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Found 32 matching records:

Displaying record number 3866

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MAb ID	PCT64-13C (PCT64 13C)
HXB2 Location	Env	Env Epitope Map
Author Location	Env
Epitope
Subtype	A1
Ab Type	gp120 V2 // V2 glycan(V2g) // V2 apex
Neutralizing	P
Species (Isotype)	human(IgG)
Patient	PC64
Immunogen	HIV-1 infection
Country	Rwanda
Keywords	antibody binding site, antibody generation, antibody lineage, antibody sequence, binding affinity, neutralization

Notes

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• PCT64-13C: The PCT64 lineage of antibodies was derived from donor PC64, who was sampled at 13, 18, 24, 29, 35 and 46 months following infection with a subtype A1 virus. Several members of the PCT64 lineage are broadly neutralizing. Studies of the lineage revealed binding to the V2 region of Env, with diversity at V2 driving antibody maturation toward breadth. The heavy and light chains of the antibodies are encoded by alleles VH3-15*01/DH3-3*01/JH6*03 and Vk3-20*01/Jk3*01, respectively. PCT64-13C neutralized 0 of 35 viruses in a multiclade panel. Landais2017 (antibody binding site, antibody generation, neutralization, binding affinity, antibody sequence, antibody lineage)

References

Showing 1 of 1 reference.

Isolation Paper
Landais2017 Elise Landais, Ben Murrell, Bryan Briney, Sasha Murrell, Kimmo Rantalainen, Zachary T. Berndsen, Alejandra Ramos, Lalinda Wickramasinghe, Melissa Laird Smith, Kemal Eren, Natalia de Val, Mengyu Wu, Audrey Cappelletti, Jeffrey Umotoy, Yolanda Lie, Terri Wrin, Paul Algate, Po-Ying Chan-Hui, Etienne Karita, IAVI Protocol C Investigators, IAVI African HIV Research Network, Andrew B. Ward, Ian A. Wilson, Dennis R. Burton, Davey Smith, Sergei L. Kosakovsky Pond, and Pascal Poignard. HIV Envelope Glycoform Heterogeneity and Localized Diversity Govern the Initiation and Maturation of a V2 Apex Broadly Neutralizing Antibody Lineage. Immunity, 47(5):990-1003.e9, 21 Nov 2017. PubMed ID: 29166592. Show all entries for this paper.

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Displaying record number 3867

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MAb ID	PCT64-13D (PCT64 13D)
HXB2 Location	Env	Env Epitope Map
Author Location	Env
Epitope
Subtype	A1
Ab Type	gp120 V2 // V2 glycan(V2g) // V2 apex
Neutralizing	P
Species (Isotype)	human(IgG)
Patient	PC64
Immunogen	HIV-1 infection
Country	Rwanda
Keywords	acute/early infection

Notes

Showing 1 of 1 note.

• PCT64-13D: The PCT64 lineage of antibodies was derived from donor PC64, who was sampled at 13, 18, 24, 29, 35 and 46 months following infection with a subtype A1 virus. Several members of the PCT64 lineage are broadly neutralizing. Studies of the lineage revealed binding to the V2 region of Env, with diversity at V2 driving antibody maturation toward breadth. The heavy and light chains of the antibodies are encoded by alleles VH3-15*01/DH3-3*01/JH6*03 and Vk3-20*01/Jk3*01, respectively. PCT64-13D failed to neutralize 2 tier-2 pseudoviruses. Landais2017 (acute/early infection)

References

Showing 1 of 1 reference.

Isolation Paper
Landais2017 Elise Landais, Ben Murrell, Bryan Briney, Sasha Murrell, Kimmo Rantalainen, Zachary T. Berndsen, Alejandra Ramos, Lalinda Wickramasinghe, Melissa Laird Smith, Kemal Eren, Natalia de Val, Mengyu Wu, Audrey Cappelletti, Jeffrey Umotoy, Yolanda Lie, Terri Wrin, Paul Algate, Po-Ying Chan-Hui, Etienne Karita, IAVI Protocol C Investigators, IAVI African HIV Research Network, Andrew B. Ward, Ian A. Wilson, Dennis R. Burton, Davey Smith, Sergei L. Kosakovsky Pond, and Pascal Poignard. HIV Envelope Glycoform Heterogeneity and Localized Diversity Govern the Initiation and Maturation of a V2 Apex Broadly Neutralizing Antibody Lineage. Immunity, 47(5):990-1003.e9, 21 Nov 2017. PubMed ID: 29166592. Show all entries for this paper.

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Displaying record number 3868

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MAb ID	PCT64-13E (PCT64 13E)
HXB2 Location	Env	Env Epitope Map
Author Location	Env
Epitope
Subtype	A1
Ab Type	gp120 V2 // V2 glycan(V2g) // V2 apex
Neutralizing	P
Species (Isotype)	human(IgG)
Patient	PC64
Immunogen	HIV-1 infection
Country	Rwanda
Keywords	antibody binding site, antibody generation, antibody lineage, antibody sequence, binding affinity, neutralization

Notes

Showing 1 of 1 note.

• PCT64-13E: The PCT64 lineage of antibodies was derived from donor PC64, who was sampled at 13, 18, 24, 29, 35 and 46 months following infection with a subtype A1 virus. Several members of the PCT64 lineage are broadly neutralizing. Studies of the lineage revealed binding to the V2 region of Env, with diversity at V2 driving antibody maturation toward breadth. The heavy and light chains of the antibodies are encoded by alleles VH3-15*01/DH3-3*01/JH6*03 and Vk3-20*01/Jk3*01, respectively. PCT64-13E neutralized 0 of 35 viruses in a multiclade panel. Landais2017 (antibody binding site, antibody generation, neutralization, binding affinity, antibody sequence, antibody lineage)

References

Showing 1 of 1 reference.

Isolation Paper
Landais2017 Elise Landais, Ben Murrell, Bryan Briney, Sasha Murrell, Kimmo Rantalainen, Zachary T. Berndsen, Alejandra Ramos, Lalinda Wickramasinghe, Melissa Laird Smith, Kemal Eren, Natalia de Val, Mengyu Wu, Audrey Cappelletti, Jeffrey Umotoy, Yolanda Lie, Terri Wrin, Paul Algate, Po-Ying Chan-Hui, Etienne Karita, IAVI Protocol C Investigators, IAVI African HIV Research Network, Andrew B. Ward, Ian A. Wilson, Dennis R. Burton, Davey Smith, Sergei L. Kosakovsky Pond, and Pascal Poignard. HIV Envelope Glycoform Heterogeneity and Localized Diversity Govern the Initiation and Maturation of a V2 Apex Broadly Neutralizing Antibody Lineage. Immunity, 47(5):990-1003.e9, 21 Nov 2017. PubMed ID: 29166592. Show all entries for this paper.

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Displaying record number 3869

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MAb ID	PCT64-13F (PCT64 13F)
HXB2 Location	Env	Env Epitope Map
Author Location	Env
Epitope
Subtype	A1
Ab Type	gp120 V2 // V2 glycan(V2g) // V2 apex
Neutralizing	P
Species (Isotype)	human(IgG)
Patient	PC64
Immunogen	HIV-1 infection
Country	Rwanda
Keywords	antibody binding site, antibody generation, antibody lineage, antibody sequence, binding affinity, neutralization

Notes

Showing 1 of 1 note.

• PCT64-13F: The PCT64 lineage of antibodies was derived from donor PC64, who was sampled at 13, 18, 24, 29, 35 and 46 months following infection with a subtype A1 virus. Several members of the PCT64 lineage are broadly neutralizing. Studies of the lineage revealed binding to the V2 region of Env, with diversity at V2 driving antibody maturation toward breadth. The heavy and light chains of the antibodies are encoded by alleles VH3-15*01/DH3-3*01/JH6*03 and Vk3-20*01/Jk3*01, respectively. PCT64-13F neutralized 0 of 35 viruses in a multiclade panel. Landais2017 (antibody binding site, antibody generation, neutralization, binding affinity, antibody sequence, antibody lineage)

References

Showing 1 of 1 reference.

Isolation Paper
Landais2017 Elise Landais, Ben Murrell, Bryan Briney, Sasha Murrell, Kimmo Rantalainen, Zachary T. Berndsen, Alejandra Ramos, Lalinda Wickramasinghe, Melissa Laird Smith, Kemal Eren, Natalia de Val, Mengyu Wu, Audrey Cappelletti, Jeffrey Umotoy, Yolanda Lie, Terri Wrin, Paul Algate, Po-Ying Chan-Hui, Etienne Karita, IAVI Protocol C Investigators, IAVI African HIV Research Network, Andrew B. Ward, Ian A. Wilson, Dennis R. Burton, Davey Smith, Sergei L. Kosakovsky Pond, and Pascal Poignard. HIV Envelope Glycoform Heterogeneity and Localized Diversity Govern the Initiation and Maturation of a V2 Apex Broadly Neutralizing Antibody Lineage. Immunity, 47(5):990-1003.e9, 21 Nov 2017. PubMed ID: 29166592. Show all entries for this paper.

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Displaying record number 3870

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MAb ID	PCT64-13G (PCT64 13G)
HXB2 Location	Env	Env Epitope Map
Author Location	Env
Epitope
Subtype	A1
Ab Type	gp120 V2 // V2 glycan(V2g) // V2 apex
Neutralizing	P
Species (Isotype)	human(IgG)
Patient	PC64
Immunogen	HIV-1 infection
Country	Rwanda
Keywords	antibody binding site, antibody generation, antibody lineage, antibody sequence, binding affinity, neutralization

Notes

Showing 1 of 1 note.

• PCT64-13G: The PCT64 lineage of antibodies was derived from donor PC64, who was sampled at 13, 18, 24, 29, 35 and 46 months following infection with a subtype A1 virus. Several members of the PCT64 lineage are broadly neutralizing. Studies of the lineage revealed binding to the V2 region of Env, with diversity at V2 driving antibody maturation toward breadth. The heavy and light chains of the antibodies are encoded by alleles VH3-15*01/DH3-3*01/JH6*03 and Vk3-20*01/Jk3*01, respectively. PCT64-13G neutralized 0 of 35 viruses in a multiclade panel. Landais2017 (antibody binding site, antibody generation, neutralization, binding affinity, antibody sequence, antibody lineage)

References

Showing 1 of 1 reference.

Isolation Paper
Landais2017 Elise Landais, Ben Murrell, Bryan Briney, Sasha Murrell, Kimmo Rantalainen, Zachary T. Berndsen, Alejandra Ramos, Lalinda Wickramasinghe, Melissa Laird Smith, Kemal Eren, Natalia de Val, Mengyu Wu, Audrey Cappelletti, Jeffrey Umotoy, Yolanda Lie, Terri Wrin, Paul Algate, Po-Ying Chan-Hui, Etienne Karita, IAVI Protocol C Investigators, IAVI African HIV Research Network, Andrew B. Ward, Ian A. Wilson, Dennis R. Burton, Davey Smith, Sergei L. Kosakovsky Pond, and Pascal Poignard. HIV Envelope Glycoform Heterogeneity and Localized Diversity Govern the Initiation and Maturation of a V2 Apex Broadly Neutralizing Antibody Lineage. Immunity, 47(5):990-1003.e9, 21 Nov 2017. PubMed ID: 29166592. Show all entries for this paper.

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Displaying record number 3871

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MAb ID	PCT64-13H (PCT64 13H)
HXB2 Location	Env	Env Epitope Map
Author Location	Cryptic
Epitope
Subtype	A1
Ab Type	gp120 V2 // V2 glycan(V2g) // V2 apex
Neutralizing	P
Species (Isotype)	human(IgG)
Patient	PC64
Immunogen	HIV-1 infection
Country	Rwanda
Keywords	antibody binding site, antibody generation, antibody lineage, antibody sequence, binding affinity, neutralization

Notes

Showing 1 of 1 note.

• PCT64-13H: The PCT64 lineage of antibodies was derived from donor PC64, who was sampled at 13, 18, 24, 29, 35 and 46 months following infection with a subtype A1 virus. Several members of the PCT64 lineage are broadly neutralizing. Studies of the lineage revealed binding to the V2 region of Env, with diversity at V2 driving antibody maturation toward breadth. The heavy and light chains of the antibodies are encoded by alleles VH3-15*01/DH3-3*01/JH6*03 and Vk3-20*01/Jk3*01, respectively. PCT64-13H neutralized 0 of 35 viruses in a multiclade panel. Landais2017 (antibody binding site, antibody generation, neutralization, binding affinity, antibody sequence, antibody lineage)

References

Showing 1 of 1 reference.

Isolation Paper
Landais2017 Elise Landais, Ben Murrell, Bryan Briney, Sasha Murrell, Kimmo Rantalainen, Zachary T. Berndsen, Alejandra Ramos, Lalinda Wickramasinghe, Melissa Laird Smith, Kemal Eren, Natalia de Val, Mengyu Wu, Audrey Cappelletti, Jeffrey Umotoy, Yolanda Lie, Terri Wrin, Paul Algate, Po-Ying Chan-Hui, Etienne Karita, IAVI Protocol C Investigators, IAVI African HIV Research Network, Andrew B. Ward, Ian A. Wilson, Dennis R. Burton, Davey Smith, Sergei L. Kosakovsky Pond, and Pascal Poignard. HIV Envelope Glycoform Heterogeneity and Localized Diversity Govern the Initiation and Maturation of a V2 Apex Broadly Neutralizing Antibody Lineage. Immunity, 47(5):990-1003.e9, 21 Nov 2017. PubMed ID: 29166592. Show all entries for this paper.

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Displaying record number 3872

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MAb ID	PCT64-18A (PCT64 18A)
HXB2 Location	Env	Env Epitope Map
Author Location	Env
Epitope
Subtype	A1
Ab Type	gp120 V2 // V2 glycan(V2g) // V2 apex
Neutralizing	P
Species (Isotype)	human(IgG)
Patient	PC64
Immunogen	HIV-1 infection
Country	Rwanda
Keywords	antibody binding site, antibody generation, antibody lineage, antibody sequence, binding affinity, neutralization

Notes

Showing 1 of 1 note.

• PCT64-18A: The PCT64 lineage of antibodies was derived from donor PC64, who was sampled at 13, 18, 24, 29, 35 and 46 months following infection with a subtype A1 virus. Several members of the PCT64 lineage are broadly neutralizing. Studies of the lineage revealed binding to the V2 region of Env, with diversity at V2 driving antibody maturation toward breadth. The heavy and light chains of the antibodies are encoded by alleles VH3-15*01/DH3-3*01/JH6*03 and Vk3-20*01/Jk3*01, respectively. PCT64-18A neutralized 0 of 35 viruses in a multiclade panel. Landais2017 (antibody binding site, antibody generation, neutralization, binding affinity, antibody sequence, antibody lineage)

References

Showing 1 of 1 reference.

Isolation Paper
Landais2017 Elise Landais, Ben Murrell, Bryan Briney, Sasha Murrell, Kimmo Rantalainen, Zachary T. Berndsen, Alejandra Ramos, Lalinda Wickramasinghe, Melissa Laird Smith, Kemal Eren, Natalia de Val, Mengyu Wu, Audrey Cappelletti, Jeffrey Umotoy, Yolanda Lie, Terri Wrin, Paul Algate, Po-Ying Chan-Hui, Etienne Karita, IAVI Protocol C Investigators, IAVI African HIV Research Network, Andrew B. Ward, Ian A. Wilson, Dennis R. Burton, Davey Smith, Sergei L. Kosakovsky Pond, and Pascal Poignard. HIV Envelope Glycoform Heterogeneity and Localized Diversity Govern the Initiation and Maturation of a V2 Apex Broadly Neutralizing Antibody Lineage. Immunity, 47(5):990-1003.e9, 21 Nov 2017. PubMed ID: 29166592. Show all entries for this paper.

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Displaying record number 3873

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MAb ID	PCT64-18B (PCT64 18B)
HXB2 Location	Env	Env Epitope Map
Author Location	Env
Epitope
Subtype	A1
Ab Type	gp120 V2 // V2 glycan(V2g) // V2 apex
Neutralizing	P  View neutralization details
Species (Isotype)	human(IgG)
Patient	PC64
Immunogen	HIV-1 infection
Country	Rwanda
Keywords	antibody binding site, antibody generation, antibody lineage, antibody sequence, binding affinity, neutralization

Notes

Showing 1 of 1 note.

• PCT64-18B: The PCT64 lineage of antibodies was derived from donor PC64, who was sampled at 13, 18, 24, 29, 35 and 46 months following infection with a subtype A1 virus. Several members of the PCT64 lineage are broadly neutralizing. Studies of the lineage revealed binding to the V2 region of Env, with diversity at V2 driving antibody maturation toward breadth. The heavy and light chains of the antibodies are encoded by alleles VH3-15*01/DH3-3*01/JH6*03 and Vk3-20*01/Jk3*01, respectively. PCT64-18B neutralized 5 of 35 viruses in a multiclade panel. Landais2017 (antibody binding site, antibody generation, neutralization, binding affinity, antibody sequence, antibody lineage)

References

Showing 1 of 1 reference.

Isolation Paper
Landais2017 Elise Landais, Ben Murrell, Bryan Briney, Sasha Murrell, Kimmo Rantalainen, Zachary T. Berndsen, Alejandra Ramos, Lalinda Wickramasinghe, Melissa Laird Smith, Kemal Eren, Natalia de Val, Mengyu Wu, Audrey Cappelletti, Jeffrey Umotoy, Yolanda Lie, Terri Wrin, Paul Algate, Po-Ying Chan-Hui, Etienne Karita, IAVI Protocol C Investigators, IAVI African HIV Research Network, Andrew B. Ward, Ian A. Wilson, Dennis R. Burton, Davey Smith, Sergei L. Kosakovsky Pond, and Pascal Poignard. HIV Envelope Glycoform Heterogeneity and Localized Diversity Govern the Initiation and Maturation of a V2 Apex Broadly Neutralizing Antibody Lineage. Immunity, 47(5):990-1003.e9, 21 Nov 2017. PubMed ID: 29166592. Show all entries for this paper.

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Displaying record number 3874

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MAb ID	PCT64-18C (PCT64 18C)
HXB2 Location	Env	Env Epitope Map
Author Location	Env
Epitope
Subtype	A1
Ab Type	gp120 V2 // V2 glycan(V2g) // V2 apex
Neutralizing	P  View neutralization details
Species (Isotype)	human(IgG)
Patient	PC64
Immunogen	HIV-1 infection
Country	Rwanda
Keywords	antibody binding site, antibody generation, antibody lineage, antibody sequence, binding affinity, neutralization

Notes

Showing 1 of 1 note.

• PCT64-18C: The PCT64 lineage of antibodies was derived from donor PC64, who was sampled at 13, 18, 24, 29, 35 and 46 months following infection with a subtype A1 virus. Several members of the PCT64 lineage are broadly neutralizing. Studies of the lineage revealed binding to the V2 region of Env, with diversity at V2 driving antibody maturation toward breadth. The heavy and light chains of the antibodies are encoded by alleles VH3-15*01/DH3-3*01/JH6*03 and Vk3-20*01/Jk3*01, respectively. PCT64-18C neutralized 3 of 35 viruses in a multiclade panel. Landais2017 (antibody binding site, antibody generation, neutralization, binding affinity, antibody sequence, antibody lineage)

References

Showing 1 of 1 reference.

Isolation Paper
Landais2017 Elise Landais, Ben Murrell, Bryan Briney, Sasha Murrell, Kimmo Rantalainen, Zachary T. Berndsen, Alejandra Ramos, Lalinda Wickramasinghe, Melissa Laird Smith, Kemal Eren, Natalia de Val, Mengyu Wu, Audrey Cappelletti, Jeffrey Umotoy, Yolanda Lie, Terri Wrin, Paul Algate, Po-Ying Chan-Hui, Etienne Karita, IAVI Protocol C Investigators, IAVI African HIV Research Network, Andrew B. Ward, Ian A. Wilson, Dennis R. Burton, Davey Smith, Sergei L. Kosakovsky Pond, and Pascal Poignard. HIV Envelope Glycoform Heterogeneity and Localized Diversity Govern the Initiation and Maturation of a V2 Apex Broadly Neutralizing Antibody Lineage. Immunity, 47(5):990-1003.e9, 21 Nov 2017. PubMed ID: 29166592. Show all entries for this paper.

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Displaying record number 3875

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MAb ID	PCT64-18D (PCT64 18D)
HXB2 Location	Env	Env Epitope Map
Author Location	Env
Epitope
Subtype	A1
Ab Type	gp120 V2 // V2 glycan(V2g) // V2 apex
Neutralizing	P  View neutralization details
Species (Isotype)	human(IgG)
Patient	PC64
Immunogen	HIV-1 infection
Country	Rwanda
Keywords	antibody binding site, antibody generation, antibody lineage, antibody sequence, binding affinity, neutralization

Notes

Showing 1 of 1 note.

• PCT64-18D: The PCT64 lineage of antibodies was derived from donor PC64, who was sampled at 13, 18, 24, 29, 35 and 46 months following infection with a subtype A1 virus. Several members of the PCT64 lineage are broadly neutralizing. Studies of the lineage revealed binding to the V2 region of Env, with diversity at V2 driving antibody maturation toward breadth. The heavy and light chains of the antibodies are encoded by alleles VH3-15*01/DH3-3*01/JH6*03 and Vk3-20*01/Jk3*01, respectively. PCT64-18D neutralized 8 of 35 viruses in a multiclade panel and 23% of 109 viruses in a larger multiclade panel. Landais2017 (antibody binding site, antibody generation, neutralization, binding affinity, antibody sequence, antibody lineage)

References

Showing 1 of 1 reference.

Isolation Paper
Landais2017 Elise Landais, Ben Murrell, Bryan Briney, Sasha Murrell, Kimmo Rantalainen, Zachary T. Berndsen, Alejandra Ramos, Lalinda Wickramasinghe, Melissa Laird Smith, Kemal Eren, Natalia de Val, Mengyu Wu, Audrey Cappelletti, Jeffrey Umotoy, Yolanda Lie, Terri Wrin, Paul Algate, Po-Ying Chan-Hui, Etienne Karita, IAVI Protocol C Investigators, IAVI African HIV Research Network, Andrew B. Ward, Ian A. Wilson, Dennis R. Burton, Davey Smith, Sergei L. Kosakovsky Pond, and Pascal Poignard. HIV Envelope Glycoform Heterogeneity and Localized Diversity Govern the Initiation and Maturation of a V2 Apex Broadly Neutralizing Antibody Lineage. Immunity, 47(5):990-1003.e9, 21 Nov 2017. PubMed ID: 29166592. Show all entries for this paper.

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Displaying record number 3876

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MAb ID	PCT64-18F (PCT64 18F)
HXB2 Location	Env	Env Epitope Map
Author Location	Env
Epitope
Subtype	A1
Ab Type	gp120 V2 // V2 glycan(V2g) // V2 apex
Neutralizing	P  View neutralization details
Species (Isotype)	human(IgG)
Patient	PC64
Immunogen	HIV-1 infection
Country	Rwanda
Keywords	antibody binding site, antibody generation, antibody lineage, antibody sequence, binding affinity, neutralization

Notes

Showing 1 of 1 note.

• PCT64-18F: The PCT64 lineage of antibodies was derived from donor PC64, who was sampled at 13, 18, 24, 29, 35 and 46 months following infection with a subtype A1 virus. Several members of the PCT64 lineage are broadly neutralizing. Studies of the lineage revealed binding to the V2 region of Env, with diversity at V2 driving antibody maturation toward breadth. The heavy and light chains of the antibodies are encoded by alleles VH3-15*01/DH3-3*01/JH6*03 and Vk3-20*01/Jk3*01, respectively. PCT64-18F neutralized 8 of 35 viruses in a multiclade panel. Landais2017 (antibody binding site, antibody generation, neutralization, binding affinity, antibody sequence, antibody lineage)

References

Showing 1 of 1 reference.

Isolation Paper
Landais2017 Elise Landais, Ben Murrell, Bryan Briney, Sasha Murrell, Kimmo Rantalainen, Zachary T. Berndsen, Alejandra Ramos, Lalinda Wickramasinghe, Melissa Laird Smith, Kemal Eren, Natalia de Val, Mengyu Wu, Audrey Cappelletti, Jeffrey Umotoy, Yolanda Lie, Terri Wrin, Paul Algate, Po-Ying Chan-Hui, Etienne Karita, IAVI Protocol C Investigators, IAVI African HIV Research Network, Andrew B. Ward, Ian A. Wilson, Dennis R. Burton, Davey Smith, Sergei L. Kosakovsky Pond, and Pascal Poignard. HIV Envelope Glycoform Heterogeneity and Localized Diversity Govern the Initiation and Maturation of a V2 Apex Broadly Neutralizing Antibody Lineage. Immunity, 47(5):990-1003.e9, 21 Nov 2017. PubMed ID: 29166592. Show all entries for this paper.

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Displaying record number 3877

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MAb ID	PCT64-24A (PCT64 24A)
HXB2 Location	Env	Env Epitope Map
Author Location	Env
Epitope
Subtype	A1
Ab Type	gp120 V2 // V2 glycan(V2g) // V2 apex
Neutralizing	P  View neutralization details
Species (Isotype)	human(IgG)
Patient	PC64
Immunogen	HIV-1 infection
Country	Rwanda
Keywords	antibody binding site, antibody generation, antibody lineage, antibody sequence, binding affinity, neutralization

Notes

Showing 1 of 1 note.

• PCT64-24A: The PCT64 lineage of antibodies was derived from donor PC64, who was sampled at 13, 18, 24, 29, 35 and 46 months following infection with a subtype A1 virus. Several members of the PCT64 lineage are broadly neutralizing. Studies of the lineage revealed binding to the V2 region of Env, with diversity at V2 driving antibody maturation toward breadth. The heavy and light chains of the antibodies are encoded by alleles VH3-15*01/DH3-3*01/JH6*03 and Vk3-20*01/Jk3*01, respectively. PCT64-24A neutralized 7 of 35 viruses in a multiclade panel. Landais2017 (antibody binding site, antibody generation, neutralization, binding affinity, antibody sequence, antibody lineage)

References

Showing 1 of 1 reference.

Isolation Paper
Landais2017 Elise Landais, Ben Murrell, Bryan Briney, Sasha Murrell, Kimmo Rantalainen, Zachary T. Berndsen, Alejandra Ramos, Lalinda Wickramasinghe, Melissa Laird Smith, Kemal Eren, Natalia de Val, Mengyu Wu, Audrey Cappelletti, Jeffrey Umotoy, Yolanda Lie, Terri Wrin, Paul Algate, Po-Ying Chan-Hui, Etienne Karita, IAVI Protocol C Investigators, IAVI African HIV Research Network, Andrew B. Ward, Ian A. Wilson, Dennis R. Burton, Davey Smith, Sergei L. Kosakovsky Pond, and Pascal Poignard. HIV Envelope Glycoform Heterogeneity and Localized Diversity Govern the Initiation and Maturation of a V2 Apex Broadly Neutralizing Antibody Lineage. Immunity, 47(5):990-1003.e9, 21 Nov 2017. PubMed ID: 29166592. Show all entries for this paper.

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Displaying record number 3878

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MAb ID	PCT64-24B (PCT64 24B)
HXB2 Location	Env	Env Epitope Map
Author Location	Env
Epitope
Subtype	A1
Ab Type	gp120 V2 // V2 glycan(V2g) // V2 apex
Neutralizing	P  View neutralization details
Species (Isotype)	human(IgG)
Patient	PC64
Immunogen	HIV-1 infection
Country	Rwanda
Keywords	antibody binding site, antibody generation, antibody lineage, antibody sequence, binding affinity, neutralization

Notes

Showing 1 of 1 note.

• PCT64-24B: The PCT64 lineage of antibodies was derived from donor PC64, who was sampled at 13, 18, 24, 29, 35 and 46 months following infection with a subtype A1 virus. Several members of the PCT64 lineage are broadly neutralizing. Studies of the lineage revealed binding to the V2 region of Env, with diversity at V2 driving antibody maturation toward breadth. The heavy and light chains of the antibodies are encoded by alleles VH3-15*01/DH3-3*01/JH6*03 and Vk3-20*01/Jk3*01, respectively. PCT64-24B neutralized 6 of 35 viruses in a multiclade panel. Landais2017 (antibody binding site, antibody generation, neutralization, binding affinity, antibody sequence, antibody lineage)

References

Showing 1 of 1 reference.

Isolation Paper
Landais2017 Elise Landais, Ben Murrell, Bryan Briney, Sasha Murrell, Kimmo Rantalainen, Zachary T. Berndsen, Alejandra Ramos, Lalinda Wickramasinghe, Melissa Laird Smith, Kemal Eren, Natalia de Val, Mengyu Wu, Audrey Cappelletti, Jeffrey Umotoy, Yolanda Lie, Terri Wrin, Paul Algate, Po-Ying Chan-Hui, Etienne Karita, IAVI Protocol C Investigators, IAVI African HIV Research Network, Andrew B. Ward, Ian A. Wilson, Dennis R. Burton, Davey Smith, Sergei L. Kosakovsky Pond, and Pascal Poignard. HIV Envelope Glycoform Heterogeneity and Localized Diversity Govern the Initiation and Maturation of a V2 Apex Broadly Neutralizing Antibody Lineage. Immunity, 47(5):990-1003.e9, 21 Nov 2017. PubMed ID: 29166592. Show all entries for this paper.

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Displaying record number 3879

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MAb ID	PCT64-24E (PCT64 24E)
HXB2 Location	Env	Env Epitope Map
Author Location	Env
Epitope
Subtype	A1
Ab Type	gp120 V2 // V2 glycan(V2g) // V2 apex
Neutralizing	P  View neutralization details
Species (Isotype)	human(IgG)
Patient	PC64
Immunogen	HIV-1 infection
Country	Rwanda
Keywords	antibody binding site, antibody generation, antibody lineage, antibody sequence, binding affinity, neutralization

Notes

Showing 1 of 1 note.

• PCT64-24E: The PCT64 lineage of antibodies was derived from donor PC64, who was sampled at 13, 18, 24, 29, 35 and 46 months following infection with a subtype A1 virus. Several members of the PCT64 lineage are broadly neutralizing. Studies of the lineage revealed binding to the V2 region of Env, with diversity at V2 driving antibody maturation toward breadth. The heavy and light chains of the antibodies are encoded by alleles VH3-15*01/DH3-3*01/JH6*03 and Vk3-20*01/Jk3*01, respectively. PCT64-24E neutralized 6 of 35 viruses in a multiclade panel and 26% of 109 viruses in a larger multiclade panel. Landais2017 (antibody binding site, antibody generation, neutralization, binding affinity, antibody sequence, antibody lineage)

References

Showing 1 of 1 reference.

Isolation Paper
Landais2017 Elise Landais, Ben Murrell, Bryan Briney, Sasha Murrell, Kimmo Rantalainen, Zachary T. Berndsen, Alejandra Ramos, Lalinda Wickramasinghe, Melissa Laird Smith, Kemal Eren, Natalia de Val, Mengyu Wu, Audrey Cappelletti, Jeffrey Umotoy, Yolanda Lie, Terri Wrin, Paul Algate, Po-Ying Chan-Hui, Etienne Karita, IAVI Protocol C Investigators, IAVI African HIV Research Network, Andrew B. Ward, Ian A. Wilson, Dennis R. Burton, Davey Smith, Sergei L. Kosakovsky Pond, and Pascal Poignard. HIV Envelope Glycoform Heterogeneity and Localized Diversity Govern the Initiation and Maturation of a V2 Apex Broadly Neutralizing Antibody Lineage. Immunity, 47(5):990-1003.e9, 21 Nov 2017. PubMed ID: 29166592. Show all entries for this paper.

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Displaying record number 3880

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MAb ID	PCT64-24F (PCT64 24F)
HXB2 Location	Env	Env Epitope Map
Author Location	Env
Epitope
Subtype	A1
Ab Type	gp120 V2 // V2 glycan(V2g) // V2 apex
Neutralizing	P  View neutralization details
Species (Isotype)	human(IgG)
Patient	PC64
Immunogen	HIV-1 infection
Country	Rwanda
Keywords	antibody binding site, antibody generation, antibody lineage, antibody sequence, binding affinity, neutralization

Notes

Showing 1 of 1 note.

• PCT64-24F: The PCT64 lineage of antibodies was derived from donor PC64, who was sampled at 13, 18, 24, 29, 35 and 46 months following infection with a subtype A1 virus. Several members of the PCT64 lineage are broadly neutralizing. Studies of the lineage revealed binding to the V2 region of Env, with diversity at V2 driving antibody maturation toward breadth. The heavy and light chains of the antibodies are encoded by alleles VH3-15*01/DH3-3*01/JH6*03 and Vk3-20*01/Jk3*01, respectively. PCT64-24F neutralized 8 of 35 viruses in a multiclade panel and 24% of 109 viruses in a larger multiclade panel. Landais2017 (antibody binding site, antibody generation, neutralization, binding affinity, antibody sequence, antibody lineage)

References

Showing 1 of 1 reference.

Isolation Paper
Landais2017 Elise Landais, Ben Murrell, Bryan Briney, Sasha Murrell, Kimmo Rantalainen, Zachary T. Berndsen, Alejandra Ramos, Lalinda Wickramasinghe, Melissa Laird Smith, Kemal Eren, Natalia de Val, Mengyu Wu, Audrey Cappelletti, Jeffrey Umotoy, Yolanda Lie, Terri Wrin, Paul Algate, Po-Ying Chan-Hui, Etienne Karita, IAVI Protocol C Investigators, IAVI African HIV Research Network, Andrew B. Ward, Ian A. Wilson, Dennis R. Burton, Davey Smith, Sergei L. Kosakovsky Pond, and Pascal Poignard. HIV Envelope Glycoform Heterogeneity and Localized Diversity Govern the Initiation and Maturation of a V2 Apex Broadly Neutralizing Antibody Lineage. Immunity, 47(5):990-1003.e9, 21 Nov 2017. PubMed ID: 29166592. Show all entries for this paper.

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Displaying record number 3881

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MAb ID	PCT64-24G (PCT64 24G)
HXB2 Location	Env	Env Epitope Map
Author Location	Env
Epitope
Subtype	A1
Ab Type	gp120 V2 // V2 glycan(V2g) // V2 apex
Neutralizing	P  View neutralization details
Species (Isotype)	human(IgG)
Patient	PC64
Immunogen	HIV-1 infection
Country	Rwanda
Keywords	antibody binding site, antibody generation, antibody lineage, antibody sequence, binding affinity, neutralization

Notes

Showing 1 of 1 note.

• PCT64-24G: The PCT64 lineage of antibodies was derived from donor PC64, who was sampled at 13, 18, 24, 29, 35 and 46 months following infection with a subtype A1 virus. Several members of the PCT64 lineage are broadly neutralizing. Studies of the lineage revealed binding to the V2 region of Env, with diversity at V2 driving antibody maturation toward breadth. The heavy and light chains of the antibodies are encoded by alleles VH3-15*01/DH3-3*01/JH6*03 and Vk3-20*01/Jk3*01, respectively. PCT64-24G neutralized 8 of 35 viruses in a multiclade panel. Landais2017 (antibody binding site, antibody generation, neutralization, binding affinity, antibody sequence, antibody lineage)

References

Showing 1 of 1 reference.

Isolation Paper
Landais2017 Elise Landais, Ben Murrell, Bryan Briney, Sasha Murrell, Kimmo Rantalainen, Zachary T. Berndsen, Alejandra Ramos, Lalinda Wickramasinghe, Melissa Laird Smith, Kemal Eren, Natalia de Val, Mengyu Wu, Audrey Cappelletti, Jeffrey Umotoy, Yolanda Lie, Terri Wrin, Paul Algate, Po-Ying Chan-Hui, Etienne Karita, IAVI Protocol C Investigators, IAVI African HIV Research Network, Andrew B. Ward, Ian A. Wilson, Dennis R. Burton, Davey Smith, Sergei L. Kosakovsky Pond, and Pascal Poignard. HIV Envelope Glycoform Heterogeneity and Localized Diversity Govern the Initiation and Maturation of a V2 Apex Broadly Neutralizing Antibody Lineage. Immunity, 47(5):990-1003.e9, 21 Nov 2017. PubMed ID: 29166592. Show all entries for this paper.

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Displaying record number 3882

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MAb ID	PCT64-24H (PCT64 24H)
HXB2 Location	Env	Env Epitope Map
Author Location	Env
Epitope
Subtype	A1
Ab Type	gp120 V2 // V2 glycan(V2g) // V2 apex
Neutralizing	P  View neutralization details
Species (Isotype)	human(IgG)
Patient	PC64
Immunogen	HIV-1 infection
Country	Rwanda
Keywords	antibody binding site, antibody generation, antibody lineage, antibody sequence, binding affinity, neutralization

Notes

Showing 1 of 1 note.

• PCT64-24H: The PCT64 lineage of antibodies was derived from donor PC64, who was sampled at 13, 18, 24, 29, 35 and 46 months following infection with a subtype A1 virus. Several members of the PCT64 lineage are broadly neutralizing. Studies of the lineage revealed binding to the V2 region of Env, with diversity at V2 driving antibody maturation toward breadth. The heavy and light chains of the antibodies are encoded by alleles VH3-15*01/DH3-3*01/JH6*03 and Vk3-20*01/Jk3*01, respectively. PCT64-24H neutralized 6 of 35 viruses in a multiclade panel. Landais2017 (antibody binding site, antibody generation, neutralization, binding affinity, antibody sequence, antibody lineage)

References

Showing 1 of 1 reference.

Isolation Paper
Landais2017 Elise Landais, Ben Murrell, Bryan Briney, Sasha Murrell, Kimmo Rantalainen, Zachary T. Berndsen, Alejandra Ramos, Lalinda Wickramasinghe, Melissa Laird Smith, Kemal Eren, Natalia de Val, Mengyu Wu, Audrey Cappelletti, Jeffrey Umotoy, Yolanda Lie, Terri Wrin, Paul Algate, Po-Ying Chan-Hui, Etienne Karita, IAVI Protocol C Investigators, IAVI African HIV Research Network, Andrew B. Ward, Ian A. Wilson, Dennis R. Burton, Davey Smith, Sergei L. Kosakovsky Pond, and Pascal Poignard. HIV Envelope Glycoform Heterogeneity and Localized Diversity Govern the Initiation and Maturation of a V2 Apex Broadly Neutralizing Antibody Lineage. Immunity, 47(5):990-1003.e9, 21 Nov 2017. PubMed ID: 29166592. Show all entries for this paper.

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Displaying record number 3883

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MAb ID	PCT64-35A (PCT64 35A)
HXB2 Location	Env	Env Epitope Map
Author Location	Env
Epitope
Subtype	A1
Ab Type	gp120 V2 // V2 glycan(V2g) // V2 apex
Neutralizing	P
Species (Isotype)	human(IgG)
Patient	PC64
Immunogen	HIV-1 infection
Country	Rwanda
Keywords	antibody binding site, antibody generation, antibody lineage, antibody sequence, binding affinity, neutralization

Notes

Showing 1 of 1 note.

• PCT64-35A: The PCT64 lineage of antibodies was derived from donor PC64, who was sampled at 13, 18, 24, 29, 35 and 46 months following infection with a subtype A1 virus. Several members of the PCT64 lineage are broadly neutralizing. Studies of the lineage revealed binding to the V2 region of Env, with diversity at V2 driving antibody maturation toward breadth. The heavy and light chains of the antibodies are encoded by alleles VH3-15*01/DH3-3*01/JH6*03 and Vk3-20*01/Jk3*01, respectively. PCT64-35A neutralized 0 of 35 viruses in a multiclade panel. Landais2017 (antibody binding site, antibody generation, neutralization, binding affinity, antibody sequence, antibody lineage)

References

Showing 1 of 1 reference.

Isolation Paper
Landais2017 Elise Landais, Ben Murrell, Bryan Briney, Sasha Murrell, Kimmo Rantalainen, Zachary T. Berndsen, Alejandra Ramos, Lalinda Wickramasinghe, Melissa Laird Smith, Kemal Eren, Natalia de Val, Mengyu Wu, Audrey Cappelletti, Jeffrey Umotoy, Yolanda Lie, Terri Wrin, Paul Algate, Po-Ying Chan-Hui, Etienne Karita, IAVI Protocol C Investigators, IAVI African HIV Research Network, Andrew B. Ward, Ian A. Wilson, Dennis R. Burton, Davey Smith, Sergei L. Kosakovsky Pond, and Pascal Poignard. HIV Envelope Glycoform Heterogeneity and Localized Diversity Govern the Initiation and Maturation of a V2 Apex Broadly Neutralizing Antibody Lineage. Immunity, 47(5):990-1003.e9, 21 Nov 2017. PubMed ID: 29166592. Show all entries for this paper.

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Displaying record number 3884

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MAb ID	PCT64-35B (PCT64 35B)
HXB2 Location	Env	Env Epitope Map
Author Location	Env
Epitope
Subtype	A1
Ab Type	gp120 V2 // V2 glycan(V2g) // V2 apex
Neutralizing	P  View neutralization details
Species (Isotype)	human(IgG)
Patient	PC64
Immunogen	HIV-1 infection
Country	Rwanda
Keywords	antibody binding site, antibody generation, antibody lineage, antibody sequence, binding affinity, neutralization

Notes

Showing 1 of 1 note.

• PCT64-35B: The PCT64 lineage of antibodies was derived from donor PC64, who was sampled at 13, 18, 24, 29, 35 and 46 months following infection with a subtype A1 virus. Several members of the PCT64 lineage are broadly neutralizing. Studies of the lineage revealed binding to the V2 region of Env, with diversity at V2 driving antibody maturation toward breadth. The heavy and light chains of the antibodies are encoded by alleles VH3-15*01/DH3-3*01/JH6*03 and Vk3-20*01/Jk3*01, respectively. PCT64-35B neutralized 9 of 35 viruses in a multiclade panel and 28% of 109 viruses in a larger multiclade panel. Landais2017 (antibody binding site, antibody generation, neutralization, binding affinity, antibody sequence, antibody lineage)

References

Showing 1 of 1 reference.

Isolation Paper
Landais2017 Elise Landais, Ben Murrell, Bryan Briney, Sasha Murrell, Kimmo Rantalainen, Zachary T. Berndsen, Alejandra Ramos, Lalinda Wickramasinghe, Melissa Laird Smith, Kemal Eren, Natalia de Val, Mengyu Wu, Audrey Cappelletti, Jeffrey Umotoy, Yolanda Lie, Terri Wrin, Paul Algate, Po-Ying Chan-Hui, Etienne Karita, IAVI Protocol C Investigators, IAVI African HIV Research Network, Andrew B. Ward, Ian A. Wilson, Dennis R. Burton, Davey Smith, Sergei L. Kosakovsky Pond, and Pascal Poignard. HIV Envelope Glycoform Heterogeneity and Localized Diversity Govern the Initiation and Maturation of a V2 Apex Broadly Neutralizing Antibody Lineage. Immunity, 47(5):990-1003.e9, 21 Nov 2017. PubMed ID: 29166592. Show all entries for this paper.

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Displaying record number 3885

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MAb ID	PCT64-35C (PCT64 35C)
HXB2 Location	Env	Env Epitope Map
Author Location	Env
Epitope
Subtype	A1
Ab Type	gp120 V2 // V2 glycan(V2g) // V2 apex
Neutralizing	P  View neutralization details
Species (Isotype)	human(IgG)
Patient	PC64
Immunogen	HIV-1 infection
Country	Rwanda
Keywords	antibody binding site, antibody generation, antibody lineage, antibody sequence, binding affinity, neutralization

Notes

Showing 1 of 1 note.

• PCT64-35C: The PCT64 lineage of antibodies was derived from donor PC64, who was sampled at 13, 18, 24, 29, 35 and 46 months following infection with a subtype A1 virus. Several members of the PCT64 lineage are broadly neutralizing. Studies of the lineage revealed binding to the V2 region of Env, with diversity at V2 driving antibody maturation toward breadth. The heavy and light chains of the antibodies are encoded by alleles VH3-15*01/DH3-3*01/JH6*03 and Vk3-20*01/Jk3*01, respectively. PCT64-35C neutralized 9 of 35 viruses in a multiclade panel. Landais2017 (antibody binding site, antibody generation, neutralization, binding affinity, antibody sequence, antibody lineage)

References

Showing 1 of 1 reference.

Isolation Paper
Landais2017 Elise Landais, Ben Murrell, Bryan Briney, Sasha Murrell, Kimmo Rantalainen, Zachary T. Berndsen, Alejandra Ramos, Lalinda Wickramasinghe, Melissa Laird Smith, Kemal Eren, Natalia de Val, Mengyu Wu, Audrey Cappelletti, Jeffrey Umotoy, Yolanda Lie, Terri Wrin, Paul Algate, Po-Ying Chan-Hui, Etienne Karita, IAVI Protocol C Investigators, IAVI African HIV Research Network, Andrew B. Ward, Ian A. Wilson, Dennis R. Burton, Davey Smith, Sergei L. Kosakovsky Pond, and Pascal Poignard. HIV Envelope Glycoform Heterogeneity and Localized Diversity Govern the Initiation and Maturation of a V2 Apex Broadly Neutralizing Antibody Lineage. Immunity, 47(5):990-1003.e9, 21 Nov 2017. PubMed ID: 29166592. Show all entries for this paper.

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Displaying record number 3886

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MAb ID	PCT64-35D (PCT64 35D)
HXB2 Location	Env	Env Epitope Map
Author Location	Env
Epitope
Subtype	A1
Ab Type	gp120 V2 // V2 glycan(V2g) // V2 apex
Neutralizing	P  View neutralization details
Species (Isotype)	human(IgG)
Patient	PC64
Immunogen	HIV-1 infection
Country	Rwanda
Keywords	antibody binding site, antibody generation, antibody lineage, antibody sequence, binding affinity, neutralization

Notes

Showing 1 of 1 note.

• PCT64-35D: The PCT64 lineage of antibodies was derived from donor PC64, who was sampled at 13, 18, 24, 29, 35 and 46 months following infection with a subtype A1 virus. Several members of the PCT64 lineage are broadly neutralizing. Studies of the lineage revealed binding to the V2 region of Env, with diversity at V2 driving antibody maturation toward breadth. The heavy and light chains of the antibodies are encoded by alleles VH3-15*01/DH3-3*01/JH6*03 and Vk3-20*01/Jk3*01, respectively. PCT64-35D neutralized 8 of 35 viruses in a multiclade panel and 29% of 109 viruses in a larger multiclade panel. Landais2017 (antibody binding site, antibody generation, neutralization, binding affinity, antibody sequence, antibody lineage)

References

Showing 1 of 1 reference.

Isolation Paper
Landais2017 Elise Landais, Ben Murrell, Bryan Briney, Sasha Murrell, Kimmo Rantalainen, Zachary T. Berndsen, Alejandra Ramos, Lalinda Wickramasinghe, Melissa Laird Smith, Kemal Eren, Natalia de Val, Mengyu Wu, Audrey Cappelletti, Jeffrey Umotoy, Yolanda Lie, Terri Wrin, Paul Algate, Po-Ying Chan-Hui, Etienne Karita, IAVI Protocol C Investigators, IAVI African HIV Research Network, Andrew B. Ward, Ian A. Wilson, Dennis R. Burton, Davey Smith, Sergei L. Kosakovsky Pond, and Pascal Poignard. HIV Envelope Glycoform Heterogeneity and Localized Diversity Govern the Initiation and Maturation of a V2 Apex Broadly Neutralizing Antibody Lineage. Immunity, 47(5):990-1003.e9, 21 Nov 2017. PubMed ID: 29166592. Show all entries for this paper.

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Displaying record number 3887

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MAb ID	PCT64-35E (PCT64 35E)
HXB2 Location	Env	Env Epitope Map
Author Location	Env
Epitope
Subtype	A1
Ab Type	gp120 V2 // V2 glycan(V2g) // V2 apex
Neutralizing	P  View neutralization details
Species (Isotype)	human(IgG)
Patient	PC64
Immunogen	HIV-1 infection
Country	Rwanda
Keywords	antibody binding site, antibody generation, antibody lineage, antibody sequence, binding affinity, neutralization

Notes

Showing 1 of 1 note.

• PCT64-35E: The PCT64 lineage of antibodies was derived from donor PC64, who was sampled at 13, 18, 24, 29, 35 and 46 months following infection with a subtype A1 virus. Several members of the PCT64 lineage are broadly neutralizing. Studies of the lineage revealed binding to the V2 region of Env, with diversity at V2 driving antibody maturation toward breadth. The heavy and light chains of the antibodies are encoded by alleles VH3-15*01/DH3-3*01/JH6*03 and Vk3-20*01/Jk3*01, respectively. PCT64-35E neutralized 8 of 35 viruses in a multiclade panel. Landais2017 (antibody binding site, antibody generation, neutralization, binding affinity, antibody sequence, antibody lineage)

References

Showing 1 of 1 reference.

Isolation Paper
Landais2017 Elise Landais, Ben Murrell, Bryan Briney, Sasha Murrell, Kimmo Rantalainen, Zachary T. Berndsen, Alejandra Ramos, Lalinda Wickramasinghe, Melissa Laird Smith, Kemal Eren, Natalia de Val, Mengyu Wu, Audrey Cappelletti, Jeffrey Umotoy, Yolanda Lie, Terri Wrin, Paul Algate, Po-Ying Chan-Hui, Etienne Karita, IAVI Protocol C Investigators, IAVI African HIV Research Network, Andrew B. Ward, Ian A. Wilson, Dennis R. Burton, Davey Smith, Sergei L. Kosakovsky Pond, and Pascal Poignard. HIV Envelope Glycoform Heterogeneity and Localized Diversity Govern the Initiation and Maturation of a V2 Apex Broadly Neutralizing Antibody Lineage. Immunity, 47(5):990-1003.e9, 21 Nov 2017. PubMed ID: 29166592. Show all entries for this paper.

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Displaying record number 3888

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MAb ID	PCT64-35F (PCT64 35F)
HXB2 Location	Env	Env Epitope Map
Author Location	Env
Epitope
Subtype	A1
Ab Type	gp120 V2 // V2 glycan(V2g) // V2 apex
Neutralizing	P  View neutralization details
Species (Isotype)	human(IgG)
Patient	PC64
Immunogen	HIV-1 infection
Country	Rwanda
Keywords	antibody binding site, antibody generation, antibody lineage, antibody sequence, binding affinity, neutralization

Notes

Showing 1 of 1 note.

• PCT64-35F: The PCT64 lineage of antibodies was derived from donor PC64, who was sampled at 13, 18, 24, 29, 35 and 46 months following infection with a subtype A1 virus. Several members of the PCT64 lineage are broadly neutralizing. Studies of the lineage revealed binding to the V2 region of Env, with diversity at V2 driving antibody maturation toward breadth. The heavy and light chains of the antibodies are encoded by alleles VH3-15*01/DH3-3*01/JH6*03 and Vk3-20*01/Jk3*01, respectively. PCT64-35F neutralized 8 of 35 viruses in a multiclade panel. Landais2017 (antibody binding site, antibody generation, neutralization, binding affinity, antibody sequence, antibody lineage)

References

Showing 1 of 1 reference.

Isolation Paper
Landais2017 Elise Landais, Ben Murrell, Bryan Briney, Sasha Murrell, Kimmo Rantalainen, Zachary T. Berndsen, Alejandra Ramos, Lalinda Wickramasinghe, Melissa Laird Smith, Kemal Eren, Natalia de Val, Mengyu Wu, Audrey Cappelletti, Jeffrey Umotoy, Yolanda Lie, Terri Wrin, Paul Algate, Po-Ying Chan-Hui, Etienne Karita, IAVI Protocol C Investigators, IAVI African HIV Research Network, Andrew B. Ward, Ian A. Wilson, Dennis R. Burton, Davey Smith, Sergei L. Kosakovsky Pond, and Pascal Poignard. HIV Envelope Glycoform Heterogeneity and Localized Diversity Govern the Initiation and Maturation of a V2 Apex Broadly Neutralizing Antibody Lineage. Immunity, 47(5):990-1003.e9, 21 Nov 2017. PubMed ID: 29166592. Show all entries for this paper.

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Displaying record number 3889

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MAb ID	PCT64-35G (PCT64 35G)
HXB2 Location	Env	Env Epitope Map
Author Location	Env
Epitope
Subtype	A1
Ab Type	gp120 V2 // V2 glycan(V2g) // V2 apex
Neutralizing	P  View neutralization details
Species (Isotype)	human(IgG)
Patient	PC64
Immunogen	HIV-1 infection
Country	Rwanda
Keywords	antibody binding site, antibody generation, antibody lineage, antibody sequence, binding affinity, neutralization

Notes

Showing 1 of 1 note.

• PCT64-35G: The PCT64 lineage of antibodies was derived from donor PC64, who was sampled at 13, 18, 24, 29, 35 and 46 months following infection with a subtype A1 virus. Several members of the PCT64 lineage are broadly neutralizing. Studies of the lineage revealed binding to the V2 region of Env, with diversity at V2 driving antibody maturation toward breadth. The heavy and light chains of the antibodies are encoded by alleles VH3-15*01/DH3-3*01/JH6*03 and Vk3-20*01/Jk3*01, respectively. PCT64-35G neutralized 9 of 35 viruses in a multiclade panel and 28% of 109 viruses in a larger multiclade panel. Landais2017 (antibody binding site, antibody generation, neutralization, binding affinity, antibody sequence, antibody lineage)

References

Showing 1 of 1 reference.

Isolation Paper
Landais2017 Elise Landais, Ben Murrell, Bryan Briney, Sasha Murrell, Kimmo Rantalainen, Zachary T. Berndsen, Alejandra Ramos, Lalinda Wickramasinghe, Melissa Laird Smith, Kemal Eren, Natalia de Val, Mengyu Wu, Audrey Cappelletti, Jeffrey Umotoy, Yolanda Lie, Terri Wrin, Paul Algate, Po-Ying Chan-Hui, Etienne Karita, IAVI Protocol C Investigators, IAVI African HIV Research Network, Andrew B. Ward, Ian A. Wilson, Dennis R. Burton, Davey Smith, Sergei L. Kosakovsky Pond, and Pascal Poignard. HIV Envelope Glycoform Heterogeneity and Localized Diversity Govern the Initiation and Maturation of a V2 Apex Broadly Neutralizing Antibody Lineage. Immunity, 47(5):990-1003.e9, 21 Nov 2017. PubMed ID: 29166592. Show all entries for this paper.

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Displaying record number 3890

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MAb ID	PCT64-35H (PCT64 35H)
HXB2 Location	Env	Env Epitope Map
Author Location	Env
Epitope
Subtype	A1
Ab Type	gp120 V2 // V2 glycan(V2g) // V2 apex
Neutralizing	P  View neutralization details
Species (Isotype)	human(IgG)
Patient	PC64
Immunogen	HIV-1 infection
Country	Rwanda
Keywords	antibody binding site, antibody generation, antibody lineage, antibody sequence, binding affinity, neutralization

Notes

Showing 1 of 1 note.

• PCT64-35H: The PCT64 lineage of antibodies was derived from donor PC64, who was sampled at 13, 18, 24, 29, 35 and 46 months following infection with a subtype A1 virus. Several members of the PCT64 lineage are broadly neutralizing. Studies of the lineage revealed binding to the V2 region of Env, with diversity at V2 driving antibody maturation toward breadth. The heavy and light chains of the antibodies are encoded by alleles VH3-15*01/DH3-3*01/JH6*03 and Vk3-20*01/Jk3*01, respectively. PCT64-35H neutralized 7 of 35 viruses in a multiclade panel. Landais2017 (antibody binding site, antibody generation, neutralization, binding affinity, antibody sequence, antibody lineage)

References

Showing 1 of 1 reference.

Isolation Paper
Landais2017 Elise Landais, Ben Murrell, Bryan Briney, Sasha Murrell, Kimmo Rantalainen, Zachary T. Berndsen, Alejandra Ramos, Lalinda Wickramasinghe, Melissa Laird Smith, Kemal Eren, Natalia de Val, Mengyu Wu, Audrey Cappelletti, Jeffrey Umotoy, Yolanda Lie, Terri Wrin, Paul Algate, Po-Ying Chan-Hui, Etienne Karita, IAVI Protocol C Investigators, IAVI African HIV Research Network, Andrew B. Ward, Ian A. Wilson, Dennis R. Burton, Davey Smith, Sergei L. Kosakovsky Pond, and Pascal Poignard. HIV Envelope Glycoform Heterogeneity and Localized Diversity Govern the Initiation and Maturation of a V2 Apex Broadly Neutralizing Antibody Lineage. Immunity, 47(5):990-1003.e9, 21 Nov 2017. PubMed ID: 29166592. Show all entries for this paper.

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Displaying record number 3891

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MAb ID	PCT64-35I (PCT64 35I)
HXB2 Location	Env	Env Epitope Map
Author Location	Env
Epitope
Subtype	A1
Ab Type	gp120 V2 // V2 glycan(V2g) // V2 apex
Neutralizing	P  View neutralization details
Species (Isotype)	human(IgG)
Patient	PC64
Immunogen	HIV-1 infection
Country	Rwanda
Keywords	antibody binding site, antibody generation, antibody lineage, antibody sequence, binding affinity, neutralization

Notes

Showing 1 of 1 note.

• PCT64-35I: The PCT64 lineage of antibodies was derived from donor PC64, who was sampled at 13, 18, 24, 29, 35 and 46 months following infection with a subtype A1 virus. Several members of the PCT64 lineage are broadly neutralizing. Studies of the lineage revealed binding to the V2 region of Env, with diversity at V2 driving antibody maturation toward breadth. The heavy and light chains of the antibodies are encoded by alleles VH3-15*01/DH3-3*01/JH6*03 and Vk3-20*01/Jk3*01, respectively. PCT64-35I neutralized 2 of 35 viruses in a multiclade panel. Landais2017 (antibody binding site, antibody generation, neutralization, binding affinity, antibody sequence, antibody lineage)

References

Showing 1 of 1 reference.

Isolation Paper
Landais2017 Elise Landais, Ben Murrell, Bryan Briney, Sasha Murrell, Kimmo Rantalainen, Zachary T. Berndsen, Alejandra Ramos, Lalinda Wickramasinghe, Melissa Laird Smith, Kemal Eren, Natalia de Val, Mengyu Wu, Audrey Cappelletti, Jeffrey Umotoy, Yolanda Lie, Terri Wrin, Paul Algate, Po-Ying Chan-Hui, Etienne Karita, IAVI Protocol C Investigators, IAVI African HIV Research Network, Andrew B. Ward, Ian A. Wilson, Dennis R. Burton, Davey Smith, Sergei L. Kosakovsky Pond, and Pascal Poignard. HIV Envelope Glycoform Heterogeneity and Localized Diversity Govern the Initiation and Maturation of a V2 Apex Broadly Neutralizing Antibody Lineage. Immunity, 47(5):990-1003.e9, 21 Nov 2017. PubMed ID: 29166592. Show all entries for this paper.

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Displaying record number 3892

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MAb ID	PCT64-35K (PCT64 35K)
HXB2 Location	Env	Env Epitope Map
Author Location	Env
Epitope
Subtype	A1
Ab Type	gp120 V2 // V2 glycan(V2g) // V2 apex
Neutralizing	P  View neutralization details
Species (Isotype)	human(IgG)
Patient	PC64
Immunogen	HIV-1 infection
Country	Rwanda
Keywords	antibody binding site, antibody generation, antibody lineage, antibody sequence, binding affinity, neutralization

Notes

Showing 1 of 1 note.

• PCT64-35K: The PCT64 lineage of antibodies was derived from donor PC64, who was sampled at 13, 18, 24, 29, 35 and 46 months following infection with a subtype A1 virus. Several members of the PCT64 lineage are broadly neutralizing. Studies of the lineage revealed binding to the V2 region of Env, with diversity at V2 driving antibody maturation toward breadth. The heavy and light chains of the antibodies are encoded by alleles VH3-15*01/DH3-3*01/JH6*03 and Vk3-20*01/Jk3*01, respectively. PCT64-35K neutralized 6 of 35 viruses in a multiclade panel. Landais2017 (antibody binding site, antibody generation, neutralization, binding affinity, antibody sequence, antibody lineage)

References

Showing 1 of 1 reference.

Isolation Paper
Landais2017 Elise Landais, Ben Murrell, Bryan Briney, Sasha Murrell, Kimmo Rantalainen, Zachary T. Berndsen, Alejandra Ramos, Lalinda Wickramasinghe, Melissa Laird Smith, Kemal Eren, Natalia de Val, Mengyu Wu, Audrey Cappelletti, Jeffrey Umotoy, Yolanda Lie, Terri Wrin, Paul Algate, Po-Ying Chan-Hui, Etienne Karita, IAVI Protocol C Investigators, IAVI African HIV Research Network, Andrew B. Ward, Ian A. Wilson, Dennis R. Burton, Davey Smith, Sergei L. Kosakovsky Pond, and Pascal Poignard. HIV Envelope Glycoform Heterogeneity and Localized Diversity Govern the Initiation and Maturation of a V2 Apex Broadly Neutralizing Antibody Lineage. Immunity, 47(5):990-1003.e9, 21 Nov 2017. PubMed ID: 29166592. Show all entries for this paper.

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Displaying record number 3893

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MAb ID	PCT64-35M (PCT64 35M)
HXB2 Location	Env	Env Epitope Map
Author Location	Env
Epitope
Subtype	A1
Ab Type	gp120 V2 // V2 glycan(V2g) // V2 apex
Neutralizing	P  View neutralization details
Species (Isotype)	human(IgG)
Patient	PC64
Immunogen	HIV-1 infection
Country	Rwanda
Keywords	antibody binding site, antibody generation, antibody lineage, antibody sequence, binding affinity, neutralization, structure

Notes

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• PCT64-35M: The PCT64 lineage of antibodies was derived from donor PC64, who was sampled at 13, 18, 24, 29, 35 and 46 months following infection with a subtype A1 virus. Several members of the PCT64 lineage are broadly neutralizing. Studies of the lineage revealed binding to the V2 region of Env, with diversity at V2 driving antibody maturation toward breadth. The heavy and light chains of the antibodies are encoded by alleles VH3-15*01/DH3-3*01/JH6*03 and Vk3-20*01/Jk3*01, respectively. PCT64-35M neutralized 12 of 35 viruses in a multiclade panel and 26% of 109 viruses in a larger multiclade panel, and had the highest potency of the viruses in the PCT64 lineage. They crystal structure of PCT64-35M was determined. Landais2017 (antibody binding site, antibody generation, neutralization, binding affinity, antibody sequence, structure, antibody lineage)

References

Showing 1 of 1 reference.

Isolation Paper
Landais2017 Elise Landais, Ben Murrell, Bryan Briney, Sasha Murrell, Kimmo Rantalainen, Zachary T. Berndsen, Alejandra Ramos, Lalinda Wickramasinghe, Melissa Laird Smith, Kemal Eren, Natalia de Val, Mengyu Wu, Audrey Cappelletti, Jeffrey Umotoy, Yolanda Lie, Terri Wrin, Paul Algate, Po-Ying Chan-Hui, Etienne Karita, IAVI Protocol C Investigators, IAVI African HIV Research Network, Andrew B. Ward, Ian A. Wilson, Dennis R. Burton, Davey Smith, Sergei L. Kosakovsky Pond, and Pascal Poignard. HIV Envelope Glycoform Heterogeneity and Localized Diversity Govern the Initiation and Maturation of a V2 Apex Broadly Neutralizing Antibody Lineage. Immunity, 47(5):990-1003.e9, 21 Nov 2017. PubMed ID: 29166592. Show all entries for this paper.

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Displaying record number 3894

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MAb ID	PCT64-35N (PCT64 35N)
HXB2 Location	Env	Env Epitope Map
Author Location	Env
Epitope
Subtype	A1
Ab Type	gp120 V2 // V2 glycan(V2g) // V2 apex
Neutralizing	P  View neutralization details
Species (Isotype)	human(IgG)
Patient	PC64
Immunogen	HIV-1 infection
Country	Rwanda
Keywords	antibody binding site, antibody generation, antibody lineage, antibody sequence, binding affinity, neutralization

Notes

Showing 1 of 1 note.

• PCT64-35N: The PCT64 lineage of antibodies was derived from donor PC64, who was sampled at 13, 18, 24, 29, 35 and 46 months following infection with a subtype A1 virus. Several members of the PCT64 lineage are broadly neutralizing. Studies of the lineage revealed binding to the V2 region of Env, with diversity at V2 driving antibody maturation toward breadth. The heavy and light chains of the antibodies are encoded by alleles VH3-15*01/DH3-3*01/JH6*03 and Vk3-20*01/Jk3*01, respectively. PCT64-35N neutralized 6 of 35 viruses in a multiclade panel. Landais2017 (antibody binding site, antibody generation, neutralization, binding affinity, antibody sequence, antibody lineage)

References

Showing 1 of 1 reference.

Isolation Paper
Landais2017 Elise Landais, Ben Murrell, Bryan Briney, Sasha Murrell, Kimmo Rantalainen, Zachary T. Berndsen, Alejandra Ramos, Lalinda Wickramasinghe, Melissa Laird Smith, Kemal Eren, Natalia de Val, Mengyu Wu, Audrey Cappelletti, Jeffrey Umotoy, Yolanda Lie, Terri Wrin, Paul Algate, Po-Ying Chan-Hui, Etienne Karita, IAVI Protocol C Investigators, IAVI African HIV Research Network, Andrew B. Ward, Ian A. Wilson, Dennis R. Burton, Davey Smith, Sergei L. Kosakovsky Pond, and Pascal Poignard. HIV Envelope Glycoform Heterogeneity and Localized Diversity Govern the Initiation and Maturation of a V2 Apex Broadly Neutralizing Antibody Lineage. Immunity, 47(5):990-1003.e9, 21 Nov 2017. PubMed ID: 29166592. Show all entries for this paper.

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Displaying record number 3895

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MAb ID	PCT64-35O (PCT64 35O)
HXB2 Location	Env	Env Epitope Map
Author Location	Env
Epitope
Subtype	A1
Ab Type	gp120 V2 // V2 glycan(V2g) // V2 apex
Neutralizing	P  View neutralization details
Species (Isotype)	human(IgG)
Patient	PC64
Immunogen	HIV-1 infection
Country	Rwanda
Keywords	antibody binding site, antibody generation, antibody lineage, antibody sequence, binding affinity, neutralization

Notes

Showing 1 of 1 note.

• PCT64-35O: The PCT64 lineage of antibodies was derived from donor PC64, who was sampled at 13, 18, 24, 29, 35 and 46 months following infection with a subtype A1 virus. Several members of the PCT64 lineage are broadly neutralizing. Studies of the lineage revealed binding to the V2 region of Env, with diversity at V2 driving antibody maturation toward breadth. The heavy and light chains of the antibodies are encoded by alleles VH3-15*01/DH3-3*01/JH6*03 and Vk3-20*01/Jk3*01, respectively. PCT64-35O neutralized 7 of 35 viruses in a multiclade panel and 23% of 109 viruses in a larger multiclade panel. Landais2017 (antibody binding site, antibody generation, neutralization, binding affinity, antibody sequence, antibody lineage)

References

Showing 1 of 1 reference.

Isolation Paper
Landais2017 Elise Landais, Ben Murrell, Bryan Briney, Sasha Murrell, Kimmo Rantalainen, Zachary T. Berndsen, Alejandra Ramos, Lalinda Wickramasinghe, Melissa Laird Smith, Kemal Eren, Natalia de Val, Mengyu Wu, Audrey Cappelletti, Jeffrey Umotoy, Yolanda Lie, Terri Wrin, Paul Algate, Po-Ying Chan-Hui, Etienne Karita, IAVI Protocol C Investigators, IAVI African HIV Research Network, Andrew B. Ward, Ian A. Wilson, Dennis R. Burton, Davey Smith, Sergei L. Kosakovsky Pond, and Pascal Poignard. HIV Envelope Glycoform Heterogeneity and Localized Diversity Govern the Initiation and Maturation of a V2 Apex Broadly Neutralizing Antibody Lineage. Immunity, 47(5):990-1003.e9, 21 Nov 2017. PubMed ID: 29166592. Show all entries for this paper.

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Displaying record number 3896

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MAb ID	PCT64-35S (PCT64 35S)
HXB2 Location	Env	Env Epitope Map
Author Location	Env
Epitope
Subtype	A1
Ab Type	gp120 V2 // V2 glycan(V2g) // V2 apex
Neutralizing	P  View neutralization details
Species (Isotype)	human(IgG)
Patient	PC64
Immunogen	HIV-1 infection
Country	Rwanda
Keywords	antibody binding site, antibody generation, antibody lineage, antibody sequence, binding affinity, neutralization

Notes

Showing 1 of 1 note.

• PCT64-35S: The PCT64 lineage of antibodies was derived from donor PC64, who was sampled at 13, 18, 24, 29, 35 and 46 months following infection with a subtype A1 virus. Several members of the PCT64 lineage are broadly neutralizing. Studies of the lineage revealed binding to the V2 region of Env, with diversity at V2 driving antibody maturation toward breadth. The heavy and light chains of the antibodies are encoded by alleles VH3-15*01/DH3-3*01/JH6*03 and Vk3-20*01/Jk3*01, respectively. PCT64-35S neutralized 8 of 35 viruses in a multiclade panel and 27% of 109 viruses in a larger multiclade panel. Landais2017 (antibody binding site, antibody generation, neutralization, binding affinity, antibody sequence, antibody lineage)

References

Showing 1 of 1 reference.

Isolation Paper
Landais2017 Elise Landais, Ben Murrell, Bryan Briney, Sasha Murrell, Kimmo Rantalainen, Zachary T. Berndsen, Alejandra Ramos, Lalinda Wickramasinghe, Melissa Laird Smith, Kemal Eren, Natalia de Val, Mengyu Wu, Audrey Cappelletti, Jeffrey Umotoy, Yolanda Lie, Terri Wrin, Paul Algate, Po-Ying Chan-Hui, Etienne Karita, IAVI Protocol C Investigators, IAVI African HIV Research Network, Andrew B. Ward, Ian A. Wilson, Dennis R. Burton, Davey Smith, Sergei L. Kosakovsky Pond, and Pascal Poignard. HIV Envelope Glycoform Heterogeneity and Localized Diversity Govern the Initiation and Maturation of a V2 Apex Broadly Neutralizing Antibody Lineage. Immunity, 47(5):990-1003.e9, 21 Nov 2017. PubMed ID: 29166592. Show all entries for this paper.

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Displaying record number 3968

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MAb ID	polyclonal PC64-M35
HXB2 Location	Env	Env Epitope Map
Author Location	Env
Epitope
Subtype	A1
Ab Type
Neutralizing	P  View neutralization details
Species (Isotype)	human
Patient	PC64
Immunogen	HIV-1 infection
Country	Rwanda
Keywords	neutralization, polyclonal antibodies

Notes

Showing 1 of 1 note.

• The PCT64 lineage of monoclonal antibodies was derived from donor PC64, who was sampled at 13, 18, 24, 29, 35 and 46 months following infection with a subtype A1 virus. Several members of the PCT64 lineage are broadly neutralizing. Studies of the lineage revealed binding to the V2 region of Env, with diversity at V2 driving antibody maturation toward breadth. The neutralization of the donor serum was assayed at the month 35 (M35) timepoint. Landais2017 (neutralization, polyclonal antibodies)

References

Showing 1 of 1 reference.

Isolation Paper
Landais2017 Elise Landais, Ben Murrell, Bryan Briney, Sasha Murrell, Kimmo Rantalainen, Zachary T. Berndsen, Alejandra Ramos, Lalinda Wickramasinghe, Melissa Laird Smith, Kemal Eren, Natalia de Val, Mengyu Wu, Audrey Cappelletti, Jeffrey Umotoy, Yolanda Lie, Terri Wrin, Paul Algate, Po-Ying Chan-Hui, Etienne Karita, IAVI Protocol C Investigators, IAVI African HIV Research Network, Andrew B. Ward, Ian A. Wilson, Dennis R. Burton, Davey Smith, Sergei L. Kosakovsky Pond, and Pascal Poignard. HIV Envelope Glycoform Heterogeneity and Localized Diversity Govern the Initiation and Maturation of a V2 Apex Broadly Neutralizing Antibody Lineage. Immunity, 47(5):990-1003.e9, 21 Nov 2017. PubMed ID: 29166592. Show all entries for this paper.

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