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Found 12 matching records:

Displaying record number 24

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MAb ID	11H9
HXB2 Location	Gag(101-115) DNA(1090..1134)	Gag Epitope Map
Author Location	p17(101-115 SF2)
Research Contact	R. B. Ferns and R. S. Tedder
Epitope	`LEKIEEEQNKSKKKA?`	Epitope Alignment
Ab Type
Neutralizing
Species (Isotype)	mouse(IgG1)
Patient
Immunogen	vaccine
Keywords

Vaccine Details

Vaccine type	inactivated HIV
Vaccine strain	B clade CBL-1
Vaccine component	HIV-1

Notes

Showing 3 of 3 notes.

11H9: UK Medical Research Council AIDS reagent: ARP344.
11H9: This epitope is similar to a fragment of Lens-epithelium-derived growth factor, DIITEEDKSKKKGQ. Maksiutov2002
11H9: Reactive against p18 and p55. Ferns1987

References

Showing 3 of 3 references.

Ferns1987 R. B. Ferns, R. S. Tedder, and R. A. Weiss. Characterization of Monoclonal Antibodies against the Human Immunodeficiency Virus gag Products and Their Use in Monitoring HIV Isolate Variation. J. Gen. Virol., 68:1543-1551, 1987. PubMed ID: 2438375. Show all entries for this paper.

Ferns1989 R. B. Ferns, J. C. Partridge, R. P. Spence, N. Hunt, and R. S. Tedder. Epitope Location of 13 Anti-Gag HIV-1 Monoclonal Antibodies Using Oligopeptides and their Cross-Reactivity with HIV-2. AIDS, 3:829-834, 1989. PubMed ID: 2483619. Show all entries for this paper.

Maksiutov2002 A. Z. Maksiutov, A. G. Bachinskii, and S. I. Bazhan. [Searching for Local Similarities Between HIV-1 and Human Proteins. Application to Vaccines]. Mol Biol (Mosk), 36(3):447-459, May-Jun 2002. Article in Russian. PubMed ID: 12068630. Show all entries for this paper.

Displaying record number 30

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MAb ID	4H2B1
HXB2 Location	Gag(119-132) DNA(1144..1185)	Gag Epitope Map
Author Location	p17(121-134 SF2)
Research Contact	R. B. Ferns and R. S. Tedder
Epitope	`AAGTGNSSQVSQNY`	Epitope Alignment
Ab Type
Neutralizing
Species (Isotype)	mouse(IgG1)
Patient
Immunogen
Keywords

Notes

Showing 2 of 2 notes.

4H2B1: UK Medical Research Council AIDS reagent: ARP315.
4H2B1: Reactive against p18 and p55 of multiple isolates. Ferns1987

References

Showing 2 of 2 references.

Displaying record number 31

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MAb ID	1D9
HXB2 Location	Gag(119-132) DNA(1144..1185)	Gag Epitope Map
Author Location	p17(121-134 SF2)
Research Contact	R. B. Ferns and R. S. Tedder
Epitope	`AAGTGNSSQVSQNY`	Epitope Alignment
Ab Type
Neutralizing
Species (Isotype)	mouse(IgG2a)
Patient
Immunogen	vaccine
Keywords

Vaccine Details

Vaccine type	inactivated HIV
Vaccine strain	B clade CBL-1
Vaccine component	HIV-1

Notes

Showing 3 of 3 notes.

1d9: Database comment: the database contains distinct antibodies named 1D9 and 1d9. Also, Ab 1D9D5 is referred to as 1D9 by Theisen2006.
1D9: UK Medical Research Council AIDS reagent: ARP316.
1D9: Reactive against p18, but not p55. Ferns1987

References

Showing 2 of 2 references.

Displaying record number 32

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MAb ID	4C9
HXB2 Location	Gag(119-132) DNA(1144..1185)	Gag Epitope Map
Author Location	p18(121-134 SF2)
Research Contact	R. B. Ferns and R. S. Tedder
Epitope	`AAGTGNSSQVSQNY`	Epitope Alignment
Ab Type
Neutralizing
Species (Isotype)	mouse(IgG2a)
Patient
Immunogen	vaccine
Keywords

Vaccine Details

Vaccine type	inactivated HIV
Vaccine strain	B clade CBL-1
Vaccine component	HIV-1

Notes

Showing 2 of 2 notes.

4C9: UK Medical Research Council AIDS reagent: ARP342.
4C9: Reactive against p18, but not p55. Ferns1987

References

Showing 2 of 2 references.

Displaying record number 33

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MAb ID	9G5
HXB2 Location	Gag(119-132) DNA(1144..1185)	Gag Epitope Map
Author Location	p17(121-134 SF2)
Research Contact	R. B. Ferns and R. S. Tedder
Epitope	`AAGTGNSSQVSQNY`	Epitope Alignment
Ab Type
Neutralizing
Species (Isotype)	mouse(IgM)
Patient
Immunogen	vaccine
Keywords

Vaccine Details

Vaccine type	inactivated HIV
Vaccine strain	B clade CBL-1
Vaccine component	HIV-1

Notes

Showing 2 of 2 notes.

9G5: UK Medical Research Council AIDS reagent: ARP343.
9G5: Reactive against p18, but not p55. Ferns1987

References

Showing 2 of 2 references.

Displaying record number 50

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MAb ID	ID8F6
HXB2 Location	Gag(143-157) DNA(1216..1260)	Gag Epitope Map
Author Location	p24(143-157 BRU)
Research Contact	R. B. Ferns and R. S. Tedder
Epitope	`VHQAISPRTLNAWVK`	Epitope Alignment
Ab Type
Neutralizing
Species (Isotype)	mouse(IgG1)
Patient
Immunogen	vaccine
Keywords

Vaccine Details

Vaccine type	inactivated HIV
Vaccine strain	B clade CBL-1
Vaccine component	HIV-1

Notes

Showing 3 of 3 notes.

ID8F6: Similarity level of the ID8F6 binding site pentapeptide LNAWV to the host proteome was low, with the low-similarity 5-mer occurring in the host proteome 0 times, indicating that this peptide can be used to elicit Abs for active/passive immunotherapy with low risk of cross-reaction with the host proteome. Kanduc2008
ID8F6: UK Medical Research Council AIDS reagent: ARP348.
ID8F6: Reacted with both p55 and p24 -- showed less than 75% homologous inhibition. Ferns1987

References

Showing 3 of 3 references.

Kanduc2008 Darja Kanduc, Rosario Serpico, Alberta Lucchese, and Yehuda Shoenfeld. Correlating Low-Similarity Peptide Sequences and HIV B-Cell Epitopes. Autoimmun. Rev., 7(4):291-296, Feb 2008. PubMed ID: 18295732. Show all entries for this paper.

Displaying record number 133

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MAb ID	3D3
HXB2 Location	Gag(177-182) DNA(1318..1335)	Gag Epitope Map
Author Location	p24(177-182 LAI)
Research Contact	R. B. Ferns and R. S. Tedder
Epitope	`EGATPQ`	Epitope Alignment
Subtype	B
Ab Type
Neutralizing
Species (Isotype)	mouse(IgG2b)
Patient
Immunogen	vaccine
Keywords

Vaccine Details

Vaccine type	inactivated HIV
Vaccine strain	B clade CBL-1
Vaccine component	HIV-1

Notes

Showing 2 of 2 notes.

3D3: UK Medical Research Council AIDS reagent: ARP314.
3D3: Most broadly reactive of all the antibodies in this study. Ferns1987

References

Showing 2 of 2 references.

Displaying record number 134

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MAb ID	EB1A9
HXB2 Location	Gag(253-267) DNA(1546..1590)	Gag Epitope Map
Author Location	p24(253-267 LAI)
Research Contact	R. B. Ferns and R. S. Tedder
Epitope	`NPPIPVGEIYKRWII`	Epitope Alignment
Subtype	B
Ab Type
Neutralizing
Species (Isotype)	mouse(IgG1)
Patient
Immunogen	vaccine
Keywords

Vaccine Details

Vaccine type	inactivated HIV
Vaccine strain	B clade CBL-1
Vaccine component	HIV-1

Notes

Showing 3 of 3 notes.

EB1A9: Similarity level of the EB1A9 binding site pentapeptide IYKRW to the host proteome was low, with the low-similarity 5-mer occurring in the host proteome 0 times, indicating that this peptide can be used to elicit Abs for active/passive immunotherapy with low risk of cross-reaction with the host proteome. Kanduc2008
EB1A9: UK Medical Research Council AIDS reagent: ARP345.
EB1A9: Reacted with both p55 and p24 -- showed less than 75% homologous inhibition. Ferns1987

References

Showing 3 of 3 references.

Displaying record number 135

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MAb ID	CD12B4
HXB2 Location	Gag(303-317) DNA(1696..1740)	Gag Epitope Map
Author Location	p24(303-317 LAI)
Research Contact	R. B. Ferns and R. S. Tedder
Epitope	`TLRAEQASQEVKNWM`	Epitope Alignment
Subtype	B
Ab Type
Neutralizing
Species (Isotype)	mouse(IgG1)
Patient
Immunogen	vaccine
Keywords

Vaccine Details

Vaccine type	inactivated HIV
Vaccine strain	B clade CBL-1
Vaccine component	HIV-1

Notes

Showing 2 of 2 notes.

CD12B4: UK Medical Research Council AIDS reagent: ARP346.
CD12B4: Reacted with both p55 and p24 -- strain-specific binding. Ferns1987

References

Showing 2 of 2 references.

Displaying record number 34

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MAb ID	CH9B2
HXB2 Location	Gag	Gag Epitope Map
Author Location	p17
Research Contact	R. B. Ferns and R. S. Tedder
Epitope
Ab Type
Neutralizing
Species (Isotype)	mouse(IgG1)
Patient
Immunogen	vaccine
Keywords

Vaccine Details

Vaccine type	inactivated HIV
Vaccine strain	B clade CBL-1
Vaccine component	HIV-1

Notes

Showing 2 of 2 notes.

CH9B2: UK Medical Research Council AIDS reagent: ARP349.
CH9B2: Reactive against p18 and p55. Ferns1987

References

Showing 2 of 2 references.

Displaying record number 127

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MAb ID	EH12E1 (BC1071)
HXB2 Location	Gag	Gag Epitope Map
Author Location	p24( CBL-1)
Research Contact	R. B. Ferns and R. S. Tedder; Aalto BioReagents
Epitope
Ab Type
Neutralizing
Species (Isotype)	mouse(IgG1)
Patient
Immunogen	vaccine
Keywords

Vaccine Details

Vaccine type	inactivated HIV
Vaccine strain	B clade CBL-1
Vaccine component	HIV-1

Notes

Showing 4 of 4 notes.

From Aalto BioReagents website: Product B1071 is clone EH12E1. Generated in mouse using strain CBL-1. Epitope mapped to a complex epitope incorporating 2 distinct peptide sequences: GHQAAMQMLKETINEEAAEWDRVHPVHAGPIAPGQ (aa 193-227) and NPPIPVGEIYKRWII (aa 253-267). These regions of p24 are conserved between HIV-1 strains, and also substantially between HIV-1 and HIV-2. The specific reactivity with the structural p24 gag protein of HIV-1 was demonstrated by Western Blot.
BC1071: The stoichiometry of MAb neutralization was tested and MAb BC1071 was used in this study for virion quantification. Schonning1999
EH12E1: UK Medical Research Council AIDS reagent: ARP313.
EH12E1: Reacted with p55 and p24 in WB. Ferns1987

References

Showing 3 of 3 references.

Isolation Paper
Ferns1987 R. B. Ferns, R. S. Tedder, and R. A. Weiss. Characterization of Monoclonal Antibodies against the Human Immunodeficiency Virus gag Products and Their Use in Monitoring HIV Isolate Variation. J. Gen. Virol., 68:1543-1551, 1987. PubMed ID: 2438375. Show all entries for this paper.

Schonning1999 K. Schonning, O. Lund, O. S. Lund, and J. E. Hansen. Stoichiometry of monoclonal antibody neutralization of T-cell line-adapted human immunodeficiency virus type 1. J. Virol., 73:8364-8370, 1999. PubMed ID: 10482587. Show all entries for this paper.

Displaying record number 137

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MAb ID	IE8G2
HXB2 Location	Gag	Gag Epitope Map
Author Location	p24
Research Contact	R. B. Ferns and R. S. Tedder
Epitope
Ab Type
Neutralizing
Species (Isotype)	mouse(IgG1)
Patient
Immunogen	vaccine
Keywords

Vaccine Details

Vaccine type	inactivated HIV
Vaccine strain	B clade CBL-1
Vaccine component	HIV-1

Notes

Showing 2 of 2 notes.

IE8G2: UK Medical Research Council AIDS reagent: ARP347.
IE8G2: Reacted with both p55 and p24 -- broadly reactive -- showed less than 75% homologous inhibition. Ferns1987

References

Showing 2 of 2 references.