barton F. Haynes, Morgane Rolland, Gary R. Matyas, Victoria R. Polonis, Adrian B. McDermott, Daniel C. Douek, Lawrence Shapiro, Sodsai Tovanabutra, Nelson L. Michael, John R. Mascola, Merlin L. Robb, Peter D. Kwong, and Nicole A. Doria-Rose. Longitudinal Analysis Reveals Early Development of Three MPER-Directed Neutralizing Antibody Lineages from an HIV-1-Infected Individual. Immunity, 50(3):677-691.e13, 19 Mar 2019. PubMed ID: 30876875. Show all entries for this paper.

Pinto2019 Dora Pinto, Craig Fenwick, Christophe Caillat, Chiara Silacci, Serafima Guseva, François Dehez, Christophe Chipot, Sonia Barbieri, Andrea Minola, David Jarrossay, Georgia D. Tomaras, Xiaoying Shen, Agostino Riva, Maciej Tarkowski, Olivier Schwartz, Timothée Bruel, Jérémy Dufloo, Michael S. Seaman, David C. Montefiori, Antonio Lanzavecchia, Davide Corti, Giuseppe Pantaleo, and Winfried Weissenhorn. Structural Basis for Broad HIV-1 Neutralization by the MPER-Specific Human Broadly Neutralizing Antibody LN01. Cell Host Microbe, 26(5):623-637.e8, 13 Nov 2019. PubMed ID: 31653484. Show all entries for this paper.

Haynes2016a B. F. Haynes, H. X. Liao, M. A. Moody, L. Williams, K. J. Wiehe, and G. A. Ofek. HIV-1 Neutralizing Antibodies and Uses Thereof. WIPO patent application, Sep 2016. URL: https://patentscope.wipo.int/search/en/detail.jsf?docId=WO2016149710. Application number PCT/US2016/023488. Show all entries for this paper.


Displaying record number 3848

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MAb ID DH511.3 (DH513)
HXB2 Location Env Env Epitope Map
Author Location gp120
Epitope
Subtype C
Ab Type gp41 MPER (membrane proximal external region)
Neutralizing P (tier 2)  View neutralization details
Species (Isotype) human(IgG)
Patient CH0210
Immunogen HIV-1 infection
Country South Africa
Keywords antibody generation, antibody lineage, antibody polyreactivity, antibody sequence, broad neutralizer, neutralization

Notes

Showing 2 of 2 notes.

References

Showing 2 of 2 references.

Isolation Paper
Williams2017 LaTonya D. Williams, Gilad Ofek, Sebastian Schätzle, Jonathan R. McDaniel, Xiaozhi Lu, Nathan I. Nicely, Liming Wu, Caleb S. Lougheed, Todd Bradley, Mark K. Louder, Krisha McKee, Robert T. Bailer, Sijy O'Dell, Ivelin S. Georgiev, Michael S. Seaman, Robert J. Parks, Dawn J. Marshall, Kara Anasti, Guang Yang, Xiaoyan Nie, Nancy L. Tumba, Kevin Wiehe, Kshitij Wagh, Bette Korber, Thomas B. Kepler, S. Munir Alam, Lynn Morris, Gift Kamanga, Myron S. Cohen, Mattia Bonsignori, Shi-Mao Xia, David C. Montefiori, Garnett Kelsoe, Feng Gao, John R. Mascola, M. Anthony Moody, Kevin O. Saunders, Hua-Xin Liao, Georgia D. Tomaras, George Georgiou, and Barton F. Haynes. Potent and Broad HIV-Neutralizing Antibodies in Memory B Cells and Plasma. Sci. Immunol., 2(7), 27 Jan 2017. PubMed ID: 28783671. Show all entries for this paper.

Haynes2016a B. F. Haynes, H. X. Liao, M. A. Moody, L. Williams, K. J. Wiehe, and G. A. Ofek. HIV-1 Neutralizing Antibodies and Uses Thereof. WIPO patent application, Sep 2016. URL: https://patentscope.wipo.int/search/en/detail.jsf?docId=WO2016149710. Application number PCT/US2016/023488. Show all entries for this paper.


Displaying record number 3849

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MAb ID DH511.4 (DH514)
HXB2 Location Env Env Epitope Map
Author Location gp120
Epitope
Subtype C
Ab Type gp41 MPER (membrane proximal external region)
Neutralizing P (tier 2)  View neutralization details
Species (Isotype) human(IgG)
Patient CH0210
Immunogen HIV-1 infection
Country South Africa
Keywords antibody generation, antibody lineage, antibody polyreactivity, antibody sequence, broad neutralizer, neutralization, structure

Notes

Showing 2 of 2 notes.

References

Showing 2 of 2 references.

Isolation Paper
Williams2017 LaTonya D. Williams, Gilad Ofek, Sebastian Schätzle, Jonathan R. McDaniel, Xiaozhi Lu, Nathan I. Nicely, Liming Wu, Caleb S. Lougheed, Todd Bradley, Mark K. Louder, Krisha McKee, Robert T. Bailer, Sijy O'Dell, Ivelin S. Georgiev, Michael S. Seaman, Robert J. Parks, Dawn J. Marshall, Kara Anasti, Guang Yang, Xiaoyan Nie, Nancy L. Tumba, Kevin Wiehe, Kshitij Wagh, Bette Korber, Thomas B. Kepler, S. Munir Alam, Lynn Morris, Gift Kamanga, Myron S. Cohen, Mattia Bonsignori, Shi-Mao Xia, David C. Montefiori, Garnett Kelsoe, Feng Gao, John R. Mascola, M. Anthony Moody, Kevin O. Saunders, Hua-Xin Liao, Georgia D. Tomaras, George Georgiou, and Barton F. Haynes. Potent and Broad HIV-Neutralizing Antibodies in Memory B Cells and Plasma. Sci. Immunol., 2(7), 27 Jan 2017. PubMed ID: 28783671. Show all entries for this paper.

Haynes2016a B. F. Haynes, H. X. Liao, M. A. Moody, L. Williams, K. J. Wiehe, and G. A. Ofek. HIV-1 Neutralizing Antibodies and Uses Thereof. WIPO patent application, Sep 2016. URL: https://patentscope.wipo.int/search/en/detail.jsf?docId=WO2016149710. Application number PCT/US2016/023488. Show all entries for this paper.


Displaying record number 3850

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MAb ID DH511.5 (DH515)
HXB2 Location Env Env Epitope Map
Author Location gp120
Epitope
Subtype C
Ab Type gp41 MPER (membrane proximal external region)
Neutralizing P (tier 2)  View neutralization details
Species (Isotype) human(IgG)
Patient CH0210
Immunogen HIV-1 infection
Country South Africa
Keywords antibody generation, antibody lineage, antibody polyreactivity, antibody sequence, broad neutralizer, neutralization

Notes

Showing 2 of 2 notes.

References

Showing 2 of 2 references.

Isolation Paper
Williams2017 LaTonya D. Williams, Gilad Ofek, Sebastian Schätzle, Jonathan R. McDaniel, Xiaozhi Lu, Nathan I. Nicely, Liming Wu, Caleb S. Lougheed, Todd Bradley, Mark K. Louder, Krisha McKee, Robert T. Bailer, Sijy O'Dell, Ivelin S. Georgiev, Michael S. Seaman, Robert J. Parks, Dawn J. Marshall, Kara Anasti, Guang Yang, Xiaoyan Nie, Nancy L. Tumba, Kevin Wiehe, Kshitij Wagh, Bette Korber, Thomas B. Kepler, S. Munir Alam, Lynn Morris, Gift Kamanga, Myron S. Cohen, Mattia Bonsignori, Shi-Mao Xia, David C. Montefiori, Garnett Kelsoe, Feng Gao, John R. Mascola, M. Anthony Moody, Kevin O. Saunders, Hua-Xin Liao, Georgia D. Tomaras, George Georgiou, and Barton F. Haynes. Potent and Broad HIV-Neutralizing Antibodies in Memory B Cells and Plasma. Sci. Immunol., 2(7), 27 Jan 2017. PubMed ID: 28783671. Show all entries for this paper.

Haynes2016a B. F. Haynes, H. X. Liao, M. A. Moody, L. Williams, K. J. Wiehe, and G. A. Ofek. HIV-1 Neutralizing Antibodies and Uses Thereof. WIPO patent application, Sep 2016. URL: https://patentscope.wipo.int/search/en/detail.jsf?docId=WO2016149710. Application number PCT/US2016/023488. Show all entries for this paper.


Displaying record number 3851

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MAb ID DH511.6 (DH516)
HXB2 Location Env Env Epitope Map
Author Location gp120
Epitope
Subtype C
Ab Type gp41 MPER (membrane proximal external region)
Neutralizing P (tier 2)  View neutralization details
Species (Isotype) human(IgG)
Patient CH0210
Immunogen HIV-1 infection
Country South Africa
Keywords antibody generation, antibody lineage, antibody polyreactivity, antibody sequence, broad neutralizer, neutralization

Notes

Showing 2 of 2 notes.

References

Showing 2 of 2 references.

Isolation Paper
Williams2017 LaTonya D. Williams, Gilad Ofek, Sebastian Schätzle, Jonathan R. McDaniel, Xiaozhi Lu, Nathan I. Nicely, Liming Wu, Caleb S. Lougheed, Todd Bradley, Mark K. Louder, Krisha McKee, Robert T. Bailer, Sijy O'Dell, Ivelin S. Georgiev, Michael S. Seaman, Robert J. Parks, Dawn J. Marshall, Kara Anasti, Guang Yang, Xiaoyan Nie, Nancy L. Tumba, Kevin Wiehe, Kshitij Wagh, Bette Korber, Thomas B. Kepler, S. Munir Alam, Lynn Morris, Gift Kamanga, Myron S. Cohen, Mattia Bonsignori, Shi-Mao Xia, David C. Montefiori, Garnett Kelsoe, Feng Gao, John R. Mascola, M. Anthony Moody, Kevin O. Saunders, Hua-Xin Liao, Georgia D. Tomaras, George Georgiou, and Barton F. Haynes. Potent and Broad HIV-Neutralizing Antibodies in Memory B Cells and Plasma. Sci. Immunol., 2(7), 27 Jan 2017. PubMed ID: 28783671. Show all entries for this paper.

Haynes2016a B. F. Haynes, H. X. Liao, M. A. Moody, L. Williams, K. J. Wiehe, and G. A. Ofek. HIV-1 Neutralizing Antibodies and Uses Thereof. WIPO patent application, Sep 2016. URL: https://patentscope.wipo.int/search/en/detail.jsf?docId=WO2016149710. Application number PCT/US2016/023488. Show all entries for this paper.


Displaying record number 3852

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MAb ID DH511.7P
HXB2 Location Env Env Epitope Map
Author Location gp120
Epitope
Subtype C
Ab Type gp41 MPER (membrane proximal external region)
Neutralizing P (tier 2)  View neutralization details
Species (Isotype) human(IgG)
Patient CH0210
Immunogen HIV-1 infection
Country South Africa
Keywords antibody generation, antibody lineage, antibody polyreactivity, antibody sequence, broad neutralizer, neutralization

Notes

Showing 1 of 1 note.

References

Showing 1 of 1 reference.

Isolation Paper
Williams2017 LaTonya D. Williams, Gilad Ofek, Sebastian Schätzle, Jonathan R. McDaniel, Xiaozhi Lu, Nathan I. Nicely, Liming Wu, Caleb S. Lougheed, Todd Bradley, Mark K. Louder, Krisha McKee, Robert T. Bailer, Sijy O'Dell, Ivelin S. Georgiev, Michael S. Seaman, Robert J. Parks, Dawn J. Marshall, Kara Anasti, Guang Yang, Xiaoyan Nie, Nancy L. Tumba, Kevin Wiehe, Kshitij Wagh, Bette Korber, Thomas B. Kepler, S. Munir Alam, Lynn Morris, Gift Kamanga, Myron S. Cohen, Mattia Bonsignori, Shi-Mao Xia, David C. Montefiori, Garnett Kelsoe, Feng Gao, John R. Mascola, M. Anthony Moody, Kevin O. Saunders, Hua-Xin Liao, Georgia D. Tomaras, George Georgiou, and Barton F. Haynes. Potent and Broad HIV-Neutralizing Antibodies in Memory B Cells and Plasma. Sci. Immunol., 2(7), 27 Jan 2017. PubMed ID: 28783671. Show all entries for this paper.


Displaying record number 3853

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MAb ID DH511.8P
HXB2 Location Env Env Epitope Map
Author Location gp120
Epitope
Subtype C
Ab Type gp41 MPER (membrane proximal external region)
Neutralizing P (tier 2)  View neutralization details
Species (Isotype) human(IgG)
Patient CH0210
Immunogen HIV-1 infection
Country South Africa
Keywords antibody generation, antibody lineage, antibody polyreactivity, antibody sequence, broad neutralizer, neutralization

Notes

Showing 1 of 1 note.

References

Showing 1 of 1 reference.

Isolation Paper
Williams2017 LaTonya D. Williams, Gilad Ofek, Sebastian Schätzle, Jonathan R. McDaniel, Xiaozhi Lu, Nathan I. Nicely, Liming Wu, Caleb S. Lougheed, Todd Bradley, Mark K. Louder, Krisha McKee, Robert T. Bailer, Sijy O'Dell, Ivelin S. Georgiev, Michael S. Seaman, Robert J. Parks, Dawn J. Marshall, Kara Anasti, Guang Yang, Xiaoyan Nie, Nancy L. Tumba, Kevin Wiehe, Kshitij Wagh, Bette Korber, Thomas B. Kepler, S. Munir Alam, Lynn Morris, Gift Kamanga, Myron S. Cohen, Mattia Bonsignori, Shi-Mao Xia, David C. Montefiori, Garnett Kelsoe, Feng Gao, John R. Mascola, M. Anthony Moody, Kevin O. Saunders, Hua-Xin Liao, Georgia D. Tomaras, George Georgiou, and Barton F. Haynes. Potent and Broad HIV-Neutralizing Antibodies in Memory B Cells and Plasma. Sci. Immunol., 2(7), 27 Jan 2017. PubMed ID: 28783671. Show all entries for this paper.


Displaying record number 3854

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MAb ID DH511.9P
HXB2 Location Env Env Epitope Map
Author Location gp120
Epitope
Subtype C
Ab Type gp41 MPER (membrane proximal external region)
Neutralizing P (tier 2)  View neutralization details
Species (Isotype) human(IgG)
Patient CH0210
Immunogen HIV-1 infection
Country South Africa
Keywords antibody generation, antibody lineage, antibody polyreactivity, antibody sequence, broad neutralizer, neutralization

Notes

Showing 1 of 1 note.

References

Showing 1 of 1 reference.

Isolation Paper
Williams2017 LaTonya D. Williams, Gilad Ofek, Sebastian Schätzle, Jonathan R. McDaniel, Xiaozhi Lu, Nathan I. Nicely, Liming Wu, Caleb S. Lougheed, Todd Bradley, Mark K. Louder, Krisha McKee, Robert T. Bailer, Sijy O'Dell, Ivelin S. Georgiev, Michael S. Seaman, Robert J. Parks, Dawn J. Marshall, Kara Anasti, Guang Yang, Xiaoyan Nie, Nancy L. Tumba, Kevin Wiehe, Kshitij Wagh, Bette Korber, Thomas B. Kepler, S. Munir Alam, Lynn Morris, Gift Kamanga, Myron S. Cohen, Mattia Bonsignori, Shi-Mao Xia, David C. Montefiori, Garnett Kelsoe, Feng Gao, John R. Mascola, M. Anthony Moody, Kevin O. Saunders, Hua-Xin Liao, Georgia D. Tomaras, George Georgiou, and Barton F. Haynes. Potent and Broad HIV-Neutralizing Antibodies in Memory B Cells and Plasma. Sci. Immunol., 2(7), 27 Jan 2017. PubMed ID: 28783671. Show all entries for this paper.


Displaying record number 3855

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MAb ID DH511.10P
HXB2 Location Env Env Epitope Map
Author Location gp120
Epitope
Subtype C
Ab Type gp41 MPER (membrane proximal external region)
Neutralizing P (tier 2)  View neutralization details
Species (Isotype) human(IgG)
Patient CH0210
Immunogen HIV-1 infection
Country South Africa
Keywords antibody generation, antibody lineage, antibody polyreactivity, antibody sequence, broad neutralizer, neutralization

Notes

Showing 1 of 1 note.

References

Showing 1 of 1 reference.

Isolation Paper
Williams2017 LaTonya D. Williams, Gilad Ofek, Sebastian Schätzle, Jonathan R. McDaniel, Xiaozhi Lu, Nathan I. Nicely, Liming Wu, Caleb S. Lougheed, Todd Bradley, Mark K. Louder, Krisha McKee, Robert T. Bailer, Sijy O'Dell, Ivelin S. Georgiev, Michael S. Seaman, Robert J. Parks, Dawn J. Marshall, Kara Anasti, Guang Yang, Xiaoyan Nie, Nancy L. Tumba, Kevin Wiehe, Kshitij Wagh, Bette Korber, Thomas B. Kepler, S. Munir Alam, Lynn Morris, Gift Kamanga, Myron S. Cohen, Mattia Bonsignori, Shi-Mao Xia, David C. Montefiori, Garnett Kelsoe, Feng Gao, John R. Mascola, M. Anthony Moody, Kevin O. Saunders, Hua-Xin Liao, Georgia D. Tomaras, George Georgiou, and Barton F. Haynes. Potent and Broad HIV-Neutralizing Antibodies in Memory B Cells and Plasma. Sci. Immunol., 2(7), 27 Jan 2017. PubMed ID: 28783671. Show all entries for this paper.


Displaying record number 3856

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MAb ID DH511.11P
HXB2 Location Env Env Epitope Map
Author Location gp120
Epitope
Subtype C
Ab Type gp41 MPER (membrane proximal external region)
Neutralizing P (tier 2)  View neutralization details
Species (Isotype) human(IgG)
Patient CH0210
Immunogen HIV-1 infection
Country South Africa
Keywords antibody generation, antibody lineage, antibody polyreactivity, antibody sequence, broad neutralizer, neutralization

Notes

Showing 1 of 1 note.

References

Showing 2 of 2 reference.

Isolation Paper
Williams2017 LaTonya D. Williams, Gilad Ofek, Sebastian Schätzle, Jonathan R. McDaniel, Xiaozhi Lu, Nathan I. Nicely, Liming Wu, Caleb S. Lougheed, Todd Bradley, Mark K. Louder, Krisha McKee, Robert T. Bailer, Sijy O'Dell, Ivelin S. Georgiev, Michael S. Seaman, Robert J. Parks, Dawn J. Marshall, Kara Anasti, Guang Yang, Xiaoyan Nie, Nancy L. Tumba, Kevin Wiehe, Kshitij Wagh, Bette Korber, Thomas B. Kepler, S. Munir Alam, Lynn Morris, Gift Kamanga, Myron S. Cohen, Mattia Bonsignori, Shi-Mao Xia, David C. Montefiori, Garnett Kelsoe, Feng Gao, John R. Mascola, M. Anthony Moody, Kevin O. Saunders, Hua-Xin Liao, Georgia D. Tomaras, George Georgiou, and Barton F. Haynes. Potent and Broad HIV-Neutralizing Antibodies in Memory B Cells and Plasma. Sci. Immunol., 2(7), 27 Jan 2017. PubMed ID: 28783671. Show all entries for this paper.

Kreer2023 Christoph Kreer, Cosimo Lupo, Meryem S. Ercanoglu, Lutz Gieselmann, Natanael Spisak, Jan Grossbach, Maike Schlotz, Philipp Schommers, Henning Gruell, Leona Dold, Andreas Beyer, Armita Nourmohammad, Thierry Mora, Aleksandra M. Walczak, and Florian Klein. Probabilities of developing HIV-1 bNAb sequence features in uninfected and chronically infected individuals. Nat Commun, 14(1):7137 doi, Nov 2023. PubMed ID: 37932288 Show all entries for this paper.


Displaying record number 3857

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MAb ID DH511.12P
HXB2 Location Env Env Epitope Map
Author Location gp120
Epitope
Subtype C
Ab Type gp41 MPER (membrane proximal external region)
Neutralizing P (tier 2)  View neutralization details
Species (Isotype) human(IgG)
Patient CH0210
Immunogen HIV-1 infection
Country South Africa
Keywords antibody generation, antibody lineage, antibody polyreactivity, antibody sequence, broad neutralizer, neutralization

Notes

Showing 1 of 1 note.

References

Showing 1 of 1 reference.

Isolation Paper
Williams2017 LaTonya D. Williams, Gilad Ofek, Sebastian Schätzle, Jonathan R. McDaniel, Xiaozhi Lu, Nathan I. Nicely, Liming Wu, Caleb S. Lougheed, Todd Bradley, Mark K. Louder, Krisha McKee, Robert T. Bailer, Sijy O'Dell, Ivelin S. Georgiev, Michael S. Seaman, Robert J. Parks, Dawn J. Marshall, Kara Anasti, Guang Yang, Xiaoyan Nie, Nancy L. Tumba, Kevin Wiehe, Kshitij Wagh, Bette Korber, Thomas B. Kepler, S. Munir Alam, Lynn Morris, Gift Kamanga, Myron S. Cohen, Mattia Bonsignori, Shi-Mao Xia, David C. Montefiori, Garnett Kelsoe, Feng Gao, John R. Mascola, M. Anthony Moody, Kevin O. Saunders, Hua-Xin Liao, Georgia D. Tomaras, George Georgiou, and Barton F. Haynes. Potent and Broad HIV-Neutralizing Antibodies in Memory B Cells and Plasma. Sci. Immunol., 2(7), 27 Jan 2017. PubMed ID: 28783671. Show all entries for this paper.


Displaying record number 4185

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MAb ID DH511_I1
HXB2 Location Env Env Epitope Map
Author Location gp120
Epitope
Subtype C
Ab Type gp41 MPER (membrane proximal external region)
Neutralizing yes, tier 2  View neutralization details
Species (Isotype) human(IgG)
Patient CH0210
Immunogen HIV-1 infection
Country South Africa
Keywords antibody generation, antibody lineage, antibody polyreactivity, antibody sequence, broad neutralizer, neutralization

Notes

Showing 1 of 1 note.

References

Showing 1 of 1 reference.

Isolation Paper
Williams2017 LaTonya D. Williams, Gilad Ofek, Sebastian Schätzle, Jonathan R. McDaniel, Xiaozhi Lu, Nathan I. Nicely, Liming Wu, Caleb S. Lougheed, Todd Bradley, Mark K. Louder, Krisha McKee, Robert T. Bailer, Sijy O'Dell, Ivelin S. Georgiev, Michael S. Seaman, Robert J. Parks, Dawn J. Marshall, Kara Anasti, Guang Yang, Xiaoyan Nie, Nancy L. Tumba, Kevin Wiehe, Kshitij Wagh, Bette Korber, Thomas B. Kepler, S. Munir Alam, Lynn Morris, Gift Kamanga, Myron S. Cohen, Mattia Bonsignori, Shi-Mao Xia, David C. Montefiori, Garnett Kelsoe, Feng Gao, John R. Mascola, M. Anthony Moody, Kevin O. Saunders, Hua-Xin Liao, Georgia D. Tomaras, George Georgiou, and Barton F. Haynes. Potent and Broad HIV-Neutralizing Antibodies in Memory B Cells and Plasma. Sci. Immunol., 2(7), 27 Jan 2017. PubMed ID: 28783671. Show all entries for this paper.


Displaying record number 4186

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MAb ID DH511_I2
HXB2 Location Env Env Epitope Map
Author Location gp120
Epitope
Subtype C
Ab Type gp41 MPER (membrane proximal external region)
Neutralizing yes, tier 2  View neutralization details
Species (Isotype) human(IgG)
Patient CH0210
Immunogen HIV-1 infection
Country South Africa
Keywords antibody generation, antibody lineage, antibody polyreactivity, antibody sequence, broad neutralizer, neutralization

Notes

Showing 1 of 1 note.

References

Showing 1 of 1 reference.

Isolation Paper
Williams2017 LaTonya D. Williams, Gilad Ofek, Sebastian Schätzle, Jonathan R. McDaniel, Xiaozhi Lu, Nathan I. Nicely, Liming Wu, Caleb S. Lougheed, Todd Bradley, Mark K. Louder, Krisha McKee, Robert T. Bailer, Sijy O'Dell, Ivelin S. Georgiev, Michael S. Seaman, Robert J. Parks, Dawn J. Marshall, Kara Anasti, Guang Yang, Xiaoyan Nie, Nancy L. Tumba, Kevin Wiehe, Kshitij Wagh, Bette Korber, Thomas B. Kepler, S. Munir Alam, Lynn Morris, Gift Kamanga, Myron S. Cohen, Mattia Bonsignori, Shi-Mao Xia, David C. Montefiori, Garnett Kelsoe, Feng Gao, John R. Mascola, M. Anthony Moody, Kevin O. Saunders, Hua-Xin Liao, Georgia D. Tomaras, George Georgiou, and Barton F. Haynes. Potent and Broad HIV-Neutralizing Antibodies in Memory B Cells and Plasma. Sci. Immunol., 2(7), 27 Jan 2017. PubMed ID: 28783671. Show all entries for this paper.


Displaying record number 4187

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MAb ID DH511_I3
HXB2 Location Env Env Epitope Map
Author Location gp120
Epitope
Subtype C
Ab Type gp41 MPER (membrane proximal external region)
Neutralizing yes, tier 2  View neutralization details
Species (Isotype) human(IgG)
Patient CH0210
Immunogen HIV-1 infection
Country South Africa
Keywords antibody generation, antibody lineage, antibody polyreactivity, antibody sequence, broad neutralizer, neutralization

Notes

Showing 1 of 1 note.

References

Showing 1 of 1 reference.

Isolation Paper
Williams2017 LaTonya D. Williams, Gilad Ofek, Sebastian Schätzle, Jonathan R. McDaniel, Xiaozhi Lu, Nathan I. Nicely, Liming Wu, Caleb S. Lougheed, Todd Bradley, Mark K. Louder, Krisha McKee, Robert T. Bailer, Sijy O'Dell, Ivelin S. Georgiev, Michael S. Seaman, Robert J. Parks, Dawn J. Marshall, Kara Anasti, Guang Yang, Xiaoyan Nie, Nancy L. Tumba, Kevin Wiehe, Kshitij Wagh, Bette Korber, Thomas B. Kepler, S. Munir Alam, Lynn Morris, Gift Kamanga, Myron S. Cohen, Mattia Bonsignori, Shi-Mao Xia, David C. Montefiori, Garnett Kelsoe, Feng Gao, John R. Mascola, M. Anthony Moody, Kevin O. Saunders, Hua-Xin Liao, Georgia D. Tomaras, George Georgiou, and Barton F. Haynes. Potent and Broad HIV-Neutralizing Antibodies in Memory B Cells and Plasma. Sci. Immunol., 2(7), 27 Jan 2017. PubMed ID: 28783671. Show all entries for this paper.


Displaying record number 4188

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MAb ID DH511_I4
HXB2 Location Env Env Epitope Map
Author Location gp120
Epitope
Subtype C
Ab Type gp41 MPER (membrane proximal external region)
Neutralizing yes, tier 2  View neutralization details
Species (Isotype) human(IgG)
Patient CH0210
Immunogen HIV-1 infection
Country South Africa
Keywords antibody generation, antibody lineage, antibody polyreactivity, antibody sequence, broad neutralizer, neutralization

Notes

Showing 1 of 1 note.

References

Showing 1 of 1 reference.

Isolation Paper
Williams2017 LaTonya D. Williams, Gilad Ofek, Sebastian Schätzle, Jonathan R. McDaniel, Xiaozhi Lu, Nathan I. Nicely, Liming Wu, Caleb S. Lougheed, Todd Bradley, Mark K. Louder, Krisha McKee, Robert T. Bailer, Sijy O'Dell, Ivelin S. Georgiev, Michael S. Seaman, Robert J. Parks, Dawn J. Marshall, Kara Anasti, Guang Yang, Xiaoyan Nie, Nancy L. Tumba, Kevin Wiehe, Kshitij Wagh, Bette Korber, Thomas B. Kepler, S. Munir Alam, Lynn Morris, Gift Kamanga, Myron S. Cohen, Mattia Bonsignori, Shi-Mao Xia, David C. Montefiori, Garnett Kelsoe, Feng Gao, John R. Mascola, M. Anthony Moody, Kevin O. Saunders, Hua-Xin Liao, Georgia D. Tomaras, George Georgiou, and Barton F. Haynes. Potent and Broad HIV-Neutralizing Antibodies in Memory B Cells and Plasma. Sci. Immunol., 2(7), 27 Jan 2017. PubMed ID: 28783671. Show all entries for this paper.


Displaying record number 4189

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MAb ID DH511_I5
HXB2 Location Env Env Epitope Map
Author Location gp120
Epitope
Subtype C
Ab Type gp41 MPER (membrane proximal external region)
Neutralizing yes, tier 2  View neutralization details
Species (Isotype) human(IgG)
Patient CH0210
Immunogen HIV-1 infection
Country South Africa
Keywords antibody generation, antibody lineage, antibody polyreactivity, antibody sequence, broad neutralizer, neutralization

Notes

Showing 1 of 1 note.

References

Showing 1 of 1 reference.

Isolation Paper
Williams2017 LaTonya D. Williams, Gilad Ofek, Sebastian Schätzle, Jonathan R. McDaniel, Xiaozhi Lu, Nathan I. Nicely, Liming Wu, Caleb S. Lougheed, Todd Bradley, Mark K. Louder, Krisha McKee, Robert T. Bailer, Sijy O'Dell, Ivelin S. Georgiev, Michael S. Seaman, Robert J. Parks, Dawn J. Marshall, Kara Anasti, Guang Yang, Xiaoyan Nie, Nancy L. Tumba, Kevin Wiehe, Kshitij Wagh, Bette Korber, Thomas B. Kepler, S. Munir Alam, Lynn Morris, Gift Kamanga, Myron S. Cohen, Mattia Bonsignori, Shi-Mao Xia, David C. Montefiori, Garnett Kelsoe, Feng Gao, John R. Mascola, M. Anthony Moody, Kevin O. Saunders, Hua-Xin Liao, Georgia D. Tomaras, George Georgiou, and Barton F. Haynes. Potent and Broad HIV-Neutralizing Antibodies in Memory B Cells and Plasma. Sci. Immunol., 2(7), 27 Jan 2017. PubMed ID: 28783671. Show all entries for this paper.


Displaying record number 4190

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MAb ID DH511_I6
HXB2 Location Env Env Epitope Map
Author Location gp120
Epitope
Subtype C
Ab Type gp41 MPER (membrane proximal external region)
Neutralizing no  View neutralization details
Species (Isotype) human(IgG)
Patient CH0210
Immunogen HIV-1 infection
Country South Africa
Keywords antibody generation, antibody lineage, antibody polyreactivity, antibody sequence, broad neutralizer, neutralization

Notes

Showing 1 of 1 note.

References

Showing 1 of 1 reference.

Isolation Paper
Williams2017 LaTonya D. Williams, Gilad Ofek, Sebastian Schätzle, Jonathan R. McDaniel, Xiaozhi Lu, Nathan I. Nicely, Liming Wu, Caleb S. Lougheed, Todd Bradley, Mark K. Louder, Krisha McKee, Robert T. Bailer, Sijy O'Dell, Ivelin S. Georgiev, Michael S. Seaman, Robert J. Parks, Dawn J. Marshall, Kara Anasti, Guang Yang, Xiaoyan Nie, Nancy L. Tumba, Kevin Wiehe, Kshitij Wagh, Bette Korber, Thomas B. Kepler, S. Munir Alam, Lynn Morris, Gift Kamanga, Myron S. Cohen, Mattia Bonsignori, Shi-Mao Xia, David C. Montefiori, Garnett Kelsoe, Feng Gao, John R. Mascola, M. Anthony Moody, Kevin O. Saunders, Hua-Xin Liao, Georgia D. Tomaras, George Georgiou, and Barton F. Haynes. Potent and Broad HIV-Neutralizing Antibodies in Memory B Cells and Plasma. Sci. Immunol., 2(7), 27 Jan 2017. PubMed ID: 28783671. Show all entries for this paper.


Displaying record number 4191

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MAb ID DH511_UCA
HXB2 Location Env Env Epitope Map
Author Location gp120
Epitope
Subtype C
Ab Type gp41 MPER (membrane proximal external region)
Neutralizing no  View neutralization details
Species (Isotype) human(IgG)
Patient CH0210
Immunogen HIV-1 infection
Country South Africa
Keywords antibody generation, antibody lineage, antibody sequence, broad neutralizer, neutralization

Notes

Showing 1 of 1 note.

References

Showing 1 of 1 reference.

Isolation Paper
Williams2017 LaTonya D. Williams, Gilad Ofek, Sebastian Schätzle, Jonathan R. McDaniel, Xiaozhi Lu, Nathan I. Nicely, Liming Wu, Caleb S. Lougheed, Todd Bradley, Mark K. Louder, Krisha McKee, Robert T. Bailer, Sijy O'Dell, Ivelin S. Georgiev, Michael S. Seaman, Robert J. Parks, Dawn J. Marshall, Kara Anasti, Guang Yang, Xiaoyan Nie, Nancy L. Tumba, Kevin Wiehe, Kshitij Wagh, Bette Korber, Thomas B. Kepler, S. Munir Alam, Lynn Morris, Gift Kamanga, Myron S. Cohen, Mattia Bonsignori, Shi-Mao Xia, David C. Montefiori, Garnett Kelsoe, Feng Gao, John R. Mascola, M. Anthony Moody, Kevin O. Saunders, Hua-Xin Liao, Georgia D. Tomaras, George Georgiou, and Barton F. Haynes. Potent and Broad HIV-Neutralizing Antibodies in Memory B Cells and Plasma. Sci. Immunol., 2(7), 27 Jan 2017. PubMed ID: 28783671. Show all entries for this paper.


Displaying record number 4214

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MAb ID CH01-31 (CHO1-31, CH01/31, CH01+CH31, CH01+VRC-CH31)
HXB2 Location Env Env Epitope Map
Author Location Env
Epitope (Discontinuous epitope)
Subtype A
Ab Type gp120 CD4bs, gp120 V2 // V2 glycan(V2g) // V2 apex
Neutralizing P (tier2)
Species (Isotype) human
Patient CH0219
Immunogen HIV-1 infection
Keywords anti-idiotype, antibody lineage, immunotherapy, neutralization, structure, vaccine-induced immune responses

Notes

Showing 11 of 11 notes.

References

Showing 10 of 10 references.

Bonsignori2012 Mattia Bonsignori, David C. Montefiori, Xueling Wu, Xi Chen, Kwan-Ki Hwang, Chun-Yen Tsao, Daniel M. Kozink, Robert J. Parks, Georgia D. Tomaras, John A. Crump, Saidi H. Kapiga, Noel E. Sam, Peter D. Kwong, Thomas B. Kepler, Hua-Xin Liao, John R. Mascola, and Barton F. Haynes. Two Distinct Broadly Neutralizing Antibody Specificities of Different Clonal Lineages in a Single HIV-1-Infected Donor: Implications for Vaccine Design. J. Virol., 86(8):4688-4692, Apr 2012. PubMed ID: 22301150. Show all entries for this paper.

Bonsignori2017 Mattia Bonsignori, Edward F. Kreider, Daniela Fera, R. Ryan Meyerhoff, Todd Bradley, Kevin Wiehe, S. Munir Alam, Baptiste Aussedat, William E. Walkowicz, Kwan-Ki Hwang, Kevin O. Saunders, Ruijun Zhang, Morgan A. Gladden, Anthony Monroe, Amit Kumar, Shi-Mao Xia, Melissa Cooper, Mark K. Louder, Krisha McKee, Robert T. Bailer, Brendan W. Pier, Claudia A. Jette, Garnett Kelsoe, Wilton B. Williams, Lynn Morris, John Kappes, Kshitij Wagh, Gift Kamanga, Myron S. Cohen, Peter T. Hraber, David C. Montefiori, Ashley Trama, Hua-Xin Liao, Thomas B. Kepler, M. Anthony Moody, Feng Gao, Samuel J. Danishefsky, John R. Mascola, George M. Shaw, Beatrice H. Hahn, Stephen C. Harrison, Bette T. Korber, and Barton F. Haynes. Staged Induction of HIV-1 Glycan-Dependent Broadly Neutralizing Antibodies. Sci. Transl. Med., 9(381), 15 Mar 2017. PubMed ID: 28298420. Show all entries for this paper.

Bonsignori2018 Mattia Bonsignori, Eric Scott, Kevin Wiehe, David Easterhoff, S. Munir Alam, Kwan-Ki Hwang, Melissa Cooper, Shi-Mao Xia, Ruijun Zhang, David C. Montefiori, Rory Henderson, Xiaoyan Nie, Garnett Kelsoe, M. Anthony Moody, Xuejun Chen, M. Gordon Joyce, Peter D. Kwong, Mark Connors, John R. Mascola, Andrew T. McGuire, Leonidas Stamatatos, Max Medina-Ramirez, Rogier W. Sanders, Kevin O. Saunders, Thomas B. Kepler, and Barton F. Haynes. Inference of the HIV-1 VRC01 Antibody Lineage Unmutated Common Ancestor Reveals Alternative Pathways to Overcome a Key Glycan Barrier. Immunity, 49(6):1162-1174.e8, 18 Dec 2018. PubMed ID: 30552024. Show all entries for this paper.

Heydarchi2022 Behnaz Heydarchi, Danielle S. Fong, Hongmei Gao, Natalia A. Salazar-Quiroz, Jack M. Edwards, Christopher A. Gonelli, Samantha Grimley, Turgut E. Aktepe, Charlene Mackenzie, William J. Wales, Marit J. van Gils, Albert Cupo, Isabelle Rouiller, Paul R. Gooley, John P. Moore, Rogier W. Sanders, David Montefiori, Ashish Sethi, and Damian F. J. Purcell. Broad and Ultra-Potent Cross-Clade Neutralization of HIV-1 by a Vaccine-Induced CD4 Binding Site Bovine Antibody. Cell Rep. Med., 3(5):100635, 17 May 2022. PubMed ID: 35584627. Show all entries for this paper.

Kumar2018 Amit Kumar, Claire E. P. Smith, Elena E. Giorgi, Joshua Eudailey, David R. Martinez, Karina Yusim, Ayooluwa O. Douglas, Lisa Stamper, Erin McGuire, Celia C. LaBranche, David C. Montefiori, Genevieve G. Fouda, Feng Gao, and Sallie R. Permar. Infant Transmitted/Founder HIV-1 Viruses from Peripartum Transmission Are Neutralization Resistant to Paired Maternal Plasma. PLoS Pathog., 14(4):e1006944, Apr 2018. PubMed ID: 29672607. Show all entries for this paper.

Qin2015 Yali Qin, Saikat Banerjee, Aditi Agrawal, Heliang Shi, Marisa Banasik, Feng Lin, Kari Rohl, Celia LaBranche, David C. Montefiori, and Michael W. Cho. Characterization of a Large Panel of Rabbit Monoclonal Antibodies against HIV-1 gp120 and Isolation of Novel Neutralizing Antibodies against the V3 Loop. PLoS One, 10(6):e0128823, 2015. PubMed ID: 26039641. Show all entries for this paper.

Rosenberg2015 Yvonne Rosenberg, Markus Sack, David Montefiori, Celia Labranche, Mark Lewis, Lori Urban, Lingjun Mao, Rainer Fischer, and Xiaoming Jiang. Pharmacokinetics and Immunogenicity of Broadly Neutralizing HIV Monoclonal Antibodies in Macaques. PLoS One, 10(3):e0120451, 25 Mar 2015. PubMed ID: 25807114. Show all entries for this paper.

Wiehe2018 Kevin Wiehe, Todd Bradley, R. Ryan Meyerhoff, Connor Hart, Wilton B. Williams, David Easterhoff, William J. Faison, Thomas B. Kepler, Kevin O. Saunders, S. Munir Alam, Mattia Bonsignori, and Barton F. Haynes. Functional Relevance of Improbable Antibody Mutations for HIV Broadly Neutralizing Antibody Development. Cell Host Microbe, 23(6):759-765.e6, 13 Jun 2018. PubMed ID: 29861171. Show all entries for this paper.

Williams2017 LaTonya D. Williams, Gilad Ofek, Sebastian Schätzle, Jonathan R. McDaniel, Xiaozhi Lu, Nathan I. Nicely, Liming Wu, Caleb S. Lougheed, Todd Bradley, Mark K. Louder, Krisha McKee, Robert T. Bailer, Sijy O'Dell, Ivelin S. Georgiev, Michael S. Seaman, Robert J. Parks, Dawn J. Marshall, Kara Anasti, Guang Yang, Xiaoyan Nie, Nancy L. Tumba, Kevin Wiehe, Kshitij Wagh, Bette Korber, Thomas B. Kepler, S. Munir Alam, Lynn Morris, Gift Kamanga, Myron S. Cohen, Mattia Bonsignori, Shi-Mao Xia, David C. Montefiori, Garnett Kelsoe, Feng Gao, John R. Mascola, M. Anthony Moody, Kevin O. Saunders, Hua-Xin Liao, Georgia D. Tomaras, George Georgiou, and Barton F. Haynes. Potent and Broad HIV-Neutralizing Antibodies in Memory B Cells and Plasma. Sci. Immunol., 2(7), 27 Jan 2017. PubMed ID: 28783671. Show all entries for this paper.

Schorcht2020 Anna Schorcht, Tom L. G. M. van den Kerkhof, Christopher A. Cottrell, Joel D. Allen, Jonathan L. Torres, Anna-Janina Behrens, Edith E. Schermer, Judith A. Burger, Steven W. de Taeye, Alba Torrents de la Peña, Ilja Bontjer, Stephanie Gumbs, Gabriel Ozorowski, Celia C. LaBranche, Natalia de Val, Anila Yasmeen, Per Johan Klasse, David C. Montefiori, John P. Moore, Hanneke Schuitemaker, Max Crispin, Marit J. van Gils, Andrew B. Ward, and Rogier W. Sanders. Neutralizing Antibody Responses Induced by HIV-1 Envelope Glycoprotein SOSIP Trimers Derived from Elite Neutralizers. J. Virol., 94(24), 23 Nov 2020. PubMed ID: 32999024. Show all entries for this paper.


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