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Found 5 matching records:

Displaying record number 378

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MAb ID IIIB-V3-21 (V3-21, EVA3048)
HXB2 Location gp160(294-299)
DNA(7104..7121)
gp160 Epitope Map
Author Location gp120(299-304 IIIB)
Research Contact J. Laman
Epitope INCTRP Epitope Alignment
INCTRP epitope logo
Ab Type gp120 V3 // V3 glycan (V3g)
Neutralizing  
Species (Isotype) mouse(IgG1)
Patient  
Immunogen vaccine
Keywords antibody binding site, co-receptor, dendritic cells, enhancing activity, mimics, neutralization

Vaccine Details

Vaccine type peptide
Vaccine strain B clade IIIB

Notes

Showing 12 of 12 notes.

References

Showing 10 of 10 references.

Laman1992 J. D. Laman, M. M. Schellekens, Y. H. Abacioglu, G. K. Lewis, M. Tersmette, R. A. M. Fouchier, J. P. M. Langeduk, E. Claassen, and W. J. A. Boersma. Variant-specific monoclonal and group-specific polyclonal human immunodeficiency virus type 1 neutralizing antibodies raised with synthetic peptides from the gp120 third variable domain. J. Virol., 66:1823-1831, 1992. PubMed ID: 1629971. Show all entries for this paper.

Laman1993 J. D. Laman, M. M. Schellekens, G. K. Lewis, J. P. Moore, T. J. Matthews, J. P. M. Langedijk, R. H. Meloen, W. J. A. Boersma, and E. Claassen. A Hidden Region in the Third Variable Domain of HIV-1 IIIB gp120 Identified by a Monoclonal Antibody. AIDS Res. Hum. Retroviruses, 9:605-612, 1993. A peptide (FVTIGKIGNMRQAHC) induced MAb binds to the carboxy-terminal flank of the V3-loop, but the epitope is only exposed on gp120 when it is treated with SDS-DTT. PubMed ID: 8369165. Show all entries for this paper.

Valenzuela1998 A. Valenzuela, J. Blanco, B. Krust, R. Franco, and A. G. Hovanessian. Neutralizing Antibodies against the V3 Loop of Human Immunodeficiency Type 1 gp120 Block the CD4-Dependent and Independent Binding of the Virus to Cells. J. Virol., 71:8289-8298, 1998. PubMed ID: 9343181. Show all entries for this paper.

Zhang2002 Peng Fei Zhang, Peter Bouma, Eun Ju Park, Joseph B. Margolick, James E. Robinson, Susan Zolla-Pazner, Michael N. Flora, and Gerald V. Quinnan, Jr. A Variable Region 3 (V3) Mutation Determines a Global Neutralization Phenotype and CD4-Independent Infectivity of a Human Immunodeficiency Virus Type 1 Envelope Associated with a Broadly Cross-Reactive, Primary Virus-Neutralizing Antibody Response. J. Virol., 76(2):644-655, Jan 2002. PubMed ID: 11752155. Show all entries for this paper.

Maksiutov2002 A. Z. Maksiutov, A. G. Bachinskii, and S. I. Bazhan. [Searching for Local Similarities Between HIV-1 and Human Proteins. Application to Vaccines]. Mol Biol (Mosk), 36(3):447-459, May-Jun 2002. Article in Russian. PubMed ID: 12068630. Show all entries for this paper.

Ling2004 Hong Ling, Peng Xiao, Osamu Usami, and Toshio Hattori. Thrombin Activates Envelope Glycoproteins of HIV Type 1 and Enhances Fusion. Microbes Infect., 6(5):414-420, Apr 2004. PubMed ID: 15109955. Show all entries for this paper.

vanMontfort2007 Thijs van Montfort, Alexey A. Nabatov, Teunis B. H. Geijtenbeek, Georgios Pollakis, and William A. Paxton. Efficient Capture of Antibody Neutralized HIV-1 by Cells Expressing DC-SIGN and Transfer to CD4+ T Lymphocytes. J. Immunol., 178(5):3177-85, 1 Mar 2007. PubMed ID: 17312166. Show all entries for this paper.

Cadogan2008 Martin Cadogan, Brian Austen, Jonathan L. Heeney, and Angus G. Dalgleish. HLA Homology within the C5 Domain Promotes Peptide Binding by HIV Type 1 gp120. AIDS Res. Hum. Retroviruses, 24(6):845-855, Jun 2008. PubMed ID: 18544021. Show all entries for this paper.

Chomont2008 Nicolas Chomont, Hakim Hocini, Jean-Chrysostome Gody, Hicham Bouhlal, Pierre Becquart, Corinne Krief-Bouillet, Michel Kazatchkine, and Laurent Bélec. Neutralizing Monoclonal Antibodies to Human Immunodeficiency Virus Type 1 Do Not Inhibit Viral Transcytosis Through Mucosal Epithelial Cells. Virology, 370(2):246-254, 20 Jan 2008. PubMed ID: 17920650. Show all entries for this paper.

vanMontfort2008 Thijs van Montfort, Adri A. M. Thomas, Georgios Pollakis, and William A. Paxton. Dendritic Cells Preferentially Transfer CXCR4-Using Human Immunodeficiency Virus Type 1 Variants to CD4+ T Lymphocytes in trans. J. Viro.l, 82(16):7886-7896, Aug 2008. PubMed ID: 18524826. Show all entries for this paper.


Displaying record number 482

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MAb ID IIIB-34 V3 (IIIB-V3-34, EVA3047)
HXB2 Location gp160(309-317)
DNA(7149..7175)
gp160 Epitope Map
Author Location gp120(308-316 IIIB)
Epitope IQRGPGRAF Epitope Alignment
IQRGPGRAF epitope logo
Ab Type gp120 V3 // V3 glycan (V3g)
Neutralizing L
Species (Isotype) mouse(IgG1)
Patient  
Immunogen vaccine
Keywords mimics

Vaccine Details

Vaccine type peptide
Vaccine strain B clade IIIB

Notes

Showing 4 of 4 notes.

References

Showing 3 of 3 references.

Laman1992 J. D. Laman, M. M. Schellekens, Y. H. Abacioglu, G. K. Lewis, M. Tersmette, R. A. M. Fouchier, J. P. M. Langeduk, E. Claassen, and W. J. A. Boersma. Variant-specific monoclonal and group-specific polyclonal human immunodeficiency virus type 1 neutralizing antibodies raised with synthetic peptides from the gp120 third variable domain. J. Virol., 66:1823-1831, 1992. PubMed ID: 1629971. Show all entries for this paper.

Laman1993 J. D. Laman, M. M. Schellekens, G. K. Lewis, J. P. Moore, T. J. Matthews, J. P. M. Langedijk, R. H. Meloen, W. J. A. Boersma, and E. Claassen. A Hidden Region in the Third Variable Domain of HIV-1 IIIB gp120 Identified by a Monoclonal Antibody. AIDS Res. Hum. Retroviruses, 9:605-612, 1993. A peptide (FVTIGKIGNMRQAHC) induced MAb binds to the carboxy-terminal flank of the V3-loop, but the epitope is only exposed on gp120 when it is treated with SDS-DTT. PubMed ID: 8369165. Show all entries for this paper.

Cadogan2008 Martin Cadogan, Brian Austen, Jonathan L. Heeney, and Angus G. Dalgleish. HLA Homology within the C5 Domain Promotes Peptide Binding by HIV Type 1 gp120. AIDS Res. Hum. Retroviruses, 24(6):845-855, Jun 2008. PubMed ID: 18544021. Show all entries for this paper.


Displaying record number 483

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MAb ID IIIB-13 V3 (1044-13 IIIB-V3-13 1727)
HXB2 Location gp160(309-317)
DNA(7149..7175)
gp160 Epitope Map
Author Location gp120(308-316 IIIB)
Epitope IQRGPGRAF Epitope Alignment
IQRGPGRAF epitope logo
Ab Type gp120 V3 // V3 glycan (V3g)
Neutralizing L
Species (Isotype) mouse(IgG1)
Patient  
Immunogen vaccine
Keywords dendritic cells, neutralization

Vaccine Details

Vaccine type peptide
Vaccine strain B clade IIIB

Notes

Showing 9 of 9 notes.

References

Showing 7 of 7 references.

Laman1992 J. D. Laman, M. M. Schellekens, Y. H. Abacioglu, G. K. Lewis, M. Tersmette, R. A. M. Fouchier, J. P. M. Langeduk, E. Claassen, and W. J. A. Boersma. Variant-specific monoclonal and group-specific polyclonal human immunodeficiency virus type 1 neutralizing antibodies raised with synthetic peptides from the gp120 third variable domain. J. Virol., 66:1823-1831, 1992. PubMed ID: 1629971. Show all entries for this paper.

Laman1993 J. D. Laman, M. M. Schellekens, G. K. Lewis, J. P. Moore, T. J. Matthews, J. P. M. Langedijk, R. H. Meloen, W. J. A. Boersma, and E. Claassen. A Hidden Region in the Third Variable Domain of HIV-1 IIIB gp120 Identified by a Monoclonal Antibody. AIDS Res. Hum. Retroviruses, 9:605-612, 1993. A peptide (FVTIGKIGNMRQAHC) induced MAb binds to the carboxy-terminal flank of the V3-loop, but the epitope is only exposed on gp120 when it is treated with SDS-DTT. PubMed ID: 8369165. Show all entries for this paper.

DSouza1994 M. P. D'Souza, S. J. Geyer, C. V. Hanson, R. M. Hendry, G. Milman, and Collaborating Investigators. Evaluation of Monoclonal Antibodies to HIV-1 Envelope by Neutralization and Binding Assays: An International Collaboration. AIDS, 8:169-181, 1994. PubMed ID: 7519019. Show all entries for this paper.

Watkins1993 B. A. Watkins, M. S. Reitz, Jr., C. A. Wilson, K. Aldrich, A. E. Davis, and M. Robert-Guroff. Immune escape by human immunodeficiency virus type 1 from neutralizing antibodies: evidence for multiple pathways. J. Virol., 67:7493-7500, 1993. A neutralization resistance point mutation (HXB2 A281V) was studied using a variety of MAbs, and it was shown that this substitution affects a different epitope than a previously characterized neutralization escape mutant (A582T) (Reitz 1988, Wilson 1990). PubMed ID: 7693973. Show all entries for this paper.

Chakrabarti2002 Bimal K. Chakrabarti, Wing-pui Kong, Bei-yue Wu, Zhi-Yong Yang, Jacques Friborg, Xu Ling, Steven R. King, David C. Montefiori, and Gary J. Nabel. Modifications of the Human Immunodeficiency Virus Envelope Glycoprotein Enhance Immunogenicity for Genetic Immunization. J. Virol., 76(11):5357-5368, Jun 2002. PubMed ID: 11991964. Show all entries for this paper.

Zhang2002 Peng Fei Zhang, Peter Bouma, Eun Ju Park, Joseph B. Margolick, James E. Robinson, Susan Zolla-Pazner, Michael N. Flora, and Gerald V. Quinnan, Jr. A Variable Region 3 (V3) Mutation Determines a Global Neutralization Phenotype and CD4-Independent Infectivity of a Human Immunodeficiency Virus Type 1 Envelope Associated with a Broadly Cross-Reactive, Primary Virus-Neutralizing Antibody Response. J. Virol., 76(2):644-655, Jan 2002. PubMed ID: 11752155. Show all entries for this paper.

Holl2006 Vincent Holl, Maryse Peressin, Thomas Decoville, Sylvie Schmidt, Susan Zolla-Pazner, Anne-Marie Aubertin, and Christiane Moog. Nonneutralizing Antibodies Are Able To Inhibit Human Immunodeficiency Virus Type 1 Replication in Macrophages and Immature Dendritic Cells. J. Virol., 80(12):6177-6181, Jun 2006. PubMed ID: 16731957. Show all entries for this paper.


Displaying record number 509

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MAb ID 902 (H902)
HXB2 Location gp160(313-324)
DNA(7161..7196)
gp160 Epitope Map
Author Location gp120( IIIB)
Research Contact Bruce Chesebro, Rocky Mountain National Laboratory, Montana
Epitope PGRAFVTIGKIG Epitope Alignment
PGRAFVTIGKIG epitope logo
Ab Type gp120 V3 // V3 glycan (V3g)
Neutralizing L
Species (Isotype) mouse(IgG1κ)
Patient  
Immunogen vaccine
Keywords antibody binding site, neutralization, rate of progression

Vaccine Details

Vaccine type vaccinia
Vaccine strain B clade IIIB
Vaccine component gp160

Notes

Showing 8 of 8 notes.

References

Showing 9 of 9 references.

Chesebro1988 B. Chesebro and K. Wehrly. Development of a Sensitive Quantitative Focal Assay for Human Immunodeficiency Virus Infectivity. J. Virol., 62:3779-3788, 1988. PubMed ID: 3047430. Show all entries for this paper.

Laman1993 J. D. Laman, M. M. Schellekens, G. K. Lewis, J. P. Moore, T. J. Matthews, J. P. M. Langedijk, R. H. Meloen, W. J. A. Boersma, and E. Claassen. A Hidden Region in the Third Variable Domain of HIV-1 IIIB gp120 Identified by a Monoclonal Antibody. AIDS Res. Hum. Retroviruses, 9:605-612, 1993. A peptide (FVTIGKIGNMRQAHC) induced MAb binds to the carboxy-terminal flank of the V3-loop, but the epitope is only exposed on gp120 when it is treated with SDS-DTT. PubMed ID: 8369165. Show all entries for this paper.

Broder1994 C.C. Broder, P.L. Earl, D. Long, S.T. Abedon, B. Moss, and R.W. Doms. Antigenic implications of human immunodeficiency virus type 1 envelope quaternary structure: Oligomer-specific and -sensitive monoclonal antibodies. Proc. Natl. Acad. Sci. U.S.A., 91:11699-11703, 1994. 35 anti-gp41 and 27 anti-gp120 murine MAbs generated by immunization with oligomeric HIV-1 IIIB envelope were studied. These MAbs tended to react with conformational epitopes. 21 of the anti-gp41 MAbs reacted preferentially with oligomeric env, while only 1 of the anti-gp120 MAbs reacted more strongly with the oligomer, and 14 of the anti-gp120 preferentially recognized monomeric env. PubMed ID: 7972127. Show all entries for this paper.

Earl1994 P. L. Earl, C. C. Broder, D. Long, S. A. Lee, J. Peterson, S. Chakrabarti, R. W. Doms, and B. Moss. Native oligomeric human immunodeficiency virus type 1 Envelope glycoprotein elicits diverse monoclonal antibody reactivities. J. Virol., 68:3015-3026, 1994. In a study of the repertoire of response to oligomeric versus monomeric Env protein, 138 murine MAbs were generated in response to an immunogen that was a gp120/bp41 oligomeric molecule that was not cleaved due to a mutation in the cleavage site. The oligomeric molecule was found to elicit a response that was very different than the monomer. Most MAbs were conformational, many were to gp41 or if in gp120, to the CD4 BS. Few MAbs to linear V3 epitopes were produced in response to oligomeric protein, though this was a common specificity in response to immunization with gp120 monomeric protein. PubMed ID: 7512157. Show all entries for this paper.

Sakaida1997 H. Sakaida, T. Murakami, S. Kawamata, T. Hattori, and T. Uchiyama. V3 Loop of Human Immunodeficiency Virus Type 1 Suppresses Interleukin 2-Induced T Cell Growth. AIDS Res. Hum. Retroviruses, 13:151-159, 1997. See comments in AIDS Res Hum Retroviruses 13:633 (1997). PubMed ID: 9007200. Show all entries for this paper.

Ling2004 Hong Ling, Peng Xiao, Osamu Usami, and Toshio Hattori. Thrombin Activates Envelope Glycoproteins of HIV Type 1 and Enhances Fusion. Microbes Infect., 6(5):414-420, Apr 2004. PubMed ID: 15109955. Show all entries for this paper.

Usami2005 Osamu Usami, Peng Xiao, Hong Ling, Yi Liu, Tadashi Nakasone, and Toshio Hattori. Properties of Anti-gp41 Core Structure Antibodies, Which Compete with Sera of HIV-1-Infected Patients. Microbes Infect., 7(4):650-657, Apr 2005. PubMed ID: 15823513. Show all entries for this paper.

Bosch2009 Valerie Bosch, Tanya Pfeiffer, Gerard Devitt, Ina Allespach, Thomas Ebensen, Vanessa Emerson, Carlos A. Guzman, and Oliver T. Keppler. HIV Pseudovirion Vaccine Exposing Env ``fusion intermediates''---Response to Immunisation in Human CD4/CCR5-Transgenic Rats. Vaccine, 27(16):2202-2212, 6 Apr 2009. PubMed ID: 19428834. Show all entries for this paper.

Mizukami1988 Tamio Mizukami, Thomas R. Fuerst, Edward A. Berger, and Bernard Moss. Binding Region for Human Immunodeficiency Virus (HIV) and Epitopes for HIV-Blocking Monoclonal Antibodies of the CD4 Molecule Defined by Site-Directed Mutagenesis. Proc. Natl. Acad. Sci. U.S.A., 85(23):9273-9277, Dec 1988. PubMed ID: 2461565. Show all entries for this paper.


Displaying record number 510

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MAb ID IIIB-V3-01
HXB2 Location gp160(320-328)
DNA(7182..7208)
gp160 Epitope Map
Author Location gp120( IIIB)
Research Contact Jon Laman
Epitope IGKIGNMRQ Epitope Alignment
IGKIGNMRQ epitope logo
Ab Type gp120 V3 // V3 glycan (V3g)
Neutralizing  
Species (Isotype) mouse(IgG1)
Patient  
Immunogen vaccine
Keywords  

Vaccine Details

Vaccine type peptide
Vaccine strain B clade IIIB
Vaccine component Env V3

Notes

Showing 4 of 4 notes.

References

Showing 2 of 2 references.

Laman1993 J. D. Laman, M. M. Schellekens, G. K. Lewis, J. P. Moore, T. J. Matthews, J. P. M. Langedijk, R. H. Meloen, W. J. A. Boersma, and E. Claassen. A Hidden Region in the Third Variable Domain of HIV-1 IIIB gp120 Identified by a Monoclonal Antibody. AIDS Res. Hum. Retroviruses, 9:605-612, 1993. A peptide (FVTIGKIGNMRQAHC) induced MAb binds to the carboxy-terminal flank of the V3-loop, but the epitope is only exposed on gp120 when it is treated with SDS-DTT. PubMed ID: 8369165. Show all entries for this paper.

Kanduc2008 Darja Kanduc, Rosario Serpico, Alberta Lucchese, and Yehuda Shoenfeld. Correlating Low-Similarity Peptide Sequences and HIV B-Cell Epitopes. Autoimmun. Rev., 7(4):291-296, Feb 2008. PubMed ID: 18295732. Show all entries for this paper.


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