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Found 3 matching records:

Displaying record number 3277

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MAb ID PG9-iMab (PG9-ibalizumab)
HXB2 Location Env Env Epitope Map
Author Location  
Epitope
Ab Type gp120 V2 // V2 glycan(V2g) // V2 apex, non-HIV: host CD4R
Neutralizing P (tier 2)  View neutralization details
Species (Isotype) human
Patient Donor 24
Immunogen  
Keywords antibody generation, bispecific/trispecific, chimeric antibody, immunotherapy, neutralization, review, subtype comparisons

Notes

Showing 4 of 4 notes.

References

Showing 4 of 4 references.

Isolation Paper
Pace2013a Craig S. Pace, Ruijiang Song, Christina Ochsenbauer, Chasity D. Andrews, David Franco, Jian Yu, Deena A. Oren, Michael S. Seaman, and David D. Ho. Bispecific Antibodies Directed to CD4 Domain 2 and HIV Envelope Exhibit Exceptional Breadth and Picomolar Potency against HIV-1. Proc. Natl. Acad. Sci. U.S.A., 110(33):13540-13545, 13 Aug 2013. PubMed ID: 23878231. Show all entries for this paper.

Bouvin-Pley2014 M. Bouvin-Pley, M. Morgand, L. Meyer, C. Goujard, A. Moreau, H. Mouquet, M. Nussenzweig, C. Pace, D. Ho, P. J. Bjorkman, D. Baty, P. Chames, M. Pancera, P. D. Kwong, P. Poignard, F. Barin, and M. Braibant. Drift of the HIV-1 Envelope Glycoprotein gp120 Toward Increased Neutralization Resistance over the Course of the Epidemic: A Comprehensive Study Using the Most Potent and Broadly Neutralizing Monoclonal Antibodies. J. Virol., 88(23):13910-13917, Dec 2014. PubMed ID: 25231299. Show all entries for this paper.

Hua2016 Casey K. Hua and Margaret E. Ackerman. Engineering Broadly Neutralizing Antibodies for HIV Prevention and Therapy. Adv. Drug Deliv. Rev., 103:157-173, 1 Aug 2016. PubMed ID: 26827912. Show all entries for this paper.

Morgand2015 Marion Morgand, Mélanie Bouvin-Pley, Jean-Christophe Plantier, Alain Moreau, Elodie Alessandri, François Simon, Craig S. Pace, Marie Pancera, David D. Ho, Pascal Poignard, Pamela J. Bjorkman, Hugo Mouquet, Michel C. Nussenzweig, Peter D. Kwong, Daniel Baty, Patrick Chames, Martine Braibant, and Francis Barin. A V1V2 Neutralizing Epitope Is Conserved in Divergent Non-M Groups of HIV-1. J. Acquir. Immune Defic. Syndr., 21 Sep 2015. PubMed ID: 26413851. Show all entries for this paper.


Displaying record number 3278

Download this epitope record as JSON.

MAb ID PG16-iMab (PG16-ibalizumab)
HXB2 Location Env Env Epitope Map
Author Location  
Epitope
Ab Type gp120 V2 // V2 glycan(V2g) // V2 apex, non-HIV: host CD4R
Neutralizing P (tier 2)  View neutralization details
Species (Isotype) human
Patient Donor 24
Immunogen  
Keywords antibody generation, bispecific/trispecific, chimeric antibody, immunotherapy, neutralization, review, subtype comparisons

Notes

Showing 4 of 4 notes.

References

Showing 4 of 4 references.

Isolation Paper
Pace2013a Craig S. Pace, Ruijiang Song, Christina Ochsenbauer, Chasity D. Andrews, David Franco, Jian Yu, Deena A. Oren, Michael S. Seaman, and David D. Ho. Bispecific Antibodies Directed to CD4 Domain 2 and HIV Envelope Exhibit Exceptional Breadth and Picomolar Potency against HIV-1. Proc. Natl. Acad. Sci. U.S.A., 110(33):13540-13545, 13 Aug 2013. PubMed ID: 23878231. Show all entries for this paper.

Bouvin-Pley2014 M. Bouvin-Pley, M. Morgand, L. Meyer, C. Goujard, A. Moreau, H. Mouquet, M. Nussenzweig, C. Pace, D. Ho, P. J. Bjorkman, D. Baty, P. Chames, M. Pancera, P. D. Kwong, P. Poignard, F. Barin, and M. Braibant. Drift of the HIV-1 Envelope Glycoprotein gp120 Toward Increased Neutralization Resistance over the Course of the Epidemic: A Comprehensive Study Using the Most Potent and Broadly Neutralizing Monoclonal Antibodies. J. Virol., 88(23):13910-13917, Dec 2014. PubMed ID: 25231299. Show all entries for this paper.

Hua2016 Casey K. Hua and Margaret E. Ackerman. Engineering Broadly Neutralizing Antibodies for HIV Prevention and Therapy. Adv. Drug Deliv. Rev., 103:157-173, 1 Aug 2016. PubMed ID: 26827912. Show all entries for this paper.

Morgand2015 Marion Morgand, Mélanie Bouvin-Pley, Jean-Christophe Plantier, Alain Moreau, Elodie Alessandri, François Simon, Craig S. Pace, Marie Pancera, David D. Ho, Pascal Poignard, Pamela J. Bjorkman, Hugo Mouquet, Michel C. Nussenzweig, Peter D. Kwong, Daniel Baty, Patrick Chames, Martine Braibant, and Francis Barin. A V1V2 Neutralizing Epitope Is Conserved in Divergent Non-M Groups of HIV-1. J. Acquir. Immune Defic. Syndr., 21 Sep 2015. PubMed ID: 26413851. Show all entries for this paper.


Displaying record number 3410

Download this epitope record as JSON.

MAb ID iMab (ibalizumab, TNX-335, TMB-355, Hu5A8, 5A8)
HXB2 Location non-HIV non-HIV Epitope Map
Author Location non-HIV
Epitope
Ab Type non-HIV: host CD4R
Neutralizing P (tier 2)  View neutralization details
Species (Isotype) humanized mouse
Patient  
Immunogen vaccine
Keywords antibody binding site, antibody generation, bispecific/trispecific, broad neutralizer, chimeric antibody, immunoprophylaxis, immunotherapy, neutralization, review, subtype comparisons

Vaccine Details

Vaccine type other
Vaccine component other

Notes

Showing 7 of 7 notes.

References

Showing 6 of 6 references.

Huang2016 Yaoxing Huang, Jian Yu, Anastasia Lanzi, Xin Yao, Chasity D. Andrews, Lily Tsai, Mili R. Gajjar, Ming Sun, Michael S. Seaman, Neal N. Padte, and David D. Ho. Engineered Bispecific Antibodies with Exquisite HIV-1-Neutralizing Activity. Cell, 165(7):1621-1631, 16 Jun 2016. PubMed ID: 27315479. Show all entries for this paper.

Morgand2015 Marion Morgand, Mélanie Bouvin-Pley, Jean-Christophe Plantier, Alain Moreau, Elodie Alessandri, François Simon, Craig S. Pace, Marie Pancera, David D. Ho, Pascal Poignard, Pamela J. Bjorkman, Hugo Mouquet, Michel C. Nussenzweig, Peter D. Kwong, Daniel Baty, Patrick Chames, Martine Braibant, and Francis Barin. A V1V2 Neutralizing Epitope Is Conserved in Divergent Non-M Groups of HIV-1. J. Acquir. Immune Defic. Syndr., 21 Sep 2015. PubMed ID: 26413851. Show all entries for this paper.

Pace2013a Craig S. Pace, Ruijiang Song, Christina Ochsenbauer, Chasity D. Andrews, David Franco, Jian Yu, Deena A. Oren, Michael S. Seaman, and David D. Ho. Bispecific Antibodies Directed to CD4 Domain 2 and HIV Envelope Exhibit Exceptional Breadth and Picomolar Potency against HIV-1. Proc. Natl. Acad. Sci. U.S.A., 110(33):13540-13545, 13 Aug 2013. PubMed ID: 23878231. Show all entries for this paper.

Wagh2018 Kshitij Wagh, Michael S. Seaman, Marshall Zingg, Tomas Fitzsimons, Dan H. Barouch, Dennis R. Burton, Mark Connors, David D. Ho, John R. Mascola, Michel C. Nussenzweig, Jeffrey Ravetch, Rajeev Gautam, Malcolm A. Martin, David C. Montefiori, and Bette Korber. Potential of Conventional \& Bispecific Broadly Neutralizing Antibodies for Prevention of HIV-1 Subtype A, C \& D Infections. PLoS Pathog., 14(3):e1006860, Mar 2018. PubMed ID: 29505593. Show all entries for this paper.

Walker2018 Laura M. Walker and Dennis R. Burton. Passive Immunotherapy of Viral Infections: `Super-Antibodies' Enter the Fray. Nat. Rev. Immunol., 18(5):297-308, May 2018. PubMed ID: 29379211. Show all entries for this paper.

Wu2018 Xilin Wu, Jia Guo, Mengyue Niu, Minghui An, Li Liu, Hui Wang, Xia Jin, Qi Zhang, Ka Shing Lam, Tongjin Wu, Hua Wang, Qian Wang, Yanhua Du, Jingjing Li, Lin Cheng, Hang Ying Tang, Hong Shang, Linqi Zhang, Paul Zhou, and Zhiwei Chen. Tandem bispecific neutralizing antibody eliminates HIV-1 infection in humanized mice. J Clin Invest, 128(6):2239-2251, Jun 1 2018. PubMed ID: 29461979. Show all entries for this paper.


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