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Found 4 matching records:

Displaying record number 218

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MAb ID 17 (mAb17)
HXB2 Location Pol(740-750)
DNA(4302..4334)
Pol Epitope Map
Author Location Integrase(25-35)
Epitope DFNLPPVVAKE Epitope Alignment
DFNLPPVVAKE epitope logo
Ab Type  
Neutralizing  
Species (Isotype) mouse(IgG1)
Patient  
Immunogen vaccine
Keywords review

Vaccine Details

Vaccine type protein
Vaccine component Int

Notes

Showing 4 of 4 notes.

References

Showing 4 of 4 references.

Bizub-Bender1994 D. Bizub-Bender, J. Kulkosky, and A. M. Skalka. Monoclonal Antibodies against HIV Type 1 Integrase: Clues to Molecular Structure. AIDS Res. Hum. Retroviruses, 10:1105-1115, 1994. PubMed ID: 7530024. Show all entries for this paper.

Levy-Mintz1996 P. Levy-Mintz, L. Duan, H. Zhang, B. Hu, G. Dornadula, M. Zhu, J. Kulkosky, D. Bizub-Bender, A. M. Skalka, and R. J. Pomerantz. Intracellular Expression of Single-Chain Variable Fragments to Inhibit Early Stages of the Viral Life Cycle by Targeting Human Immunodeficiency Virus Type 1 Integrase. J. Virol., 70:8821-8832, 1996. Comments in J Virol 1998 Apr;72(4):3505-6. PubMed ID: 8971011. Show all entries for this paper.

Yi2000b J izu Yi, Jonathan W. Arthur, Roland L. Dunbrack, Jr., and Anna Marie Skalka. An Inhibitory Monoclonal Antibody Binds at the Turn of the Helix-Turn-Helix Motif in the N-Terminal Domain of HIV-1 Integrase. J. Biol. Chem., 275(49):38739-38748, 8 Dec 2000. PubMed ID: 10969077. Show all entries for this paper.

Marchand2009 Christophe Marchand, Kasthuraiah Maddali, Mathieu Metifiot, and Yves Pommier. HIV-1 IN Inhibitors: 2010 Update and Perspectives. Curr. Top. Med. Chem., 9(11):1016-1037, 2009. PubMed ID: 19747122. Show all entries for this paper.


Displaying record number 220

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MAb ID 4
HXB2 Location Pol Pol Epitope Map
Author Location Integrase(141-172)
Epitope
Ab Type  
Neutralizing  
Species (Isotype) mouse(IgG2b)
Patient  
Immunogen vaccine
Keywords review

Vaccine Details

Vaccine type protein
Vaccine component Int

Notes

Showing 4 of 4 notes.

References

Showing 3 of 3 references.

Bizub-Bender1994 D. Bizub-Bender, J. Kulkosky, and A. M. Skalka. Monoclonal Antibodies against HIV Type 1 Integrase: Clues to Molecular Structure. AIDS Res. Hum. Retroviruses, 10:1105-1115, 1994. PubMed ID: 7530024. Show all entries for this paper.

Levy-Mintz1996 P. Levy-Mintz, L. Duan, H. Zhang, B. Hu, G. Dornadula, M. Zhu, J. Kulkosky, D. Bizub-Bender, A. M. Skalka, and R. J. Pomerantz. Intracellular Expression of Single-Chain Variable Fragments to Inhibit Early Stages of the Viral Life Cycle by Targeting Human Immunodeficiency Virus Type 1 Integrase. J. Virol., 70:8821-8832, 1996. Comments in J Virol 1998 Apr;72(4):3505-6. PubMed ID: 8971011. Show all entries for this paper.

Marchand2009 Christophe Marchand, Kasthuraiah Maddali, Mathieu Metifiot, and Yves Pommier. HIV-1 IN Inhibitors: 2010 Update and Perspectives. Curr. Top. Med. Chem., 9(11):1016-1037, 2009. PubMed ID: 19747122. Show all entries for this paper.


Displaying record number 223

Download this epitope record as JSON.

MAb ID 32 (mAb32, Fab32)
HXB2 Location Pol Pol Epitope Map
Author Location Integrase(223-266)
Epitope
Ab Type  
Neutralizing  
Species (Isotype) mouse(IgG2b)
Patient  
Immunogen vaccine
Keywords review

Vaccine Details

Vaccine type protein
Vaccine component Int

Notes

Showing 4 of 4 notes.

References

Showing 4 of 4 references.

Bizub-Bender1994 D. Bizub-Bender, J. Kulkosky, and A. M. Skalka. Monoclonal Antibodies against HIV Type 1 Integrase: Clues to Molecular Structure. AIDS Res. Hum. Retroviruses, 10:1105-1115, 1994. PubMed ID: 7530024. Show all entries for this paper.

Yi2000a Jizu Yi and Anna Marie Skalka. Mapping Epitopes of Monoclonal Antibodies Against HIV-1 Integrase with Limited Proteolysis and Matrix-Assisted Laser Desorption Ionization Time-of-Flight Mass Spectrometry. Biopolymers, 55(4):308-318, 2000. PubMed ID: 11169922. Show all entries for this paper.

Yi2002 Jizu Yi, Hong Cheng, Mark D. Andrake, Roland L. Dunbrack, Jr., Heinrich Roder, and Anna Marie Skalka. Mapping the Epitope of an Inhibitory Monoclonal Antibody to the C-Terminal DNA-Binding Domain of HIV-1 Integrase. J. Biol. Chem., 277(14):12164-12174, 5 Apr 2002. PubMed ID: 11805085. Show all entries for this paper.

Marchand2009 Christophe Marchand, Kasthuraiah Maddali, Mathieu Metifiot, and Yves Pommier. HIV-1 IN Inhibitors: 2010 Update and Perspectives. Curr. Top. Med. Chem., 9(11):1016-1037, 2009. PubMed ID: 19747122. Show all entries for this paper.


Displaying record number 224

Download this epitope record as JSON.

MAb ID 33 (mAb33, Fab33, 33D5, mab 33)
HXB2 Location Pol Pol Epitope Map
Author Location Integrase(223-268 HXB2)
Epitope (Discontinuous epitope)
Subtype B
Ab Type C-term
Neutralizing  
Species (Isotype) mouse(IgG2b)
Patient  
Immunogen vaccine
Keywords antibody binding site, computational epitope prediction, mimotopes, review, structure

Vaccine Details

Vaccine type protein
Vaccine component Int

Notes

Showing 6 of 6 notes.

References

Showing 6 of 6 references.

Bizub-Bender1994 D. Bizub-Bender, J. Kulkosky, and A. M. Skalka. Monoclonal Antibodies against HIV Type 1 Integrase: Clues to Molecular Structure. AIDS Res. Hum. Retroviruses, 10:1105-1115, 1994. PubMed ID: 7530024. Show all entries for this paper.

Levy-Mintz1996 P. Levy-Mintz, L. Duan, H. Zhang, B. Hu, G. Dornadula, M. Zhu, J. Kulkosky, D. Bizub-Bender, A. M. Skalka, and R. J. Pomerantz. Intracellular Expression of Single-Chain Variable Fragments to Inhibit Early Stages of the Viral Life Cycle by Targeting Human Immunodeficiency Virus Type 1 Integrase. J. Virol., 70:8821-8832, 1996. Comments in J Virol 1998 Apr;72(4):3505-6. PubMed ID: 8971011. Show all entries for this paper.

Yi2000a Jizu Yi and Anna Marie Skalka. Mapping Epitopes of Monoclonal Antibodies Against HIV-1 Integrase with Limited Proteolysis and Matrix-Assisted Laser Desorption Ionization Time-of-Flight Mass Spectrometry. Biopolymers, 55(4):308-318, 2000. PubMed ID: 11169922. Show all entries for this paper.

Yi2002 Jizu Yi, Hong Cheng, Mark D. Andrake, Roland L. Dunbrack, Jr., Heinrich Roder, and Anna Marie Skalka. Mapping the Epitope of an Inhibitory Monoclonal Antibody to the C-Terminal DNA-Binding Domain of HIV-1 Integrase. J. Biol. Chem., 277(14):12164-12174, 5 Apr 2002. PubMed ID: 11805085. Show all entries for this paper.

Schreiber2005 Andreas Schreiber, Michael Humbert, Alexander Benz, and Ursula Dietrich. 3D-Epitope-Explorer (3DEX): Localization of Conformational Epitopes within Three-Dimensional Structures of Proteins. J. Comput. Chem., 26(9):879-887, 15 Jul 2005. PubMed ID: 15834923. Show all entries for this paper.

Marchand2009 Christophe Marchand, Kasthuraiah Maddali, Mathieu Metifiot, and Yves Pommier. HIV-1 IN Inhibitors: 2010 Update and Perspectives. Curr. Top. Med. Chem., 9(11):1016-1037, 2009. PubMed ID: 19747122. Show all entries for this paper.


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