HIV molecular immunology database

 

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Found 8 matching records:

Displaying record number 15

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MAb ID B4f8
HXB2 Location Gag(51-65)
DNA(940..984)
Gag Epitope Map
Author Location p17(51-65)
Epitope LETSEGCRQILGQLQ Epitope Alignment
LETSEGCRQILGQLQ epitope logo
Ab Type  
Neutralizing  
Species (Isotype) rat(IgG2a)
Patient  
Immunogen vaccine
Keywords  

Vaccine Details

Vaccine type HIV infected-cell lysate
Vaccine strain B clade IIIB
Vaccine component HIV-1

Notes

Showing 1 of 1 note.

References

Showing 1 of 1 reference.

Shang1991 F. Shang, H. Huang, K. Revesz, H.-C. Chen, R. Herz, and A. Pinter. Characterization of monoclonal antibodies against the human immunodeficiency virus matrix protein, p17gag: identification of epitopes exposed at the surfaces of infected cells. J. Virol., 65:4798-4804, 1991. Six MAbs with linear epitopes were mapped. These Abs could only bind to HIV-infected cells that had been permeablized with acetone. Only G11g1 and G11h3, two antibodies that did not bind to peptides, but only to intact p17, could react with live HIV-1 infected cells. These antibodies were not neutralizing. PubMed ID: 1714518. Show all entries for this paper.


Displaying record number 16

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MAb ID 12H-D3b3
HXB2 Location Gag(62-78)
DNA(973..1023)
Gag Epitope Map
Author Location p17(62-78)
Epitope GQLQPSLQTGSEELRSL Epitope Alignment
GQLQPSLQTGSEELRSL epitope logo
Ab Type  
Neutralizing  
Species (Isotype) rat(IgG2a)
Patient  
Immunogen vaccine
Keywords  

Vaccine Details

Vaccine type HIV infected-cell lysate
Vaccine strain B clade IIIB
Vaccine component HIV-1

Notes

Showing 1 of 1 note.

References

Showing 1 of 1 reference.

Shang1991 F. Shang, H. Huang, K. Revesz, H.-C. Chen, R. Herz, and A. Pinter. Characterization of monoclonal antibodies against the human immunodeficiency virus matrix protein, p17gag: identification of epitopes exposed at the surfaces of infected cells. J. Virol., 65:4798-4804, 1991. Six MAbs with linear epitopes were mapped. These Abs could only bind to HIV-infected cells that had been permeablized with acetone. Only G11g1 and G11h3, two antibodies that did not bind to peptides, but only to intact p17, could react with live HIV-1 infected cells. These antibodies were not neutralizing. PubMed ID: 1714518. Show all entries for this paper.


Displaying record number 17

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MAb ID 12G-A8g2
HXB2 Location Gag(86-115)
DNA(1045..1134)
Gag Epitope Map
Author Location p17(86-115)
Epitope YCVHQRIEIKDTKEALDKIEEEQNKSKKKA Epitope Alignment
Ab Type  
Neutralizing  
Species (Isotype) rat(IgG2a)
Patient  
Immunogen vaccine
Keywords  

Vaccine Details

Vaccine type HIV infected-cell lysate
Vaccine strain B clade IIIB
Vaccine component HIV-1

Notes

Showing 2 of 2 notes.

References

Showing 2 of 2 references.

Maksiutov2002 A. Z. Maksiutov, A. G. Bachinskii, and S. I. Bazhan. [Searching for Local Similarities Between HIV-1 and Human Proteins. Application to Vaccines]. Mol Biol (Mosk), 36(3):447-459, May-Jun 2002. Article in Russian. PubMed ID: 12068630. Show all entries for this paper.

Shang1991 F. Shang, H. Huang, K. Revesz, H.-C. Chen, R. Herz, and A. Pinter. Characterization of monoclonal antibodies against the human immunodeficiency virus matrix protein, p17gag: identification of epitopes exposed at the surfaces of infected cells. J. Virol., 65:4798-4804, 1991. Six MAbs with linear epitopes were mapped. These Abs could only bind to HIV-infected cells that had been permeablized with acetone. Only G11g1 and G11h3, two antibodies that did not bind to peptides, but only to intact p17, could react with live HIV-1 infected cells. These antibodies were not neutralizing. PubMed ID: 1714518. Show all entries for this paper.


Displaying record number 18

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MAb ID 12G-D7h11
HXB2 Location Gag(86-115)
DNA(1045..1134)
Gag Epitope Map
Author Location p17(86-115)
Epitope YCVHQRIEIKDTKEALDKIEEEQNKSKKKA Epitope Alignment
Ab Type  
Neutralizing  
Species (Isotype) rat(IgG2a)
Patient  
Immunogen vaccine
Keywords  

Vaccine Details

Vaccine type HIV infected-cell lysate
Vaccine strain B clade IIIB
Vaccine component HIV-1

Notes

Showing 2 of 2 notes.

References

Showing 2 of 2 references.

Shang1991 F. Shang, H. Huang, K. Revesz, H.-C. Chen, R. Herz, and A. Pinter. Characterization of monoclonal antibodies against the human immunodeficiency virus matrix protein, p17gag: identification of epitopes exposed at the surfaces of infected cells. J. Virol., 65:4798-4804, 1991. Six MAbs with linear epitopes were mapped. These Abs could only bind to HIV-infected cells that had been permeablized with acetone. Only G11g1 and G11h3, two antibodies that did not bind to peptides, but only to intact p17, could react with live HIV-1 infected cells. These antibodies were not neutralizing. PubMed ID: 1714518. Show all entries for this paper.

Maksiutov2002 A. Z. Maksiutov, A. G. Bachinskii, and S. I. Bazhan. [Searching for Local Similarities Between HIV-1 and Human Proteins. Application to Vaccines]. Mol Biol (Mosk), 36(3):447-459, May-Jun 2002. Article in Russian. PubMed ID: 12068630. Show all entries for this paper.


Displaying record number 19

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MAb ID 12I-D12g2
HXB2 Location Gag(86-115)
DNA(1045..1134)
Gag Epitope Map
Author Location p17(86-115)
Epitope YCVHQRIEIKDTKEALDKIEEEQNKSKKKA Epitope Alignment
Ab Type  
Neutralizing  
Species (Isotype) rat(IgG2a)
Patient  
Immunogen vaccine
Keywords  

Vaccine Details

Vaccine type HIV infected-cell lysate
Vaccine strain B clade IIIB
Vaccine component HIV-1

Notes

Showing 2 of 2 notes.

References

Showing 2 of 2 references.

Shang1991 F. Shang, H. Huang, K. Revesz, H.-C. Chen, R. Herz, and A. Pinter. Characterization of monoclonal antibodies against the human immunodeficiency virus matrix protein, p17gag: identification of epitopes exposed at the surfaces of infected cells. J. Virol., 65:4798-4804, 1991. Six MAbs with linear epitopes were mapped. These Abs could only bind to HIV-infected cells that had been permeablized with acetone. Only G11g1 and G11h3, two antibodies that did not bind to peptides, but only to intact p17, could react with live HIV-1 infected cells. These antibodies were not neutralizing. PubMed ID: 1714518. Show all entries for this paper.

Maksiutov2002 A. Z. Maksiutov, A. G. Bachinskii, and S. I. Bazhan. [Searching for Local Similarities Between HIV-1 and Human Proteins. Application to Vaccines]. Mol Biol (Mosk), 36(3):447-459, May-Jun 2002. Article in Russian. PubMed ID: 12068630. Show all entries for this paper.


Displaying record number 20

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MAb ID 12G-H1c7
HXB2 Location Gag(86-115)
DNA(1045..1134)
Gag Epitope Map
Author Location p17(86-115)
Epitope YCVHQRIEIKDTKEALDKIEEEQNKSKKKA Epitope Alignment
Ab Type  
Neutralizing  
Species (Isotype) rat(IgG)
Patient  
Immunogen vaccine
Keywords  

Vaccine Details

Vaccine type HIV infected-cell lysate
Vaccine strain B clade IIIB
Vaccine component HIV-1

Notes

Showing 2 of 2 notes.

References

Showing 2 of 2 references.

Shang1991 F. Shang, H. Huang, K. Revesz, H.-C. Chen, R. Herz, and A. Pinter. Characterization of monoclonal antibodies against the human immunodeficiency virus matrix protein, p17gag: identification of epitopes exposed at the surfaces of infected cells. J. Virol., 65:4798-4804, 1991. Six MAbs with linear epitopes were mapped. These Abs could only bind to HIV-infected cells that had been permeablized with acetone. Only G11g1 and G11h3, two antibodies that did not bind to peptides, but only to intact p17, could react with live HIV-1 infected cells. These antibodies were not neutralizing. PubMed ID: 1714518. Show all entries for this paper.

Maksiutov2002 A. Z. Maksiutov, A. G. Bachinskii, and S. I. Bazhan. [Searching for Local Similarities Between HIV-1 and Human Proteins. Application to Vaccines]. Mol Biol (Mosk), 36(3):447-459, May-Jun 2002. Article in Russian. PubMed ID: 12068630. Show all entries for this paper.


Displaying record number 36

Download this epitope record as JSON.

MAb ID G11G1 (12A-Gllgl)
HXB2 Location Gag Gag Epitope Map
Author Location p17
Epitope
Ab Type  
Neutralizing  
Species (Isotype) rat(IgG2a)
Patient  
Immunogen  
Keywords antibody generation

Notes

Showing 2 of 2 notes.

References

Showing 2 of 2 references.

Isolation Paper
Shang1991 F. Shang, H. Huang, K. Revesz, H.-C. Chen, R. Herz, and A. Pinter. Characterization of monoclonal antibodies against the human immunodeficiency virus matrix protein, p17gag: identification of epitopes exposed at the surfaces of infected cells. J. Virol., 65:4798-4804, 1991. Six MAbs with linear epitopes were mapped. These Abs could only bind to HIV-infected cells that had been permeablized with acetone. Only G11g1 and G11h3, two antibodies that did not bind to peptides, but only to intact p17, could react with live HIV-1 infected cells. These antibodies were not neutralizing. PubMed ID: 1714518. Show all entries for this paper.

Pincus1996 S. H. Pincus, K. Wehrly, R. Cole, H. Fang, G. K. Lewis, J. McClure, A. J. Conley, B. Wahren, M. R. Posner, A. L. Notkins, S. A. Tilley, A. Pinter, L. Eiden, M. Teintze, D. Dorward, and V. V. Tolstikov. In Vitro Effects of Anti-HIV Immunotoxins Directed against Multiple Epitopes on HIV Type 1 Envelope Glycoprotein 160. AIDS Res. Hum. Retroviruses, 12:1041-1051, 1996. A panel of anti-gp160 MAbs to was used to construct anti-HIV immunotoxins by coupling antibodies to ricin A chain (RAC). The ability of the immunotoxins to kill HIV-1-infected cells was tested in tissue culture. Immunotoxins that bind epitopes on the cell surface killed infected cells, although killing was not directly proportional to binding. The activity of anti-gp41 immunotoxins was markedly enhanced in the presence of sCD4. PubMed ID: 8827220. Show all entries for this paper.


Displaying record number 38

Download this epitope record as JSON.

MAb ID G11H3 (12A-Gllh3)
HXB2 Location Gag Gag Epitope Map
Author Location p17
Epitope
Ab Type  
Neutralizing  
Species (Isotype) rat(IgG2a)
Patient  
Immunogen  
Keywords antibody generation

Notes

Showing 2 of 2 notes.

References

Showing 2 of 2 references.

Isolation Paper
Shang1991 F. Shang, H. Huang, K. Revesz, H.-C. Chen, R. Herz, and A. Pinter. Characterization of monoclonal antibodies against the human immunodeficiency virus matrix protein, p17gag: identification of epitopes exposed at the surfaces of infected cells. J. Virol., 65:4798-4804, 1991. Six MAbs with linear epitopes were mapped. These Abs could only bind to HIV-infected cells that had been permeablized with acetone. Only G11g1 and G11h3, two antibodies that did not bind to peptides, but only to intact p17, could react with live HIV-1 infected cells. These antibodies were not neutralizing. PubMed ID: 1714518. Show all entries for this paper.

Pincus1998 S. H. Pincus, R. L. Cole, R. Watson-McKown, A. Pinter, W. Honnen, B. Cole, and K. S. Wise. Immunologic Cross-Reaction between HIV Type 1 p17 and Mycoplasma hyorhinis Variable Lipoprotein. AIDS Res. Hum. Retroviruses, 14:419-425, 1998. PubMed ID: 9546801. Show all entries for this paper.


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