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Found 3 matching records:

Displaying record number 127

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MAb ID EH12E1 (BC1071)
HXB2 Location Gag Gag Epitope Map
Author Location p24( CBL-1)
Research Contact R. B. Ferns and R. S. Tedder; Aalto BioReagents
Epitope
Ab Type  
Neutralizing  
Species (Isotype) mouse(IgG1)
Patient  
Immunogen vaccine
Keywords  

Vaccine Details

Vaccine type inactivated HIV
Vaccine strain B clade CBL-1
Vaccine component HIV-1

Notes

Showing 4 of 4 notes.

References

Showing 3 of 3 references.

Isolation Paper
Ferns1987 R. B. Ferns, R. S. Tedder, and R. A. Weiss. Characterization of Monoclonal Antibodies against the Human Immunodeficiency Virus gag Products and Their Use in Monitoring HIV Isolate Variation. J. Gen. Virol., 68:1543-1551, 1987. PubMed ID: 2438375. Show all entries for this paper.

Ferns1989 R. B. Ferns, J. C. Partridge, R. P. Spence, N. Hunt, and R. S. Tedder. Epitope Location of 13 Anti-Gag HIV-1 Monoclonal Antibodies Using Oligopeptides and their Cross-Reactivity with HIV-2. AIDS, 3:829-834, 1989. PubMed ID: 2483619. Show all entries for this paper.

Schonning1999 K. Schonning, O. Lund, O. S. Lund, and J. E. Hansen. Stoichiometry of monoclonal antibody neutralization of T-cell line-adapted human immunodeficiency virus type 1. J. Virol., 73:8364-8370, 1999. PubMed ID: 10482587. Show all entries for this paper.


Displaying record number 496

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MAb ID P4/D10 (P4D10)
HXB2 Location gp160(309-316)
DNA(7149..7172)
gp160 Epitope Map
Author Location gp120
Epitope IxxGPGRA Epitope Alignment
IxxGPGRA epitope logo
Ab Type gp120 V3 // V3 glycan (V3g)
Neutralizing L
Species (Isotype) mouse(IgG1κ)
Patient  
Immunogen vaccine
Keywords  

Vaccine Details

Vaccine type virus derived protein
Vaccine strain B clade IIIB
Vaccine component gp120

Notes

Showing 8 of 8 notes.

References

Showing 10 of 10 references.

Akerblom1990 L. Akerblom, J. Hinkula, P.-A. Broliden, B. Makitalo, T. Fridberger, J. Rosen, M. Villacres-Eriksson, B. Morein, and B. Wahren. Neutralizing cross-reactive and non-neutralizing monoclonal antibodies to HIV-1 gp120. AIDS, 4:953-960, 1990. PubMed ID: 1702001. Show all entries for this paper.

Broliden1990 P. A. Broliden, K. Ljunggren, J. Hinkula, E. Norrby, L. Akerblom, and B. Wahren. A monoclonal antibody to human immunodeficiency virus type 1 which mediates cellular cytotoxicity and neutralization. J. Virol., 64:936-940, 1990. PubMed ID: 2296090. Show all entries for this paper.

Broliden1991 P. A. Broliden, B. Makitalo, L. Akerblom, J. Rosen, K. Broliden, G. Utter, M. Jondal, E. Norrby, and B. Wahren. Identification of Amino Acids in the V3 Region of gp120 Critical for Virus Neutralization by Human HIV-1 Specific Antibodies. Immunology, 73:371-376, 1991. PubMed ID: 1916888. Show all entries for this paper.

Marks1991 J. D. Marks, B. Wahren, G. Gilljam, J. Hinkula, and G. Winter. Cloning of an HIV-1 Neutralizing V3 Specific Monoclonal Antibody and Expression as a Mouse-Human Chimaeric Antigen Binding Fragment and Antibody. J. Acquir. Immune Defic. Syndr., 1991:1162, 1992. Aidsline: 1116291Abstract: VIIth International Conference on AIDS, Florence, Italy, proceedings. Show all entries for this paper.

Moore1993c J. P. Moore, M. Thali, B. A. Jameson, F. Vignaux, G. K. Lewis, S.-W. Poon, M. S. Fung, P. J. Durda, L. Akerblom, B. Wahren, D. D. Ho, Q. J. Sattentau, and J. Sodroski. Immunochemical Analysis of the gp120 Surface Glycoprotein of Human Immunodeficiency Virus Type 1: Probing the Structure of the C4 and V4 Domains and the Interaction of the C4 Domain with the V3 Loop. J. Virol., 73:4785-4796, 1993. General observations: C4 and V3 MAbs are sensitive to the way the epitopes are presented, and this sensitivity cannot be correlated to peptide binding. Some V3-C4 domain interaction was indicated based on mutation and interference studies. PubMed ID: 7687303. Show all entries for this paper.

Arendrup1993 M. Arendrup, A. Sonnerborg, B. Svennerholm, L. Akerblom, C. Nielsen, H. Clausen, S. Olofsson, J. O. Nielsen, and J. E. S. Hensen. Neutralizing antibody response during human immunodeficiency virus type 1 infection: type and group specificity and viral escape. J. Gen. Virol., 74:855-863, 1993. PubMed ID: 7684062. Show all entries for this paper.

Hinkula1994 J. Hinkula, G. Bratt, G. Gilljam, S. Nordlund, P.A. Broliden, V. Holmberg, E. Olausson-Hansson, J. Albert, E. Sandstrom, and B. Wahren. Immunological and Virological Interaction in Patients Receiving Passive Immunotherapy with HIV-1 neutralizing monoclonal antibodies. J. Acquir. Immune Defic. Syndr., 7:940-951, 1994. Eleven HIV-1 infected patients in the late stages were treated with mouse MAbs that showed high HIV-1 neutralization. The amount of p24 in the sera of patients decreased in five patients, but remained the same or increased in six of them. The level of viral RNA in the plasma of patients decreased in four, showed no changes in another four and increased in the other three. By themselves, the MAbs did not appear to be efficient enough to decrease the virus burden in a permanent form in late-stage HIV patients. PubMed ID: 8051620. Show all entries for this paper.

Jacobson1998 J. M. Jacobson. Passive Immunization for the Treatment of HIV Infection. Mt. Sinai J. Med., 65:22-26, 1998. Review. PubMed ID: 9458680. Show all entries for this paper.

Schonning1998 K. Schonning, A. Bolmstedt, J. Novotny, O. S. Lund, S. Olofsson, and J. E. Hansen. Induction of Antibodies against Epitopes Inaccessible on the HIV Type 1 Envelope Oligomer by Immunization with Recombinant Monomeric Glycoprotein 120. AIDS Res. Hum. Retroviruses, 14:1451-1456, 1998. PubMed ID: 9824323. Show all entries for this paper.

Schonning1999 K. Schonning, O. Lund, O. S. Lund, and J. E. Hansen. Stoichiometry of monoclonal antibody neutralization of T-cell line-adapted human immunodeficiency virus type 1. J. Virol., 73:8364-8370, 1999. PubMed ID: 10482587. Show all entries for this paper.


Displaying record number 507

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MAb ID 9205 (NEA-9205 NEA9205)
HXB2 Location gp160(315-317)
DNA(7167..7175)
gp160 Epitope Map
Author Location gp120( IIIB)
Research Contact NEN, Boston MA, commercial
Epitope RAF Epitope Alignment
RAF epitope logo
Ab Type gp120 V3 // V3 glycan (V3g)
Neutralizing L
Species (Isotype) mouse(IgG1)
Patient  
Immunogen vaccine
Keywords variant cross-reactivity

Vaccine Details

Vaccine type peptide
Vaccine strain B clade IIIB
Vaccine component Env V3

Notes

Showing 8 of 8 notes.

References

Showing 9 of 9 references.

Durda1990 P. J. Durda, L. Bacheler, P. Clapham, A. M. Jenoski, B. Leece, T. J. Matthews, A. McKnight, R. Pomerantz, M. Rayner, and K. J. Weinhold. HIV-1 Neutralizing Monoclonal Antibodies Induced by a Synthetic Peptide. AIDS Res. Hum. Retroviruses, 6:1115, 1990. PubMed ID: 1702301. Show all entries for this paper.

Trujillo1993 J. R. Trujillo, M. F. McLane, T.-H. Lee, and M. Essex. Molecular Mimicry between the Human Immunodeficiency Virus Type 1 gp120 V3 Loop and Human Brain Proteins. J. Virol., 67:7711-7715, 1993. PubMed ID: 8230494. Show all entries for this paper.

Allaway1993 G. P. Allaway, A. M. Ryder, G. A. Beaudry, and P. J. Madden. Synergistic inhibition of HIV-1 envelope-mediated cell fusion by CD4-based molecules in combination with antibodies to gp120 or gp41. AIDS Res. Hum. Retroviruses, 9:581-587, 1993. PubMed ID: 8369162. Show all entries for this paper.

VanCott1994 T. C. VanCott, F. R. Bethke, V. R. Polonis, M. K. Gorny, S. Zolla-Pazner, R. R. Redfield, and D. L. Birx. Dissociation Rate of Antibody-gp120 Binding Interactions Is Predictive of V3-Mediated Neutralization of HIV-1. J. Immunol., 153:449-459, 1994. Using surface plasmon resonance it was found that the rate of the dissociation of the MAb-gp120 complex, but not the association rate, correlated with MAbs ability to neutralize homologous virus (measured by 50\% inhibition of p24 production). Association constants were similar for all MAbs tested, varying less than 4-fold. Dissociation rate constants were quite variable, with 100-fold differences observed. PubMed ID: 7515931. Show all entries for this paper.

Fontenot1995 J. D. Fontenot, T. C. VanCott, B. S. Parekh, C. P. Pau, J. R. George, D. L. Birx, S. Zolla-Pazner, M. K. Gorny, and J. M. Gatewood. Presentation of HIV V3 Loop Epitopes for Enhanced Antigenicity, Immunogenicity and Diagnostic Potential. AIDS, 9:1121-1129, 1995. PubMed ID: 8519447. Show all entries for this paper.

Schonning1998 K. Schonning, A. Bolmstedt, J. Novotny, O. S. Lund, S. Olofsson, and J. E. Hansen. Induction of Antibodies against Epitopes Inaccessible on the HIV Type 1 Envelope Oligomer by Immunization with Recombinant Monomeric Glycoprotein 120. AIDS Res. Hum. Retroviruses, 14:1451-1456, 1998. PubMed ID: 9824323. Show all entries for this paper.

Schonning1999 K. Schonning, O. Lund, O. S. Lund, and J. E. Hansen. Stoichiometry of monoclonal antibody neutralization of T-cell line-adapted human immunodeficiency virus type 1. J. Virol., 73:8364-8370, 1999. PubMed ID: 10482587. Show all entries for this paper.

Gram2002 G. J. Gram, A. Bolmstedt, K. Schonning, M. Biller, J.-E. S. Hansen, and S. Olofsson. Detection of Orientation-Specific Anti-gp120 Antibodies by a New N-Glycanase Protection Assay. APMIS, 110(2):123-131, Feb 2002. PubMed ID: 12064867. Show all entries for this paper.

Huskens2007 Dana Huskens, Kristel Van Laethem, Kurt Vermeire, Jan Balzarini, and Dominique Schols. Resistance of HIV-1 to the Broadly HIV-1-Neutralizing, Anti-Carbohydrate Antibody 2G12. Virology, 360(2):294-304, 10 Apr 2007. PubMed ID: 17123566. Show all entries for this paper.


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