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Found 17 matching records:

Displaying record number 2

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MAb ID	L14.17
HXB2 Location	Gag(11-25) DNA(820..864)	Gag Epitope Map
Author Location	p17(11-25 BRU)
Epitope	`GELDRWEKIRLRPGG`	Epitope Alignment
Ab Type
Neutralizing
Species (Isotype)	mouse(IgG)
Patient
Immunogen	vaccine
Keywords

Vaccine Details

Vaccine type	viral lysate
Vaccine strain	B clade BRU
Vaccine component	HIV-1

Notes

Showing 1 of 1 note.

L14.17: Similarity level of the L14.17 binding site pentapeptide WEKIR to the host proteome was low, with the low-similarity 5-mer occurring in the host proteome 1 time, indicating that this peptide can be used to elicit Abs for active/passive immunotherapy with low risk of cross-reaction with the host proteome. Kanduc2008

References

Showing 4 of 4 reference.

Tatsumi1990 M. Tatsumi, C. Devaux, F. Kourilsky, and J. C. Chermann. Characterization of monoclonal antibodies directed against distinct conserved epitopes of human immunodeficiency virus type 1 core proteins. Mol Cell Biochem, 96:127-136, 1990. PubMed ID: 1703272. Show all entries for this paper.

RobertHebmann1992a V. Robert-Hebmann, S. Emiliani, M. Resnicoff, F. Jean, and C. Devaux. Subtyping of human immunodeficiency virus isolates with a panel of monoclonal antibodies: identification of conserved and divergent epitopes on p17 and p25 core proteins. Mol. Immunol., 29:1175-1183, 1992. PubMed ID: 1382219. Show all entries for this paper.

RobertHebmann1992b V. Robert-Hebmann, S. Emiliani, F. Jean, M. Resnicoff, and C. Devaux. Clonal Analysis of Murine B-Cell Response to the Human Immunodeficiency Virus Type 1 (HIV-1)-gag p17 and p25 Antigens. Mol. Immunol., 29:729-738, 1992. PubMed ID: 1376412. Show all entries for this paper.

Kanduc2008 Darja Kanduc, Rosario Serpico, Alberta Lucchese, and Yehuda Shoenfeld. Correlating Low-Similarity Peptide Sequences and HIV B-Cell Epitopes. Autoimmun. Rev., 7(4):291-296, Feb 2008. PubMed ID: 18295732. Show all entries for this paper.

Displaying record number 26

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MAb ID	3-H-7 (3H7)
HXB2 Location	Gag(113-122) DNA(1126..1155)	Gag Epitope Map
Author Location	p17(113-122 BH10)
Epitope	`KKAQQAAADT`	Epitope Alignment
Ab Type
Neutralizing
Species (Isotype)	mouse(IgG)
Patient
Immunogen	vaccine
Keywords

Vaccine Details

Vaccine strain	B clade IIIB

Notes

Showing 2 of 2 notes.

3-H-7: Called 3H7 -- using a bicistronic vector, an intracellular Fab intrabody, 3H7, can inhibit HIV-1 infection when expressed in the cytoplasm of dividing CD4+ T cells -- HXBIIIB and SI primary isolate virions from 3H7 expressing cells were far less infectious -- 3H7 intrabody acts both at the stage of nuclear import and virus particle assembly. Levin1997
3-H-7: No cross-reactivity with HIV-2 ROD or SIV MAC by immunoblot. Niedrig1989

References

Showing 4 of 4 references.

Levin1997 R. Levin, A. M. Mhashilkar, T. Dorfman, A. Bukovsky, C. Zani, J. Bagley, J. Hinkula, M. Niedrig, J. Albert, B. Wahren, H. G. Gottlinger, and W. A. Marasco. Inhibition of Early and Late Events of the HIV-1 Replication Cycle by Cytoplasmic Fab Intrabodies against the Matrix Protein, p17. Mol. Med., 3:96-110, 1997. PubMed ID: 9085253. Show all entries for this paper.

Niedrig1989 M. Niedrig, J. Hinkula, W. Weigelt, J. L'Age-Stehr, G. Pauli, J. Rosen, and B. Wahren. Epitope mapping of monoclonal antibodies against human immunodeficiency virus type 1 structural proteins by using peptides. J. Virol., 63:3525-3528, 1989. Multiple linear MAb epitopes were described in p24 and p17. Several MAbs were able to react with HIV-2 ROD and SIV MAC in an immunoblot assay, as well as with HIV-1. PubMed ID: 2473220. Show all entries for this paper.

Displaying record number 27

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MAb ID	31-11
HXB2 Location	Gag(121-132) DNA(1150..1185)	Gag Epitope Map
Author Location	p17(121-132 BRU)
Epitope	`DTGHSSQVSQNY`	Epitope Alignment
Ab Type
Neutralizing
Species (Isotype)	mouse(IgG)
Patient
Immunogen	vaccine
Keywords

Vaccine Details

Vaccine strain	B clade BRU

References

Showing 2 of 2 references.

Displaying record number 28

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MAb ID	15-21
HXB2 Location	Gag(121-132) DNA(1150..1185)	Gag Epitope Map
Author Location	p17(121-132 BRU)
Epitope	`DTGHSSQVSQNY`	Epitope Alignment
Ab Type
Neutralizing
Species (Isotype)	mouse(IgG)
Patient
Immunogen	vaccine
Keywords

Vaccine Details

Vaccine strain	B clade BRU

References

Showing 2 of 2 references.

Displaying record number 69

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MAb ID	47-2
HXB2 Location	Gag(201-218) DNA(1390..1443)	Gag Epitope Map
Author Location	p24(201-218 BRU)
Epitope	`LKETINEEAAEWDRVHPV`	Epitope Alignment
Ab Type
Neutralizing
Species (Isotype)	mouse(IgG)
Patient
Immunogen	vaccine
Keywords

Vaccine Details

Vaccine strain	B clade BRU

References

Showing 2 of 2 references.

Displaying record number 70

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MAb ID	714/01
HXB2 Location	Gag(201-218) DNA(1390..1443)	Gag Epitope Map
Author Location	p24(201-218 BRU)
Epitope	`LKETINEEAAEWDRVHPV`	Epitope Alignment
Ab Type
Neutralizing
Species (Isotype)	mouse(IgG)
Patient
Immunogen	vaccine
Keywords

Vaccine Details

Vaccine strain	B clade IIIB
Vaccine component	HIV-1

References

Showing 2 of 2 references.

Displaying record number 71

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MAb ID	1109/01
HXB2 Location	Gag(201-218) DNA(1390..1443)	Gag Epitope Map
Author Location	p24(201-218 BRU)
Epitope	`LKETINEEAAEWDRVHPV`	Epitope Alignment
Ab Type
Neutralizing
Species (Isotype)	mouse(IgG)
Patient
Immunogen	vaccine
Keywords

Vaccine Details

Vaccine strain	B clade IIIB
Vaccine component	HIV-1

References

Showing 2 of 2 references.

Displaying record number 72

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MAb ID	1G5C8
HXB2 Location	Gag(201-218) DNA(1390..1443)	Gag Epitope Map
Author Location	p24(201-218 BRU)
Epitope	`LKETINEEAAEWDRVHPV`	Epitope Alignment
Ab Type
Neutralizing
Species (Isotype)	mouse(IgG2b)
Patient
Immunogen	vaccine
Keywords

Vaccine Details

Vaccine type	protein
Vaccine component	p24 Gag

Notes

Showing 1 of 1 note.

1G5C8: Mapped to aa209-217 through Pepscan method (original paper, AAEWDRVHP) Janvier1990 and to aa203-217 through EIA pentadecapeptide Janvier1992. Janvier1990,Janvier1992

References

Showing 4 of 4 reference.

Janvier1990 B. Janvier, P. Archinard, B. Mandrand, A. Goudeau, and F. Barin. Linear B-Cell Epitopes of the Major Core Protein of Human Immunodeficiency Virus Types 1 and 2. J. Virol., 64:4258-4263, 1990. PubMed ID: 1696638. Show all entries for this paper.

Janvier1992 B. Janvier, P. Archinard, B. Mandrand, A. Goudeau, and F. Barin. Linear B-Cell Epitopes of the Major Core Protein of Human Immunodeficiency Virus Types 1 and 2 (Author's Correction). J. Virol., 66:613, 1992. Show all entries for this paper.

Displaying record number 73

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MAb ID	14D4E11
HXB2 Location	Gag(201-218) DNA(1390..1443)	Gag Epitope Map
Author Location	p24(201-218 BRU)
Epitope	`LKETINEEAAEWDRVHPV`	Epitope Alignment
Ab Type
Neutralizing
Species (Isotype)	mouse(IgG1)
Patient
Immunogen	vaccine
Keywords

Vaccine Details

Vaccine type	purified HIV-1

Notes

Showing 1 of 1 note.

14D4E11: Mapped to aa209-217 through Pepscan method (original paper, AAEWDRVHP) -- cross-reacts with HIV-2 Janvier1990 and to aa203-217 through EIA pentadecapeptide Janvier1992. Janvier1990,Janvier1992

References

Showing 4 of 4 reference.

Displaying record number 81

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MAb ID	8-D-2
HXB2 Location	Gag(203-217) DNA(1396..1440)	Gag Epitope Map
Author Location	p24(203-217)
Epitope	`ETINEEAAEWDRVHP`	Epitope Alignment
Ab Type
Neutralizing
Species (Isotype)	mouse(IgG2a)
Patient
Immunogen	vaccine
Keywords

Vaccine Details

Vaccine strain	B clade IIIB
Vaccine component	HIV-1

Notes

Showing 2 of 2 notes.

8-D-2: One of nine MAbs that bind to this peptide. Niedrig1989
8-D-2: HIV-1 specific. Niedrig1988

References

Showing 4 of 4 references.

Niedrig1988 M. Niedrig, J.-P. Rabanus, J. L. Stehr, H. R. Gelderblom, and G. Pauli. Monoclonal Antibodies Directed against Human Immunodeficiency Virus Gag Proteins with Specificity for Conserved Epitopes in HIV-1, HIV-2 and Simian Immunodeficiency Virus. J. Gen. Virol., 69:2109-2114, 1988. PubMed ID: 2457067. Show all entries for this paper.

Displaying record number 82

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MAb ID	8-H-7
HXB2 Location	Gag(203-217) DNA(1396..1440)	Gag Epitope Map
Author Location	p24(203-217)
Epitope	`ETINEEAAEWDRVHP`	Epitope Alignment
Ab Type
Neutralizing
Species (Isotype)	mouse(IgG3)
Patient
Immunogen	vaccine
Keywords

Vaccine Details

Vaccine strain	B clade IIIB
Vaccine component	HIV-1

Notes

Showing 1 of 1 note.

8-H-7: One of nine MAbs that bind to this peptide. Niedrig1989

References

Showing 4 of 4 reference.

Displaying record number 95

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MAb ID	RL4.72.1
HXB2 Location	Gag(219-233) DNA(1444..1488)	Gag Epitope Map
Author Location	p24(219-233 BRU)
Epitope	`HAGPIAPGQMREPRG`	Epitope Alignment
Ab Type
Neutralizing
Species (Isotype)	mouse(IgG)
Patient
Immunogen	vaccine
Keywords

Vaccine Details

Vaccine type	inactivated HIV
Vaccine strain	D clade NDK
Vaccine component	HIV-1

Notes

Showing 2 of 2 notes.

RL4.72.1: Similarity level of the RL4.72.1 binding site pentapeptide PGQMR to the host proteome was low, with the low-similarity 5-mer occurring in the host proteome 0 times, indicating that this peptide can be used to elicit Abs for active/passive immunotherapy with low risk of cross-reaction with the host proteome. Kanduc2008
RL4.72.1: Immunized with inactivated HIV NDK, D clade, reacts with B clade peptide. RobertHebmann1992b

References

Showing 4 of 4 references.

Displaying record number 96

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MAb ID	406/01
HXB2 Location	Gag(233-253) DNA(1486..1548)	Gag Epitope Map
Author Location	p24(233-253 BRU)
Epitope	`GSDIAGTTSTLQEQIGWMTNN`	Epitope Alignment
Ab Type
Neutralizing
Species (Isotype)	mouse(IgG)
Patient
Immunogen	vaccine
Keywords

Vaccine Details

Vaccine strain	B clade IIIB

References

Showing 2 of 2 references.

Displaying record number 103

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MAb ID	23A5G5
HXB2 Location	Gag(285-304) DNA(1642..1701)	Gag Epitope Map
Author Location	p24(285-304 BRU)
Epitope	`IRQGPKEPFRDYVDRFYKTL`	Epitope Alignment
Ab Type
Neutralizing
Species (Isotype)	mouse(IgG)
Patient
Immunogen	vaccine
Keywords

Vaccine Details

Vaccine type	protein
Vaccine strain	B clade IIIB
Vaccine component	p24 Gag

References

Showing 2 of 2 references.

Displaying record number 106

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MAb ID	MO9.42.2
HXB2 Location	Gag(285-310) DNA(1642..1719)	Gag Epitope Map
Author Location	p24(285-310 BRU)
Epitope	`IRQGPKEPFRDYVDRFYKTLRAEQAS`	Epitope Alignment
Ab Type
Neutralizing
Species (Isotype)	mouse(IgG)
Patient
Immunogen	vaccine
Keywords

Vaccine Details

Vaccine type	virus
Vaccine strain	HIV-2 ROD
Vaccine component	HIV-1

Notes

Showing 1 of 1 note.

MO9.42.2: Reacts with HIV-1s, HIV-2s, and SIVs in rec protein ELISA. RobertHebmann1992a

References

Showing 2 of 2 reference.

Displaying record number 107

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MAb ID	MO9.50.2
HXB2 Location	Gag(285-310) DNA(1642..1719)	Gag Epitope Map
Author Location	p24(285-310 BRU)
Epitope	`IRQGPKEPFRDYVDRFYKTLRAEQAS`	Epitope Alignment
Ab Type
Neutralizing
Species (Isotype)	mouse(IgG)
Patient
Immunogen	vaccine
Keywords

Vaccine Details

Vaccine strain	HIV-2 ROD

Notes

Showing 1 of 1 note.

MO9.50.2: Reacts with HIV-1s, HIV-2s, and SIVs in rec protein ELISA. RobertHebmann1992a

References

Showing 2 of 2 reference.

Displaying record number 114

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MAb ID	9A4C4
HXB2 Location	Gag(302-320) DNA(1693..1749)	Gag Epitope Map
Author Location	p24(303-317 IIIB)
Epitope	`KTLRAEQASQEVKNWMTET`	Epitope Alignment
Ab Type
Neutralizing
Species (Isotype)	mouse(IgG1)
Patient
Immunogen	vaccine
Keywords

Vaccine Details

Vaccine type	protein
Vaccine strain	B clade IIIB
Vaccine component	p24 Gag

Notes

Showing 1 of 1 note.

9A4C4: Mapped to aa260-267 through Pepscan method Janvier1990 -- and to aa303-317 through EIA pentadecapeptide method Janvier1992. Janvier1990,Janvier1992

References

Showing 4 of 4 reference.