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HXB2 Location gp160(87-101)
gp160 Epitope Map
Author Location gp120(86-100 LAV)
Epitope VNVTENFNMWKNNMV (Discontinuous epitope) Epitope Alignment
Subtype B
Ab Type N-term
Species (Isotype) mouse(IgG1)
Immunogen vaccine
Keywords antibody binding site, antibody generation, antibody interactions

Vaccine Details

Vaccine type protein
Vaccine component gp160


Showing 6 of 6 notes.


Showing 5 of 5 references.

Isolation Paper
Dickey2000 C. Dickey, U. Ziegner, M. G. Agadjanyan, V. Srikantan, Y. Refaeli, A. Prabhu, A. Sato, W. V. Williams, D. B. Weiner, and K. E. Ugen. Murine Monoclonal Antibodies Biologically Active against the Amino Region of HIV-1 gp120: Isolation and Characterization. DNA Cell Biol., 19:243-252, 2000. PubMed ID: 10798448. Show all entries for this paper.

Cook1994 D. G. Cook, J. Fantini, S. L. Spitalnik, and F. Gonzalez-Scarano. Binding of Human Immunodeficiency Virus Type 1 HIV-1 gp120 to Galactosylceramide (GalCer): Relationship to the V3 Loop. Virol., 201:206-214, 1994. Antibodies against GalCer can block infection of CD4-negative cells from the brain and colon that are susceptible to HIV infection. This paper explores the ability of a panel of MAbs to inhibit binding of gp120 to GalCer, and also of the binding of GalCer to inhibit MAb-gp120 interaction. MAbs to the V3 loop and GalCer showed mutual inhibition of binding to gp120, and anti-CD4 binding site MAbs showed reduced inhibition. N- and C-terminal MAbs didn't influence GalCer binding. PubMed ID: 8184533. Show all entries for this paper.

Gomez-Roman2002 Victor Raul Gómez-Román, Chuanhai Cao, Yun Bai, Hugo Santamaría, Gonzalo Acero, Karen Manoutcharian, David B Weiner, Kenneth E Ugen, and Goar Gevorkian. Phage-Displayed Mimotopes Recognizing a Biologically Active Anti-HIV-1 gp120 Murine Monoclonal Antibody. J. Acquir. Immune Defic. Syndr., 31(2):147-153, 1 Oct 2002. PubMed ID: 12394792. Show all entries for this paper.

Ugen1993 K. E. Ugen, Y. Refaleli, U. Ziegner, M. Agadjanyan, M. A. R. Satre, V. Srikantan, B. Wang, A. Sato, W. V. Williams, and D. B. Weiner. Generation of monoclonal antibodies against the amino terminus of gp120 that elicit antibody-dependent cellular cytotoxicity. Vaccines 93, :215-221, 1993. Editors: F. Brown, H. S. Ginsberg and R. Lerner, Cold Spring Harbor Laboratory Press, Cold Spring Harbor, NY. Show all entries for this paper.

Vincent2012 Nadine Vincent and Etienne Malvoisin. Ability of Antibodies Specific to the HIV-1 Envelope Glycoprotein to Block the Fusion Inhibitor T20 in a Cell-Cell Fusion Assay. Immunobiology, 217(10):943-950, Oct 2012. PubMed ID: 22387075. Show all entries for this paper.

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