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Found 12 matching records:

Displaying record number 537

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MAb ID G3-537
HXB2 Location gp160(423-437)
DNA(7491..7535)
gp160 Epitope Map
Author Location gp120(423-437 IIIB)
Epitope IINMWQKVGKAMYAP Epitope Alignment
IINMWQKVGKAMYAP epitope logo
Ab Type gp120 C4
Neutralizing L
Species (Isotype) mouse(IgG1)
Patient  
Immunogen vaccine
Keywords antibody interactions

Vaccine Details

Vaccine type virus derived protein
Vaccine strain B clade IIIB
Vaccine component gp120

Notes

Showing 3 of 3 notes.

References

Showing 4 of 4 references.

Isolation Paper
Sun1989 N. C. Sun, D. D. Ho, C. R. Y. Sun, R.-S. Liou, W. Gordon, M. S. C. Fung, X. L. Li, R. C. Ting, T.-H. Lee, N. T. Chang, and T. W. Chang. Generation and Characterization of Monoclonal Antibodies to the Putative CD4-Binding Domain of Human Immunodeficiency Virus Type 1 gp120. J. Virol., 63:3579-3585, 1989. PubMed ID: 2474670. Show all entries for this paper.

Ho1991a D. D. Ho, J. A. McKeating, X. L. Li, T. Moudgil, E. S. Daar, N.-C. Sun, and J. E. Robinson. Conformational Epitope of gp120 Important in CD4 Binding and Human Immunodeficiency Virus Type 1 Neutralization Identified by a Human Monoclonal Antibody. J. Virol., 65:489-493, 1991. A description of the neutralizing human MAb 15e. It binds to HIV-1 with a broad specificity, and blocks gp120 binding to CD4, and is a discontinuous epitope; DTT reduction of env abrogates binding. PubMed ID: 1702163. Show all entries for this paper.

McKeating1992 J. A. McKeating, J. P. Moore, M. Ferguson, H. S. Marsden, S. Graham, J. W. Almond, D. J. Evans, and R. A. Weiss. Monoclonal Antibodies to the C4 Region of Human Immunodeficiency Virus Type 1 gp120: Use in Topological Analysis of a CD4 Binding Site. AIDS Res. Hum. Retroviruses, 8:451-459, 1992. Antibodies were generated using an antigen poliovirus chimera, expressing aa430-446 of gp120. Results suggest that WQEVGKAMYA may be exposed on the surface of rec gp120. PubMed ID: 1376134. Show all entries for this paper.

Zwick2003a Michael B. Zwick, Robert Kelleher, Richard Jensen, Aran F. Labrijn, Meng Wang, Gerald V. Quinnan, Jr., Paul W. H. I. Parren, and Dennis R. Burton. A Novel Human Antibody against Human Immunodeficiency Virus Type 1 gp120 Is V1, V2, and V3 Loop Dependent and Helps Delimit the Epitope of the Broadly Neutralizing Antibody Immunoglobulin G1 b12. J. Virol., 77(12):6965-6978, Jun 2003. PubMed ID: 12768015. Show all entries for this paper.


Displaying record number 597

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MAb ID 1795
HXB2 Location gp160(425-441)
DNA(7497..7547)
gp160 Epitope Map
Author Location gp120(425-441 IIIB)
Epitope NMWQEVGKAMYAPPISG Epitope Alignment
NMWQEVGKAMYAPPISG epitope logo
Ab Type gp120 CD4BS
Neutralizing L
Species (Isotype)  
Patient  
Immunogen vaccine
Keywords  

Vaccine Details

Vaccine type poliovirus
Vaccine component Env

Notes

Showing 1 of 1 note.

References

Showing 1 of 1 reference.

McKeating1992 J. A. McKeating, J. P. Moore, M. Ferguson, H. S. Marsden, S. Graham, J. W. Almond, D. J. Evans, and R. A. Weiss. Monoclonal Antibodies to the C4 Region of Human Immunodeficiency Virus Type 1 gp120: Use in Topological Analysis of a CD4 Binding Site. AIDS Res. Hum. Retroviruses, 8:451-459, 1992. Antibodies were generated using an antigen poliovirus chimera, expressing aa430-446 of gp120. Results suggest that WQEVGKAMYA may be exposed on the surface of rec gp120. PubMed ID: 1376134. Show all entries for this paper.


Displaying record number 545

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MAb ID ICR38.1a (38.1a, 388/389, ARP388/389)
HXB2 Location gp160(429-438)
DNA(7509..7538)
gp160 Epitope Map
Author Location gp120(427-436 BRU)
Epitope EVGKAMYAPP (Discontinuous epitope) Epitope Alignment
EVGKAMYAPP epitope logo
Ab Type gp120 C3, gp120 C4
Neutralizing L
Species (Isotype) rat(IgG2b)
Patient  
Immunogen vaccine
Keywords antibody binding site, antibody generation, dendritic cells

Vaccine Details

Vaccine type protein
Vaccine strain B clade BH10
Vaccine component gp120

Notes

Showing 10 of 10 notes.

References

Showing 12 of 12 references.

Isolation Paper
Cordell1991 J. Cordell, J. P. Moore, C. J. Dean, P. J. Klasse, R. A. Weiss, and J. A. McKeating. Rat Monoclonal Antibodies to Nonoverlapping Epitopes of Human Immunodeficiency Virus Type I gp120 Block CD4 Binding In Vitro. Virology, 185:72-79, 1991. PubMed ID: 1718090. Show all entries for this paper.

McKeating1992 J. A. McKeating, J. P. Moore, M. Ferguson, H. S. Marsden, S. Graham, J. W. Almond, D. J. Evans, and R. A. Weiss. Monoclonal Antibodies to the C4 Region of Human Immunodeficiency Virus Type 1 gp120: Use in Topological Analysis of a CD4 Binding Site. AIDS Res. Hum. Retroviruses, 8:451-459, 1992. Antibodies were generated using an antigen poliovirus chimera, expressing aa430-446 of gp120. Results suggest that WQEVGKAMYA may be exposed on the surface of rec gp120. PubMed ID: 1376134. Show all entries for this paper.

McKeating1992a J. A. McKeating, J. Cordell, C. J. Dean, and P. Balfe. Synergistic Interaction between Ligands Binding to the CD4 Binding Site and V3 Domain of Human Immunodeficiency Virus Type I gp120. Virology, 191:732-742, 1992. PubMed ID: 1280382. Show all entries for this paper.

McKeating1992b J. A. McKeating, M. Thali, C. Furman, S. Karwowska, M. K. Gorny, J. Cordell, S. Zolla-Pazner, J. Sodroski, and R. A. Weiss. Amino Acid Residues of the Human Immunodeficiency Virus Type 1 gp120 Critical for the Binding of Rat and Human Neutralizing Antibodies That Block the gp120-sCD4 Interaction. Virology, 190:134-142, 1992. PubMed ID: 1382339. Show all entries for this paper.

McKeating1993a J. A. McKeating, C. Shotton, J. Cordell, S. Graham, P. Balfe, N. Sullivan, M. Charles, M. Page, A. Bolmstedt, S. Olofsson, S. C. Kayman, Z. Wu, A. Pinter, C. Dean, J. Sodroski, and R. A. Weiss. Characterization of neutralizing monoclonal antibodies to linear and conformation-dependent epitopes within the first and second variable domains of human immunodeficiency virus type 1 gp120. J. Virol., 67:4932-4944, 1993. Substitutions in the V2 loop can result in complete dissociation of gp120 and gp41, suggesting alterations in V2 can affect subunit assembly. Other substitutions allowed gp120-gp41 association and expression, but inhibited viral entry or syncytia. Binding of some neutralizing MAbs was altered by V2 substitutions. For MAb CRA-4, changes at residues 191/192/193 (YSL/GSS), and for 11/68b, changes at residues 183/184 (PI/SG), within V2, and for both MAbs a position 435 (Y/H) change in C4, abrogate binding. These MAbs can bind to V1 and V2 domains in the absence of C4 domain, so the C4 substitution probably results in conformational change. PubMed ID: 7687306. Show all entries for this paper.

McKeating1993b J. A. McKeating, J. Bennett, S. Zolla-Pazner, M. Schutten, S. Ashelford, A. Leigh-Brown, and P. Balfe. Resistance of a Human Serum-Selected Human Immunodeficiency Virus Type 1 Escape Mutant to Neutralization by CD4 Binding Site Monoclonal Antibodies Is Conferred by a Single Amino Acid Change in gp120. J. Virol., 67:5216-5225, 1993. PubMed ID: 7688820. Show all entries for this paper.

Moore1993c J. P. Moore, M. Thali, B. A. Jameson, F. Vignaux, G. K. Lewis, S.-W. Poon, M. S. Fung, P. J. Durda, L. Akerblom, B. Wahren, D. D. Ho, Q. J. Sattentau, and J. Sodroski. Immunochemical Analysis of the gp120 Surface Glycoprotein of Human Immunodeficiency Virus Type 1: Probing the Structure of the C4 and V4 Domains and the Interaction of the C4 Domain with the V3 Loop. J. Virol., 73:4785-4796, 1993. General observations: C4 and V3 MAbs are sensitive to the way the epitopes are presented, and this sensitivity cannot be correlated to peptide binding. Some V3-C4 domain interaction was indicated based on mutation and interference studies. PubMed ID: 7687303. Show all entries for this paper.

Jeffs1996 S. A. Jeffs, J. McKeating, S. Lewis, H. Craft, D. Biram, P. E. Stephens, and R. L. Brady. Antigenicity of truncated forms of the human immunodeficiency virus type 1 envelope glycoprotein. J. Gen. Virol., 77:1403-1410, 1996. PubMed ID: 8757980. Show all entries for this paper.

Peet1998 N. M. Peet, J. A. McKeating, J. B. de Souza, I. M. Roitt, P. J. Delves, and T. Lund. The Effect of Low-Profile Serine Substitutions in the V3 Loop of HIV-1. Virology, 251:59-70, 1998. PubMed ID: 9813203. Show all entries for this paper.

Kropelin1998 M. Kropelin, C. Susal, V. Daniel, and G. Opelz. Inhibition of HIV-1 rgp120 Binding to CD4+ T Cells by Monoclonal Antibodies Directed against the gp120 C1 or C4 Region. Immunol. Lett., 63:19-25, 1998. PubMed ID: 9719434. Show all entries for this paper.

Vella2002 Cherelyn Vella, Natalie N. Zheng, Philippa Easterbrook, and Rod S. Daniels. Herpesvirus saimiri-Immortalized Human Lymphocytes: Novel Hosts for Analyzing HIV Type 1 in Vitro Neutralization. AIDS Res. Hum. Retroviruses, 18(13):933-946, 1 Sep 2002. PubMed ID: 12230936. Show all entries for this paper.

Holl2006 Vincent Holl, Maryse Peressin, Thomas Decoville, Sylvie Schmidt, Susan Zolla-Pazner, Anne-Marie Aubertin, and Christiane Moog. Nonneutralizing Antibodies Are Able To Inhibit Human Immunodeficiency Virus Type 1 Replication in Macrophages and Immature Dendritic Cells. J. Virol., 80(12):6177-6181, Jun 2006. PubMed ID: 16731957. Show all entries for this paper.


Displaying record number 544

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MAb ID G3-536
HXB2 Location gp160(429-438)
DNA(7509..7538)
gp160 Epitope Map
Author Location gp120(429-438 BRU)
Research Contact Tanox Biosystems Inc and David Ho, ADARC, NY
Epitope EVGKAMYAPP Epitope Alignment
EVGKAMYAPP epitope logo
Ab Type gp120 C4
Neutralizing L
Species (Isotype) mouse(IgG1)
Patient  
Immunogen vaccine
Keywords  

Vaccine Details

Vaccine type virus derived protein
Vaccine strain B clade IIIB
Vaccine component gp120

Notes

Showing 10 of 10 notes.

References

Showing 11 of 11 references.

Isolation Paper
Sun1989 N. C. Sun, D. D. Ho, C. R. Y. Sun, R.-S. Liou, W. Gordon, M. S. C. Fung, X. L. Li, R. C. Ting, T.-H. Lee, N. T. Chang, and T. W. Chang. Generation and Characterization of Monoclonal Antibodies to the Putative CD4-Binding Domain of Human Immunodeficiency Virus Type 1 gp120. J. Virol., 63:3579-3585, 1989. PubMed ID: 2474670. Show all entries for this paper.

Ho1991a D. D. Ho, J. A. McKeating, X. L. Li, T. Moudgil, E. S. Daar, N.-C. Sun, and J. E. Robinson. Conformational Epitope of gp120 Important in CD4 Binding and Human Immunodeficiency Virus Type 1 Neutralization Identified by a Human Monoclonal Antibody. J. Virol., 65:489-493, 1991. A description of the neutralizing human MAb 15e. It binds to HIV-1 with a broad specificity, and blocks gp120 binding to CD4, and is a discontinuous epitope; DTT reduction of env abrogates binding. PubMed ID: 1702163. Show all entries for this paper.

Cordell1991 J. Cordell, J. P. Moore, C. J. Dean, P. J. Klasse, R. A. Weiss, and J. A. McKeating. Rat Monoclonal Antibodies to Nonoverlapping Epitopes of Human Immunodeficiency Virus Type I gp120 Block CD4 Binding In Vitro. Virology, 185:72-79, 1991. PubMed ID: 1718090. Show all entries for this paper.

McKeating1992 J. A. McKeating, J. P. Moore, M. Ferguson, H. S. Marsden, S. Graham, J. W. Almond, D. J. Evans, and R. A. Weiss. Monoclonal Antibodies to the C4 Region of Human Immunodeficiency Virus Type 1 gp120: Use in Topological Analysis of a CD4 Binding Site. AIDS Res. Hum. Retroviruses, 8:451-459, 1992. Antibodies were generated using an antigen poliovirus chimera, expressing aa430-446 of gp120. Results suggest that WQEVGKAMYA may be exposed on the surface of rec gp120. PubMed ID: 1376134. Show all entries for this paper.

Moore1993a J. P. Moore and D. D. Ho. Antibodies to discontinuous or conformationally sensitive epitopes on the gp120 glycoprotein of human immunodeficiency virus type 1 are highly prevalent in sera of infected humans. J. Virol., 67:863-875, 1993. CD4BS antibodies are prevalent in HIV-1-positive sera, while neutralizing MAbs to C4, V2, and V3 and MAbs to linear epitopes are less common. Most linear epitope MAbs in human sera are directed against the V3 region, and cross-reactive MAbs tend to be directed against discontinuous epitopes. PubMed ID: 7678308. Show all entries for this paper.

Moore1993c J. P. Moore, M. Thali, B. A. Jameson, F. Vignaux, G. K. Lewis, S.-W. Poon, M. S. Fung, P. J. Durda, L. Akerblom, B. Wahren, D. D. Ho, Q. J. Sattentau, and J. Sodroski. Immunochemical Analysis of the gp120 Surface Glycoprotein of Human Immunodeficiency Virus Type 1: Probing the Structure of the C4 and V4 Domains and the Interaction of the C4 Domain with the V3 Loop. J. Virol., 73:4785-4796, 1993. General observations: C4 and V3 MAbs are sensitive to the way the epitopes are presented, and this sensitivity cannot be correlated to peptide binding. Some V3-C4 domain interaction was indicated based on mutation and interference studies. PubMed ID: 7687303. Show all entries for this paper.

Gorny1994 M. K. Gorny, J. P. Moore, A. J. Conley, S. Karwowska, J. Sodroski, C. Williams, S. Burda, L. J. Boots, and S. Zolla-Pazner. Human Anti-V2 Monoclonal Antibody That Neutralizes Primary but Not Laboratory Isolates of Human Immunodeficiency Virus Type 1. J. Virol., 68:8312-8320, 1994. Detailed characterization of the MAb 697-D. PubMed ID: 7525987. Show all entries for this paper.

Sattentau1995a Q. J. Sattentau and J. P. Moore. Human immunodeficiency virus type 1 neutralization is determined by epitope exposure on the gp120 oligomer. J. Exp. Med., 182:185-196, 1995. This study suggests that antibodies specific for one of five different binding regions on gp120 are associated with viral neutralization: V2, V3, C4, the CD4 binding site, and a complex discontinuous epitope that does not interfere with CD4 binding. Kinetic binding properties of a set of MAbs that bind to these regions were studied, analyzing binding to both functional oligomeric LAI gp120 and soluble monomeric LAI BH10 gp120; neutralization ID$_50$s were also evaluated. It was found that the neutralization ID$_50$s was related to the ability to bind oligomeric, not monomeric, gp120, and concluded that with the exception of the V3 loop, regions of gp120 that are immunogenic will be poorly presented on cell-line-adapted virions. Further, the association rate, estimated as the t$_1/2$ to reach equilibrium binding to multimeric, virion associated, gp120, appears to be a major factor relating to affinity and potency of the neutralization response to cell-line-adapted virus. PubMed ID: 7540648. Show all entries for this paper.

Moore1996 J. P. Moore and J. Sodroski. Antibody cross-competition analysis of the human immunodeficiency virus type 1 gp120 exterior envelope glycoprotein. J. Virol., 70:1863-1872, 1996. 46 anti-gp120 monomer MAbs were used to create a competition matrix, and MAb competition groups were defined. The data suggests that there are two faces of the gp120 glycoprotein: a face occupied by the CD4BS, which is presumably also exposed on the oligomeric envelope glycoprotein complex, and a second face which is presumably inaccessible on the oligomer and interacts with a number of nonneutralizing antibodies. PubMed ID: 8627711. Show all entries for this paper.

Poignard1996b P. Poignard, T. Fouts, D. Naniche, J. P. Moore, and Q. J. Sattentau. Neutralizing antibodies to human immunodeficiency virus type-1 gp120 induce envelope glycoprotein subunit dissociation. J. Exp. Med., 183:473-484, 1996. Binding of Anti-V3 and the CD4I neutralizing MAbs induces shedding of gp120 on cells infected with the T-cell line-adapted HIV-1 molecular clone Hx10. This was shown by significant increases of gp120 in the supernatant, and exposure of a gp41 epitope that is masked in the oligomer. MAbs binding either to the V2 loop or to CD4BS discontinuous epitopes do not induce gp120 dissociation. This suggests HIV neutralization probably is caused by several mechanisms, and one of the mechanisms may involve gp120 dissociation. PubMed ID: 8627160. Show all entries for this paper.

Parren1998 P. W. Parren, I. Mondor, D. Naniche, H. J. Ditzel, P. J. Klasse, D. R. Burton, and Q. J. Sattentau. Neutralization of human immunodeficiency virus type 1 by antibody to gp120 is determined primarily by occupancy of sites on the virion irrespective of epitope specificity. J. Virol., 72:3512-9, 1998. The authors propose that the occupancy of binding sites on HIV-1 virions is the major factor in determining neutralization, irrespective of epitope specificity. Neutralization was assayed T-cell-line-adapted HIV-1 isolates. Binding of Fabs to monomeric rgp120 was not correlated with binding to functional oligomeric gp120 or neutralization, while binding to functional oligomeric gp120 was highly correlated with neutralization. The ratios of oligomer binding/neutralization were similar for antibodies to different neutralization epitopes, with a few exceptions. PubMed ID: 9557629. Show all entries for this paper.


Displaying record number 549

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MAb ID 1663
HXB2 Location gp160(433-439)
DNA(7521..7541)
gp160 Epitope Map
Author Location gp120( IIIB)
Epitope AMYAPPI Epitope Alignment
AMYAPPI epitope logo
Ab Type gp120 C4
Neutralizing  
Species (Isotype)  
Patient  
Immunogen vaccine
Keywords  

Vaccine Details

Vaccine type poliovirus
Vaccine component Env

Notes

Showing 1 of 1 note.

References

Showing 1 of 1 reference.

McKeating1992 J. A. McKeating, J. P. Moore, M. Ferguson, H. S. Marsden, S. Graham, J. W. Almond, D. J. Evans, and R. A. Weiss. Monoclonal Antibodies to the C4 Region of Human Immunodeficiency Virus Type 1 gp120: Use in Topological Analysis of a CD4 Binding Site. AIDS Res. Hum. Retroviruses, 8:451-459, 1992. Antibodies were generated using an antigen poliovirus chimera, expressing aa430-446 of gp120. Results suggest that WQEVGKAMYA may be exposed on the surface of rec gp120. PubMed ID: 1376134. Show all entries for this paper.


Displaying record number 550

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MAb ID 1664
HXB2 Location gp160(433-439)
DNA(7521..7541)
gp160 Epitope Map
Author Location gp120( IIIB)
Epitope AMYAPPI Epitope Alignment
AMYAPPI epitope logo
Ab Type gp120 C4
Neutralizing  
Species (Isotype)  
Patient  
Immunogen vaccine
Keywords  

Vaccine Details

Vaccine type poliovirus
Vaccine component Env

Notes

Showing 1 of 1 note.

References

Showing 1 of 1 reference.

McKeating1992 J. A. McKeating, J. P. Moore, M. Ferguson, H. S. Marsden, S. Graham, J. W. Almond, D. J. Evans, and R. A. Weiss. Monoclonal Antibodies to the C4 Region of Human Immunodeficiency Virus Type 1 gp120: Use in Topological Analysis of a CD4 Binding Site. AIDS Res. Hum. Retroviruses, 8:451-459, 1992. Antibodies were generated using an antigen poliovirus chimera, expressing aa430-446 of gp120. Results suggest that WQEVGKAMYA may be exposed on the surface of rec gp120. PubMed ID: 1376134. Show all entries for this paper.


Displaying record number 551

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MAb ID 1697
HXB2 Location gp160(433-439)
DNA(7521..7541)
gp160 Epitope Map
Author Location gp120( IIIB)
Epitope AMYAPPI Epitope Alignment
AMYAPPI epitope logo
Ab Type gp120 C4
Neutralizing  
Species (Isotype)  
Patient  
Immunogen vaccine
Keywords  

Vaccine Details

Vaccine type poliovirus
Vaccine component Env

Notes

Showing 1 of 1 note.

References

Showing 1 of 1 reference.

McKeating1992 J. A. McKeating, J. P. Moore, M. Ferguson, H. S. Marsden, S. Graham, J. W. Almond, D. J. Evans, and R. A. Weiss. Monoclonal Antibodies to the C4 Region of Human Immunodeficiency Virus Type 1 gp120: Use in Topological Analysis of a CD4 Binding Site. AIDS Res. Hum. Retroviruses, 8:451-459, 1992. Antibodies were generated using an antigen poliovirus chimera, expressing aa430-446 of gp120. Results suggest that WQEVGKAMYA may be exposed on the surface of rec gp120. PubMed ID: 1376134. Show all entries for this paper.


Displaying record number 548

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MAb ID 1662
HXB2 Location gp160(433-439)
DNA(7521..7541)
gp160 Epitope Map
Author Location gp120( IIIB)
Epitope AMYAPPI Epitope Alignment
AMYAPPI epitope logo
Ab Type gp120 C4
Neutralizing  
Species (Isotype)  
Patient  
Immunogen vaccine
Keywords  

Vaccine Details

Vaccine type poliovirus
Vaccine component Env

Notes

Showing 1 of 1 note.

References

Showing 1 of 1 reference.

McKeating1992 J. A. McKeating, J. P. Moore, M. Ferguson, H. S. Marsden, S. Graham, J. W. Almond, D. J. Evans, and R. A. Weiss. Monoclonal Antibodies to the C4 Region of Human Immunodeficiency Virus Type 1 gp120: Use in Topological Analysis of a CD4 Binding Site. AIDS Res. Hum. Retroviruses, 8:451-459, 1992. Antibodies were generated using an antigen poliovirus chimera, expressing aa430-446 of gp120. Results suggest that WQEVGKAMYA may be exposed on the surface of rec gp120. PubMed ID: 1376134. Show all entries for this paper.


Displaying record number 553

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MAb ID 1804
HXB2 Location gp160(433-442)
DNA(7521..7550)
gp160 Epitope Map
Author Location gp120( IIIB)
Epitope AMYAPPISGQ Epitope Alignment
AMYAPPISGQ epitope logo
Ab Type gp120 C4
Neutralizing  
Species (Isotype)  
Patient  
Immunogen vaccine
Keywords  

Vaccine Details

Vaccine type poliovirus
Vaccine component Env

Notes

Showing 1 of 1 note.

References

Showing 1 of 1 reference.

McKeating1992 J. A. McKeating, J. P. Moore, M. Ferguson, H. S. Marsden, S. Graham, J. W. Almond, D. J. Evans, and R. A. Weiss. Monoclonal Antibodies to the C4 Region of Human Immunodeficiency Virus Type 1 gp120: Use in Topological Analysis of a CD4 Binding Site. AIDS Res. Hum. Retroviruses, 8:451-459, 1992. Antibodies were generated using an antigen poliovirus chimera, expressing aa430-446 of gp120. Results suggest that WQEVGKAMYA may be exposed on the surface of rec gp120. PubMed ID: 1376134. Show all entries for this paper.


Displaying record number 554

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MAb ID 1807
HXB2 Location gp160(433-442)
DNA(7521..7550)
gp160 Epitope Map
Author Location gp120( IIIB)
Epitope AMYAPPISGQ Epitope Alignment
AMYAPPISGQ epitope logo
Ab Type gp120 C4
Neutralizing  
Species (Isotype)  
Patient  
Immunogen vaccine
Keywords  

Vaccine Details

Vaccine type poliovirus
Vaccine component Env

Notes

Showing 1 of 1 note.

References

Showing 1 of 1 reference.

McKeating1992 J. A. McKeating, J. P. Moore, M. Ferguson, H. S. Marsden, S. Graham, J. W. Almond, D. J. Evans, and R. A. Weiss. Monoclonal Antibodies to the C4 Region of Human Immunodeficiency Virus Type 1 gp120: Use in Topological Analysis of a CD4 Binding Site. AIDS Res. Hum. Retroviruses, 8:451-459, 1992. Antibodies were generated using an antigen poliovirus chimera, expressing aa430-446 of gp120. Results suggest that WQEVGKAMYA may be exposed on the surface of rec gp120. PubMed ID: 1376134. Show all entries for this paper.


Displaying record number 555

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MAb ID 1808
HXB2 Location gp160(433-442)
DNA(7521..7550)
gp160 Epitope Map
Author Location gp120( IIIB)
Epitope AMYAPPISGQ Epitope Alignment
AMYAPPISGQ epitope logo
Ab Type gp120 C4
Neutralizing  
Species (Isotype)  
Patient  
Immunogen vaccine
Keywords  

Vaccine Details

Vaccine type poliovirus
Vaccine component Env

Notes

Showing 1 of 1 note.

References

Showing 1 of 1 reference.

McKeating1992 J. A. McKeating, J. P. Moore, M. Ferguson, H. S. Marsden, S. Graham, J. W. Almond, D. J. Evans, and R. A. Weiss. Monoclonal Antibodies to the C4 Region of Human Immunodeficiency Virus Type 1 gp120: Use in Topological Analysis of a CD4 Binding Site. AIDS Res. Hum. Retroviruses, 8:451-459, 1992. Antibodies were generated using an antigen poliovirus chimera, expressing aa430-446 of gp120. Results suggest that WQEVGKAMYA may be exposed on the surface of rec gp120. PubMed ID: 1376134. Show all entries for this paper.


Displaying record number 552

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MAb ID 1794
HXB2 Location gp160(433-442)
DNA(7521..7550)
gp160 Epitope Map
Author Location gp120( IIIB)
Epitope AMYAPPISGQ Epitope Alignment
AMYAPPISGQ epitope logo
Ab Type gp120 C4
Neutralizing  
Species (Isotype)  
Patient  
Immunogen vaccine
Keywords  

Vaccine Details

Vaccine type poliovirus
Vaccine component Env

Notes

Showing 1 of 1 note.

References

Showing 1 of 1 reference.

McKeating1992 J. A. McKeating, J. P. Moore, M. Ferguson, H. S. Marsden, S. Graham, J. W. Almond, D. J. Evans, and R. A. Weiss. Monoclonal Antibodies to the C4 Region of Human Immunodeficiency Virus Type 1 gp120: Use in Topological Analysis of a CD4 Binding Site. AIDS Res. Hum. Retroviruses, 8:451-459, 1992. Antibodies were generated using an antigen poliovirus chimera, expressing aa430-446 of gp120. Results suggest that WQEVGKAMYA may be exposed on the surface of rec gp120. PubMed ID: 1376134. Show all entries for this paper.


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