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Displaying record number 578

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MAb ID	M38
HXB2 Location	gp160(485-504) DNA(7677..7736)	gp160 Epitope Map
Author Location	gp120(490-508)
Epitope	KYKVVKEIPLGVAPTKAKRR	Epitope Alignment
Ab Type	gp120 C5
Neutralizing
Species (Isotype)	mouse
Patient
Immunogen	vaccine
Keywords

Vaccine Details

Notes

Showing 4 of 4 notes.

• M38: This epitope is similar to a fragment of the human protein mast/stem cell growth factor receptor precursor, VVPTKADKRRSV, as well as to a fragment of IFN-related IFRD2 (PC4-B) protein, ARTKARSRVRDKRA. Maksiutov2002
• M38: Infected individuals have HLA class I-gp120 cross-reactive antibodies. DeSantis1994
• M38: Binds to the carboxy terminus of gp120, in a gp41 binding region, and also to denatured human HLAs (antigenic homology) Lopalco1993
• M38: Binds to gp120 and to a 80 kd human protein expressed on a small fraction of mononuclear cells in the lymph nodes. Beretta1987

References

Showing 6 of 6 references.

Beretta1987 A. Beretta, F. Grassi, M. Pelagi, A. Clivio, C. Parravicini, G. Giovinazzo, F. Andronico, L. Lopalco, P. Verani, S. Butto, F. Titti, G. B. Rossi, G. Viale, E. Ginelli, and A. G. Siccardi. HIV Env Glycoprotein Shares a Cross-Reacting Epitope with a Surface Protein Present on Activated Human Monocytes and Involved in Antigen Presentation. Eur. J. Immunol., 17:1793-1798, 1987. The MAb M38 binds to gp120 and also to a human protein of 80 kd that is expressed on a small fraction of mononuclear cells in the lymph nodes. M38 inhibits proliferation in autologous tetanus toxoid presentation, so is involved in antigen presentation. Suggested molecular mimicry. PubMed ID: 2446880. Show all entries for this paper.

Grassi1991 F. Grassi, R. Meneveri, M. Gullberg, L. Lopalco, G. B. Rossi, P. Lanza, C. DeSantis, G. Brattsand, S. Butto, E. Ginelli, A. Berretta, and A. G. Siccardi. Human Immunodeficiency Virus Type 1 gp120 Mimics a Hidden Monomorphic Epitope Borne by Class I Major Histocompatibility Complex Heavy Chains. J. Exp. Med., 174:53-62, 1991. PubMed ID: 1711567. Show all entries for this paper.

Lopalco1993 L. Lopalco, R. Longhi, F. Ciccomascolo, A. De Rossi, M. Pelagi, F. Andronico, J. P. Moore, B T. Schulz, A. Beretta, and A. G. Siccardi. Identification of human immunodeficiency virus type 1 glycoprotein gp120/gp41 interacting sites by the idiotypic mimicry of two monoclonal antibodies. AIDS Res. Hum. Retroviruses, 9:33-39, 1993. The MAb M38 binds to the carboxy terminus of gp120, in a gp41 binding region. This MAb was used to create an anti-idiotype MAb, 9G5A, which can bind to gp41 at the base of the cysteine loop. The binding domains of these two monoclonals are consistent with the C5 domain of gp120 being able to bind to the gp41 cysteine loop. The MAb M38 also binds to human HLA molecules, in antigenic homology or possibly molecular mimicry. PubMed ID: 7678970. Show all entries for this paper.

DeSantis1994 C. DeSantis, L. Lopalco, P. Robbioni, R. Longhi, G. Rappocciolo, A. G. Siccardi, and A. Beretta. Human Antibodies to Immunodominant C5 Region of HIV-1 gp120 Cross-React with HLA Class I on Activated Cells. AIDS Res. Hum. Retroviruses, 10:157-162, 1994. PubMed ID: 7515259. Show all entries for this paper.

Beretta1994 A. Beretta and A.G. Dalgleish. B-Cell Epitopes. AIDS, 8(suppl 1):S133-S145, 1994. Show all entries for this paper.

Maksiutov2002 A. Z. Maksiutov, A. G. Bachinskii, and S. I. Bazhan. [Searching for Local Similarities Between HIV-1 and Human Proteins. Application to Vaccines]. Mol Biol (Mosk), 36(3):447-459, May-Jun 2002. Article in Russian. PubMed ID: 12068630. Show all entries for this paper.