Search Antibody Database

Found 7 matching records:

Displaying record number 102

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MAb ID	LH-104-E
HXB2 Location	Gag(275-280) DNA(1612..1629)	Gag Epitope Map
Author Location	p24(275-280 BRU)
Epitope	RMYSPT	Epitope Alignment
Ab Type
Neutralizing
Species (Isotype)	mouse(IgG1κ)
Patient
Immunogen	vaccine
Keywords

Vaccine Details

Vaccine type	peptide
Vaccine strain	B clade BRU

Notes

Showing 3 of 3 notes.

• LH-104-E: Similarity level of the LH-104-E binding site pentapeptide MYSPT to the host proteome was low, with the low-similarity 5-mer occurring in the host proteome 0 times, indicating that this peptide can be used to elicit Abs for active/passive immunotherapy with low risk of cross-reaction with the host proteome. Kanduc2008
• LH-104-E: UK Medical Research Council AIDS reagent: ARP319.
• LH-104-E: Reacts with both p24 and p55. Haaheim1991

References

Showing 2 of 2 references.

Haaheim1991 L. R. Haaheim, J. P. Maskell, P. Mascagni, and A. R. M. Coates. Fine Molecular Specificity of Linear and Assembled Antibody Binding Sites in HIV-1 p24. Scand. J. Immunol., 34:341-350, 1991. Seven murine MAbs to a 104-mer peptide spanning residues 270-373 of p24 gag were generated. PubMed ID: 1715604. Show all entries for this paper.

Kanduc2008 Darja Kanduc, Rosario Serpico, Alberta Lucchese, and Yehuda Shoenfeld. Correlating Low-Similarity Peptide Sequences and HIV B-Cell Epitopes. Autoimmun. Rev., 7(4):291-296, Feb 2008. PubMed ID: 18295732. Show all entries for this paper.

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Displaying record number 101

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MAb ID	LH-104-K
HXB2 Location	Gag(281-286) DNA(1630..1647)	Gag Epitope Map
Author Location	p24(281-286 BRU)
Epitope	SILDIR	Epitope Alignment
Ab Type
Neutralizing
Species (Isotype)	mouse(IgG1κ)
Patient
Immunogen	vaccine
Keywords

Vaccine Details

Vaccine type	peptide
Vaccine strain	B clade BRU

Notes

Showing 2 of 2 notes.

• LH-104-K: UK Medical Research Council AIDS reagent: ARP322.
• LH-104-K: Binds exclusively with p24 (not p55) Haaheim1991

References

Showing 1 of 1 references.

Haaheim1991 L. R. Haaheim, J. P. Maskell, P. Mascagni, and A. R. M. Coates. Fine Molecular Specificity of Linear and Assembled Antibody Binding Sites in HIV-1 p24. Scand. J. Immunol., 34:341-350, 1991. Seven murine MAbs to a 104-mer peptide spanning residues 270-373 of p24 gag were generated. PubMed ID: 1715604. Show all entries for this paper.

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Displaying record number 126

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MAb ID	LH-104-A
HXB2 Location	Gag(284-289 + 351-356) DNA(1639..1656,1840..1857)	Gag Epitope Map
Author Location	p24( BRU)
Epitope	DIRQGP + QGVGGP (Discontinuous epitope)	Epitope Alignment
Ab Type
Neutralizing
Species (Isotype)	mouse(IgG1κ)
Patient
Immunogen	vaccine
Keywords

Vaccine Details

Vaccine type	peptide
Vaccine component	p24 Gag

Notes

Showing 2 of 2 notes.

• LH-104-A: UK Medical Research Council AIDS reagent: ARP307.
• LF-104-A: A 104 amino acid peptide was used to immunize mice -- hexapeptide scans revealed two reactive p24 peptides -- cross-competition studies indicated the region 270-286. Haaheim1991

References

Showing 1 of 1 references.

Haaheim1991 L. R. Haaheim, J. P. Maskell, P. Mascagni, and A. R. M. Coates. Fine Molecular Specificity of Linear and Assembled Antibody Binding Sites in HIV-1 p24. Scand. J. Immunol., 34:341-350, 1991. Seven murine MAbs to a 104-mer peptide spanning residues 270-373 of p24 gag were generated. PubMed ID: 1715604. Show all entries for this paper.

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Displaying record number 128

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MAb ID	LH-104-C
HXB2 Location	Gag(288-293 + 351-356) DNA(1651..1668,1840..1857)	Gag Epitope Map
Author Location	p24( BRU)
Epitope	GPKEPF + QGVGGP (Discontinuous epitope)	Epitope Alignment
Ab Type
Neutralizing
Species (Isotype)	mouse(IgG3κ)
Patient
Immunogen	vaccine
Keywords

Vaccine Details

Vaccine type	peptide
Vaccine component	p24 Gag

Notes

Showing 2 of 2 notes.

• LH-104-C: UK Medical Research Council AIDS reagent: ARP309.
• LF-104-C: A 104 amino acid peptide was used to immunize mice -- hexapeptide scans revealed two reactive p24 peptides -- cross-competition studies indicated the region 351-373. Haaheim1991

References

Showing 1 of 1 references.

Haaheim1991 L. R. Haaheim, J. P. Maskell, P. Mascagni, and A. R. M. Coates. Fine Molecular Specificity of Linear and Assembled Antibody Binding Sites in HIV-1 p24. Scand. J. Immunol., 34:341-350, 1991. Seven murine MAbs to a 104-mer peptide spanning residues 270-373 of p24 gag were generated. PubMed ID: 1715604. Show all entries for this paper.

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Displaying record number 123

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MAb ID	LH-104-B
HXB2 Location	Gag(357-362) DNA(1858..1875)	Gag Epitope Map
Author Location	p24(357-362 BRU)
Epitope	GHKARV	Epitope Alignment
Ab Type
Neutralizing
Species (Isotype)	mouse(IgG1κ)
Patient
Immunogen	vaccine
Keywords

Vaccine Details

Vaccine type	peptide
Vaccine strain	B clade BRU

Notes

Showing 2 of 2 notes.

• LH-104-B: UK Medical Research Council AIDS reagent: ARP308.
• LH-104-B: Binds exclusively with p55 (not p24), in contrast to LH-104-I. Haaheim1991

References

Showing 1 of 1 references.

Haaheim1991 L. R. Haaheim, J. P. Maskell, P. Mascagni, and A. R. M. Coates. Fine Molecular Specificity of Linear and Assembled Antibody Binding Sites in HIV-1 p24. Scand. J. Immunol., 34:341-350, 1991. Seven murine MAbs to a 104-mer peptide spanning residues 270-373 of p24 gag were generated. PubMed ID: 1715604. Show all entries for this paper.

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Displaying record number 124

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MAb ID	LH-104-I
HXB2 Location	Gag(358-363) DNA(1861..1878)	Gag Epitope Map
Author Location	p24(358-363 BRU)
Epitope	HKARVL	Epitope Alignment
Ab Type
Neutralizing
Species (Isotype)	mouse(IgG1κ)
Patient
Immunogen	vaccine
Keywords

Vaccine Details

Vaccine type	peptide
Vaccine strain	B clade BRU

Notes

Showing 3 of 3 notes.

• LH-104-I: Similarity level of the LH-104-I binding site pentapeptide HKARV to the host proteome was low, with the low-similarity 5-mer occurring in the host proteome 3 times, indicating that this peptide can be used to elicit Abs for active/passive immunotherapy with low risk of cross-reaction with the host proteome. Kanduc2008
• LH-104-I: UK Medical Research Council AIDS reagent: ARP321.
• LH-104-I: Binds exclusively with p24 (not p55), in contrast to LH-104-B. Haaheim1991

References

Showing 2 of 2 references.

Haaheim1991 L. R. Haaheim, J. P. Maskell, P. Mascagni, and A. R. M. Coates. Fine Molecular Specificity of Linear and Assembled Antibody Binding Sites in HIV-1 p24. Scand. J. Immunol., 34:341-350, 1991. Seven murine MAbs to a 104-mer peptide spanning residues 270-373 of p24 gag were generated. PubMed ID: 1715604. Show all entries for this paper.

Kanduc2008 Darja Kanduc, Rosario Serpico, Alberta Lucchese, and Yehuda Shoenfeld. Correlating Low-Similarity Peptide Sequences and HIV B-Cell Epitopes. Autoimmun. Rev., 7(4):291-296, Feb 2008. PubMed ID: 18295732. Show all entries for this paper.

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Displaying record number 125

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MAb ID	LH-104-G
HXB2 Location	Gag(363-368) DNA(1876..1893)	Gag Epitope Map
Author Location	p24(363-368 BRU)
Epitope	LAEAMS	Epitope Alignment
Ab Type
Neutralizing
Species (Isotype)	mouse(IgG1κ)
Patient
Immunogen	vaccine
Keywords

Vaccine Details

Vaccine type	peptide
Vaccine strain	B clade BRU

Notes

Showing 3 of 3 notes.

• LH-104-G: UK Medical Research Council AIDS reagent: ARP320.
• LH-104-G database comment: This epitope overlaps the p24-p2 cleavage site.
• LH-104-G: Reacts with both p24 and p55, in contrast to LH-104-I. Haaheim1991

References

Showing 1 of 1 references.

Haaheim1991 L. R. Haaheim, J. P. Maskell, P. Mascagni, and A. R. M. Coates. Fine Molecular Specificity of Linear and Assembled Antibody Binding Sites in HIV-1 p24. Scand. J. Immunol., 34:341-350, 1991. Seven murine MAbs to a 104-mer peptide spanning residues 270-373 of p24 gag were generated. PubMed ID: 1715604. Show all entries for this paper.

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