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Displaying record number 1095

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MAb ID	polyclonal
HXB2 Location	Env	Env Epitope Map
Author Location	(gp120 )
Epitope
Ab Type	gp120 C3
Neutralizing	P
Species (Isotype)	human(IgG)
Patient
Immunogen	HIV-1 infection
Keywords

Notes

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Autologous NAbs were studied in 3 patients on HAART that rebounded -- phylogenetic analysis of env (V1-V5) sequences indicated that rebound viruses had evolved from or preexisted in baseline populations -- HIV-1 rebound viruses from all 3 patients were resistant to neutralization by autologous IgG, unlike the baseline viruses -- mutations in the C3 region was responsible for conferring neutralization resistance against autologous antibody in 2 of 3 patients. WangF2002

References

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WangF2002 Feng-Xiang Wang, Tetsuya Kimura, Kumiko Nishihara, Kazuhisa Yoshimura, Atsushi Koito, and Shuzo Matsushita. Emergence of Autologous Neutralization-Resistant Variants from Preexisting Human Immunodeficiency Virus (HIV) Quasi Species during Virus Rebound in HIV Type 1-Infected Patients Undergoing Highly Active Antiretroviral Therapy. J. Infect. Dis., 185(5):608-617, 1 Mar 2002. PubMed ID: 11865417. Show all entries for this paper.