HIV molecular immunology database

 

Search Antibody Database

Found 26 matching records:

Displaying record number 2475

Download this epitope record as JSON.

MAb ID 0.5γ (1C10)
HXB2 Location gp160(308-317) gp160 Epitope Map
Author Location gp120
Epitope SIHIGPGRAF Epitope Alignment
SIHIGPGRAF epitope logo
Subtype B
Ab Type gp120 V3 // V3 glycan (V3g)
Neutralizing P (tier 2)  View neutralization details
Contacts and Features View contacts and features
Species (Isotype) human(IgG1κ)
Patient KTS376
Immunogen HIV-1 infection
Country Japan
Keywords ADCC, antibody binding site, antibody generation, binding affinity, drug resistance, mimics, neutralization

Notes

Showing 3 of 3 notes.

References

Showing 3 of 3 references.

Isolation Paper
Yoshimura2010 Kazuhisa Yoshimura, Shigeyoshi Harada, Junji Shibata, Makiko Hatada, Yuko Yamada, Chihiro Ochiai, Hirokazu Tamamura, and Shuzo Matsushita. Enhanced Exposure of Human Immunodeficiency Virus Type 1 Primary Isolate Neutralization Epitopes through Binding of CD4 Mimetic Compounds. J. Virol., 84(15):7558-7568, Aug 2010. PubMed ID: 20504942. Show all entries for this paper.

Kuwata2016 Takeo Kuwata, Ikumi Enomoto, Masanori Baba, and Shuzo Matsushita. Incompatible Natures of the HIV-1 Envelope in Resistance to the CCR5 Antagonist Cenicriviroc and to Neutralizing Antibodies. Antimicrob. Agents Chemother., 60(1):437-450, 2 Nov 2015. PubMed ID: 26525792. Show all entries for this paper.

RamirezValdez2015 Kristel Paola Ramirez Valdez, Takeo Kuwata, Yasuhiro Maruta, Kazuki Tanaka, Muntasir Alam, Kazuhisa Yoshimura, and Shuzo Matsushita. Complementary and Synergistic Activities of Anti-V3, CD4bs and CD4i Antibodies Derived from a Single Individual Can Cover a Wide Range of HIV-1 Strains. Virology, 475:187-203, 15 Jan 2015. PubMed ID: 25486586. Show all entries for this paper.


Displaying record number 1593

Download this epitope record as JSON.

MAb ID KD-247
HXB2 Location gp160(311-315)
DNA(7155..7169)
gp160 Epitope Map
Author Location Env
Research Contact Shuzo Matsushita, Kumamoto University, Japan shuzo@kaiju.medic.kumamoto-u.ac.jp
Epitope IGPGR Epitope Alignment
IGPGR epitope logo
Subtype B
Ab Type gp120 V3 // V3 glycan (V3g)
Neutralizing P (tier 2)  View neutralization details
Species (Isotype) humanized mouse(IgG)
Patient  
Immunogen engineered, vaccine
Country Japan
Keywords ADCC, anti-idiotype, antibody binding site, antibody generation, antibody sequence, binding affinity, compensatory mutation, escape, glycosylation, immunoprophylaxis, immunotherapy, mimics, neutralization, review, structure, variant cross-reactivity, viral fitness and reversion

Vaccine Details

Vaccine type peptide
Vaccine strain B clade, B clade MN, B clade RF, other
Vaccine component Env V3
Adjuvant Complete Freund's Adjuvant (CFA), Incomplete Freund's Adjuvant (IFA)

Notes

Showing 14 of 14 notes.

References

Showing 14 of 14 references.

Isolation Paper
Eda2006a Yasuyuki Eda, Mari Takizawa, Toshio Murakami, Hiroaki Maeda, Kazuhiko Kimachi, Hiroshi Yonemura, Satoshi Koyanagi, Kouichi Shiosaki, Hirofumi Higuchi, Keiichi Makizumi, Toshihiro Nakashima, Kiyoshi Osatomi, Sachio Tokiyoshi, Shuzo Matsushita, Naoki Yamamoto, and Mitsuo Honda. Sequential Immunization with V3 Peptides from Primary Human Immunodeficiency Virus Type 1 Produces Cross-Neutralizing Antibodies against Primary Isolates with a Matching Narrow-Neutralization Sequence Motif. J. Virol., 80(11):5552-5562, Jun 2006. PubMed ID: 16699036. Show all entries for this paper.

Chen2009b Weizao Chen and Dimiter S. Dimitrov. Human Monoclonal Antibodies and Engineered Antibody Domains as HIV-1 Entry Inhibitors. Curr. Opin. HIV AIDS, 4(2):112-117, Mar 2009. PubMed ID: 19339949. Show all entries for this paper.

Eda2006 Yasuyuki Eda, Toshio Murakami, Yasushi Ami, Tadashi Nakasone, Mari Takizawa, Kenji Someya, Masahiko Kaizu, Yasuyuki Izumi, Naoto Yoshino, Shuzo Matsushita, Hirofumi Higuchi, Hajime Matsui, Katsuaki Shinohara, Hiroaki Takeuchi, Yoshio Koyanagi, Naoki Yamamoto, and Mitsuo Honda. Anti-V3 Humanized Antibody KD-247 Effectively Suppresses Ex Vivo Generation of Human Immunodeficiency Virus Type 1 and Affords Sterile Protection of Monkeys against a Heterologous Simian/Human Immunodeficiency Virus Infection. J. Virol., 80(11):5563-5570, Jun 2006. PubMed ID: 16699037. Show all entries for this paper.

Hatada2010 Makiko Hatada, Kazuhisa Yoshimura, Shigeyoshi Harada, Yoko Kawanami, Junji Shibata, and Shuzo Matsushita. Human Immunodeficiency Virus Type 1 Evasion of a Neutralizing Anti-V3 Antibody Involves Acquisition of a Potential Glycosylation Site in V2. J. Gen. Virol., 91(Pt 5):1335-1345, May 2010. PubMed ID: 20032207. Show all entries for this paper.

Kirby2015 Karen A. Kirby, Yee Tsuey Ong, Atsuko Hachiya, Thomas G. Laughlin, Leslie A. Chiang, Yun Pan, Jennifer .L Moran, Bruno Marchand, Kamalendra Singh, Fabio Gallazzi, Thomas P. Quinn, Kazuhisa Yoshimura, Toshio Murakami, Shuzo Matsushita, and Stefan G. Sarafianos. Structural Basis of Clade-Specific HIV-1 Neutralization by Humanized Anti-V3 Monoclonal Antibody KD-247. FASEB J., 29(1):70-80, Jan 2015. PubMed ID: 25351987. Show all entries for this paper.

Matsushita2005 Shuzo Matsushita, Soichiro Takahama, Junji Shibata, Tetsuya Kimura, Koichi Shiozaki, Yasuyuki Eda, Atsushi Koito, Toshio Murakami, and Kazuhisa Yoshimura. Ex Vivo Neutralization of HIV-1 Quasi-Species by a Broadly Reactive Humanized Monoclonal Antibody KD-247. Hum. Antibodies, 14(3-4):81-88, 2005. PubMed ID: 16720978. Show all entries for this paper.

Matsushita2015 Shuzo Matsushita, Kazuhisa Yoshimura, Kristel Paola Ramirez, Jaya Pisupati, Toshio Murakami, and KD-1002 Study Group. Passive Transfer of Neutralizing mAb KD-247 Reduces Plasma Viral Load in Patients Chronically Infected with HIV-1. AIDS, 29(4):453-462, 20 Feb 2015. PubMed ID: 25630040. Show all entries for this paper.

Murakami2009 Toshio Murakami, Yasuyuki Eda, Tadashi Nakasone, Yasushi Ami, Kenji Someya, Naoto Yoshino, Masahiko Kaizu, Yasuyuki Izumi, Hajime Matsui, Katsuaki Shinohara, Naoki Yamamoto, and Mitsuo Honda. Postinfection Passive Transfer of KD-247 Protects against Simian/Human Immunodeficiency Virus-Induced CD4+ T-Cell Loss in Macaque Lymphoid Tissue. AIDS, 23(12):1485-1494, 31 Jul 2009. PubMed ID: 19528788. Show all entries for this paper.

Ong2012 Y. T. Ong, K. A. Kirby, A. Hachiya, L. A. Chiang, B. Marchand, K. Yoshimura, T. Murakami, K. Singh, S. Matsushita, and S. G. Sarafianos. Preparation of Biologically Active Single-Chain Variable Antibody Fragments That Target the HIV-1 gp120 V3 Loop. Cell. Mol. Biol. (Noisy-le-grand), 58(1):71-79, 2012. PubMed ID: 23273194. Show all entries for this paper.

RamirezValdez2015 Kristel Paola Ramirez Valdez, Takeo Kuwata, Yasuhiro Maruta, Kazuki Tanaka, Muntasir Alam, Kazuhisa Yoshimura, and Shuzo Matsushita. Complementary and Synergistic Activities of Anti-V3, CD4bs and CD4i Antibodies Derived from a Single Individual Can Cover a Wide Range of HIV-1 Strains. Virology, 475:187-203, 15 Jan 2015. PubMed ID: 25486586. Show all entries for this paper.

Shibata2007 Junji Shibata, Kazuhisa Yoshimura, Akiko Honda, Atsushi Koito, Toshio Murakami, and Shuzo Matsushita. Impact of V2 Mutations on Escape from a Potent Neutralizing Anti-V3 Monoclonal Antibody during In Vitro Selection of a Primary Human Immunodeficiency Virus Type 1 Isolate. J. Virol., 81(8):3757-3768, Apr 2007. PubMed ID: 17251298. Show all entries for this paper.

Takizawa2011 Mari Takizawa, Kosuke Miyauchi, Emiko Urano, Shigeru Kusagawa, Katsuhiko Kitamura, Satoshi Naganawa, Toshio Murakami, Mitsuo Honda, Naoki Yamamoto, and Jun Komano. Regulation of the Susceptibility of HIV-1 to a Neutralizing Antibody KD-247 by Nonepitope Mutations Distant from its Epitope. AIDS, 25(18):2209-2216, 28 Nov 2011. PubMed ID: 21866041. Show all entries for this paper.

Yoshimura2006 Kazuhisa Yoshimura, Junji Shibata, Tetsuya Kimura, Akiko Honda, Yosuke Maeda, Atsushi Koito, Toshio Murakami, Hiroaki Mitsuya, and Shuzo Matsushita. Resistance Profile of a Neutralizing Anti-HIV Monoclonal Antibody, KD-247, that Shows Favourable Synergism with Anti-CCR5 Inhibitors. AIDS, 20(16):2065-2073, 24 Oct 2006. PubMed ID: 17053352. Show all entries for this paper.

Yoshimura2010 Kazuhisa Yoshimura, Shigeyoshi Harada, Junji Shibata, Makiko Hatada, Yuko Yamada, Chihiro Ochiai, Hirokazu Tamamura, and Shuzo Matsushita. Enhanced Exposure of Human Immunodeficiency Virus Type 1 Primary Isolate Neutralization Epitopes through Binding of CD4 Mimetic Compounds. J. Virol., 84(15):7558-7568, Aug 2010. PubMed ID: 20504942. Show all entries for this paper.


Displaying record number 2474

Download this epitope record as JSON.

MAb ID 3E4
HXB2 Location Env Env Epitope Map
Author Location gp120
Epitope
Subtype B
Ab Type gp120 V3 // V3 glycan (V3g)
Neutralizing  
Species (Isotype) human(IgG1κ)
Patient KTS376
Immunogen HIV-1 infection
Country Japan
Keywords antibody generation, binding affinity, mimics, neutralization

Notes

Showing 2 of 2 notes.

References

Showing 2 of 2 references.

Isolation Paper
Yoshimura2010 Kazuhisa Yoshimura, Shigeyoshi Harada, Junji Shibata, Makiko Hatada, Yuko Yamada, Chihiro Ochiai, Hirokazu Tamamura, and Shuzo Matsushita. Enhanced Exposure of Human Immunodeficiency Virus Type 1 Primary Isolate Neutralization Epitopes through Binding of CD4 Mimetic Compounds. J. Virol., 84(15):7558-7568, Aug 2010. PubMed ID: 20504942. Show all entries for this paper.

RamirezValdez2015 Kristel Paola Ramirez Valdez, Takeo Kuwata, Yasuhiro Maruta, Kazuki Tanaka, Muntasir Alam, Kazuhisa Yoshimura, and Shuzo Matsushita. Complementary and Synergistic Activities of Anti-V3, CD4bs and CD4i Antibodies Derived from a Single Individual Can Cover a Wide Range of HIV-1 Strains. Virology, 475:187-203, 15 Jan 2015. PubMed ID: 25486586. Show all entries for this paper.


Displaying record number 2476

Download this epitope record as JSON.

MAb ID 0.5δ (3D6)
HXB2 Location Env Env Epitope Map
Author Location gp120
Epitope
Subtype B
Ab Type gp120 CD4BS
Neutralizing P (tier 2)
Species (Isotype) human(IgG1λ)
Patient KTS376
Immunogen HIV-1 infection
Country Japan
Keywords antibody generation, binding affinity, mimics, neutralization

Notes

Showing 2 of 2 notes.

References

Showing 2 of 2 references.

Isolation Paper
Yoshimura2010 Kazuhisa Yoshimura, Shigeyoshi Harada, Junji Shibata, Makiko Hatada, Yuko Yamada, Chihiro Ochiai, Hirokazu Tamamura, and Shuzo Matsushita. Enhanced Exposure of Human Immunodeficiency Virus Type 1 Primary Isolate Neutralization Epitopes through Binding of CD4 Mimetic Compounds. J. Virol., 84(15):7558-7568, Aug 2010. PubMed ID: 20504942. Show all entries for this paper.

RamirezValdez2015 Kristel Paola Ramirez Valdez, Takeo Kuwata, Yasuhiro Maruta, Kazuki Tanaka, Muntasir Alam, Kazuhisa Yoshimura, and Shuzo Matsushita. Complementary and Synergistic Activities of Anti-V3, CD4bs and CD4i Antibodies Derived from a Single Individual Can Cover a Wide Range of HIV-1 Strains. Virology, 475:187-203, 15 Jan 2015. PubMed ID: 25486586. Show all entries for this paper.


Displaying record number 2477

Download this epitope record as JSON.

MAb ID 4E9C
HXB2 Location Env Env Epitope Map
Author Location gp120
Epitope
Subtype B
Ab Type gp120 CD4i
Neutralizing View neutralization details
Contacts and Features View contacts and features
Species (Isotype) human(IgG1κ)
Patient KTS376
Immunogen HIV-1 infection
Country Japan
Keywords ADCC, antibody binding site, antibody generation, antibody interactions, binding affinity, drug resistance, mimics, neutralization, subtype comparisons

Notes

Showing 6 of 6 notes.

References

Showing 6 of 6 references.

Isolation Paper
Yoshimura2010 Kazuhisa Yoshimura, Shigeyoshi Harada, Junji Shibata, Makiko Hatada, Yuko Yamada, Chihiro Ochiai, Hirokazu Tamamura, and Shuzo Matsushita. Enhanced Exposure of Human Immunodeficiency Virus Type 1 Primary Isolate Neutralization Epitopes through Binding of CD4 Mimetic Compounds. J. Virol., 84(15):7558-7568, Aug 2010. PubMed ID: 20504942. Show all entries for this paper.

Kuwata2016 Takeo Kuwata, Ikumi Enomoto, Masanori Baba, and Shuzo Matsushita. Incompatible Natures of the HIV-1 Envelope in Resistance to the CCR5 Antagonist Cenicriviroc and to Neutralizing Antibodies. Antimicrob. Agents Chemother., 60(1):437-450, 2 Nov 2015. PubMed ID: 26525792. Show all entries for this paper.

MdZahid2021 Hasan Md Zahid, Takeo Kuwata, Shokichi Takahama, Yu Kaku, Shashwata Biswas, Kaho Matsumoto, Hirokazu Tamamura, and Shuzo Matsushita. Functional analysis of a monoclonal antibody reactive against the C1C2 of Env obtained from a patient infected with HIV-1 CRF02_AG. Retrovirology, 18(1):23 doi, Aug 2021. PubMed ID: 34419098 Show all entries for this paper.

RamirezValdez2015 Kristel Paola Ramirez Valdez, Takeo Kuwata, Yasuhiro Maruta, Kazuki Tanaka, Muntasir Alam, Kazuhisa Yoshimura, and Shuzo Matsushita. Complementary and Synergistic Activities of Anti-V3, CD4bs and CD4i Antibodies Derived from a Single Individual Can Cover a Wide Range of HIV-1 Strains. Virology, 475:187-203, 15 Jan 2015. PubMed ID: 25486586. Show all entries for this paper.

Tanaka2017 Kazuki Tanaka, Takeo Kuwata, Muntasir Alam, Gilad Kaplan, Shokichi Takahama, Kristel Paola Ramirez Valdez, Anna Roitburd-Berman, Jonathan M. Gershoni, and Shuzo Matsushita. Unique binding modes for the broad neutralizing activity of single-chain variable fragments (scFv) targeting CD4-induced epitopes. Retrovirology, 14(1):44 doi, Sep 2017. PubMed ID: 28938888 Show all entries for this paper.

Thida2019 Win Thida, Takeo Kuwata, Yosuke Maeda, Tetsu Yamashiro, Giang Van Tran, Kinh Van Nguyen, Masafumi Takiguchi, Hiroyuki Gatanaga, Kazuki Tanaka, and Shuzo Matsushita. The role of conventional antibodies targeting the CD4 binding site and CD4-induced epitopes in the control of HIV-1 CRF01_AE viruses. Biochem Biophys Res Commun, 508(1):46-51 doi, Jan 2019. PubMed ID: 30470571 Show all entries for this paper.


Displaying record number 3257

Download this epitope record as JSON.

MAb ID 1D9
HXB2 Location Env Env Epitope Map
Author Location  
Epitope
Subtype B
Ab Type gp120 V3 // V3 glycan (V3g)
Neutralizing P (tier 2)  View neutralization details
Species (Isotype) human(IgG1κ)
Patient KTS376
Immunogen HIV-1 infection
Country Japan
Keywords ADCC, antibody generation, binding affinity, neutralization

Notes

Showing 1 of 1 note.

References

Showing 1 of 1 reference.

Isolation Paper
RamirezValdez2015 Kristel Paola Ramirez Valdez, Takeo Kuwata, Yasuhiro Maruta, Kazuki Tanaka, Muntasir Alam, Kazuhisa Yoshimura, and Shuzo Matsushita. Complementary and Synergistic Activities of Anti-V3, CD4bs and CD4i Antibodies Derived from a Single Individual Can Cover a Wide Range of HIV-1 Strains. Virology, 475:187-203, 15 Jan 2015. PubMed ID: 25486586. Show all entries for this paper.


Displaying record number 3258

Download this epitope record as JSON.

MAb ID 5G2
HXB2 Location Env Env Epitope Map
Author Location  
Epitope
Subtype B
Ab Type gp120 V3 // V3 glycan (V3g)
Neutralizing P (tier 2)  View neutralization details
Species (Isotype) human(IgG1κ)
Patient KTS376
Immunogen HIV-1 infection
Country Japan
Keywords ADCC, antibody generation, binding affinity, neutralization

Notes

Showing 1 of 1 note.

References

Showing 1 of 1 reference.

Isolation Paper
RamirezValdez2015 Kristel Paola Ramirez Valdez, Takeo Kuwata, Yasuhiro Maruta, Kazuki Tanaka, Muntasir Alam, Kazuhisa Yoshimura, and Shuzo Matsushita. Complementary and Synergistic Activities of Anti-V3, CD4bs and CD4i Antibodies Derived from a Single Individual Can Cover a Wide Range of HIV-1 Strains. Virology, 475:187-203, 15 Jan 2015. PubMed ID: 25486586. Show all entries for this paper.


Displaying record number 3259

Download this epitope record as JSON.

MAb ID 16G6
HXB2 Location Env Env Epitope Map
Author Location  
Epitope
Subtype B
Ab Type gp120 V3 // V3 glycan (V3g)
Neutralizing P (tier 2)  View neutralization details
Species (Isotype) human(IgG1λ)
Patient KTS376
Immunogen HIV-1 infection
Country Japan
Keywords ADCC, antibody generation, binding affinity, neutralization

Notes

Showing 1 of 1 note.

References

Showing 1 of 1 reference.

Isolation Paper
RamirezValdez2015 Kristel Paola Ramirez Valdez, Takeo Kuwata, Yasuhiro Maruta, Kazuki Tanaka, Muntasir Alam, Kazuhisa Yoshimura, and Shuzo Matsushita. Complementary and Synergistic Activities of Anti-V3, CD4bs and CD4i Antibodies Derived from a Single Individual Can Cover a Wide Range of HIV-1 Strains. Virology, 475:187-203, 15 Jan 2015. PubMed ID: 25486586. Show all entries for this paper.


Displaying record number 3260

Download this epitope record as JSON.

MAb ID 717G2
HXB2 Location Env Env Epitope Map
Author Location  
Epitope
Subtype B
Ab Type gp120 V3 // V3 glycan (V3g)
Neutralizing P (tier 2)  View neutralization details
Species (Isotype) human(IgG2κ)
Patient KTS376
Immunogen HIV-1 infection
Country Japan
Keywords ADCC, antibody generation, binding affinity, neutralization

Notes

Showing 1 of 1 note.

References

Showing 1 of 1 reference.

Isolation Paper
RamirezValdez2015 Kristel Paola Ramirez Valdez, Takeo Kuwata, Yasuhiro Maruta, Kazuki Tanaka, Muntasir Alam, Kazuhisa Yoshimura, and Shuzo Matsushita. Complementary and Synergistic Activities of Anti-V3, CD4bs and CD4i Antibodies Derived from a Single Individual Can Cover a Wide Range of HIV-1 Strains. Virology, 475:187-203, 15 Jan 2015. PubMed ID: 25486586. Show all entries for this paper.


Displaying record number 3261

Download this epitope record as JSON.

MAb ID 2F8
HXB2 Location Env Env Epitope Map
Author Location  
Epitope
Subtype B
Ab Type gp120 V3 // V3 glycan (V3g)
Neutralizing  
Species (Isotype) human(IgG1λ)
Patient KTS376
Immunogen HIV-1 infection
Country Japan
Keywords antibody generation, binding affinity, neutralization

Notes

Showing 1 of 1 note.

References

Showing 1 of 1 reference.

Isolation Paper
RamirezValdez2015 Kristel Paola Ramirez Valdez, Takeo Kuwata, Yasuhiro Maruta, Kazuki Tanaka, Muntasir Alam, Kazuhisa Yoshimura, and Shuzo Matsushita. Complementary and Synergistic Activities of Anti-V3, CD4bs and CD4i Antibodies Derived from a Single Individual Can Cover a Wide Range of HIV-1 Strains. Virology, 475:187-203, 15 Jan 2015. PubMed ID: 25486586. Show all entries for this paper.


Displaying record number 3262

Download this epitope record as JSON.

MAb ID 3G8
HXB2 Location Env Env Epitope Map
Author Location  
Epitope
Subtype B
Ab Type gp120 V3 // V3 glycan (V3g)
Neutralizing  
Species (Isotype) human(IgG1κ)
Patient KTS376
Immunogen HIV-1 infection
Country Japan
Keywords antibody generation, binding affinity, neutralization

Notes

Showing 1 of 1 note.

References

Showing 1 of 1 reference.

Isolation Paper
RamirezValdez2015 Kristel Paola Ramirez Valdez, Takeo Kuwata, Yasuhiro Maruta, Kazuki Tanaka, Muntasir Alam, Kazuhisa Yoshimura, and Shuzo Matsushita. Complementary and Synergistic Activities of Anti-V3, CD4bs and CD4i Antibodies Derived from a Single Individual Can Cover a Wide Range of HIV-1 Strains. Virology, 475:187-203, 15 Jan 2015. PubMed ID: 25486586. Show all entries for this paper.


Displaying record number 3263

Download this epitope record as JSON.

MAb ID 42F9
HXB2 Location Env Env Epitope Map
Author Location  
Epitope
Subtype B
Ab Type gp120 CD4BS
Neutralizing P (tier 2)
Species (Isotype) human(IgG1κ)
Patient KTS376
Immunogen HIV-1 infection
Country Japan
Keywords ADCC, antibody generation, binding affinity, neutralization

Notes

Showing 1 of 1 note.

References

Showing 1 of 1 reference.

Isolation Paper
RamirezValdez2015 Kristel Paola Ramirez Valdez, Takeo Kuwata, Yasuhiro Maruta, Kazuki Tanaka, Muntasir Alam, Kazuhisa Yoshimura, and Shuzo Matsushita. Complementary and Synergistic Activities of Anti-V3, CD4bs and CD4i Antibodies Derived from a Single Individual Can Cover a Wide Range of HIV-1 Strains. Virology, 475:187-203, 15 Jan 2015. PubMed ID: 25486586. Show all entries for this paper.


Displaying record number 3264

Download this epitope record as JSON.

MAb ID 49G2
HXB2 Location Env Env Epitope Map
Author Location  
Epitope
Subtype B
Ab Type gp120 CD4BS
Neutralizing P (tier 2)  View neutralization details
Species (Isotype) human(IgG1λ)
Patient KTS376
Immunogen HIV-1 infection
Country Japan
Keywords ADCC, antibody generation, binding affinity, drug resistance, neutralization, subtype comparisons

Notes

Showing 3 of 3 notes.

References

Showing 3 of 3 references.

Isolation Paper
RamirezValdez2015 Kristel Paola Ramirez Valdez, Takeo Kuwata, Yasuhiro Maruta, Kazuki Tanaka, Muntasir Alam, Kazuhisa Yoshimura, and Shuzo Matsushita. Complementary and Synergistic Activities of Anti-V3, CD4bs and CD4i Antibodies Derived from a Single Individual Can Cover a Wide Range of HIV-1 Strains. Virology, 475:187-203, 15 Jan 2015. PubMed ID: 25486586. Show all entries for this paper.

Kuwata2016 Takeo Kuwata, Ikumi Enomoto, Masanori Baba, and Shuzo Matsushita. Incompatible Natures of the HIV-1 Envelope in Resistance to the CCR5 Antagonist Cenicriviroc and to Neutralizing Antibodies. Antimicrob. Agents Chemother., 60(1):437-450, 2 Nov 2015. PubMed ID: 26525792. Show all entries for this paper.

Thida2019 Win Thida, Takeo Kuwata, Yosuke Maeda, Tetsu Yamashiro, Giang Van Tran, Kinh Van Nguyen, Masafumi Takiguchi, Hiroyuki Gatanaga, Kazuki Tanaka, and Shuzo Matsushita. The role of conventional antibodies targeting the CD4 binding site and CD4-induced epitopes in the control of HIV-1 CRF01_AE viruses. Biochem Biophys Res Commun, 508(1):46-51 doi, Jan 2019. PubMed ID: 30470571 Show all entries for this paper.


Displaying record number 3265

Download this epitope record as JSON.

MAb ID 82D5
HXB2 Location Env Env Epitope Map
Author Location  
Epitope
Subtype B
Ab Type gp120 CD4BS
Neutralizing P (tier 2)
Species (Isotype) human(IgG1λ)
Patient KTS376
Immunogen HIV-1 infection
Country Japan
Keywords ADCC, antibody generation, binding affinity, neutralization

Notes

Showing 1 of 1 note.

References

Showing 1 of 1 reference.

Isolation Paper
RamirezValdez2015 Kristel Paola Ramirez Valdez, Takeo Kuwata, Yasuhiro Maruta, Kazuki Tanaka, Muntasir Alam, Kazuhisa Yoshimura, and Shuzo Matsushita. Complementary and Synergistic Activities of Anti-V3, CD4bs and CD4i Antibodies Derived from a Single Individual Can Cover a Wide Range of HIV-1 Strains. Virology, 475:187-203, 15 Jan 2015. PubMed ID: 25486586. Show all entries for this paper.


Displaying record number 3266

Download this epitope record as JSON.

MAb ID 4E3
HXB2 Location Env Env Epitope Map
Author Location  
Epitope
Subtype B
Ab Type gp120 CD4BS
Neutralizing  
Species (Isotype) human(IgG1κ)
Patient KTS376
Immunogen HIV-1 infection
Country Japan
Keywords antibody generation, binding affinity, neutralization

Notes

Showing 1 of 1 note.

References

Showing 1 of 1 reference.

Isolation Paper
RamirezValdez2015 Kristel Paola Ramirez Valdez, Takeo Kuwata, Yasuhiro Maruta, Kazuki Tanaka, Muntasir Alam, Kazuhisa Yoshimura, and Shuzo Matsushita. Complementary and Synergistic Activities of Anti-V3, CD4bs and CD4i Antibodies Derived from a Single Individual Can Cover a Wide Range of HIV-1 Strains. Virology, 475:187-203, 15 Jan 2015. PubMed ID: 25486586. Show all entries for this paper.


Displaying record number 3267

Download this epitope record as JSON.

MAb ID 7B5
HXB2 Location Env Env Epitope Map
Author Location  
Epitope
Subtype B
Ab Type gp120 CD4BS
Neutralizing  
Species (Isotype) human(IgG2λ)
Patient KTS376
Immunogen HIV-1 infection
Country Japan
Keywords antibody generation, binding affinity, neutralization

Notes

Showing 1 of 1 note.

References

Showing 1 of 1 reference.

Isolation Paper
RamirezValdez2015 Kristel Paola Ramirez Valdez, Takeo Kuwata, Yasuhiro Maruta, Kazuki Tanaka, Muntasir Alam, Kazuhisa Yoshimura, and Shuzo Matsushita. Complementary and Synergistic Activities of Anti-V3, CD4bs and CD4i Antibodies Derived from a Single Individual Can Cover a Wide Range of HIV-1 Strains. Virology, 475:187-203, 15 Jan 2015. PubMed ID: 25486586. Show all entries for this paper.


Displaying record number 3268

Download this epitope record as JSON.

MAb ID 916B2
HXB2 Location Env Env Epitope Map
Author Location  
Epitope
Subtype B
Ab Type gp120 CD4i
Neutralizing View neutralization details
Species (Isotype) human(IgG1λ)
Patient KTS376
Immunogen HIV-1 infection
Country Japan
Keywords ADCC, antibody binding site, antibody generation, binding affinity, neutralization, subtype comparisons

Notes

Showing 3 of 3 notes.

References

Showing 3 of 3 references.

Isolation Paper
RamirezValdez2015 Kristel Paola Ramirez Valdez, Takeo Kuwata, Yasuhiro Maruta, Kazuki Tanaka, Muntasir Alam, Kazuhisa Yoshimura, and Shuzo Matsushita. Complementary and Synergistic Activities of Anti-V3, CD4bs and CD4i Antibodies Derived from a Single Individual Can Cover a Wide Range of HIV-1 Strains. Virology, 475:187-203, 15 Jan 2015. PubMed ID: 25486586. Show all entries for this paper.

Tanaka2017 Kazuki Tanaka, Takeo Kuwata, Muntasir Alam, Gilad Kaplan, Shokichi Takahama, Kristel Paola Ramirez Valdez, Anna Roitburd-Berman, Jonathan M. Gershoni, and Shuzo Matsushita. Unique binding modes for the broad neutralizing activity of single-chain variable fragments (scFv) targeting CD4-induced epitopes. Retrovirology, 14(1):44 doi, Sep 2017. PubMed ID: 28938888 Show all entries for this paper.

Thida2019 Win Thida, Takeo Kuwata, Yosuke Maeda, Tetsu Yamashiro, Giang Van Tran, Kinh Van Nguyen, Masafumi Takiguchi, Hiroyuki Gatanaga, Kazuki Tanaka, and Shuzo Matsushita. The role of conventional antibodies targeting the CD4 binding site and CD4-induced epitopes in the control of HIV-1 CRF01_AE viruses. Biochem Biophys Res Commun, 508(1):46-51 doi, Jan 2019. PubMed ID: 30470571 Show all entries for this paper.


Displaying record number 3269

Download this epitope record as JSON.

MAb ID 917B11
HXB2 Location Env Env Epitope Map
Author Location  
Epitope
Subtype B
Ab Type gp120 CD4i
Neutralizing P (tier 2)  View neutralization details
Species (Isotype) human(IgG1λ)
Patient KTS376
Immunogen HIV-1 infection
Country Japan
Keywords ADCC, antibody binding site, antibody generation, binding affinity, neutralization, subtype comparisons

Notes

Showing 3 of 3 notes.

References

Showing 3 of 3 references.

Isolation Paper
RamirezValdez2015 Kristel Paola Ramirez Valdez, Takeo Kuwata, Yasuhiro Maruta, Kazuki Tanaka, Muntasir Alam, Kazuhisa Yoshimura, and Shuzo Matsushita. Complementary and Synergistic Activities of Anti-V3, CD4bs and CD4i Antibodies Derived from a Single Individual Can Cover a Wide Range of HIV-1 Strains. Virology, 475:187-203, 15 Jan 2015. PubMed ID: 25486586. Show all entries for this paper.

Tanaka2017 Kazuki Tanaka, Takeo Kuwata, Muntasir Alam, Gilad Kaplan, Shokichi Takahama, Kristel Paola Ramirez Valdez, Anna Roitburd-Berman, Jonathan M. Gershoni, and Shuzo Matsushita. Unique binding modes for the broad neutralizing activity of single-chain variable fragments (scFv) targeting CD4-induced epitopes. Retrovirology, 14(1):44 doi, Sep 2017. PubMed ID: 28938888 Show all entries for this paper.

Thida2019 Win Thida, Takeo Kuwata, Yosuke Maeda, Tetsu Yamashiro, Giang Van Tran, Kinh Van Nguyen, Masafumi Takiguchi, Hiroyuki Gatanaga, Kazuki Tanaka, and Shuzo Matsushita. The role of conventional antibodies targeting the CD4 binding site and CD4-induced epitopes in the control of HIV-1 CRF01_AE viruses. Biochem Biophys Res Commun, 508(1):46-51 doi, Jan 2019. PubMed ID: 30470571 Show all entries for this paper.


Displaying record number 3270

Download this epitope record as JSON.

MAb ID 5D6S
HXB2 Location Env Env Epitope Map
Author Location  
Epitope
Subtype B
Ab Type gp120 CD4i
Neutralizing  
Species (Isotype) human(IgG1κ)
Patient KTS376
Immunogen HIV-1 infection
Country Japan
Keywords antibody binding site, antibody generation, binding affinity, neutralization

Notes

Showing 2 of 2 notes.

References

Showing 2 of 2 references.

Isolation Paper
RamirezValdez2015 Kristel Paola Ramirez Valdez, Takeo Kuwata, Yasuhiro Maruta, Kazuki Tanaka, Muntasir Alam, Kazuhisa Yoshimura, and Shuzo Matsushita. Complementary and Synergistic Activities of Anti-V3, CD4bs and CD4i Antibodies Derived from a Single Individual Can Cover a Wide Range of HIV-1 Strains. Virology, 475:187-203, 15 Jan 2015. PubMed ID: 25486586. Show all entries for this paper.

Tanaka2017 Kazuki Tanaka, Takeo Kuwata, Muntasir Alam, Gilad Kaplan, Shokichi Takahama, Kristel Paola Ramirez Valdez, Anna Roitburd-Berman, Jonathan M. Gershoni, and Shuzo Matsushita. Unique binding modes for the broad neutralizing activity of single-chain variable fragments (scFv) targeting CD4-induced epitopes. Retrovirology, 14(1):44 doi, Sep 2017. PubMed ID: 28938888 Show all entries for this paper.


Displaying record number 3271

Download this epitope record as JSON.

MAb ID 7F11
HXB2 Location Env Env Epitope Map
Author Location  
Epitope
Subtype B
Ab Type gp120 CD4i
Neutralizing  
Species (Isotype) human(IgG2κ)
Patient KTS376
Immunogen HIV-1 infection
Country Japan
Keywords antibody generation, binding affinity, neutralization

Notes

Showing 2 of 2 notes.

References

Showing 1 of 1 references.

Isolation Paper
RamirezValdez2015 Kristel Paola Ramirez Valdez, Takeo Kuwata, Yasuhiro Maruta, Kazuki Tanaka, Muntasir Alam, Kazuhisa Yoshimura, and Shuzo Matsushita. Complementary and Synergistic Activities of Anti-V3, CD4bs and CD4i Antibodies Derived from a Single Individual Can Cover a Wide Range of HIV-1 Strains. Virology, 475:187-203, 15 Jan 2015. PubMed ID: 25486586. Show all entries for this paper.


Displaying record number 3272

Download this epitope record as JSON.

MAb ID 5E8
HXB2 Location Env Env Epitope Map
Author Location  
Epitope
Subtype B
Ab Type gp120
Neutralizing  
Species (Isotype) human(IgG2κ)
Patient KTS376
Immunogen HIV-1 infection
Country Japan
Keywords antibody generation, binding affinity, neutralization

Notes

Showing 1 of 1 note.

References

Showing 1 of 1 reference.

Isolation Paper
RamirezValdez2015 Kristel Paola Ramirez Valdez, Takeo Kuwata, Yasuhiro Maruta, Kazuki Tanaka, Muntasir Alam, Kazuhisa Yoshimura, and Shuzo Matsushita. Complementary and Synergistic Activities of Anti-V3, CD4bs and CD4i Antibodies Derived from a Single Individual Can Cover a Wide Range of HIV-1 Strains. Virology, 475:187-203, 15 Jan 2015. PubMed ID: 25486586. Show all entries for this paper.


Displaying record number 3273

Download this epitope record as JSON.

MAb ID 7B9N
HXB2 Location Env Env Epitope Map
Author Location  
Epitope
Subtype B
Ab Type gp120
Neutralizing  
Species (Isotype) human(IgG3κ)
Patient KTS376
Immunogen HIV-1 infection
Country Japan
Keywords antibody generation, binding affinity, neutralization

Notes

Showing 1 of 1 note.

References

Showing 1 of 1 reference.

Isolation Paper
RamirezValdez2015 Kristel Paola Ramirez Valdez, Takeo Kuwata, Yasuhiro Maruta, Kazuki Tanaka, Muntasir Alam, Kazuhisa Yoshimura, and Shuzo Matsushita. Complementary and Synergistic Activities of Anti-V3, CD4bs and CD4i Antibodies Derived from a Single Individual Can Cover a Wide Range of HIV-1 Strains. Virology, 475:187-203, 15 Jan 2015. PubMed ID: 25486586. Show all entries for this paper.


Displaying record number 3274

Download this epitope record as JSON.

MAb ID 9F7
HXB2 Location Env Env Epitope Map
Author Location  
Epitope
Subtype B
Ab Type gp120
Neutralizing  
Species (Isotype) human(IgG1κ)
Patient KTS376
Immunogen HIV-1 infection
Country Japan
Keywords antibody generation, binding affinity, neutralization

Notes

Showing 1 of 1 note.

References

Showing 1 of 1 reference.

Isolation Paper
RamirezValdez2015 Kristel Paola Ramirez Valdez, Takeo Kuwata, Yasuhiro Maruta, Kazuki Tanaka, Muntasir Alam, Kazuhisa Yoshimura, and Shuzo Matsushita. Complementary and Synergistic Activities of Anti-V3, CD4bs and CD4i Antibodies Derived from a Single Individual Can Cover a Wide Range of HIV-1 Strains. Virology, 475:187-203, 15 Jan 2015. PubMed ID: 25486586. Show all entries for this paper.


Displaying record number 3275

Download this epitope record as JSON.

MAb ID 39D5
HXB2 Location Env Env Epitope Map
Author Location  
Epitope
Subtype B
Ab Type gp120
Neutralizing  
Species (Isotype) human(IgG3κ)
Patient KTS376
Immunogen HIV-1 infection
Country Japan
Keywords antibody generation, binding affinity, neutralization

Notes

Showing 1 of 1 note.

References

Showing 1 of 1 reference.

Isolation Paper
RamirezValdez2015 Kristel Paola Ramirez Valdez, Takeo Kuwata, Yasuhiro Maruta, Kazuki Tanaka, Muntasir Alam, Kazuhisa Yoshimura, and Shuzo Matsushita. Complementary and Synergistic Activities of Anti-V3, CD4bs and CD4i Antibodies Derived from a Single Individual Can Cover a Wide Range of HIV-1 Strains. Virology, 475:187-203, 15 Jan 2015. PubMed ID: 25486586. Show all entries for this paper.


Displaying record number 3276

Download this epitope record as JSON.

MAb ID 43D7
HXB2 Location Env Env Epitope Map
Author Location  
Epitope
Subtype B
Ab Type gp120
Neutralizing  
Species (Isotype) human(IgG2κ)
Patient KTS376
Immunogen HIV-1 infection
Country Japan
Keywords antibody generation, binding affinity, neutralization

Notes

Showing 1 of 1 note.

References

Showing 1 of 1 reference.

Isolation Paper
RamirezValdez2015 Kristel Paola Ramirez Valdez, Takeo Kuwata, Yasuhiro Maruta, Kazuki Tanaka, Muntasir Alam, Kazuhisa Yoshimura, and Shuzo Matsushita. Complementary and Synergistic Activities of Anti-V3, CD4bs and CD4i Antibodies Derived from a Single Individual Can Cover a Wide Range of HIV-1 Strains. Virology, 475:187-203, 15 Jan 2015. PubMed ID: 25486586. Show all entries for this paper.


Displaying record number 2473

Download this epitope record as JSON.

MAb ID 4C11
HXB2 Location Env Env Epitope Map
Author Location gp120
Epitope
Subtype B
Ab Type gp120 CD4i
Neutralizing  
Species (Isotype) human(IgG1λ)
Patient KTS376
Immunogen HIV-1 infection
Country Japan
Keywords antibody generation, binding affinity, mimics, neutralization

Notes

Showing 2 of 2 notes.

References

Showing 2 of 2 references.

Isolation Paper
Yoshimura2010 Kazuhisa Yoshimura, Shigeyoshi Harada, Junji Shibata, Makiko Hatada, Yuko Yamada, Chihiro Ochiai, Hirokazu Tamamura, and Shuzo Matsushita. Enhanced Exposure of Human Immunodeficiency Virus Type 1 Primary Isolate Neutralization Epitopes through Binding of CD4 Mimetic Compounds. J. Virol., 84(15):7558-7568, Aug 2010. PubMed ID: 20504942. Show all entries for this paper.

RamirezValdez2015 Kristel Paola Ramirez Valdez, Takeo Kuwata, Yasuhiro Maruta, Kazuki Tanaka, Muntasir Alam, Kazuhisa Yoshimura, and Shuzo Matsushita. Complementary and Synergistic Activities of Anti-V3, CD4bs and CD4i Antibodies Derived from a Single Individual Can Cover a Wide Range of HIV-1 Strains. Virology, 475:187-203, 15 Jan 2015. PubMed ID: 25486586. Show all entries for this paper.


Questions or comments? Contact us at immuno@lanl.gov
 
Managed by Triad National Security, LLC for the U.S. Department of Energy’s National Nuclear Security Administration
Copyright © 2022 Triad National Security, LLC | Disclaimer/Privacy

Dept of Health & Human Services Los Alamos National Institutes of Health