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Displaying record number 1341

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MAb ID	polyclonal
HXB2 Location	Env	Env Epitope Map
Author Location	gp120( JRFL)
Epitope
Subtype	B
Ab Type
Neutralizing
Species (Isotype)	humanized mouse(IgG)
Patient
Immunogen	vaccine
Keywords	ADCC

Vaccine Details

Vaccine type	DNA
Vaccine strain	B clade JRFL
Vaccine component	gp120
Adjuvant	C3d fusion

Notes

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BALB/c mice were immunized with codon-optimized or C3d-fused DNA vaccine constructs and analyzed for their ability to elicit humoral and cell-mediated immune responses. Each strategy increased binding and gave rise to earlier appearance of neutralizing antibody responses against IIIB and MN viruses, but the combination did not act synergistically. C3d and codon optimization also gave enhanced CD8+ T cell responses to the epitope SIHIGPGRAFYTTGE. Liu2004 (ADCC)

References

Showing 1 of 1 reference.

Liu2004 Fangjun Liu, Innocent Mboudjeka, Siyuan Shen, Te-Hui W. Chou, Shixia Wang, Ted M. Ross, and Shan Lu. Independent but not Synergistic Enhancement to the Immunogenicity of DNA Vaccine Expressing HIV-1 gp120 Glycoprotein by Codon Optimization and C3d Fusion in a Mouse Model. Vaccine, 22(13-14):1764-1772, 16 Apr 2004. PubMed ID: 15068860. Show all entries for this paper.