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Found 5 matching records:

Displaying record number 2085

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• 37F6: This MAb was selected from mice immunized with the N36(L8)C34 polypeptide where the N36- terminus is connected by a linker to the C34 N-terminus. 37F6 bound strongly to the N36/C34 but did not bind to the isolated peptides N36 and C34, indicating that this Ab is specific for the gp41 6-HB core. 37F6 could not inhibit infection and Env-mediated cell-cell fusion under conventional temperature, but became active at a lower temperature. The inhibitory activity of this Ab at suboptimal temperature was closely correlated with its binding affinity to the gp41 6-HB core. The critical binding sites for 37F6 were localized in the N-terminal region of the NHR and the C-terminal region of the CHR in gp41. Li2009a (antibody binding site, antibody generation, kinetics, binding affinity)

References

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Isolation Paper
Li2009a Jing Li, Xi Chen, Jinghe Huang, Shibo Jiang, and Ying-Hua Chen. Identification of Critical Antibody-Binding Sites in the HIV-1 gp41 Six-Helix Bundle Core as Potential Targets for HIV-1 Fusion Inhibitors. Immunobiology, 214(1):51-60, 2009. PubMed ID: 19159827. Show all entries for this paper.

Displaying record number 2086

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• 2G8: This MAb was selected from mice immunized with the N36(L8)C34 polypeptide where the N36- terminus is connected by a linker to the C34 N-terminus. 2G8 bound strongly to the N36/C34 but did not bind to the isolated peptides N36 and C34, indicating that this Ab is specific for the gp41 6-HB core. 2G8 could not inhibit infection and Env-mediated cell-cell fusion under conventional temperature, but became active at a lower temperature. The inhibitory activity of this Ab at suboptimal temperature was closely correlated with its binding affinity to the gp41 6-HB core. The critical binding sites for 2G8 were localized in the N-terminal region of the NHR and the C-terminal region of the CHR in gp41. Li2009a (antibody binding site, antibody generation, kinetics, binding affinity)

References

Showing 1 of 1 reference.

Isolation Paper
Li2009a Jing Li, Xi Chen, Jinghe Huang, Shibo Jiang, and Ying-Hua Chen. Identification of Critical Antibody-Binding Sites in the HIV-1 gp41 Six-Helix Bundle Core as Potential Targets for HIV-1 Fusion Inhibitors. Immunobiology, 214(1):51-60, 2009. PubMed ID: 19159827. Show all entries for this paper.

Displaying record number 2087

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• 9F5: This MAb was selected from mice immunized with the N36(L8)C34 polypeptide where the N36- terminus is connected by a linker to the C34 N-terminus. 9F5 bound strongly to the N36/C34 but did not bind to the isolated peptides N36 and C34, indicating that this Ab is specific for the gp41 6-HB core. 9F5 could not inhibit infection and Env-mediated cell-cell fusion under conventional temperature, but became active at a lower temperature. The inhibitory activity of this Ab at suboptimal temperature was closely correlated with its binding affinity to the gp41 6-HB core. The critical binding sites for 9F5 were localized in the N-terminal region of the NHR and the C-terminal region of the CHR in gp41. Li2009a (antibody binding site, antibody generation, kinetics, binding affinity)

References

Showing 1 of 1 reference.

Isolation Paper
Li2009a Jing Li, Xi Chen, Jinghe Huang, Shibo Jiang, and Ying-Hua Chen. Identification of Critical Antibody-Binding Sites in the HIV-1 gp41 Six-Helix Bundle Core as Potential Targets for HIV-1 Fusion Inhibitors. Immunobiology, 214(1):51-60, 2009. PubMed ID: 19159827. Show all entries for this paper.

Displaying record number 2088

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• 17C8: This MAb was selected from mice immunized with the N36(L8)C34 polypeptide where the N36- terminus is connected by a linker to the C34 N-terminus. 17C8 bound strongly to the N36/C34 but did not bind to the isolated peptides N36 and C34, indicating that this Ab is specific for the gp41 6-HB core. 17C8 could not inhibit infection and Env-mediated cell-cell fusion under conventional temperature, but became active at a lower temperature. The inhibitory activity of this Ab at suboptimal temperature was closely correlated with its binding affinity to the gp41 6-HB core. The critical binding sites for 17C8 were localized in the N-terminal region of the NHR and the C-terminal region of the CHR in gp41. Li2009a (antibody binding site, antibody generation, kinetics, binding affinity)

References

Showing 1 of 1 reference.

Isolation Paper
Li2009a Jing Li, Xi Chen, Jinghe Huang, Shibo Jiang, and Ying-Hua Chen. Identification of Critical Antibody-Binding Sites in the HIV-1 gp41 Six-Helix Bundle Core as Potential Targets for HIV-1 Fusion Inhibitors. Immunobiology, 214(1):51-60, 2009. PubMed ID: 19159827. Show all entries for this paper.

Displaying record number 2089

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Notes

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• 32G4: This MAb was selected from mice immunized with the N36(L8)C34 polypeptide where the N36- terminus is connected by a linker to the C34 N-terminus. 32G4 bound strongly to the N36/C34 but did not bind to the isolated peptides N36 and C34, indicating that this Ab is specific for the gp41 6-HB core. 32G4 could not inhibit infection and Env-mediated cell-cell fusion under conventional temperature, but became active at a lower temperature. The inhibitory activity of this Ab at suboptimal temperature was closely correlated with its binding affinity to the gp41 6-HB core. The critical binding sites for 32G4 were localized in the N-terminal region of the NHR and the C-terminal region of the CHR in gp41. Li2009a (antibody binding site, antibody generation, kinetics, binding affinity)

References

Showing 1 of 1 reference.

Isolation Paper
Li2009a Jing Li, Xi Chen, Jinghe Huang, Shibo Jiang, and Ying-Hua Chen. Identification of Critical Antibody-Binding Sites in the HIV-1 gp41 Six-Helix Bundle Core as Potential Targets for HIV-1 Fusion Inhibitors. Immunobiology, 214(1):51-60, 2009. PubMed ID: 19159827. Show all entries for this paper.