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Displaying record number 1226

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Vaccine Details

Notes

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• Intramuscular injection of Tat-toxoid induced high titers of anti-Tat reactivity in serum samples of six HIV-1 positive and of four HIV negative study subjects. Anti-Tat antibodies successfully blocked extracellular Tat from transactivating HIV Tat-sensitive promotors. The anti-Tat IgG response in sera from two healthy and HIV infected patients inhibited cell entry of synthetic Tat, thus blocking its functional activity. Additionally, the anti-Tat antibodies inhibited intercellular Tat transfer as demonstrated by a co-culture cell system. All HIV-1 infected patients had Ab responses to the N-term region of Tat, and 4/4 HIV-1+ and 5/6 HIV-1 negative patients responded to the basic domain. Several additional peptides were recognized either exclusively or more commonly in the HIV+ people. The N-terminus region of Tat mediates binding to CD26, that may be involved in modulation of chemokine function, and may also mediate T-cell apotosis. Noonan2003 (vaccine-induced immune responses, immunotherapy)

References

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Noonan2003 Douglas M. Noonan, Alessandro Gringeri, Raffaella Meazza, Ombretta Rosso, Stefania Mazza, Myrvet Muca-Perja, Helene Le Buanec, Roberto S. Accolla, Adriana Albini, and Silvano Ferrini. Identification of immunodominant epitopes in inactivated Tat-vaccinated healthy and HIV-1-infected volunteers. J. Acquir. Immune Defic. Syndr., 33(1):47-55, 1 May 2003. PubMed ID: 12792355. Show all entries for this paper.

Displaying record number 1227

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MAb ID	polyclonal
HXB2 Location	Tat(47-60) DNA(5969..6010)	Tat Epitope Map
Author Location	Tat(46-60)
Epitope	YGRKKRRQRRRPPQ	Epitope Alignment
Ab Type	Tat basic region
Neutralizing
Species (Isotype)	human(IgG)
Patient
Immunogen	HIV-1 infection, vaccine
Keywords	immunotherapy, vaccine-induced immune responses

Vaccine Details

Notes

Showing 1 of 1 note.

• Intramuscular injection of Tat-toxoid induced high titers of anti-Tat reactivity in serum samples of six HIV-1 positive and of four HIV negative study subjects. Anti-Tat Abs successfully blocked extracellular Tat from transactivating HIV Tat-sensitive promotors. The anti-Tat IgG response in sera from two healthy and HIV infected patients inhibited cell entry of synthetic Tat, thus blocking its functional activity. Additionally, the anti-Tat Abs inhibited intercellular Tat transfer in a co-culture cell system. All HIV-1 infected patients had Ab responses to the N-term region of Tat, and 4/4 HIV-1+ and 5/6 HIV-1 negative patients responded to the basic domain. Several additional peptides were recognized either exclusively or more commonly in the HIV+ people. The basic region of Tat mediates binding to VEGFR2 on Kaposi's sarcoma cells and endothelial cells, and HIV patients with Kaposi's sarcoma lack Abs to this domain. Noonan2003 (vaccine-induced immune responses, immunotherapy)

References

Showing 1 of 1 reference.

Noonan2003 Douglas M. Noonan, Alessandro Gringeri, Raffaella Meazza, Ombretta Rosso, Stefania Mazza, Myrvet Muca-Perja, Helene Le Buanec, Roberto S. Accolla, Adriana Albini, and Silvano Ferrini. Identification of immunodominant epitopes in inactivated Tat-vaccinated healthy and HIV-1-infected volunteers. J. Acquir. Immune Defic. Syndr., 33(1):47-55, 1 May 2003. PubMed ID: 12792355. Show all entries for this paper.