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Displaying record number 1295

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MAb ID	13105100
HXB2 Location	gp160(307-320) DNA(7143..7184)	gp160 Epitope Map
Author Location	gp120( HXB2)
Research Contact	ABI, Columbia, MD
Epitope	IRIQRGPGRAFVTI	Epitope Alignment
Subtype	B
Ab Type	gp120 V3 // V3 glycan (V3g)
Neutralizing
Species (Isotype)	mouse(IgG1)
Patient
Immunogen	vaccine
Keywords	antibody binding site

Vaccine Details

Notes

Showing 1 of 1 note.

• 13105100: This MAb was raised against the peptide IRIQRGPGRAFVTI, located within the V3 loop flanking the GPGR apical motif. Two MAbs were used to determine the photodamage location in HIV-1 Env induced by sulfonated anionic porphyrins. The negatively charged porphyrins interact with positive charge in the V3 loop. When light activated, they damage amino acid side chains in the C5 region of Env, as evidenced by inhibition of binding of C5 MAb 9201, but not V3 MAb 13105100. Anionic porphyrins could be used in targeted photodynamic decontamination of biological fluids, such as blood, killing HIV without disabling the function of desirable transfusion products. Dairou2004 (antibody binding site)

References

Showing 1 of 1 reference.

Dairou2004 Julien Dairou, Christine Vever-Bizet, and Daniel Brault. Interaction of Sulfonated Anionic Porphyrins with HIV Glycoprotein gp120: Photodamages Revealed by Inhibition of Antibody Binding to V3 and C5 Domains. Antiviral. Res., 61(1):37-47, Jan 2004. PubMed ID: 14670592. Show all entries for this paper.

Displaying record number 575

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MAb ID	9201
HXB2 Location	gp160(471-482) DNA(7635..7670)	gp160 Epitope Map
Author Location	gp120(475-486 LAI)
Research Contact	Du Pont de Nemours, Boston, MA
Epitope	GGGDMRDNWRSE	Epitope Alignment
Subtype	B
Ab Type	gp120 C5
Neutralizing
Species (Isotype)	mouse(IgG1)
Patient
Immunogen	vaccine
Keywords	antibody binding site

Vaccine Details

Notes

Showing 2 of 2 notes.

• 9201: This paper describes a slightly different epitope, stating 9201 was raised against the peptide MRDNWRSELIKY, located within the alpha 5 helix in the C5 terminal region of gp120. Two MAbs were used to determine the photodamage location in HIV-1 Env induced by sulfonated anionic porphyrins. The negatively charged porphyrins interact with positive charge in the V3 loop. When light activated, they damage amino acid side chains in the C5 region of Env, as evidenced by inhibition of binding of C5 MAb 9201, but not V3 MAb 13105100. Anionic porphyrins could be used in targeted photodynamic decontamination of biological fluids, such as blood, killing HIV without disabling the function of desirable transfusion products. Dairou2004 (antibody binding site)
• 9201: Does not neutralize LAI. This paper notes the peptide binding region is GGGDMRDNWRSE. McDougal1996 (antibody binding site)

References

Showing 2 of 2 references.

McDougal1996 J. S. McDougal, M. S. Kennedy, S. L. Orloff, J. K. A. Nicholson, and T. J. Spira. Mechanisms of Human Immunodeficiency Virus Type 1 (HIV-1) Neutralization: Irreversible Inactivation of Infectivity by Anti-HIV-1 Antibody. J. Virol., 70:5236-5245, 1996. Studies of polyclonal sera autologous virus inactivation indicates that in individuals over time, viral populations emerge that are resistant to inactivating effects of earlier sera. PubMed ID: 8764033. Show all entries for this paper.

Dairou2004 Julien Dairou, Christine Vever-Bizet, and Daniel Brault. Interaction of Sulfonated Anionic Porphyrins with HIV Glycoprotein gp120: Photodamages Revealed by Inhibition of Antibody Binding to V3 and C5 Domains. Antiviral. Res., 61(1):37-47, Jan 2004. PubMed ID: 14670592. Show all entries for this paper.