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Displaying record number 1078

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MAb ID	J4
HXB2 Location	Vif	Vif Epitope Map
Author Location	( HXB2)
Epitope
Subtype	B
Ab Type
Neutralizing
Species (Isotype)	humanized rabbit
Patient
Immunogen
Keywords

Notes

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J4: The authors developed a Vif-specific intrabody single-chain FAb fragment of J4 called 14BL. When expressed intracellularly in the cytoplasm this intrabody efficiently bound Vif protein and neutralized its infectivity enhancing function. Intrabody-expressing transduced cells were highly refractory to challenge with the laboratory strain NL43 and with primary isolate strains of HIV-1. Goncalves2002

References

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Goncalves2002 Joao Goncalves, Frederico Silva, Acilino Freitas-Vieira, Mariana Santa-Marta, Rui Malhó, Xiaoyu Yang, Dana Gabuzda, and Carlos III Barbas. Functional Neutralization of HIV-1 Vif Protein by Intracellular Immunization Inhibits Reverse Transcription and Viral Replication. J. Biol. Chem., 277(35):32036-32045, 30 Aug 2002. PubMed ID: 12039955. Show all entries for this paper.