Search Antibody Database

Found 15 matching records:

Displaying record number 3741

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MAb ID	5B11
HXB2 Location	Env	Env Epitope Map
Author Location
Epitope
Ab Type	gp120 CD4BS
Neutralizing
Species (Isotype)	mouse
Patient
Immunogen	vaccine
Keywords	antibody binding site, antibody generation, SIV

Vaccine Details

Vaccine strain	SIV
Vaccine component	gp140

Notes

Showing 2 of 2 notes.

5B11: This study reported the development of a CD4-independent, CCR5-tropic variant of the pathogenic molecular clone SIVmac239, termed iMac239. This could help to evaluate SIV pathogenesis and host immune responses in the absence of the immunomodulatory effects of CD4+ T cell targeting and infection. In neutralization assay iMac239 was resistant to anti-CD4BS murine mAb 5B11. Swanstrom2016 (SIV)
5B11: In order to generate bnMAbs to SIV,two immunization protocols were compared using different preparations of oligomeric SIV envelope (Env) glycoproteins.In the first protocol, mice were immunized with soluble gp140 (sgp140) from CP-MAC variants of SIVmacBK28, SIVsm B670 CL3 and SIVsm543-3E. The Abs isolated were against V1/V2 loop and V3 loop. In the second protocol, mice were immunized with unfixed CP-MAC-infected cells and MAbs were screened for the ability to inhibit cell-cell fusion. Five classes of neutralizing MAbs were identified. 5B11 interfered with CD4 binding site.In oligomer sensitivity assay, 5B11 was more reactive with the oligomer-containing Env than with the monomeric gp120 preparation. Edinger2000 (antibody binding site, antibody generation, SIV)

References

Showing 2 of 2 references.

Isolation Paper
Edinger2000 Aimee L. Edinger, Ména Ahuja, Tina Sung, Kelly C. Baxter, Beth Haggarty, Robert W. Doms, and James A. Hoxie. Characterization and Epitope Mapping of Neutralizing Monoclonal Antibodies Produced by Immunization with Oligomeric Simian Immunodeficiency Virus Envelope Protein. J. Virol., 74(17):7922-7935, Sep 2000. PubMed ID: 10933700. Show all entries for this paper.

Swanstrom2016 Adrienne E. Swanstrom, Beth Haggarty, Andrea P. O. Jordan, Josephine Romano, George J. Leslie, Pyone P. Aye, Preston A. Marx, Andrew A. Lackner, Gregory Q. Del Prete, James E. Robinson, Michael R. Betts, David C. Montefiori, Celia C. LaBranche, and James A. Hoxie. Derivation and Characterization of a CD4-Independent, Non-CD4-Tropic Simian Immunodeficiency Virus. J. Virol., 90(10):4966-4980, 15 May 2016. PubMed ID: 26937037. Show all entries for this paper.

Displaying record number 3749

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MAb ID	171C2
HXB2 Location	Env	Env Epitope Map
Author Location	gp140(171-190)
Epitope
Ab Type	gp120 CD4BS
Neutralizing
Species (Isotype)	mouse
Patient
Immunogen	vaccine
Keywords	antibody binding site, antibody generation, SIV

Vaccine Details

Vaccine strain	SIV
Vaccine component	gp140

Notes

Showing 2 of 2 notes.

171C2: This study reported the development of a CD4-independent, CCR5-tropic variant of the pathogenic molecular clone SIVmac239, termed iMac239. This could help to evaluate SIV pathogenesis and host immune responses in the absence of the immunomodulatory effects of CD4+ T cell targeting and infection. In neutralization assay iMac239 was resistant to anti-V4 murine mAb 171C2. Swanstrom2016 (SIV)
171C2:In order to generate bnMAbs to SIV,two immunization protocols were compared using different preparations of oligomeric SIV envelope (Env) glycoproteins.In the first protocol, mice were immunized with soluble gp140 (sgp140) from CP-MAC variants of SIVmacBK28, SIVsm B670 CL3 and SIVsm543-3E. The Abs isolated were against V1/V2 loop and V3 loop. In the second protocol, mice were immunized with unfixed CP-MAC-infected cells and MAbs were screened for the ability to inhibit cell-cell fusion. Five classes of neutralizing MAbs were identified. 171C2 recognized V1/V2 loop (SIV Env coordinates 171-190), interfered with the CD4 binding site and disrupted CCR5 binding. Edinger2000 (antibody binding site, antibody generation, SIV)

References

Showing 2 of 2 references.

Edinger2000 Aimee L. Edinger, Ména Ahuja, Tina Sung, Kelly C. Baxter, Beth Haggarty, Robert W. Doms, and James A. Hoxie. Characterization and Epitope Mapping of Neutralizing Monoclonal Antibodies Produced by Immunization with Oligomeric Simian Immunodeficiency Virus Envelope Protein. J. Virol., 74(17):7922-7935, Sep 2000. PubMed ID: 10933700. Show all entries for this paper.

Displaying record number 3750

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MAb ID	4E11
HXB2 Location	Env	Env Epitope Map
Author Location
Epitope
Ab Type	gp120 CD4BS, gp120 CCR5BS
Neutralizing
Species (Isotype)	mouse
Patient
Immunogen	vaccine
Keywords	antibody binding site, antibody generation, SIV

Vaccine Details

Vaccine strain	SIV
Vaccine component	gp140

Notes

Showing 2 of 2 notes.

4E11: This study reported the development of a CD4-independent, CCR5-tropic variant of the pathogenic molecular clone SIVmac239, termed iMac239. This could help to evaluate SIV pathogenesis and host immune responses in the absence of the immunomodulatory effects of CD4+ T cell targeting and infection. In neutralization assay iMac239 was mildly sensitive to anti-CD4/CCR5BS murine mAb 4E11. Swanstrom2016 (SIV)
4E11:In order to generate bnMAbs to SIV,two immunization protocols were compared using different preparations of oligomeric SIV envelope (Env) glycoproteins.In the first protocol, mice were immunized with soluble gp140 (sgp140) from CP-MAC variants of SIVmacBK28, SIVsm B670 CL3 and SIVsm543-3E. The Abs isolated were against V1/V2 loop and V3 loop. In the second protocol, mice were immunized with unfixed CP-MAC-infected cells and MAbs were screened for the ability to inhibit cell-cell fusion. Five classes of neutralizing MAbs were identified.4E11 interfered with the CD4 binding site and disrupted CCR5 binding. Edinger2000 (antibody binding site, antibody generation, SIV)

References

Showing 2 of 2 references.

Displaying record number 3751

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MAb ID	17A11
HXB2 Location	Env	Env Epitope Map
Author Location
Epitope
Ab Type	gp120 CD4BS, gp120 CCR5BS
Neutralizing
Species (Isotype)	mouse
Patient
Immunogen	vaccine
Keywords	antibody binding site, antibody generation, SIV

Vaccine Details

Vaccine strain	SIV
Vaccine component	gp140

Notes

Showing 2 of 2 notes.

17A11: This study reported the development of a CD4-independent, CCR5-tropic variant of the pathogenic molecular clone SIVmac239, termed iMac239. This could help to evaluate SIV pathogenesis and host immune responses in the absence of the immunomodulatory effects of CD4+ T cell targeting and infection. In neutralization assay iMac239 was resistant to anti-CD4/CCR5BS binding murine mAb 17A11. Swanstrom2016 (SIV)
17A11:In order to generate bnMAbs to SIV,two immunization protocols were compared using different preparations of oligomeric SIV envelope (Env) glycoproteins.In the first protocol, mice were immunized with soluble gp140 (sgp140) from CP-MAC variants of SIVmacBK28, SIVsm B670 CL3 and SIVsm543-3E. The Abs isolated were against V1/V2 loop and V3 loop. In the second protocol, mice were immunized with unfixed CP-MAC-infected cells and MAbs were screened for the ability to inhibit cell-cell fusion. Five classes of neutralizing MAbs were identified. 17A11 interfered with the CD4 binding site and disrupted CCR5 binding. Edinger2000 (antibody binding site, antibody generation, SIV)

References

Showing 2 of 2 references.

Displaying record number 3752

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MAb ID	36D5
HXB2 Location	Env	Env Epitope Map
Author Location
Epitope
Ab Type	gp120 V3 // V3 glycan (V3g), gp120 CCR5BS
Neutralizing
Species (Isotype)	mouse
Patient
Immunogen	vaccine
Keywords	antibody binding site, antibody generation, SIV

Vaccine Details

Vaccine strain	SIV
Vaccine component	gp140

Notes

Showing 2 of 2 notes.

36D5: This study reported the development of a CD4-independent, CCR5-tropic variant of the pathogenic molecular clone SIVmac239, termed iMac239. This could help to evaluate SIV pathogenesis and host immune responses in the absence of the immunomodulatory effects of CD4+ T cell targeting and infection. In neutralization assay iMac239 was sensitive to anti-V3 loop murine mAb 36D5. Swanstrom2016 (SIV)
36D5:In order to generate bnMAbs to SIV,two immunization protocols were compared using different preparations of oligomeric SIV envelope (Env) glycoproteins.In the first protocol, mice were immunized with soluble gp140 (sgp140) from CP-MAC variants of SIVmacBK28, SIVsm B670 CL3 and SIVsm543-3E. The Abs isolated were against V1/V2 loop and V3 loop. In the second protocol, mice were immunized with unfixed CP-MAC-infected cells and MAbs were screened for the ability to inhibit cell-cell fusion. Five classes of neutralizing MAbs were identified. 36D5, a V3 loop Ab (SIV Env coordinates 321-340) also disrupted CCR5 binding. Edinger2000 (antibody binding site, antibody generation, SIV)

References

Showing 2 of 2 references.

Displaying record number 3754

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MAb ID	7D3
HXB2 Location	Env	Env Epitope Map
Author Location
Epitope
Ab Type	gp120 CCR5BS
Neutralizing
Species (Isotype)	mouse
Patient
Immunogen	vaccine
Keywords	antibody binding site, antibody generation, SIV

Vaccine Details

Vaccine strain	SIV
Vaccine component	gp140

Notes

Showing 2 of 2 notes.

7D3: This study reported the development of a CD4-independent, CCR5-tropic variant of the pathogenic molecular clone SIVmac239, termed iMac239. This could help to evaluate SIV pathogenesis and host immune responses in the absence of the immunomodulatory effects of CD4+ T cell targeting and infection. In neutralization assay iMac239 was sensitive to anti-CCR5BS murine mAb 7D3. Swanstrom2016 (SIV)
7D3:In order to generate bnMAbs to SIV,two immunization protocols were compared using different preparations of oligomeric SIV envelope (Env) glycoproteins.In the first protocol, mice were immunized with soluble gp140 (sgp140) from CP-MAC variants of SIVmacBK28, SIVsm B670 CL3 and SIVsm543-3E. The Abs isolated were against V1/V2 loop and V3 loop. In the second protocol, mice were immunized with unfixed CP-MAC-infected cells and MAbs were screened for the ability to inhibit cell-cell fusion. Five classes of neutralizing MAbs were identified. 7D3 disrupted CCR5 binding. Edinger2000 (antibody binding site, antibody generation, SIV)

References

Showing 2 of 2 references.

Displaying record number 3763

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MAb ID	11F2
HXB2 Location	Env	Env Epitope Map
Author Location
Epitope
Ab Type	gp120 CCR5BS
Neutralizing
Species (Isotype)	mouse
Patient
Immunogen	vaccine
Keywords	antibody binding site, antibody generation, SIV

Vaccine Details

Vaccine strain	SIV
Vaccine component	gp140

Notes

Showing 2 of 2 notes.

11F2: This study reported the development of a CD4-independent, CCR5-tropic variant of the pathogenic molecular clone SIVmac239, termed iMac239. This could help to evaluate SIV pathogenesis and host immune responses in the absence of the immunomodulatory effects of CD4+ T cell targeting and infection. 11F2 murine anti-SIV mAb was used in analyses. Swanstrom2016 (SIV)
11F2:In order to generate bnMAbs to SIV,two immunization protocols were compared using different preparations of oligomeric SIV envelope (Env) glycoproteins.In the first protocol, mice were immunized with soluble gp140 (sgp140) from CP-MAC variants of SIVmacBK28, SIVsm B670 CL3 and SIVsm543-3E. The Abs isolated were against V1/V2 loop and V3 loop. In the second protocol, mice were immunized with unfixed CP-MAC-infected cells and MAbs were screened for the ability to inhibit cell-cell fusion. 11F2 was minimally reactive with gp120. Edinger2000 (antibody binding site, antibody generation, SIV)

References

Showing 2 of 2 references.

Displaying record number 3827

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MAb ID	1.4H
HXB2 Location	Env	Env Epitope Map
Author Location
Epitope
Ab Type	gp120 CD4BS, gp120 CCR5BS
Neutralizing
Species (Isotype)	human
Patient
Immunogen	virus
Keywords	SIV

Notes

Showing 1 of 1 note.

1.4H: This study reported the development of a CD4-independent, CCR5-tropic variant of the pathogenic molecular clone SIVmac239, termed iMac239. This could help to evaluate SIV pathogenesis and host immune responses in the absence of the immunomodulatory effects of CD4+ T cell targeting and infection. 1.4H human anti-SIV mAb was used in analyses. Swanstrom2016 (SIV)

References

Showing 1 of 1 reference.

Displaying record number 3828

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MAb ID	6.10F
HXB2 Location	Env	Env Epitope Map
Author Location
Epitope
Ab Type	gp120 V3 // V3 glycan (V3g)
Neutralizing
Species (Isotype)	human
Patient
Immunogen	virus
Keywords	SIV

Notes

Showing 1 of 1 note.

6.10F: This study reported the development of a CD4-independent, CCR5-tropic variant of the pathogenic molecular clone SIVmac239, termed iMac239. This could help to evaluate SIV pathogenesis and host immune responses in the absence of the immunomodulatory effects of CD4+ T cell targeting and infection. In neutralization assay iMac239 was sensitive to anti-V3 loop human mAb 6.10F. Swanstrom2016 (SIV)

References

Showing 1 of 1 reference.

Displaying record number 3829

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MAb ID	6.10B
HXB2 Location	Env	Env Epitope Map
Author Location
Epitope
Ab Type	gp120 CD4BS, gp120 CCR5BS
Neutralizing
Species (Isotype)	human
Patient
Immunogen	virus
Keywords	SIV

Notes

Showing 1 of 1 note.

6.10B: This study reported the development of a CD4-independent, CCR5-tropic variant of the pathogenic molecular clone SIVmac239, termed iMac239. This could help to evaluate SIV pathogenesis and host immune responses in the absence of the immunomodulatory effects of CD4+ T cell targeting and infection. In neutralization assay iMac239 was sensitive to anti-V3 loop human mAb 6.10B. Swanstrom2016 (SIV)

References

Showing 1 of 1 reference.

Displaying record number 3830

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MAb ID	9.1A
HXB2 Location	Env	Env Epitope Map
Author Location
Epitope
Ab Type	gp120 V4
Neutralizing
Species (Isotype)	human
Patient
Immunogen	virus
Keywords	SIV

Notes

Showing 1 of 1 note.

9.1A: This study reported the development of a CD4-independent, CCR5-tropic variant of the pathogenic molecular clone SIVmac239, termed iMac239. This could help to evaluate SIV pathogenesis and host immune responses in the absence of the immunomodulatory effects of CD4+ T cell targeting and infection. In neutralization assay iMac239 was sensitive to anti-V4 loop human mAb 9.1A. Swanstrom2016 (SIV)

References

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Displaying record number 3831

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MAb ID	1.7A
HXB2 Location	Env	Env Epitope Map
Author Location
Epitope
Subtype	HIV-2
Ab Type	gp120 V4
Neutralizing
Species (Isotype)	human
Patient
Immunogen	virus
Keywords	SIV

Notes

Showing 1 of 1 note.

1.7A: This study reported the development of a CD4-independent, CCR5-tropic variant of the pathogenic molecular clone SIVmac239, termed iMac239. This could help to evaluate SIV pathogenesis and host immune responses in the absence of the immunomodulatory effects of CD4+ T cell targeting and infection. In neutralization assay iMac239 was resistant to anti-V4 loop human mAb, 1.7A. Isolated from homo sapien in Cole2001 (PMID 11883006). Swanstrom2016 (SIV)

References

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Displaying record number 3832

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MAb ID	1.10A
HXB2 Location	Env	Env Epitope Map
Author Location
Epitope
Ab Type	gp120 V4
Neutralizing
Species (Isotype)	macaque
Patient
Immunogen	virus
Keywords	SIV

Notes

Showing 1 of 1 note.

1.10A: This study reported the development of a CD4-independent, CCR5-tropic variant of the pathogenic molecular clone SIVmac239, termed iMac239. This could help to evaluate SIV pathogenesis and host immune responses in the absence of the immunomodulatory effects of CD4+ T cell targeting and infection. In neutralization assay iMac239 was sensitive to anti-V4 loop rhesus mAb 1.10A. Isolated from rhesus macaque in Cole2001 (PMID 11883006). Swanstrom2016 (SIV)

References

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Displaying record number 3833

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MAb ID	3.11H
HXB2 Location	Env	Env Epitope Map
Author Location
Epitope
Ab Type	gp120 V3 // V3 glycan (V3g)
Neutralizing
Species (Isotype)	macaque
Patient
Immunogen	virus
Keywords	SIV

Notes

Showing 1 of 1 note.

3.11H: This study reported the development of a CD4-independent, CCR5-tropic variant of the pathogenic molecular clone SIVmac239, termed iMac239. This could help to evaluate SIV pathogenesis and host immune responses in the absence of the immunomodulatory effects of CD4+ T cell targeting and infection. In neutralization assay iMac239 was sensitive to anti-V4 loop rhesus mAb 3.11H. Isolated from rhesus macaque in Cole2001 (PMID 11883006). Swanstrom2016 (SIV)

References

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Displaying record number 4001

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MAb ID	4.10F
HXB2 Location	Env	Env Epitope Map
Author Location
Epitope
Ab Type	gp120 V3 // V3 glycan (V3g)
Neutralizing
Species (Isotype)
Patient
Immunogen	virus
Keywords	SIV

Notes

Showing 1 of 1 note.

4.10F: This study reported the development of a CD4-independent, CCR5-tropic variant of the pathogenic molecular clone SIVmac239, termed iMac239. This could help to evaluate SIV pathogenesis and host immune responses in the absence of the immunomodulatory effects of CD4+ T cell targeting and infection. 4.10F rhesus anti-SIV mAb was used in analyses. Swanstrom2016 (SIV)

References

Showing 1 of 1 reference.