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Found 2 matching records:

Displaying record number 413

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MAb ID 1026
HXB2 Location gp160(312-317)
DNA(7158..7175)
gp160 Epitope Map
Author Location gp120( MN)
Epitope GPGRAF Epitope Alignment
GPGRAF epitope logo
Ab Type gp120 V3 // V3 glycan (V3g)
Neutralizing L
Species (Isotype) mouse(IgG)
Patient  
Immunogen vaccine
Keywords binding affinity

Vaccine Details

Vaccine type protein
Vaccine strain B clade MN
Vaccine component gp120

Notes

Showing 3 of 3 notes.

References

Showing 3 of 3 references.

Nakamura1993 G. R. Nakamura, R. Byrn, D. M. Wilkes, J. A. Fox, M. R. Hobbs, R. Hastings, H. C. Wessling, M. A. Norcross, B. M. Fendly, and P. W. Berman. Strain Specificity and Binding Affinity Requirements of Neutralizing Monoclonal Antibodies to the C4 Domain of gp120 from Human Immunodeficiency Virus Type 1. J. Virol., 67:6179-6191, 1993. Multiple CD4 binding domain antibodies are described; only one has a linear peptide reactivity (13H8). A V3 loop binding antibody is also described (1026). PubMed ID: 7690420. Show all entries for this paper.

Bou-Habib1994 D. C. Bou-Habib, G. Roderiquez, T. Oravecz, P. W. Berman, P. Lusso, and M. A. Norcross. Cryptic Nature of Envelope V3 Region Epitopes Protects Primary Monocytotropic Human Immunodeficiency Virus Type 1 from Antibody Neutralization. J. Virol., 68:6006-6013, 1994. This paper shows that antibodies to the tip of the V3 loop fail to neutralize primary isolate JR-CSF, and that the V3 loop is far more accessible on the JR-CSF derived T-cell tropic strain T-CSF. Anti-V3 antibodies successfully neutralize T-CSF. Weak binding of anti-V3 antibodies to the primary isolate JR-CSF suggests the V3 loop is accessible only in a minor fraction of proteins. PubMed ID: 8057475. Show all entries for this paper.

Yu2010 Bin Yu, Dora P. A. J. Fonseca, Sara M. O'Rourke, and Phillip W. Berman. Protease Cleavage Sites in HIV-1 gp120 Recognized by Antigen Processing Enzymes Are Conserved and Located at Receptor Binding Sites. J. Virol., 84(3):1513-1526, Feb 2010. PubMed ID: 19939935. Show all entries for this paper.


Displaying record number 556

Download this epitope record as JSON.

MAb ID 13H8
HXB2 Location gp160(431-440)
DNA(7515..7544)
gp160 Epitope Map
Author Location gp120(412-453)
Epitope GKAMYAPPIS Epitope Alignment
GKAMYAPPIS epitope logo
Ab Type gp120 C4
Neutralizing L
Species (Isotype) mouse(IgG)
Patient  
Immunogen vaccine
Keywords binding affinity

Vaccine Details

Vaccine type protein
Vaccine strain B clade MN

Notes

Showing 5 of 5 notes.

References

Showing 4 of 4 references.

Nakamura1992 G. R. Nakamura, R. Byrn, K. Rosenthal, J. P. Porter, M. R. Hobbs, L. Riddle, D. J. Eastman, D. Dowbenko, T. Gregory, B. M. Fendly, and P. W. Berman. Monoclonal Antibodies to the Extracellular Domain of HIV-1 IIIB gp160 That Neutralize Infectivity, Block Binding to CD4 React with Diverse Isolates. AIDS Res. Hum. Retroviruses, 8:1875-1885, 1992. PubMed ID: 1283308. Show all entries for this paper.

Nakamura1993 G. R. Nakamura, R. Byrn, D. M. Wilkes, J. A. Fox, M. R. Hobbs, R. Hastings, H. C. Wessling, M. A. Norcross, B. M. Fendly, and P. W. Berman. Strain Specificity and Binding Affinity Requirements of Neutralizing Monoclonal Antibodies to the C4 Domain of gp120 from Human Immunodeficiency Virus Type 1. J. Virol., 67:6179-6191, 1993. Multiple CD4 binding domain antibodies are described; only one has a linear peptide reactivity (13H8). A V3 loop binding antibody is also described (1026). PubMed ID: 7690420. Show all entries for this paper.

Jeffs1996 S. A. Jeffs, J. McKeating, S. Lewis, H. Craft, D. Biram, P. E. Stephens, and R. L. Brady. Antigenicity of truncated forms of the human immunodeficiency virus type 1 envelope glycoprotein. J. Gen. Virol., 77:1403-1410, 1996. PubMed ID: 8757980. Show all entries for this paper.

Yu2010 Bin Yu, Dora P. A. J. Fonseca, Sara M. O'Rourke, and Phillip W. Berman. Protease Cleavage Sites in HIV-1 gp120 Recognized by Antigen Processing Enzymes Are Conserved and Located at Receptor Binding Sites. J. Virol., 84(3):1513-1526, Feb 2010. PubMed ID: 19939935. Show all entries for this paper.


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