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Found 11 matching records:

Displaying record number 1840

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MAb ID Fab 3674
HXB2 Location Env Env Epitope Map
Author Location gp120
Epitope
Ab Type gp41 six-helix bundle
Neutralizing  
Species (Isotype) human
Patient  
Immunogen in vitro stimulation or selection
Keywords antibody binding site, binding affinity, kinetics, neutralization, review, variant cross-reactivity

Notes

Showing 4 of 4 notes.

References

Showing 4 of 4 references.

Gustchina2007 Elena Gustchina, John M. Louis, Son N. Lam, Carole A. Bewley, and G. Marius Clore. A Monoclonal Fab Derived from a Human Nonimmune Phage Library Reveals a New Epitope on gp41 and Neutralizes Diverse Human Immunodeficiency Virus Type 1 Strains. J. Virol., 81(23):12946-12953, Dec 2007. PubMed ID: 17898046. Show all entries for this paper.

Gustchina2008 Elena Gustchina, Carole A. Bewley, and G. Marius Clore. Sequestering of the Prehairpin Intermediate of gp41 by Peptide N36Mut(e,g) Potentiates the Human Immunodeficiency Virus Type 1 Neutralizing Activity of Monoclonal Antibodies Directed against the N-Terminal Helical Repeat of gp41. J. Virol., 82(20):10032-10041, Oct 2008. PubMed ID: 18667502. Show all entries for this paper.

Gustchina2009 Elena Gustchina, John M. Louis, Christian Frisch, Francisco Ylera, Annette Lechner, Carole A. Bewley, and G. Marius Clore. Affinity Maturation by Targeted Diversification of the CDR-H2 Loop of a Monoclonal Fab Derived from a Synthetic Naive Human Antibody Library and Directed against the Internal Trimeric Coiled-Coil of gp41 Yields a Set of Fabs with Improved HIV-1 Neutralization Potency and Breadth. Virology, 393(1):112-119, 10 Oct 2009. PubMed ID: 19695655. Show all entries for this paper.

Pantophlet2010 Ralph Pantophlet. Antibody Epitope Exposure and Neutralization of HIV-1. Curr. Pharm. Des., 16(33):3729-3743, 2010. PubMed ID: 21128886. Show all entries for this paper.


Displaying record number 2053

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MAb ID Fab 8059
HXB2 Location Env Env Epitope Map
Author Location gp41
Epitope
Ab Type  
Neutralizing  
Species (Isotype)  
Patient  
Immunogen in vitro stimulation or selection
Keywords binding affinity, neutralization

Notes

Showing 1 of 1 note.

References

Showing 1 of 1 reference.

Gustchina2009 Elena Gustchina, John M. Louis, Christian Frisch, Francisco Ylera, Annette Lechner, Carole A. Bewley, and G. Marius Clore. Affinity Maturation by Targeted Diversification of the CDR-H2 Loop of a Monoclonal Fab Derived from a Synthetic Naive Human Antibody Library and Directed against the Internal Trimeric Coiled-Coil of gp41 Yields a Set of Fabs with Improved HIV-1 Neutralization Potency and Breadth. Virology, 393(1):112-119, 10 Oct 2009. PubMed ID: 19695655. Show all entries for this paper.


Displaying record number 2054

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MAb ID Fab 8061
HXB2 Location Env Env Epitope Map
Author Location gp41
Epitope
Ab Type  
Neutralizing  
Species (Isotype)  
Patient  
Immunogen in vitro stimulation or selection
Keywords binding affinity, neutralization

Notes

Showing 1 of 1 note.

References

Showing 1 of 1 reference.

Gustchina2009 Elena Gustchina, John M. Louis, Christian Frisch, Francisco Ylera, Annette Lechner, Carole A. Bewley, and G. Marius Clore. Affinity Maturation by Targeted Diversification of the CDR-H2 Loop of a Monoclonal Fab Derived from a Synthetic Naive Human Antibody Library and Directed against the Internal Trimeric Coiled-Coil of gp41 Yields a Set of Fabs with Improved HIV-1 Neutralization Potency and Breadth. Virology, 393(1):112-119, 10 Oct 2009. PubMed ID: 19695655. Show all entries for this paper.


Displaying record number 2055

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MAb ID Fab 8062
HXB2 Location Env Env Epitope Map
Author Location gp41
Epitope
Ab Type  
Neutralizing  
Species (Isotype)  
Patient  
Immunogen in vitro stimulation or selection
Keywords antibody binding site, binding affinity, mimotopes, neutralization, structure

Notes

Showing 3 of 3 notes.

References

Showing 3 of 3 references.

Gustchina2009 Elena Gustchina, John M. Louis, Christian Frisch, Francisco Ylera, Annette Lechner, Carole A. Bewley, and G. Marius Clore. Affinity Maturation by Targeted Diversification of the CDR-H2 Loop of a Monoclonal Fab Derived from a Synthetic Naive Human Antibody Library and Directed against the Internal Trimeric Coiled-Coil of gp41 Yields a Set of Fabs with Improved HIV-1 Neutralization Potency and Breadth. Virology, 393(1):112-119, 10 Oct 2009. PubMed ID: 19695655. Show all entries for this paper.

Gustchina2010 Elena Gustchina, Mi Li, John M. Louis, D. Eric Anderson, John Lloyd, Christian Frisch, Carole A. Bewley, Alla Gustchina, Alexander Wlodawer, and G. Marius Clore. Structural Basis of HIV-1 Neutralization by Affinity Matured Fabs Directed against the Internal Trimeric Coiled-Coil of gp41. PLoS Pathog., 6(11):e1001182, 2010. PubMed ID: 21085615. Show all entries for this paper.

Gustchina2013 Elena Gustchina, Mi Li, Rodolfo Ghirlando, Peter Schuck, John M. Louis, Jason Pierson, Prashant Rao, Sriram Subramaniam, Alla Gustchina, G. Marius Clore, and Alexander Wlodawer. Complexes of Neutralizing and Non-Neutralizing Affinity Matured Fabs with a Mimetic of the Internal Trimeric Coiled-Coil of HIV-1 gp41. PLoS One, 8(11):e78187, 2013. PubMed ID: 24244293. Show all entries for this paper.


Displaying record number 2056

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MAb ID Fab 8063
HXB2 Location Env Env Epitope Map
Author Location gp41
Epitope
Ab Type  
Neutralizing  
Species (Isotype)  
Patient  
Immunogen in vitro stimulation or selection
Keywords binding affinity, neutralization

Notes

Showing 1 of 1 note.

References

Showing 1 of 1 reference.

Gustchina2009 Elena Gustchina, John M. Louis, Christian Frisch, Francisco Ylera, Annette Lechner, Carole A. Bewley, and G. Marius Clore. Affinity Maturation by Targeted Diversification of the CDR-H2 Loop of a Monoclonal Fab Derived from a Synthetic Naive Human Antibody Library and Directed against the Internal Trimeric Coiled-Coil of gp41 Yields a Set of Fabs with Improved HIV-1 Neutralization Potency and Breadth. Virology, 393(1):112-119, 10 Oct 2009. PubMed ID: 19695655. Show all entries for this paper.


Displaying record number 2058

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MAb ID Fab 8064
HXB2 Location Env Env Epitope Map
Author Location gp41
Epitope
Ab Type  
Neutralizing  
Species (Isotype)  
Patient  
Immunogen in vitro stimulation or selection
Keywords binding affinity, neutralization

Notes

Showing 1 of 1 note.

References

Showing 1 of 1 reference.

Gustchina2009 Elena Gustchina, John M. Louis, Christian Frisch, Francisco Ylera, Annette Lechner, Carole A. Bewley, and G. Marius Clore. Affinity Maturation by Targeted Diversification of the CDR-H2 Loop of a Monoclonal Fab Derived from a Synthetic Naive Human Antibody Library and Directed against the Internal Trimeric Coiled-Coil of gp41 Yields a Set of Fabs with Improved HIV-1 Neutralization Potency and Breadth. Virology, 393(1):112-119, 10 Oct 2009. PubMed ID: 19695655. Show all entries for this paper.


Displaying record number 2059

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MAb ID Fab 8065
HXB2 Location Env Env Epitope Map
Author Location gp41
Epitope
Ab Type  
Neutralizing  
Species (Isotype)  
Patient  
Immunogen in vitro stimulation or selection
Keywords binding affinity, neutralization

Notes

Showing 1 of 1 note.

References

Showing 1 of 1 reference.

Gustchina2009 Elena Gustchina, John M. Louis, Christian Frisch, Francisco Ylera, Annette Lechner, Carole A. Bewley, and G. Marius Clore. Affinity Maturation by Targeted Diversification of the CDR-H2 Loop of a Monoclonal Fab Derived from a Synthetic Naive Human Antibody Library and Directed against the Internal Trimeric Coiled-Coil of gp41 Yields a Set of Fabs with Improved HIV-1 Neutralization Potency and Breadth. Virology, 393(1):112-119, 10 Oct 2009. PubMed ID: 19695655. Show all entries for this paper.


Displaying record number 2060

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MAb ID Fab 8069
HXB2 Location Env Env Epitope Map
Author Location gp41
Epitope
Ab Type  
Neutralizing  
Species (Isotype)  
Patient  
Immunogen in vitro stimulation or selection
Keywords binding affinity, neutralization

Notes

Showing 1 of 1 note.

References

Showing 1 of 1 reference.

Gustchina2009 Elena Gustchina, John M. Louis, Christian Frisch, Francisco Ylera, Annette Lechner, Carole A. Bewley, and G. Marius Clore. Affinity Maturation by Targeted Diversification of the CDR-H2 Loop of a Monoclonal Fab Derived from a Synthetic Naive Human Antibody Library and Directed against the Internal Trimeric Coiled-Coil of gp41 Yields a Set of Fabs with Improved HIV-1 Neutralization Potency and Breadth. Virology, 393(1):112-119, 10 Oct 2009. PubMed ID: 19695655. Show all entries for this paper.


Displaying record number 2061

Download this epitope record as JSON.

MAb ID Fab 8060
HXB2 Location Env Env Epitope Map
Author Location gp41
Epitope
Ab Type  
Neutralizing  
Species (Isotype)  
Patient  
Immunogen in vitro stimulation or selection
Keywords binding affinity, neutralization

Notes

Showing 1 of 1 note.

References

Showing 1 of 1 reference.

Gustchina2009 Elena Gustchina, John M. Louis, Christian Frisch, Francisco Ylera, Annette Lechner, Carole A. Bewley, and G. Marius Clore. Affinity Maturation by Targeted Diversification of the CDR-H2 Loop of a Monoclonal Fab Derived from a Synthetic Naive Human Antibody Library and Directed against the Internal Trimeric Coiled-Coil of gp41 Yields a Set of Fabs with Improved HIV-1 Neutralization Potency and Breadth. Virology, 393(1):112-119, 10 Oct 2009. PubMed ID: 19695655. Show all entries for this paper.


Displaying record number 2062

Download this epitope record as JSON.

MAb ID Fab 8066 (8066)
HXB2 Location Env Env Epitope Map
Author Location gp41
Epitope
Ab Type  
Neutralizing  
Species (Isotype)  
Patient  
Immunogen in vitro stimulation or selection
Keywords ADCC, antibody binding site, binding affinity, mimotopes, neutralization, structure

Notes

Showing 4 of 4 notes.

References

Showing 4 of 4 references.

Gustchina2009 Elena Gustchina, John M. Louis, Christian Frisch, Francisco Ylera, Annette Lechner, Carole A. Bewley, and G. Marius Clore. Affinity Maturation by Targeted Diversification of the CDR-H2 Loop of a Monoclonal Fab Derived from a Synthetic Naive Human Antibody Library and Directed against the Internal Trimeric Coiled-Coil of gp41 Yields a Set of Fabs with Improved HIV-1 Neutralization Potency and Breadth. Virology, 393(1):112-119, 10 Oct 2009. PubMed ID: 19695655. Show all entries for this paper.

Gustchina2010 Elena Gustchina, Mi Li, John M. Louis, D. Eric Anderson, John Lloyd, Christian Frisch, Carole A. Bewley, Alla Gustchina, Alexander Wlodawer, and G. Marius Clore. Structural Basis of HIV-1 Neutralization by Affinity Matured Fabs Directed against the Internal Trimeric Coiled-Coil of gp41. PLoS Pathog., 6(11):e1001182, 2010. PubMed ID: 21085615. Show all entries for this paper.

Gustchina2013 Elena Gustchina, Mi Li, Rodolfo Ghirlando, Peter Schuck, John M. Louis, Jason Pierson, Prashant Rao, Sriram Subramaniam, Alla Gustchina, G. Marius Clore, and Alexander Wlodawer. Complexes of Neutralizing and Non-Neutralizing Affinity Matured Fabs with a Mimetic of the Internal Trimeric Coiled-Coil of HIV-1 gp41. PLoS One, 8(11):e78187, 2013. PubMed ID: 24244293. Show all entries for this paper.

Yang2018 Zheng Yang, Xi Liu, Zehua Sun, Jingjing Li, Weiguo Tan, Weiye Yu, and Meiyun Zhang. Identification of a HIV gp41-Specific Human Monoclonal Antibody with Potent Antibody-Dependent Cellular Cytotoxicity. Front. Immunol., 9:2613, 2018. PubMed ID: 30519238. Show all entries for this paper.


Displaying record number 2063

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MAb ID Fab 8068
HXB2 Location Env Env Epitope Map
Author Location gp41
Epitope
Ab Type  
Neutralizing  
Species (Isotype)  
Patient  
Immunogen in vitro stimulation or selection
Keywords binding affinity, neutralization

Notes

Showing 1 of 1 note.

References

Showing 1 of 1 reference.

Gustchina2009 Elena Gustchina, John M. Louis, Christian Frisch, Francisco Ylera, Annette Lechner, Carole A. Bewley, and G. Marius Clore. Affinity Maturation by Targeted Diversification of the CDR-H2 Loop of a Monoclonal Fab Derived from a Synthetic Naive Human Antibody Library and Directed against the Internal Trimeric Coiled-Coil of gp41 Yields a Set of Fabs with Improved HIV-1 Neutralization Potency and Breadth. Virology, 393(1):112-119, 10 Oct 2009. PubMed ID: 19695655. Show all entries for this paper.


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