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Found 87 matching records:

Displaying record number 3473

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MAb ID	3BNC117/10-1074
HXB2 Location	Env	Env Epitope Map
Author Location	gp120
Epitope
Ab Type	gp120 CD4BS, gp120 V3 // V3 glycan (V3g)
Neutralizing	P (tier 2) View neutralization details
Species (Isotype)	human(IgG1)
Patient	Donor 17, Patient 3
Immunogen	virus
Keywords	bispecific/trispecific, neutralization

Notes

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3BNC117/10-1074: biNAbs (bispecific anti-Env neutralizing antibodies) with potent activity were constructed using an engineered IgG3 hinge domain to increase Fab flexibility necessary for hetero-bivalent binding to HIV-1 Env trimer since biNAbs with IgG1 hinges exhibited reduced neutralization potency compared to their parental bNAbs. While neutralization was generally improved, some combinations of bNAbs were synergistic in potency. Analysis of the neutralization activity of anti-CD4bs/anti-V3 combination, 3BNC117/10-1074, against a 7-cross-clade panel of tier 2/3 showed it exhibited lower, inhibitory activity but a marginal increase in neutralization breadth compared to its respective parental counterparts. Bournazos2016 (neutralization, bispecific/trispecific)

References

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Isolation Paper
Bournazos2016 Stylianos Bournazos, Anna Gazumyan, Michael S. Seaman, Michel C. Nussenzweig, and Jeffrey V. Ravetch. Bispecific Anti-HIV-1 Antibodies with Enhanced Breadth and Potency. Cell, 165(7):1609-1620, 16 Jun 2016. PubMed ID: 27315478. Show all entries for this paper.

Displaying record number 3474

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MAb ID	3BNC117/PGT121
HXB2 Location	Env	Env Epitope Map
Author Location	gp120
Epitope
Ab Type	gp120 CD4BS, gp120 V3 // V3 glycan (V3g)
Neutralizing
Species (Isotype)	human(IgG1)
Patient	Donor 17, Patient 3
Immunogen	virus
Keywords	bispecific/trispecific, neutralization

Notes

Showing 1 of 1 note.

3BNC117/PGT121: biNAbs (bispecific anti-Env neutralizing antibodies) with potent activity were constructed using an engineered IgG3 hinge domain to increase Fab flexibility necessary for hetero-bivalent binding to HIV-1 Env trimer since biNAbs with IgG1 hinges exhibited reduced neutralization potency compared to their parental bNAbs. While neutralization was generally improved, some combinations of bNAbs were synergistic in potency. Analysis of the neutralization activity of anti-CD4bs/anti-V3 combination, 3BNC117/PGT121, against a 7-cross-clade panel of tier 2/3 showed it exhibited mildly higher activity compared to its respective parental counterparts. Bournazos2016 (neutralization, bispecific/trispecific)

References

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Displaying record number 3475

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MAb ID	3BNC117/PGT128
HXB2 Location	Env	Env Epitope Map
Author Location	gp120
Epitope
Ab Type	gp120 CD4BS, gp120 V3 // V3 glycan (V3g)
Neutralizing
Species (Isotype)	human(IgG1)
Patient	Donor 36, Patient 3
Immunogen	virus
Keywords	bispecific/trispecific, neutralization

Notes

Showing 1 of 1 note.

3BNC117/PGT128: biNAbs (bispecific anti-Env neutralizing antibodies) with potent activity were constructed using an engineered IgG3 hinge domain to increase Fab flexibility necessary for hetero-bivalent binding to HIV-1 Env trimer since biNAbs with IgG1 hinges exhibited reduced neutralization potency compared to their parental bNAbs. While neutralization was generally improved, some combinations of bNAbs were synergistic in potency. Analysis of the neutralization activity of anti-CD4bs/anti-V3 combination, 3BNC117/PGT128, against a 7-cross-clade panel of tier 2/3 showed it exhibited much lower, inhibitory activity compared to its respective parental counterparts. Bournazos2016 (neutralization, bispecific/trispecific)

References

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Displaying record number 3477

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MAb ID	3BNC117/10E8
HXB2 Location	Env	Env Epitope Map
Author Location	gp160
Epitope
Ab Type	gp120 CD4BS, gp41 MPER (membrane proximal external region)
Neutralizing
Species (Isotype)	human(IgG1)
Patient	Donor N152, Patient 3
Immunogen	virus
Keywords	bispecific/trispecific, neutralization

Notes

Showing 1 of 1 note.

3BNC117/10E8: biNAbs (bispecific anti-Env neutralizing antibodies) with potent activity were constructed using an engineered IgG3 hinge domain to increase Fab flexibility necessary for hetero-bivalent binding to HIV-1 Env trimer since biNAbs with IgG1 hinges exhibited reduced neutralization potency compared to their parental bNAbs. While neutralization was generally improved, some combinations of bNAbs were synergistic in potency. Analysis of the neutralization activity of anti-CD4bs/anti-MPER combination, 3BNC117/10E8, against a 7-cross-clade panel of tier 2/3 showed it exhibited about equal activity compared to its respective parental counterparts. Bournazos2016 (neutralization, bispecific/trispecific)

References

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Displaying record number 3478

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MAb ID	3BNC117/PGDM1400
HXB2 Location	Env	Env Epitope Map
Author Location	gp120
Epitope
Ab Type	gp120 CD4BS, gp120 V2 // V2 glycan(V2g) // V2 apex
Neutralizing
Species (Isotype)	human(IgG1)
Patient	Donor 84, Patient 3
Immunogen	virus
Keywords	bispecific/trispecific, neutralization

Notes

Showing 1 of 1 note.

3BNC117/PGDM1400: biNAbs (bispecific anti-Env neutralizing antibodies) with potent activity were constructed using an engineered IgG3 hinge domain to increase Fab flexibility necessary for hetero-bivalent binding to HIV-1 Env trimer since biNAbs with IgG1 hinges exhibited reduced neutralization potency compared to their parental bNAbs. While neutralization was generally improved, some combinations of bNAbs were synergistic in potency. Analysis of the neutralization activity of anti-CD4bs/anti-V2 combination, 3BNC117/PGDM1400, against a 7-cross-clade panel of tier 2/3 showed it exhibited slightly lower activity compared to its respective parental counterparts. Bournazos2016 (neutralization, bispecific/trispecific)

References

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Displaying record number 3479

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MAb ID	3BNC117/PGT145
HXB2 Location	Env	Env Epitope Map
Author Location	gp120
Epitope
Ab Type	gp120 CD4BS, gp120 V2 // V2 glycan(V2g) // V2 apex
Neutralizing
Species (Isotype)	human(IgG1)
Patient	Donor 84, Patient 3
Immunogen	virus
Keywords	bispecific/trispecific, neutralization

Notes

Showing 1 of 1 note.

3BNC117/PGT145: biNAbs (bispecific anti-Env neutralizing antibodies) with potent activity were constructed using an engineered IgG3 hinge domain to increase Fab flexibility necessary for hetero-bivalent binding to HIV-1 Env trimer since biNAbs with IgG1 hinges exhibited reduced neutralization potency compared to their parental bNAbs. While neutralization was generally improved, some combinations of bNAbs were synergistic in potency. Analysis of the neutralization activity of anti-CD4bs/anti-V2 combination, 3BNC117/PGT145, against a 7-cross-clade panel of tier 2/3 showed it exhibited slightly lower activity compared to its respective parental counterparts. Bournazos2016 (neutralization, bispecific/trispecific)

References

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Displaying record number 3480

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MAb ID	3BNC117/8ANC195
HXB2 Location	Env	Env Epitope Map
Author Location	gp160
Epitope
Ab Type	gp120 CD4BS, gp41-gp120 interface
Neutralizing
Species (Isotype)	human(IgG1)
Patient	Patient 3
Immunogen	virus
Keywords	bispecific/trispecific, neutralization

Notes

Showing 1 of 1 note.

3BNC117/8ANC195: biNAbs (bispecific anti-Env neutralizing antibodies) with potent activity were constructed using an engineered IgG3 hinge domain to increase Fab flexibility necessary for hetero-bivalent binding to HIV-1 Env trimer since biNAbs with IgG1 hinges exhibited reduced neutralization potency compared to their parental bNAbs. While neutralization was generally improved, some combinations of bNAbs were synergistic in potency. Analysis of the neutralization activity of anti-CD4bs/anti-gp120/gp41 interface combination, 3BNC117/8ANC195, against a 7-cross-clade panel of tier 2/3 showed it exhibited about equal activity compared to its respective parental counterparts. Bournazos2016 (neutralization, bispecific/trispecific)

References

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Displaying record number 3481

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MAb ID	3BNC117/PGT151
HXB2 Location	Env	Env Epitope Map
Author Location	gp160
Epitope
Ab Type	gp120 CD4BS, fusion peptide // near gp41-gp120 interface
Neutralizing
Species (Isotype)	human
Patient	Donor 31, Patient 3
Immunogen	virus
Keywords	bispecific/trispecific, neutralization

Notes

Showing 1 of 1 note.

3BNC117/PGT151: biNAbs (bispecific anti-Env neutralizing antibodies) with potent activity were constructed using an engineered IgG3 hinge domain to increase Fab flexibility necessary for hetero-bivalent binding to HIV-1 Env trimer since biNAbs with IgG1 hinges exhibited reduced neutralization potency compared to their parental bNAbs. While neutralization was generally improved, some combinations of bNAbs were synergistic in potency. Analysis of the neutralization activity of anti-CD4bs/anti-fusion peptide combination, 3BNC117/PGT151, against a 7-cross-clade panel of tier 2/3 showed it exhibited equal activity compared to its respective parental counterparts. Bournazos2016 (neutralization, bispecific/trispecific)

References

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Displaying record number 3482

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MAb ID	3BNC117/3BC176
HXB2 Location	Env	Env Epitope Map
Author Location	gp160
Epitope
Ab Type	gp120 CD4BS, gp41-gp41 interface
Neutralizing
Species (Isotype)	human(IgG1)
Patient	Patient 3
Immunogen	virus
Keywords	bispecific/trispecific, neutralization

Notes

Showing 1 of 1 note.

3BNC117/3BC176: biNAbs (bispecific anti-Env neutralizing antibodies) with potent activity were constructed using an engineered IgG3 hinge domain to increase Fab flexibility necessary for hetero-bivalent binding to HIV-1 Env trimer since biNAbs with IgG1 hinges exhibited reduced neutralization potency compared to their parental bNAbs. While neutralization was generally improved, some combinations of bNAbs were synergistic in potency. Analysis of the neutralization activity of anti-CD4bs antibodies, 3BNC117/3BC176, against a 7-cross-clade panel of tier 2/3 showed it exhibited synergistic activity (improved neutralization potency) compared to its respective parental counterparts. Bournazos2016 (neutralization, bispecific/trispecific)

References

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Displaying record number 3483

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MAb ID	3BNC117/PG16
HXB2 Location	Env	Env Epitope Map
Author Location	gp120
Epitope
Ab Type	gp120 CD4BS, gp120 V2 // V2 glycan(V2g) // V2 apex
Neutralizing
Species (Isotype)	human(IgG1)
Patient	Donor 24, Patient 3
Immunogen	virus
Keywords	bispecific/trispecific, neutralization

Notes

Showing 1 of 1 note.

3BNC117/PG16: biNAbs (bispecific anti-Env neutralizing antibodies) with potent activity were constructed using an engineered IgG3 hinge domain to increase Fab flexibility necessary for hetero-bivalent binding to HIV-1 Env trimer since biNAbs with IgG1 hinges exhibited reduced neutralization potency compared to their parental bNAbs. While neutralization was generally improved, some combinations of bNAbs were synergistic in potency. Analysis of the neutralization activity of anti-CD4bs/anti-V2 combination, 3BNC117/PG16, against a 7-cross-clade panel of tier 2/3 showed it exhibited about equal activity compared to its respective parental counterparts. Bournazos2016 (neutralization, bispecific/trispecific)

References

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Displaying record number 3512

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MAb ID	PG16/PGT121
HXB2 Location	Env	Env Epitope Map
Author Location	gp120
Epitope
Ab Type	gp120 V2 // V2 glycan(V2g) // V2 apex, gp120 V3 // V3 glycan (V3g)
Neutralizing	P (tier 2) View neutralization details
Species (Isotype)	human(IgG1)
Patient	Donor 17, Donor 24
Immunogen	virus
Keywords	bispecific/trispecific, neutralization

Notes

Showing 1 of 1 note.

PG16/PGT121: biNAbs (bispecific anti-Env neutralizing antibodies) with potent activity were constructed using an engineered IgG3 hinge domain to increase Fab flexibility necessary for hetero-bivalent binding to HIV-1 Env trimer since biNAbs with IgG1 hinges exhibited reduced neutralization potency compared to their parental bNAbs. While neutralization was generally improved, some combinations of bNAbs were synergistic in potency. Analysis of the neutralization activity of anti-V1-V2/anti-V3 interface combination, PG16/PGT121, against a 7-cross-clade panel of tier 2/3 showed it exhibited mildly synergistic activity compared to its respective parental counterparts. This is an improvement over the IgG1 hinge bispecific which exhibited compromised neutralization potency as compared to a predicted mix of parental antibodies. Bournazos2016 (neutralization, bispecific/trispecific)

References

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Displaying record number 3513

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MAb ID	PG16/PGT128
HXB2 Location	Env	Env Epitope Map
Author Location	gp120
Epitope
Ab Type	gp120 V2 // V2 glycan(V2g) // V2 apex, gp120 V3 // V3 glycan (V3g)
Neutralizing	P (tier 2) View neutralization details
Species (Isotype)	human(IgG1)
Patient	Donor 24, Donor 36
Immunogen	virus
Keywords	bispecific/trispecific, neutralization

Notes

Showing 1 of 1 note.

PG16/PGT128: biNAbs (bispecific anti-Env neutralizing antibodies) with potent activity were constructed using an engineered IgG3 hinge domain to increase Fab flexibility necessary for hetero-bivalent binding to HIV-1 Env trimer since biNAbs with IgG1 hinges exhibited reduced neutralization potency compared to their parental bNAbs. While neutralization was generally improved, some combinations of bNAbs were synergistic in potency. Analysis of the neutralization activity of anti-V1-V2/anti-V3 interface combination, PG16/PGT128, against a 7-cross-clade panel of tier 2/3 showed it exhibited mildly synergistic activity compared to its respective parental counterparts. This is an improvement over the IgG1 hinge bispecific which exhibited compromised neutralization potency as compared to a predicted mix of parental antibodies. Bournazos2016 (neutralization, bispecific/trispecific)

References

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Displaying record number 3514

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MAb ID	PG16/10-1074
HXB2 Location	Env	Env Epitope Map
Author Location	gp120
Epitope
Ab Type	gp120 V2 // V2 glycan(V2g) // V2 apex, gp120 V3 // V3 glycan (V3g)
Neutralizing	P (tier 2) View neutralization details
Species (Isotype)	human(IgG1)
Patient	Donor 17, Donor 24
Immunogen	virus
Keywords	bispecific/trispecific, neutralization

Notes

Showing 1 of 1 note.

PG16/10-1074: biNAbs (bispecific anti-Env neutralizing antibodies) with potent activity were constructed using an engineered IgG3 hinge domain to increase Fab flexibility necessary for hetero-bivalent binding to HIV-1 Env trimer since biNAbs with IgG1 hinges exhibited reduced neutralization potency compared to their parental bNAbs. While neutralization was generally improved, some combinations of bNAbs were synergistic in potency. Analysis of the neutralization activity of anti-V1-V2/anti-V3 interface combination, PG16/10-1074, against a 7-cross-clade panel of tier 2/3 showed it exhibited mildly synergistic activity compared to its respective parental counterparts. This is an improvement over the IgG1 hinge bispecific which exhibited compromised neutralization potency as compared to a predicted mix of parental antibodies. Bournazos2016 (neutralization, bispecific/trispecific)

References

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Displaying record number 3515

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MAb ID	PGT151/10-1074
HXB2 Location	Env	Env Epitope Map
Author Location	gp160
Epitope
Ab Type	gp120 V3 // V3 glycan (V3g), fusion peptide // near gp41-gp120 interface
Neutralizing
Species (Isotype)	human(IgG1)
Patient	Donor 17, Donor 31
Immunogen	virus
Keywords	bispecific/trispecific, neutralization

Notes

Showing 1 of 1 note.

PGT151/10-1074: biNAbs (bispecific anti-Env neutralizing antibodies) with potent activity were constructed using an engineered IgG3 hinge domain to increase Fab flexibility necessary for hetero-bivalent binding to HIV-1 Env trimer since biNAbs with IgG1 hinges exhibited reduced neutralization potency compared to their parental bNAbs. While neutralization was generally improved, some combinations of bNAbs were synergistic in potency. Analysis of the neutralization activity of anti-fusion peptide/anti-V3 interface combination, PGT151/10-1074, against a 7-cross-clade panel of tier 2/3 showed it exhibited synergistic activity compared to its respective parental counterparts. Using a multi-clade virus panel of 119 strains, the PGT151/10-1074 bispecific is more potent than either parental antibody, and equal to a predicted mix of parental antibodies. Bournazos2016 (neutralization, bispecific/trispecific)

References

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Displaying record number 3516

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MAb ID	8ANC195/10-1074
HXB2 Location	Env	Env Epitope Map
Author Location	gp160
Epitope
Ab Type	gp120 V3 // V3 glycan (V3g), gp41-gp120 interface
Neutralizing
Species (Isotype)	human(IgG1)
Patient	Donor 17, Patient 8
Immunogen	virus
Keywords	bispecific/trispecific, neutralization

Notes

Showing 1 of 1 note.

8ANC195/10-1074: biNAbs (bispecific anti-Env neutralizing antibodies) with potent activity were constructed using an engineered IgG3 hinge domain to increase Fab flexibility necessary for hetero-bivalent binding to HIV-1 Env trimer since biNAbs with IgG1 hinges exhibited reduced neutralization potency compared to their parental bNAbs. While neutralization was generally improved, some combinations of bNAbs were synergistic in potency. Analysis of the neutralization activity of anti-gp120-gp41 interface/anti-V3 interface combination, 8ANC195/10-1074, against a 7-cross-clade panel of tier 2/3 showed it exhibited mildly inhibitory activity compared to its respective parental counterparts. Bournazos2016 (neutralization, bispecific/trispecific)

References

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Displaying record number 3517

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MAb ID	8ANC195/PGT128
HXB2 Location	Env	Env Epitope Map
Author Location	gp160
Epitope
Ab Type	gp120 V3 // V3 glycan (V3g), gp41-gp120 interface
Neutralizing
Species (Isotype)	human(IgG1)
Patient	Donor 36, Patient 8
Immunogen	virus
Keywords	bispecific/trispecific, neutralization

Notes

Showing 1 of 1 note.

8ANC195/PGT128: biNAbs (bispecific anti-Env neutralizing antibodies) with potent activity were constructed using an engineered IgG3 hinge domain to increase Fab flexibility necessary for hetero-bivalent binding to HIV-1 Env trimer since biNAbs with IgG1 hinges exhibited reduced neutralization potency compared to their parental bNAbs. While neutralization was generally improved, some combinations of bNAbs were synergistic in potency. Analysis of the neutralization activity of anti-gp120-gp41 interface/anti-V3 interface combination, 8ANC195/PGT128, against a 7-cross-clade panel of tier 2/3 showed it exhibited mildly synergistic activity compared to its respective parental counterparts. Using a multi-clade virus panel of 119 strains, the 8ANC195/PGT128 bispecific is more potent than either parental antibody, and mildly synergistic over a predicted mix of parental antibodies. Bournazos2016 (neutralization, bispecific/trispecific)

References

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Displaying record number 3518

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MAb ID	PGT151/35O22
HXB2 Location	Env	Env Epitope Map
Author Location	gp160
Epitope
Ab Type	fusion peptide // near gp41-gp120 interface, gp41-gp120 interface
Neutralizing	P (tier 2) View neutralization details
Species (Isotype)	human(IgG1)
Patient	Donor 31, Donor N152
Immunogen	virus
Keywords	bispecific/trispecific, neutralization

Notes

Showing 1 of 1 note.

PGT151/35O22: biNAbs (bispecific anti-Env neutralizing antibodies) with potent activity were constructed using an engineered IgG3 hinge domain to increase Fab flexibility necessary for hetero-bivalent binding to HIV-1 Env trimer since biNAbs with IgG1 hinges exhibited reduced neutralization potency compared to their parental bNAbs. While neutralization was generally improved, some combinations of bNAbs were synergistic in potency. Analysis of the neutralization activity of anti-fusion peptide/anti-gp120-gp41 interface combination, PGT151/35O22 was not tested as an IgG3 hinge variant bispecific. Using a multi-clade virus panel, the PGT151/35O22 IgG1-hinge bispecific is equal to a predicted mix of parental antibodies. Bournazos2016 (neutralization, bispecific/trispecific)

References

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Displaying record number 3519

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MAb ID	PG16/PGT135
HXB2 Location	Env	Env Epitope Map
Author Location	gp120
Epitope
Ab Type	gp120 V2 // V2 glycan(V2g) // V2 apex, gp120 V3 // V3 glycan (V3g)
Neutralizing
Species (Isotype)	human(IgG1)
Patient	Donor 24, Donor 39
Immunogen	virus
Keywords	bispecific/trispecific, neutralization

Notes

Showing 1 of 1 note.

PG16/PGT135: biNAbs (bispecific anti-Env neutralizing antibodies) with potent activity were constructed using an engineered IgG3 hinge domain to increase Fab flexibility necessary for hetero-bivalent binding to HIV-1 Env trimer since biNAbs with IgG1 hinges exhibited reduced neutralization potency compared to their parental bNAbs. While neutralization was generally improved, some combinations of bNAbs were synergistic in potency. Analysis of the neutralization activity of anti-V1-V2/anti-V3 interface combination, PG16/PGT135, against a 7-cross-clade panel of tier 2/3 showed it exhibited about equal activity compared to its respective parental counterparts. Bournazos2016 (neutralization, bispecific/trispecific)

References

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Displaying record number 3521

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MAb ID	8ANC195/8ANC131
HXB2 Location	Env	Env Epitope Map
Author Location	gp160
Epitope
Ab Type	gp120 CD4BS, gp41-gp120 interface
Neutralizing
Species (Isotype)	human(IgG1)
Patient	Patient 8
Immunogen	virus
Keywords	bispecific/trispecific, neutralization

Notes

Showing 1 of 1 note.

8ANC195/8ANC131: biNAbs (bispecific anti-Env neutralizing antibodies) with potent activity were constructed using an engineered IgG3 hinge domain to increase Fab flexibility necessary for hetero-bivalent binding to HIV-1 Env trimer since biNAbs with IgG1 hinges exhibited reduced neutralization potency compared to their parental bNAbs. While neutralization was generally improved, some combinations of bNAbs were synergistic in potency. Analysis of the neutralization activity of anti-gp120-gp41 interface/anti-CD4bs combination, 8ANC195/8ANC131, against a 7-cross-clade panel of tier 2/3 showed it exhibited about equal activity compared to its respective parental counterparts. Bournazos2016 (neutralization, bispecific/trispecific)

References

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Displaying record number 3522

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MAb ID	8ANC195/PGT121
HXB2 Location	Env	Env Epitope Map
Author Location	gp160
Epitope
Ab Type	gp120 V3 // V3 glycan (V3g), gp41-gp120 interface
Neutralizing
Species (Isotype)	human(IgG1)
Patient	Donor 17, Patient 8
Immunogen	virus
Keywords	bispecific/trispecific, neutralization

Notes

Showing 1 of 1 note.

8ANC195/PGT121: biNAbs (bispecific anti-Env neutralizing antibodies) with potent activity were constructed using an engineered IgG3 hinge domain to increase Fab flexibility necessary for hetero-bivalent binding to HIV-1 Env trimer since biNAbs with IgG1 hinges exhibited reduced neutralization potency compared to their parental bNAbs. While neutralization was generally improved, some combinations of bNAbs were synergistic in potency. Analysis of the neutralization activity of anti-gp120-gp41 interface/anti-V3 interface combination, 8ANC195/PGT121, against a 7-cross-clade panel of tier 2/3 showed it exhibited equal activity compared to its respective parental counterparts. Bournazos2016 (neutralization, bispecific/trispecific)

References

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Displaying record number 3524

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MAb ID	8ANC195/PGT135
HXB2 Location	Env	Env Epitope Map
Author Location	gp160
Epitope
Ab Type	gp120 V3 // V3 glycan (V3g), gp41-gp120 interface
Neutralizing
Species (Isotype)	human(IgG1)
Patient	Donor 39, Patient 8
Immunogen	virus
Keywords	bispecific/trispecific, neutralization

Notes

Showing 1 of 1 note.

8ANC195/PGT135: biNAbs (bispecific anti-Env neutralizing antibodies) with potent activity were constructed using an engineered IgG3 hinge domain to increase Fab flexibility necessary for hetero-bivalent binding to HIV-1 Env trimer since biNAbs with IgG1 hinges exhibited reduced neutralization potency compared to their parental bNAbs. While neutralization was generally improved, some combinations of bNAbs were synergistic in potency. Analysis of the neutralization activity of anti-gp120-gp41 interface/anti-V3 interface combination, 8ANC195/PGT135, against a 7-cross-clade panel of tier 2/3 showed it exhibited mildly inhibitory activity compared to its respective parental counterparts. Bournazos2016 (neutralization, bispecific/trispecific)

References

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Displaying record number 3525

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MAb ID	8ANC195/PGT151
HXB2 Location	Env	Env Epitope Map
Author Location	gp160
Epitope
Ab Type	fusion peptide // near gp41-gp120 interface, gp41-gp120 interface
Neutralizing
Species (Isotype)	human(IgG1)
Patient	Donor 31, Patient 8
Immunogen	virus
Keywords	bispecific/trispecific, neutralization

Notes

Showing 1 of 1 note.

8ANC195/PGT151: biNAbs (bispecific anti-Env neutralizing antibodies) with potent activity were constructed using an engineered IgG3 hinge domain to increase Fab flexibility necessary for hetero-bivalent binding to HIV-1 Env trimer since biNAbs with IgG1 hinges exhibited reduced neutralization potency compared to their parental bNAbs. While neutralization was generally improved, some combinations of bNAbs were synergistic in potency. Analysis of the neutralization activity of anti-gp41-120 interface/anti-fusion peptide, 8ANC195/PGT151, against a 7-cross-clade panel of tier 2/3 showed it exhibited synergistic activity compared to its respective parental counterparts. Bournazos2016 (neutralization, bispecific/trispecific)

References

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Displaying record number 3526

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MAb ID	8ANC195/3BC176
HXB2 Location	Env	Env Epitope Map
Author Location	gp160
Epitope
Ab Type	gp41-gp120 interface, gp41-gp41 interface
Neutralizing
Species (Isotype)	human(IgG1)
Patient	Patient 3, Patient 8
Immunogen	virus
Keywords	bispecific/trispecific, neutralization

Notes

Showing 1 of 1 note.

8ANC195/3BC176: biNAbs (bispecific anti-Env neutralizing antibodies) with potent activity were constructed using an engineered IgG3 hinge domain to increase Fab flexibility necessary for hetero-bivalent binding to HIV-1 Env trimer since biNAbs with IgG1 hinges exhibited reduced neutralization potency compared to their parental bNAbs. While neutralization was generally improved, some combinations of bNAbs were synergistic in potency. Analysis of the neutralization activity of anti-gp120-gp41 interface/ anti-CD4 binding site, 8ANC195/3BC176, against a 7-cross-clade panel of tier 2/3 showed it exhibited synergistic activity compared to its respective parental counterparts. Bournazos2016 (neutralization, bispecific/trispecific)

References

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Displaying record number 3527

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MAb ID	8ANC195/10E8
HXB2 Location	Env	Env Epitope Map
Author Location	gp160
Epitope
Ab Type	gp41 MPER (membrane proximal external region), gp41-gp120 interface
Neutralizing
Species (Isotype)	human(IgG1)
Patient	Donor N152, Patient 8
Immunogen	virus
Keywords	bispecific/trispecific, neutralization

Notes

Showing 1 of 1 note.

8ANC195/10E8: biNAbs (bispecific anti-Env neutralizing antibodies) with potent activity were constructed using an engineered IgG3 hinge domain to increase Fab flexibility necessary for hetero-bivalent binding to HIV-1 Env trimer since biNAbs with IgG1 hinges exhibited reduced neutralization potency compared to their parental bNAbs. While neutralization was generally improved, some combinations of bNAbs were synergistic in potency. Analysis of the neutralization activity of anti-gp120-gp41 interface/anti-MPER, 8ANC195/10E8, against a 7-cross-clade panel of tier 2/3 showed it exhibited synergistic activity compared to its respective parental counterparts. Bournazos2016 (neutralization, bispecific/trispecific)

References

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Displaying record number 3528

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MAb ID	8ANC195/PG16
HXB2 Location	Env	Env Epitope Map
Author Location	gp160
Epitope
Ab Type	gp120 V2 // V2 glycan(V2g) // V2 apex, gp41-gp120 interface
Neutralizing
Species (Isotype)	human(IgG1)
Patient	Donor 24, Patient 8
Immunogen	virus
Keywords	bispecific/trispecific, neutralization

Notes

Showing 1 of 1 note.

8ANC195/PG16: biNAbs (bispecific anti-Env neutralizing antibodies) with potent activity were constructed using an engineered IgG3 hinge domain to increase Fab flexibility necessary for hetero-bivalent binding to HIV-1 Env trimer since biNAbs with IgG1 hinges exhibited reduced neutralization potency compared to their parental bNAbs. While neutralization was generally improved, some combinations of bNAbs were synergistic in potency. Analysis of the neutralization activity of anti-gp120-gp41 interface/anti-V2, 8ANC195/PG16, against a 7-cross-clade panel of tier 2/3 showed it exhibited synergistic activity compared to its respective parental counterparts. Bournazos2016 (neutralization, bispecific/trispecific)

References

Showing 1 of 1 reference.

Displaying record number 3529

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MAb ID	8ANC195/PGT145
HXB2 Location	Env	Env Epitope Map
Author Location	gp160
Epitope
Ab Type	gp120 V2 // V2 glycan(V2g) // V2 apex, gp41-gp120 interface
Neutralizing
Species (Isotype)	human(IgG1)
Patient	Donor 84, Patient 8
Immunogen	virus
Keywords	bispecific/trispecific, neutralization

Notes

Showing 1 of 1 note.

8ANC195/PGT145: biNAbs (bispecific anti-Env neutralizing antibodies) with potent activity were constructed using an engineered IgG3 hinge domain to increase Fab flexibility necessary for hetero-bivalent binding to HIV-1 Env trimer since biNAbs with IgG1 hinges exhibited reduced neutralization potency compared to their parental bNAbs. While neutralization was generally improved, some combinations of bNAbs were synergistic in potency. Analysis of the neutralization activity of anti-gp120-gp41 interface/anti-V1-V2 interface, 8ANC195/PGT145, against a 7-cross-clade panel of tier 2/3 showed it exhibited very mildly synergistic activity compared to its respective parental counterparts. Bournazos2016 (neutralization, bispecific/trispecific)

References

Showing 1 of 1 reference.

Displaying record number 3530

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MAb ID	8ANC195/PGDM1400
HXB2 Location	Env	Env Epitope Map
Author Location	gp160
Epitope
Ab Type	gp120 V2 // V2 glycan(V2g) // V2 apex, gp41-gp120 interface
Neutralizing
Species (Isotype)	human(IgG1)
Patient	Donor 84, Patient 8
Immunogen	virus
Keywords	bispecific/trispecific, neutralization

Notes

Showing 1 of 1 note.

8ANC195/PGDM1400: biNAbs (bispecific anti-Env neutralizing antibodies) with potent activity were constructed using an engineered IgG3 hinge domain to increase Fab flexibility necessary for hetero-bivalent binding to HIV-1 Env trimer since biNAbs with IgG1 hinges exhibited reduced neutralization potency compared to their parental bNAbs. While neutralization was generally improved, some combinations of bNAbs were synergistic in potency. Analysis of the neutralization activity of anti-gp120-gp41 interface/anti-V1-V2 interface, 8ANC195/PGDM1400, against a 7-cross-clade panel of tier 2/3 showed it exhibited very mildly inhibitory activity compared to its respective parental counterparts. Bournazos2016 (neutralization, bispecific/trispecific)

References

Showing 1 of 1 reference.

Displaying record number 3532

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MAb ID	8ANC195/PGT128-IgG3C
HXB2 Location	Env	Env Epitope Map
Author Location	gp160
Epitope
Ab Type	gp120 V3 // V3 glycan (V3g), gp41-gp120 interface
Neutralizing	P (tier 2) View neutralization details
Species (Isotype)	human(IgG3)
Patient	Donor 36, Patient 8
Immunogen	virus
Keywords	bispecific/trispecific, neutralization

Notes

Showing 1 of 1 note.

8ANC195/PGT128-IgG3C: biNAbs (bispecific anti-Env neutralizing antibodies) with potent activity were constructed using an engineered IgG3 hinge domain to increase Fab flexibility necessary for hetero-bivalent binding to HIV-1 Env trimer since biNAbs with IgG1 hinges exhibited reduced neutralization potency compared to their parental bNAbs. While neutralization was generally improved, some combinations of bNAbs were synergistic in potency. On a panel of 208 pseudoviruses, the IgG3C hinge variant of 8ANC195/PGT128 exhibited modestly greater neutralization than the original IgG1 version. Bournazos2016 (neutralization, bispecific/trispecific)

References

Showing 1 of 1 reference.

Displaying record number 3533

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MAb ID	PGT151/10-1074-IgG3C
HXB2 Location	Env	Env Epitope Map
Author Location	gp160
Epitope
Ab Type	gp120 V3 // V3 glycan (V3g), fusion peptide // near gp41-gp120 interface
Neutralizing	P (tier 2) View neutralization details
Species (Isotype)	human(IgG3)
Patient	Donor 17, Donor 31
Immunogen	virus
Keywords	bispecific/trispecific, neutralization

Notes

Showing 1 of 1 note.

PGT151/10-1074: biNAbs (bispecific anti-Env neutralizing antibodies) with potent activity were constructed using an engineered IgG3 hinge domain to increase Fab flexibility necessary for hetero-bivalent binding to HIV-1 Env trimer since biNAbs with IgG1 hinges exhibited reduced neutralization potency compared to their parental bNAbs. While neutralization was generally improved, some combinations of bNAbs were synergistic in potency. On a panel of 208 pseudoviruses, the IgG3C hinge variant of PGT151/10-1074 exhibited a similar degree of neutralization compared to the original IgG1 version. Bournazos2016 (neutralization, bispecific/trispecific)

References

Showing 1 of 1 reference.

Displaying record number 3534

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MAb ID	3BNC117/PGT135-IgG3C (3BNC117-PGT135)
HXB2 Location	Env	Env Epitope Map
Author Location	gp160
Epitope
Ab Type	gp120 CD4BS, gp120 V3 // V3 glycan (V3g)
Neutralizing	View neutralization details
Species (Isotype)	human(IgG3)
Patient	Donor 39, Patient 3
Immunogen	virus
Keywords	bispecific/trispecific, immunotherapy, neutralization

Notes

Showing 2 of 2 notes.

3BNC117/PGT135-IgG3C: In vitro neutralization data against 25 subtype A, 100 C, and 20 D pseudoviruses of 8 bNAbs (3BNC117, N6, VRC01, VRC07-523LS, CAP256-VRC26.25, PGDM1400, 10–1074, PGT121) and 2 bispecific Abs under clinical development (10E8-iMAb, 3BNC117-PGT135) was studied to assess the antibodies’ potential to prevent infection by dominant HIV-1 subtypes in sub-Saharan Africa. In vivo protection of these Abs and their 2-Ab combination was predicted using a function of in vitro neutralization based on data from a macaque simian-human immunodeficiency virus (SHIV) challenge study. Conclusions were that 1. bNAb combinations outperform individual bNAbs 2. Different bNAb combinations were optimal against different HIV subtypes 3. Bispecific 10E8-iMAb outperformed all combinations and 4. 10E8-iMAb in combination with other conventional Abs was predicted to be the best combination against HIV-infection. For subtype D, the bispecific 3BNC117-PGT135 showed the second most potent IC80 titers after 10E8-iMAb (median IC80 of 0.2425 μg/ml) and completely neutralized 85% of viruses at 5 μg/ml. In the case of bispecific Ab combinations - for subtype D, 10E8-iMAb with 3BNC117-PGT135 best. Wagh2018 (immunotherapy)
.3BNC117/PGT151: biNAbs (bispecific anti-Env neutralizing antibodies) with potent activity were constructed using an engineered IgG3 hinge domain to increase Fab flexibility necessary for hetero-bivalent binding to HIV-1 Env trimer since biNAbs with IgG1 hinges exhibited reduced neutralization potency compared to their parental bNAbs. While neutralization was generally improved, some combinations of bNAbs were synergistic in potency. On a panel of 208 pseudoviruses, the IgG3C hinge variant of 8ANC195/PGT135 exhibited significantly greater neutralization than the original IgG1 version; it was able to neutralize >93% of the viruses. Bournazos2016 (neutralization, bispecific/trispecific)

References

Showing 2 of 2 references.

Wagh2018 Kshitij Wagh, Michael S. Seaman, Marshall Zingg, Tomas Fitzsimons, Dan H. Barouch, Dennis R. Burton, Mark Connors, David D. Ho, John R. Mascola, Michel C. Nussenzweig, Jeffrey Ravetch, Rajeev Gautam, Malcolm A. Martin, David C. Montefiori, and Bette Korber. Potential of Conventional \& Bispecific Broadly Neutralizing Antibodies for Prevention of HIV-1 Subtype A, C \& D Infections. PLoS Pathog., 14(3):e1006860, Mar 2018. PubMed ID: 29505593. Show all entries for this paper.

Displaying record number 3537

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MAb ID	3BNC117/10-1074-IgG3C
HXB2 Location	Env	Env Epitope Map
Author Location	gp160
Epitope
Ab Type	gp120 CD4BS, gp120 V3 // V3 glycan (V3g)
Neutralizing	P (tier 2) View neutralization details
Species (Isotype)	human(IgG3)
Patient	Donor 17, Patient 3
Immunogen	virus
Keywords	bispecific/trispecific, neutralization

Notes

Showing 1 of 1 note.

3BNC117/10-1074-IgG3C: biNAbs (bispecific anti-Env neutralizing antibodies) with potent activity were constructed using an engineered IgG3 hinge domain to increase Fab flexibility necessary for hetero-bivalent binding to HIV-1 Env trimer since biNAbs with IgG1 hinges exhibited reduced neutralization potency compared to their parental bNAbs. While neutralization was generally improved, some combinations of bNAbs were synergistic in potency. On a panel of 208 pseudoviruses, the IgG3C hinge variant of 3BNC117/10-1074 exhibited a similar degree of neutralization compared to the original IgG1 version. Bournazos2016 (neutralization, bispecific/trispecific)

References

Showing 1 of 1 reference.

Displaying record number 3538

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MAb ID	3BNC117-IgG3C-
HXB2 Location	Env	Env Epitope Map
Author Location	gp120
Epitope
Ab Type	gp120 CD4BS
Neutralizing	View neutralization details
Species (Isotype)	human(IgG3)
Patient	Patient 3
Immunogen	virus
Keywords	neutralization

Notes

Showing 1 of 1 note.

3BNC117-IgG3C-: biNAbs (bispecific anti-Env neutralizing antibodies) with potent activity were constructed using an engineered IgG3 hinge domain to increase Fab flexibility necessary for hetero-bivalent binding to HIV-1 Env trimer since biNAbs with IgG1 hinges exhibited reduced neutralization potency compared to their parental bNAbs. In general, 3BNC117-IgG1 neutralized equally or slightly better than 3BNC117-IgG3C- (Fig.S2). Bournazos2016 (neutralization)

References

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Displaying record number 3539

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MAb ID	10-1074-IgG3C-
HXB2 Location	Env	Env Epitope Map
Author Location	gp120
Epitope
Ab Type	gp120 V3 // V3 glycan (V3g)
Neutralizing	P (tier 2) View neutralization details
Species (Isotype)	human(IgG3)
Patient	Donor 17
Immunogen	virus
Keywords	neutralization

Notes

Showing 1 of 1 note.

10-1074-IgG3C-: biNAbs (bispecific anti-Env neutralizing antibodies) with potent activity were constructed using an engineered IgG3 hinge domain to increase Fab flexibility necessary for hetero-bivalent binding to HIV-1 Env trimer since biNAbs with IgG1 hinges exhibited reduced neutralization potency compared to their parental bNAbs. For 7/10 viruses tested, 10-1074-IgG3C- neutralized equally or better than 10-1074-IgG1 (Fig.S2). Bournazos2016 (neutralization)

References

Showing 1 of 1 reference.

Displaying record number 3540

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MAb ID	8ANC195-IgG3C-
HXB2 Location	Env	Env Epitope Map
Author Location	gp120
Epitope
Ab Type	gp41-gp120 interface
Neutralizing	P (tier 2) View neutralization details
Species (Isotype)	human(IgG3)
Patient	Patient 8
Immunogen	virus
Keywords	neutralization

Notes

Showing 1 of 1 note.

8ANC195-IgG3C-: biNAbs (bispecific anti-Env neutralizing antibodies) with potent activity were constructed using an engineered IgG3 hinge domain to increase Fab flexibility necessary for hetero-bivalent binding to HIV-1 Env trimer since biNAbs with IgG1 hinges exhibited reduced neutralization potency compared to their parental bNAbs. In general, 8ANC195-IgG3C- neutralized slightly better than 8ANC195-IgG1 (Fig.S2). Bournazos2016 (neutralization)

References

Showing 1 of 1 reference.

Displaying record number 3541

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MAb ID	PGT128-IgG3C-
HXB2 Location	Env	Env Epitope Map
Author Location	gp120
Epitope
Ab Type	gp120 V3 // V3 glycan (V3g)
Neutralizing	P (tier 2) View neutralization details
Species (Isotype)	human(IgG3)
Patient	Donor 36
Immunogen	virus
Keywords	neutralization

Notes

Showing 1 of 1 note.

PGT128-IgG3C-: biNAbs (bispecific anti-Env neutralizing antibodies) with potent activity were constructed using an engineered IgG3 hinge domain to increase Fab flexibility necessary for hetero-bivalent binding to HIV-1 Env trimer since biNAbs with IgG1 hinges exhibited reduced neutralization potency compared to their parental bNAbs. In general, PGT128-IgG3C- neutralized about the same as PGT128-IgG1 (Fig.S2). Bournazos2016 (neutralization)

References

Showing 1 of 1 reference.

Displaying record number 3542

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MAb ID	PGT151-IgG3C-
HXB2 Location	Env	Env Epitope Map
Author Location	gp160
Epitope
Ab Type	fusion peptide // near gp41-gp120 interface
Neutralizing	P (tier 2) View neutralization details
Species (Isotype)	human(IgG3)
Patient	Donor 31
Immunogen	virus
Keywords	neutralization

Notes

Showing 1 of 1 note.

PGT151-IgG3C-: biNAbs (bispecific anti-Env neutralizing antibodies) with potent activity were constructed using an engineered IgG3 hinge domain to increase Fab flexibility necessary for hetero-bivalent binding to HIV-1 Env trimer since biNAbs with IgG1 hinges exhibited reduced neutralization potency compared to their parental bNAbs. In general, PGT151-IgG3C- neutralized slightly better than PGT151-IgG1 (Fig.S2). Bournazos2016 (neutralization)

References

Showing 1 of 1 reference.

Displaying record number 3543

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MAb ID	PGT135-IgG3C-
HXB2 Location	Env	Env Epitope Map
Author Location	gp120
Epitope
Ab Type	gp120 V3 // V3 glycan (V3g)
Neutralizing	P (tier 2) View neutralization details
Species (Isotype)	human(IgG3)
Patient	Donor 39
Immunogen	virus
Keywords	neutralization

Notes

Showing 1 of 1 note.

PGT135-IgG3C-: biNAbs (bispecific anti-Env neutralizing antibodies) with potent activity were constructed using an engineered IgG3 hinge domain to increase Fab flexibility necessary for hetero-bivalent binding to HIV-1 Env trimer since biNAbs with IgG1 hinges exhibited reduced neutralization potency compared to their parental bNAbs. In general, PGT135-IgG3C- neutralized about the same as PGT135-IgG1 (Fig.S2). Bournazos2016 (neutralization)

References

Showing 1 of 1 reference.

Displaying record number 3640

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MAb ID	8ANC131/PGT121
HXB2 Location	Env	Env Epitope Map
Author Location	gp120
Epitope
Ab Type	gp120 CD4BS, gp120 V3 // V3 glycan (V3g)
Neutralizing
Species (Isotype)	human(IgG1)
Patient
Immunogen	virus
Keywords	bispecific/trispecific, neutralization

Notes

Showing 1 of 1 note.

8ANC131/PGT121: biNAbs (bispecific anti-Env neutralizing antibodies) with potent activity were constructed using an engineered IgG3 hinge domain to increase Fab flexibility necessary for hetero-bivalent binding to HIV-1 Env trimer since biNAbs with IgG1 hinges exhibited reduced neutralization potency compared to their parental bNAbs. While neutralization was generally improved, some combinations of bNAbs were synergistic in potency. Analysis of the neutralization activity of anti-CD4bs/anti-V3 combination, 8ANC131/PGT121, against a 7-cross-clade panel of tier 2/3 showed it exhibited lower, inhibitory activity but a marginal increase in neutralization potency compared to its respective parental counterparts. Bournazos2016 (neutralization, bispecific/trispecific)

References

Showing 1 of 1 reference.

Displaying record number 3641

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MAb ID	8ANC131/10-1074
HXB2 Location	Env	Env Epitope Map
Author Location	gp120
Epitope
Ab Type	gp120 CD4BS, gp120 V3 // V3 glycan (V3g)
Neutralizing
Species (Isotype)	human(IgG1)
Patient
Immunogen	virus
Keywords	bispecific/trispecific, neutralization

Notes

Showing 1 of 1 note.

8ANC131/10-1074: biNAbs (bispecific anti-Env neutralizing antibodies) with potent activity were constructed using an engineered IgG3 hinge domain to increase Fab flexibility necessary for hetero-bivalent binding to HIV-1 Env trimer since biNAbs with IgG1 hinges exhibited reduced neutralization potency compared to their parental bNAbs. While neutralization was generally improved, some combinations of bNAbs were synergistic in potency. Analysis of the neutralization activity of anti-CD4bs/anti-V3 combination, 8ANC131/10-1074, showed it had about equal activity in neutralization potency compared to its respective parental counterparts. Bournazos2016 (neutralization, bispecific/trispecific)

References

Showing 1 of 1 reference.

Displaying record number 3642

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MAb ID	8ANC131/PGT128
HXB2 Location	Env	Env Epitope Map
Author Location	gp120
Epitope
Ab Type	gp120 CD4BS, gp120 V3 // V3 glycan (V3g)
Neutralizing
Species (Isotype)	human(IgG1)
Patient
Immunogen	virus
Keywords	bispecific/trispecific, neutralization

Notes

Showing 1 of 1 note.

8ANC131/PGT128: biNAbs (bispecific anti-Env neutralizing antibodies) with potent activity were constructed using an engineered IgG3 hinge domain to increase Fab flexibility necessary for hetero-bivalent binding to HIV-1 Env trimer since biNAbs with IgG1 hinges exhibited reduced neutralization potency compared to their parental bNAbs. While neutralization was generally improved, some combinations of bNAbs were synergistic in potency. Analysis of the neutralization activity of anti-CD4bs/anti-V3 combination, 8ANC131/PGT128, showed it had mildly synergestic neutralization activity compared to its respective parental counterparts. Bournazos2016 (neutralization, bispecific/trispecific)

References

Showing 1 of 1 reference.

Displaying record number 3671

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MAb ID	8ANC131/PGT135
HXB2 Location	Env	Env Epitope Map
Author Location	gp120
Epitope
Ab Type	gp120 CD4BS, gp120 V3 // V3 glycan (V3g)
Neutralizing
Species (Isotype)	human(IgG1)
Patient
Immunogen	virus
Keywords	bispecific/trispecific, neutralization

Notes

Showing 1 of 1 note.

8ANC131/PGT135: biNAbs (bispecific anti-Env neutralizing antibodies) with potent activity were constructed using an engineered IgG3 hinge domain to increase Fab flexibility necessary for hetero-bivalent binding to HIV-1 Env trimer since biNAbs with IgG1 hinges exhibited reduced neutralization potency compared to their parental bNAbs. While neutralization was generally improved, some combinations of bNAbs were synergistic in potency. Analysis of the neutralization activity of anti-CD4bs/anti-V3 combination, 8ANC131/PGT135, showed it had mildly synergestic neutralization activity compared to its respective parental counterparts. Bournazos2016 (neutralization, bispecific/trispecific)

References

Showing 1 of 1 reference.

Displaying record number 3672

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MAb ID	8ANC131/PG16
HXB2 Location	Env	Env Epitope Map
Author Location	gp120
Epitope
Ab Type	gp120 CD4BS, gp120 V2 // V2 glycan(V2g) // V2 apex
Neutralizing
Species (Isotype)	human(IgG1)
Patient
Immunogen	virus
Keywords	bispecific/trispecific, neutralization

Notes

Showing 1 of 1 note.

8ANC131/PG16: biNAbs (bispecific anti-Env neutralizing antibodies) with potent activity were constructed using an engineered IgG3 hinge domain to increase Fab flexibility necessary for hetero-bivalent binding to HIV-1 Env trimer since biNAbs with IgG1 hinges exhibited reduced neutralization potency compared to their parental bNAbs. While neutralization was generally improved, some combinations of bNAbs were synergistic in potency. Analysis of the neutralization activity of anti-CD4bs/anti-V1/V2 combination, 8ANC131/PG16, showed it had inhibitory neutralization activity compared to its respective parental counterparts. Bournazos2016 (neutralization, bispecific/trispecific)

References

Showing 1 of 1 reference.

Displaying record number 3673

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MAb ID	8ANC131/PGT145
HXB2 Location	Env	Env Epitope Map
Author Location	gp120
Epitope
Ab Type	gp120 CD4BS, gp120 V2 // V2 glycan(V2g) // V2 apex
Neutralizing
Species (Isotype)	human(IgG1)
Patient
Immunogen	virus
Keywords	bispecific/trispecific, neutralization

Notes

Showing 1 of 1 note.

8ANC131/PGT145: biNAbs (bispecific anti-Env neutralizing antibodies) with potent activity were constructed using an engineered IgG3 hinge domain to increase Fab flexibility necessary for hetero-bivalent binding to HIV-1 Env trimer since biNAbs with IgG1 hinges exhibited reduced neutralization potency compared to their parental bNAbs. While neutralization was generally improved, some combinations of bNAbs were synergistic in potency. Analysis of the neutralization activity of anti-CD4bs/anti-V1/V2 combination, 8ANC131/PGT145, showed it had very mildly synergistic neutralization activity compared to its respective parental counterparts. Bournazos2016 (neutralization, bispecific/trispecific)

References

Showing 1 of 1 reference.

Displaying record number 3674

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MAb ID	8ANC131/PGDM1400
HXB2 Location	Env	Env Epitope Map
Author Location	gp120
Epitope
Ab Type	gp120 CD4BS, gp120 V2 // V2 glycan(V2g) // V2 apex
Neutralizing
Species (Isotype)	human(IgG1)
Patient
Immunogen	virus
Keywords	bispecific/trispecific, neutralization

Notes

Showing 1 of 1 note.

8ANC131/PGDM1400: biNAbs (bispecific anti-Env neutralizing antibodies) with potent activity were constructed using an engineered IgG3 hinge domain to increase Fab flexibility necessary for hetero-bivalent binding to HIV-1 Env trimer since biNAbs with IgG1 hinges exhibited reduced neutralization potency compared to their parental bNAbs. While neutralization was generally improved, some combinations of bNAbs were synergistic in potency. Analysis of the neutralization activity of anti-CD4bs/anti-V1/V2 combination, 8ANC131/PGDM1400, showed it had mildly synergistic neutralization activity compared to its respective parental counterparts. Bournazos2016 (neutralization, bispecific/trispecific)

References

Showing 1 of 1 reference.

Displaying record number 3675

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MAb ID	8ANC131/PGT151
HXB2 Location	Env	Env Epitope Map
Author Location	gp120
Epitope
Ab Type	gp120 CD4BS, fusion peptide // near gp41-gp120 interface
Neutralizing
Species (Isotype)	human(IgG1)
Patient
Immunogen	virus
Keywords	bispecific/trispecific, neutralization

Notes

Showing 1 of 1 note.

8ANC131/PGT151: biNAbs (bispecific anti-Env neutralizing antibodies) with potent activity were constructed using an engineered IgG3 hinge domain to increase Fab flexibility necessary for hetero-bivalent binding to HIV-1 Env trimer since biNAbs with IgG1 hinges exhibited reduced neutralization potency compared to their parental bNAbs. While neutralization was generally improved, some combinations of bNAbs were synergistic in potency. Analysis of the neutralization activity of anti-CD4bs/anti-fusion peptide combination, 8ANC131/PGT151, showed it had mildly synergistic neutralization activity compared to its respective parental counterparts. Bournazos2016 (neutralization, bispecific/trispecific)

References

Showing 1 of 1 reference.

Displaying record number 3676

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MAb ID	8ANC131/3BC176
HXB2 Location	Env	Env Epitope Map
Author Location	gp120
Epitope
Ab Type	gp120 CD4BS, gp41-gp41 interface
Neutralizing
Species (Isotype)	human(IgG1)
Patient
Immunogen	virus
Keywords	bispecific/trispecific, neutralization

Notes

Showing 1 of 1 note.

8ANC131/3BC176: biNAbs (bispecific anti-Env neutralizing antibodies) with potent activity were constructed using an engineered IgG3 hinge domain to increase Fab flexibility necessary for hetero-bivalent binding to HIV-1 Env trimer since biNAbs with IgG1 hinges exhibited reduced neutralization potency compared to their parental bNAbs. While neutralization was generally improved, some combinations of bNAbs were synergistic in potency. Analysis of the neutralization activity of anti-CD4bs antibodies, 8ANC131/3BC176, showed it had mildly inhibitory neutralization activity compared to its respective parental counterparts. Bournazos2016 (neutralization, bispecific/trispecific)

References

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Displaying record number 3677

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MAb ID	CH103/8ANC195
HXB2 Location	Env	Env Epitope Map
Author Location	gp120
Epitope
Ab Type	gp120 CD4BS, gp41-gp120 interface
Neutralizing
Species (Isotype)	human(IgG1)
Patient
Immunogen	virus
Keywords	bispecific/trispecific, neutralization

Notes

Showing 1 of 1 note.

CH103/8ANC195: biNAbs (bispecific anti-Env neutralizing antibodies) with potent activity were constructed using an engineered IgG3 hinge domain to increase Fab flexibility necessary for hetero-bivalent binding to HIV-1 Env trimer since biNAbs with IgG1 hinges exhibited reduced neutralization potency compared to their parental bNAbs. While neutralization was generally improved, some combinations of bNAbs were synergistic in potency. Analysis of the neutralization activity of anti-gp120-gp41 interface/anti-CD4bs, 8ANC195/CH103, against a 7-cross-clade panel of tier 2/3 showed it exhibited highly inhibitory activity compared to its respective parental counterparts. Bournazos2016 (neutralization, bispecific/trispecific)

References

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Displaying record number 3678

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MAb ID	CH103/10E8
HXB2 Location	Env	Env Epitope Map
Author Location	gp120
Epitope
Ab Type	gp120 CD4BS, gp41 MPER (membrane proximal external region)
Neutralizing
Species (Isotype)	human(IgG1)
Patient
Immunogen	virus
Keywords	bispecific/trispecific, neutralization

Notes

Showing 1 of 1 note.

CH103/10E8: biNAbs (bispecific anti-Env neutralizing antibodies) with potent activity were constructed using an engineered IgG3 hinge domain to increase Fab flexibility necessary for hetero-bivalent binding to HIV-1 Env trimer since biNAbs with IgG1 hinges exhibited reduced neutralization potency compared to their parental bNAbs. While neutralization was generally improved, some combinations of bNAbs were synergistic in potency. Analysis of the neutralization activity of anti-CD4bs/anti-MPER combination, CH103/10E8, showed it had some synergistic neutralization activity compared to its respective parental counterparts. Bournazos2016 (neutralization, bispecific/trispecific)

References

Showing 1 of 1 reference.

Displaying record number 3679

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MAb ID	8ANC131/10E8
HXB2 Location	Env	Env Epitope Map
Author Location	gp120
Epitope
Ab Type	gp120 CD4BS, gp41 MPER (membrane proximal external region)
Neutralizing
Species (Isotype)	human(IgG1)
Patient
Immunogen	virus
Keywords	bispecific/trispecific, neutralization

Notes

Showing 1 of 1 note.

8ANC131/10E8: biNAbs (bispecific anti-Env neutralizing antibodies) with potent activity were constructed using an engineered IgG3 hinge domain to increase Fab flexibility necessary for hetero-bivalent binding to HIV-1 Env trimer since biNAbs with IgG1 hinges exhibited reduced neutralization potency compared to their parental bNAbs. While neutralization was generally improved, some combinations of bNAbs were synergistic in potency. Analysis of the neutralization activity of anti-CD4bs/anti-MPER combination, 8ANC131/10E8, showed it had about equal neutralization activity compared to its respective parental counterparts. Bournazos2016 (neutralization, bispecific/trispecific)

References

Showing 1 of 1 reference.

Displaying record number 3680

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MAb ID	CH103/3BC176
HXB2 Location	Env	Env Epitope Map
Author Location	gp120
Epitope
Ab Type	gp120 CD4BS, gp41-gp41 interface
Neutralizing
Species (Isotype)	human(IgG1)
Patient
Immunogen	virus
Keywords	bispecific/trispecific, neutralization

Notes

Showing 1 of 1 note.

CH103/3BC176: biNAbs (bispecific anti-Env neutralizing antibodies) with potent activity were constructed using an engineered IgG3 hinge domain to increase Fab flexibility necessary for hetero-bivalent binding to HIV-1 Env trimer since biNAbs with IgG1 hinges exhibited reduced neutralization potency compared to their parental bNAbs. While neutralization was generally improved, some combinations of bNAbs were synergistic in potency. Analysis of the neutralization activity of anti-CD4bs/anti-gp120/gp41 combination, CH103/3BC176, showed it had about equal neutralization activity compared to its respective parental counterparts. Bournazos2016 (neutralization, bispecific/trispecific)

References

Showing 1 of 1 reference.

Displaying record number 3681

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MAb ID	CH103/PGT151
HXB2 Location	Env	Env Epitope Map
Author Location	gp120
Epitope
Ab Type	gp120 CD4BS, fusion peptide // near gp41-gp120 interface
Neutralizing
Species (Isotype)	human(IgG1)
Patient
Immunogen	HIV-1 infection
Keywords	bispecific/trispecific, neutralization

Notes

Showing 1 of 1 note.

CH103/PGT151: biNAbs (bispecific anti-Env neutralizing antibodies) with potent activity were constructed using an engineered IgG3 hinge domain to increase Fab flexibility necessary for hetero-bivalent binding to HIV-1 Env trimer since biNAbs with IgG1 hinges exhibited reduced neutralization potency compared to their parental bNAbs. While neutralization was generally improved, some combinations of bNAbs were synergistic in potency. Analysis of the neutralization activity of anti-CD4bs/anti-fusion peptide combination, CH103/PGT151, showed it had mildly synergistic neutralization activity compared to its respective parental counterparts. Bournazos2016 (neutralization, bispecific/trispecific)

References

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Displaying record number 3682

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MAb ID	CH103/PGDM1400
HXB2 Location	Env	Env Epitope Map
Author Location	gp120
Epitope
Ab Type	gp120 CD4BS, gp120 V2 // V2 glycan(V2g) // V2 apex
Neutralizing
Species (Isotype)	human(IgG1)
Patient
Immunogen	virus
Keywords	bispecific/trispecific, neutralization

Notes

Showing 1 of 1 note.

CH103/PGDM1400: biNAbs (bispecific anti-Env neutralizing antibodies) with potent activity were constructed using an engineered IgG3 hinge domain to increase Fab flexibility necessary for hetero-bivalent binding to HIV-1 Env trimer since biNAbs with IgG1 hinges exhibited reduced neutralization potency compared to their parental bNAbs. While neutralization was generally improved, some combinations of bNAbs were synergistic in potency. Analysis of the neutralization activity of anti-CD4bs/anti-V1/V2 combination, CH103/PGDM1400, showed it had inhibitory neutralization activity compared to its respective parental counterparts. Bournazos2016 (neutralization, bispecific/trispecific)

References

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Displaying record number 3683

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MAb ID	CH103/PG16
HXB2 Location	Env	Env Epitope Map
Author Location	gp120
Epitope
Ab Type	gp120 CD4BS, gp120 V2 // V2 glycan(V2g) // V2 apex
Neutralizing
Species (Isotype)	human(IgG1)
Patient
Immunogen	virus
Keywords	bispecific/trispecific, neutralization

Notes

Showing 1 of 1 note.

CH103/PG16: biNAbs (bispecific anti-Env neutralizing antibodies) with potent activity were constructed using an engineered IgG3 hinge domain to increase Fab flexibility necessary for hetero-bivalent binding to HIV-1 Env trimer since biNAbs with IgG1 hinges exhibited reduced neutralization potency compared to their parental bNAbs. While neutralization was generally improved, some combinations of bNAbs were synergistic in potency. Analysis of the neutralization activity of anti-CD4bs/anti-V1/V2 combination, CH103/PG16, showed it had inhibitory neutralization activity compared to its respective parental counterparts. Bournazos2016 (neutralization, bispecific/trispecific)

References

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Displaying record number 3684

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MAb ID	CH103/PGT145
HXB2 Location	Env	Env Epitope Map
Author Location	gp120
Epitope
Ab Type	gp120 CD4BS, gp120 V2 // V2 glycan(V2g) // V2 apex
Neutralizing
Species (Isotype)	human(IgG1)
Patient
Immunogen	virus
Keywords	bispecific/trispecific, neutralization

Notes

Showing 1 of 1 note.

CH103/PGT145: biNAbs (bispecific anti-Env neutralizing antibodies) with potent activity were constructed using an engineered IgG3 hinge domain to increase Fab flexibility necessary for hetero-bivalent binding to HIV-1 Env trimer since biNAbs with IgG1 hinges exhibited reduced neutralization potency compared to their parental bNAbs. While neutralization was generally improved, some combinations of bNAbs were synergistic in potency. Analysis of the neutralization activity of anti-CD4bs/anti-V1/V2 combination, CH103/PGT145, showed it had mildly synergistic neutralization activity compared to its respective parental counterparts. Bournazos2016 (neutralization, bispecific/trispecific)

References

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Displaying record number 3685

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MAb ID	CH103/PGT135
HXB2 Location	Env	Env Epitope Map
Author Location	gp120
Epitope
Ab Type	gp120 CD4BS, gp120 V3 // V3 glycan (V3g)
Neutralizing
Species (Isotype)	human(IgG1)
Patient
Immunogen	virus
Keywords	bispecific/trispecific, neutralization

Notes

Showing 1 of 1 note.

CH103/PGT135: biNAbs (bispecific anti-Env neutralizing antibodies) with potent activity were constructed using an engineered IgG3 hinge domain to increase Fab flexibility necessary for hetero-bivalent binding to HIV-1 Env trimer since biNAbs with IgG1 hinges exhibited reduced neutralization potency compared to their parental bNAbs. While neutralization was generally improved, some combinations of bNAbs were synergistic in potency. Analysis of the neutralization activity of anti-CD4bs/anti-V3 combination, CH103/PGT135, showed it had higher, synergistic neutralization activity compared to its respective parental counterparts. Bournazos2016 (neutralization, bispecific/trispecific)

References

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Displaying record number 3686

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MAb ID	CH103/PGT128
HXB2 Location	Env	Env Epitope Map
Author Location	gp120
Epitope
Ab Type	gp120 CD4BS, gp120 V3 // V3 glycan (V3g)
Neutralizing
Species (Isotype)	human(IgG1)
Patient
Immunogen	virus
Keywords	bispecific/trispecific, neutralization

Notes

Showing 1 of 1 note.

CH103/PGT128: biNAbs (bispecific anti-Env neutralizing antibodies) with potent activity were constructed using an engineered IgG3 hinge domain to increase Fab flexibility necessary for hetero-bivalent binding to HIV-1 Env trimer since biNAbs with IgG1 hinges exhibited reduced neutralization potency compared to their parental bNAbs. While neutralization was generally improved, some combinations of bNAbs were synergistic in potency. Analysis of the neutralization activity of anti-CD4bs/anti-V3 combination, CH103/PGT128, showed it had mildly inhibitory activity compared to its respective parental counterparts. Bournazos2016 (neutralization, bispecific/trispecific)

References

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Displaying record number 3687

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MAb ID	CH103/PGT121
HXB2 Location	Env	Env Epitope Map
Author Location	gp120
Epitope
Ab Type	gp120 CD4BS, gp120 V3 // V3 glycan (V3g)
Neutralizing
Species (Isotype)	human(IgG1)
Patient
Immunogen	virus
Keywords	bispecific/trispecific, neutralization

Notes

Showing 1 of 1 note.

CH103/PGT121: biNAbs (bispecific anti-Env neutralizing antibodies) with potent activity were constructed using an engineered IgG3 hinge domain to increase Fab flexibility necessary for hetero-bivalent binding to HIV-1 Env trimer since biNAbs with IgG1 hinges exhibited reduced neutralization potency compared to their parental bNAbs. While neutralization was generally improved, some combinations of bNAbs were synergistic in potency. Analysis of the neutralization activity of anti-CD4bs/anti-V3 combination, CH103/PGT121, showed it had strongly inhibitory activity compared to its respective parental counterparts. Bournazos2016 (neutralization, bispecific/trispecific)

References

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Displaying record number 3688

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MAb ID	10-1074/PGT145
HXB2 Location	Env	Env Epitope Map
Author Location	gp120
Epitope
Ab Type	gp120 V2 // V2 glycan(V2g) // V2 apex, gp120 V3 // V3 glycan (V3g)
Neutralizing
Species (Isotype)	human(IgG1)
Patient
Immunogen	virus
Keywords	bispecific/trispecific, neutralization

Notes

Showing 1 of 1 note.

10-1074/PGT145: biNAbs (bispecific anti-Env neutralizing antibodies) with potent activity were constructed using an engineered IgG3 hinge domain to increase Fab flexibility necessary for hetero-bivalent binding to HIV-1 Env trimer since biNAbs with IgG1 hinges exhibited reduced neutralization potency compared to their parental bNAbs. While neutralization was generally improved, some combinations of bNAbs were synergistic in potency. Analysis of the neutralization activity of anti-V3/anti-V1/V2 combination, 10-1074/PGT145, showed it had inhibitory activity compared to its respective parental counterparts. Bournazos2016 (neutralization, bispecific/trispecific)

References

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Displaying record number 3689

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MAb ID	10-1074/PGDM1400
HXB2 Location	Env	Env Epitope Map
Author Location	gp120
Epitope
Ab Type	gp120 V2 // V2 glycan(V2g) // V2 apex, gp120 V3 // V3 glycan (V3g)
Neutralizing
Species (Isotype)	human(IgG1)
Patient
Immunogen	virus
Keywords	bispecific/trispecific, neutralization

Notes

Showing 1 of 1 note.

10-1074/PGDM1400: biNAbs (bispecific anti-Env neutralizing antibodies) with potent activity were constructed using an engineered IgG3 hinge domain to increase Fab flexibility necessary for hetero-bivalent binding to HIV-1 Env trimer since biNAbs with IgG1 hinges exhibited reduced neutralization potency compared to their parental bNAbs. While neutralization was generally improved, some combinations of bNAbs were synergistic in potency. Analysis of the neutralization activity of anti-V3/anti-V1/V2 combination, 10-1074/PGDM1400, showed it had inhibitory activity compared to its respective parental counterparts. Bournazos2016 (neutralization, bispecific/trispecific)

References

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Displaying record number 3690

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MAb ID	10-1074/3BC176
HXB2 Location	Env	Env Epitope Map
Author Location	gp120
Epitope
Ab Type	gp120 V3 // V3 glycan (V3g), gp41-gp41 interface
Neutralizing
Species (Isotype)	human(IgG1)
Patient
Immunogen	virus
Keywords	bispecific/trispecific, neutralization

Notes

Showing 1 of 1 note.

10-1074/3BC176: biNAbs (bispecific anti-Env neutralizing antibodies) with potent activity were constructed using an engineered IgG3 hinge domain to increase Fab flexibility necessary for hetero-bivalent binding to HIV-1 Env trimer since biNAbs with IgG1 hinges exhibited reduced neutralization potency compared to their parental bNAbs. While neutralization was generally improved, some combinations of bNAbs were synergistic in potency. Analysis of the neutralization activity of anti-V3/anti-pg120/gp41 combination, 10-1074/3BC176, showed it had inhibitory activity compared to its respective parental counterparts. Bournazos2016 (neutralization, bispecific/trispecific)

References

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Displaying record number 3691

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MAb ID	10-1074/10E8
HXB2 Location	Env	Env Epitope Map
Author Location	gp120
Epitope
Ab Type	gp120 V3 // V3 glycan (V3g), gp41 MPER (membrane proximal external region)
Neutralizing
Species (Isotype)	human(IgG1)
Patient
Immunogen	virus
Keywords	bispecific/trispecific, neutralization

Notes

Showing 1 of 1 note.

10-1074/10E8: biNAbs (bispecific anti-Env neutralizing antibodies) with potent activity were constructed using an engineered IgG3 hinge domain to increase Fab flexibility necessary for hetero-bivalent binding to HIV-1 Env trimer since biNAbs with IgG1 hinges exhibited reduced neutralization potency compared to their parental bNAbs. While neutralization was generally improved, some combinations of bNAbs were synergistic in potency. Analysis of the neutralization activity of anti-V3/anti-MPER combination, 10-1074/10E8, showed it had strongly inhibitory activity compared to its respective parental counterparts. Bournazos2016 (neutralization, bispecific/trispecific)

References

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Displaying record number 3692

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MAb ID	PGT121/PGT145
HXB2 Location	Env	Env Epitope Map
Author Location	gp120
Epitope
Ab Type	gp120 V2 // V2 glycan(V2g) // V2 apex, gp120 V3 // V3 glycan (V3g)
Neutralizing
Species (Isotype)	human(IgG1)
Patient
Immunogen	virus
Keywords	bispecific/trispecific, neutralization

Notes

Showing 1 of 1 note.

PGT121/PGT145: biNAbs (bispecific anti-Env neutralizing antibodies) with potent activity were constructed using an engineered IgG3 hinge domain to increase Fab flexibility necessary for hetero-bivalent binding to HIV-1 Env trimer since biNAbs with IgG1 hinges exhibited reduced neutralization potency compared to their parental bNAbs. While neutralization was generally improved, some combinations of bNAbs were synergistic in potency. Analysis of the neutralization activity of anti-V3/anti-V1/V2 combination, PGT121/PGT145, showed it had strongly inhibitory activity compared to its respective parental counterparts. Bournazos2016 (neutralization, bispecific/trispecific)

References

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Displaying record number 3694

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MAb ID	PGT121/PGDM1400
HXB2 Location	Env	Env Epitope Map
Author Location	gp120
Epitope
Ab Type	gp120 V2 // V2 glycan(V2g) // V2 apex, gp120 V3 // V3 glycan (V3g)
Neutralizing
Species (Isotype)	human(IgG1)
Patient
Immunogen	virus
Keywords	bispecific/trispecific, neutralization

Notes

Showing 1 of 1 note.

PGT121/PGDM1400: biNAbs (bispecific anti-Env neutralizing antibodies) with potent activity were constructed using an engineered IgG3 hinge domain to increase Fab flexibility necessary for hetero-bivalent binding to HIV-1 Env trimer since biNAbs with IgG1 hinges exhibited reduced neutralization potency compared to their parental bNAbs. While neutralization was generally improved, some combinations of bNAbs were synergistic in potency. Analysis of the neutralization activity of anti-V3/anti-V1/V2 combination, PGT121/PGDM1400, showed it had inhibitory activity compared to its respective parental counterparts. Bournazos2016 (neutralization, bispecific/trispecific)

References

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Displaying record number 3695

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MAb ID	PGT121/PGT151
HXB2 Location	Env	Env Epitope Map
Author Location	gp120
Epitope
Ab Type	gp120 V3 // V3 glycan (V3g), fusion peptide // near gp41-gp120 interface
Neutralizing
Species (Isotype)	human(IgG1)
Patient
Immunogen	virus
Keywords	bispecific/trispecific, neutralization

Notes

Showing 1 of 1 note.

PGT121/PGT151: biNAbs (bispecific anti-Env neutralizing antibodies) with potent activity were constructed using an engineered IgG3 hinge domain to increase Fab flexibility necessary for hetero-bivalent binding to HIV-1 Env trimer since biNAbs with IgG1 hinges exhibited reduced neutralization potency compared to their parental bNAbs. While neutralization was generally improved, some combinations of bNAbs were synergistic in potency. Analysis of the neutralization activity of anti-V3/anti-fusion peptide, PGT121/PGT151, showed it had strong synergistic activity compared to its respective parental counterparts. Bournazos2016 (neutralization, bispecific/trispecific)

References

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Displaying record number 3696

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MAb ID	PGT121/10E8
HXB2 Location	Env	Env Epitope Map
Author Location	gp120
Epitope
Ab Type	gp120 V3 // V3 glycan (V3g), gp41 MPER (membrane proximal external region)
Neutralizing
Species (Isotype)	human(IgG1)
Patient
Immunogen	virus
Keywords	bispecific/trispecific, neutralization

Notes

Showing 1 of 1 note.

PGT121/10E8: biNAbs (bispecific anti-Env neutralizing antibodies) with potent activity were constructed using an engineered IgG3 hinge domain to increase Fab flexibility necessary for hetero-bivalent binding to HIV-1 Env trimer since biNAbs with IgG1 hinges exhibited reduced neutralization potency compared to their parental bNAbs. While neutralization was generally improved, some combinations of bNAbs were synergistic in potency. Analysis of the neutralization activity of anti-V3/anti-MPER combination, PGT121/10E8, showed it had synergistic activity compared to its respective parental counterparts. Bournazos2016 (neutralization, bispecific/trispecific)

References

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Displaying record number 3697

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MAb ID	PGT128/10E8
HXB2 Location	Env	Env Epitope Map
Author Location	gp120
Epitope
Ab Type	gp120 V3 // V3 glycan (V3g), gp41 MPER (membrane proximal external region)
Neutralizing
Species (Isotype)	human(IgG1)
Patient
Immunogen	virus
Keywords	bispecific/trispecific, neutralization

Notes

Showing 1 of 1 note.

PGT128/10E8: biNAbs (bispecific anti-Env neutralizing antibodies) with potent activity were constructed using an engineered IgG3 hinge domain to increase Fab flexibility necessary for hetero-bivalent binding to HIV-1 Env trimer since biNAbs with IgG1 hinges exhibited reduced neutralization potency compared to their parental bNAbs. While neutralization was generally improved, some combinations of bNAbs were synergistic in potency. Analysis of the neutralization activity of anti-V3/anti-MPER combination, PGT128/10E8, showed it had inhibitory activity compared to its respective parental counterparts. Bournazos2016 (neutralization, bispecific/trispecific)

References

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Displaying record number 3698

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MAb ID	PGT128/3BC176
HXB2 Location	Env	Env Epitope Map
Author Location	gp120
Epitope
Ab Type	gp120 V3 // V3 glycan (V3g), gp41-gp41 interface
Neutralizing
Species (Isotype)	human(IgG1)
Patient
Immunogen	virus
Keywords	bispecific/trispecific, neutralization

Notes

Showing 1 of 1 note.

PGT128/3BC176: biNAbs (bispecific anti-Env neutralizing antibodies) with potent activity were constructed using an engineered IgG3 hinge domain to increase Fab flexibility necessary for hetero-bivalent binding to HIV-1 Env trimer since biNAbs with IgG1 hinges exhibited reduced neutralization potency compared to their parental bNAbs. While neutralization was generally improved, some combinations of bNAbs were synergistic in potency. Analysis of the neutralization activity of anti-V3/anti-gp120/gp41 combination, PGT128/3BC176, showed it had about equal activity compared to its respective parental counterparts. Bournazos2016 (neutralization, bispecific/trispecific)

References

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Displaying record number 3699

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MAb ID	PGT128/PGT151
HXB2 Location	Env	Env Epitope Map
Author Location	gp120
Epitope
Ab Type	gp120 V3 // V3 glycan (V3g), fusion peptide // near gp41-gp120 interface
Neutralizing
Species (Isotype)	human(IgG1)
Patient
Immunogen	virus
Keywords	bispecific/trispecific, neutralization

Notes

Showing 1 of 1 note.

PGT128/PGT151: biNAbs (bispecific anti-Env neutralizing antibodies) with potent activity were constructed using an engineered IgG3 hinge domain to increase Fab flexibility necessary for hetero-bivalent binding to HIV-1 Env trimer since biNAbs with IgG1 hinges exhibited reduced neutralization potency compared to their parental bNAbs. While neutralization was generally improved, some combinations of bNAbs were synergistic in potency. Analysis of the neutralization activity of anti-V3/anti-fusion peptide combination, PGT128/PGT151, showed it had synergistic neutralization activity compared to its respective parental counterparts. Bournazos2016 (neutralization, bispecific/trispecific)

References

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Displaying record number 3700

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MAb ID	PGT128/PGDM1400
HXB2 Location	Env	Env Epitope Map
Author Location	gp120
Epitope
Ab Type	gp120 V2 // V2 glycan(V2g) // V2 apex, gp120 V3 // V3 glycan (V3g)
Neutralizing
Species (Isotype)	human(IgG1)
Patient
Immunogen	virus
Keywords	bispecific/trispecific, neutralization

Notes

Showing 1 of 1 note.

PGT128/PGDM1400: biNAbs (bispecific anti-Env neutralizing antibodies) with potent activity were constructed using an engineered IgG3 hinge domain to increase Fab flexibility necessary for hetero-bivalent binding to HIV-1 Env trimer since biNAbs with IgG1 hinges exhibited reduced neutralization potency compared to their parental bNAbs. While neutralization was generally improved, some combinations of bNAbs were synergistic in potency. Analysis of the neutralization activity of anti-V3/anti-V1/V2 combination, PGT128/PGDM1400, showed it had about equal neutralization activity compared to its respective parental counterparts. Bournazos2016 (neutralization, bispecific/trispecific)

References

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Displaying record number 3701

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MAb ID	PGT128/PGT145
HXB2 Location	Env	Env Epitope Map
Author Location	gp120
Epitope
Ab Type	gp120 V2 // V2 glycan(V2g) // V2 apex, gp120 V3 // V3 glycan (V3g)
Neutralizing
Species (Isotype)	human(IgG1)
Patient
Immunogen	virus
Keywords	bispecific/trispecific, neutralization

Notes

Showing 1 of 1 note.

PGT128/PGT145: biNAbs (bispecific anti-Env neutralizing antibodies) with potent activity were constructed using an engineered IgG3 hinge domain to increase Fab flexibility necessary for hetero-bivalent binding to HIV-1 Env trimer since biNAbs with IgG1 hinges exhibited reduced neutralization potency compared to their parental bNAbs. While neutralization was generally improved, some combinations of bNAbs were synergistic in potency. Analysis of the neutralization activity of anti-V3/anti-V1/V2 combination, PGT128/PGT145, showed it had about equal neutralization activity compared to its respective parental counterparts. Bournazos2016 (neutralization, bispecific/trispecific)

References

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Displaying record number 3702

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MAb ID	PGT135/PGT145
HXB2 Location	Env	Env Epitope Map
Author Location	gp120
Epitope
Ab Type	gp120 V2 // V2 glycan(V2g) // V2 apex, gp120 V3 // V3 glycan (V3g)
Neutralizing
Species (Isotype)	human(IgG1)
Patient
Immunogen	virus
Keywords	bispecific/trispecific, neutralization

Notes

Showing 1 of 1 note.

PGT135/PGT145: biNAbs (bispecific anti-Env neutralizing antibodies) with potent activity were constructed using an engineered IgG3 hinge domain to increase Fab flexibility necessary for hetero-bivalent binding to HIV-1 Env trimer since biNAbs with IgG1 hinges exhibited reduced neutralization potency compared to their parental bNAbs. While neutralization was generally improved, some combinations of bNAbs were synergistic in potency. Analysis of the neutralization activity of anti-V3/anti-V1/V2 combination, PGT128/PGT145, showed it had synergistic neutralization activity compared to its respective parental counterparts. Bournazos2016 (neutralization, bispecific/trispecific)

References

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Displaying record number 3703

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MAb ID	PGT135/PGDM1400
HXB2 Location	Env	Env Epitope Map
Author Location	gp120
Epitope
Ab Type	gp120 V2 // V2 glycan(V2g) // V2 apex, gp120 V3 // V3 glycan (V3g)
Neutralizing
Species (Isotype)	human(IgG1)
Patient
Immunogen	virus
Keywords	bispecific/trispecific, neutralization

Notes

Showing 1 of 1 note.

PGT135/PGDM1400: biNAbs (bispecific anti-Env neutralizing antibodies) with potent activity were constructed using an engineered IgG3 hinge domain to increase Fab flexibility necessary for hetero-bivalent binding to HIV-1 Env trimer since biNAbs with IgG1 hinges exhibited reduced neutralization potency compared to their parental bNAbs. While neutralization was generally improved, some combinations of bNAbs were synergistic in potency. Analysis of the neutralization activity of anti-V3/anti-V1/V2 combination, PGT128/PGDM1400, showed it had synergistic neutralization activity compared to its respective parental counterparts. Bournazos2016 (neutralization, bispecific/trispecific)

References

Showing 1 of 1 reference.

Displaying record number 3704

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MAb ID	PGT135/PGT151
HXB2 Location	Env	Env Epitope Map
Author Location	gp120
Epitope
Ab Type	gp120 V3 // V3 glycan (V3g), fusion peptide // near gp41-gp120 interface
Neutralizing
Species (Isotype)	human(IgG1)
Patient
Immunogen	virus
Keywords	bispecific/trispecific, neutralization

Notes

Showing 1 of 1 note.

PGT135/PGT151: biNAbs (bispecific anti-Env neutralizing antibodies) with potent activity were constructed using an engineered IgG3 hinge domain to increase Fab flexibility necessary for hetero-bivalent binding to HIV-1 Env trimer since biNAbs with IgG1 hinges exhibited reduced neutralization potency compared to their parental bNAbs. While neutralization was generally improved, some combinations of bNAbs were synergistic in potency. Analysis of the neutralization activity of anti-V3/anti-fusion peptide combination, PGT128/PGT151, showed it had strongly synergistic neutralization activity compared to its respective parental counterparts. Bournazos2016 (neutralization, bispecific/trispecific)

References

Showing 1 of 1 reference.

Displaying record number 3705

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MAb ID	PGT135/3BC176
HXB2 Location	Env	Env Epitope Map
Author Location	gp120
Epitope
Ab Type	gp120 V3 // V3 glycan (V3g), gp41-gp41 interface
Neutralizing
Species (Isotype)	human(IgG1)
Patient
Immunogen	virus
Keywords	bispecific/trispecific, neutralization

Notes

Showing 1 of 1 note.

PGT135/3BC176: biNAbs (bispecific anti-Env neutralizing antibodies) with potent activity were constructed using an engineered IgG3 hinge domain to increase Fab flexibility necessary for hetero-bivalent binding to HIV-1 Env trimer since biNAbs with IgG1 hinges exhibited reduced neutralization potency compared to their parental bNAbs. While neutralization was generally improved, some combinations of bNAbs were synergistic in potency. Analysis of the neutralization activity of anti-V3/anti-gp120/gp41 combination, PGT128/3BC176, showed it had lower, inhibitory neutralization activity compared to its respective parental counterparts. Bournazos2016 (neutralization, bispecific/trispecific)

References

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Displaying record number 3706

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MAb ID	PGT135/10E8
HXB2 Location	Env	Env Epitope Map
Author Location	gp120
Epitope
Ab Type	gp120 V3 // V3 glycan (V3g), gp41 MPER (membrane proximal external region)
Neutralizing
Species (Isotype)	human(IgG1)
Patient
Immunogen	virus
Keywords	bispecific/trispecific, neutralization

Notes

Showing 1 of 1 note.

PGT135/10E8: biNAbs (bispecific anti-Env neutralizing antibodies) with potent activity were constructed using an engineered IgG3 hinge domain to increase Fab flexibility necessary for hetero-bivalent binding to HIV-1 Env trimer since biNAbs with IgG1 hinges exhibited reduced neutralization potency compared to their parental bNAbs. While neutralization was generally improved, some combinations of bNAbs were synergistic in potency. Analysis of the neutralization activity of anti-V3/anti-MPER combination, PGT128/10E8, showed it had synergistic neutralization activity compared to its respective parental counterparts. Bournazos2016 (neutralization, bispecific/trispecific)

References

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Displaying record number 3707

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MAb ID	PGT151/10E8
HXB2 Location	Env	Env Epitope Map
Author Location	gp120
Epitope
Ab Type	gp41 MPER (membrane proximal external region), fusion peptide // near gp41-gp120 interface
Neutralizing
Species (Isotype)	human(IgG1)
Patient
Immunogen	virus
Keywords	bispecific/trispecific, neutralization

Notes

Showing 1 of 1 note.

PGT151/10E8: biNAbs (bispecific anti-Env neutralizing antibodies) with potent activity were constructed using an engineered IgG3 hinge domain to increase Fab flexibility necessary for hetero-bivalent binding to HIV-1 Env trimer since biNAbs with IgG1 hinges exhibited reduced neutralization potency compared to their parental bNAbs. While neutralization was generally improved, some combinations of bNAbs were synergistic in potency. Analysis of the neutralization activity of anti-fusion peptide/anti-MPER combination, PGT151/10E8, showed it had strongly synergistic neutralization activity compared to its respective parental counterparts. Bournazos2016 (neutralization, bispecific/trispecific)

References

Showing 1 of 1 reference.

Displaying record number 3708

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MAb ID	PGT151/3BC176
HXB2 Location	Env	Env Epitope Map
Author Location	gp120
Epitope
Ab Type	fusion peptide // near gp41-gp120 interface, gp41-gp41 interface
Neutralizing
Species (Isotype)	human(IgG1)
Patient
Immunogen	virus
Keywords	bispecific/trispecific, neutralization

Notes

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PGT151/3BC176: biNAbs (bispecific anti-Env neutralizing antibodies) with potent activity were constructed using an engineered IgG3 hinge domain to increase Fab flexibility necessary for hetero-bivalent binding to HIV-1 Env trimer since biNAbs with IgG1 hinges exhibited reduced neutralization potency compared to their parental bNAbs. While neutralization was generally improved, some combinations of bNAbs were synergistic in potency. Analysis of the neutralization activity of anti-fusion peptide/anti-CD4bs combination, PGT151/3BC176, showed it had about equal neutralization activity as its respective parental counterparts. Bournazos2016 (neutralization, bispecific/trispecific)

References

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Displaying record number 3709

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MAb ID	PGT151/PGDM1400
HXB2 Location	Env	Env Epitope Map
Author Location	gp120
Epitope
Ab Type	gp120 V2 // V2 glycan(V2g) // V2 apex, fusion peptide // near gp41-gp120 interface
Neutralizing
Species (Isotype)	human(IgG1)
Patient
Immunogen	virus
Keywords	bispecific/trispecific, neutralization

Notes

Showing 1 of 1 note.

PGT151/PGDM1400: biNAbs (bispecific anti-Env neutralizing antibodies) with potent activity were constructed using an engineered IgG3 hinge domain to increase Fab flexibility necessary for hetero-bivalent binding to HIV-1 Env trimer since biNAbs with IgG1 hinges exhibited reduced neutralization potency compared to their parental bNAbs. While neutralization was generally improved, some combinations of bNAbs were synergistic in potency. Analysis of the neutralization activity of anti-fusion peptide/anti-V2glycan apex combination, PGT151/PGDM1400, showed it had mildly synergistic neutralization activity compared to its respective parental counterparts. Bournazos2016 (neutralization, bispecific/trispecific)

References

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Displaying record number 3710

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MAb ID	PGT151/PGT145
HXB2 Location	Env	Env Epitope Map
Author Location	gp120
Epitope
Ab Type	gp120 V2 // V2 glycan(V2g) // V2 apex, fusion peptide // near gp41-gp120 interface
Neutralizing
Species (Isotype)	human(IgG1)
Patient
Immunogen	virus
Keywords	bispecific/trispecific, neutralization

Notes

Showing 1 of 1 note.

PGT151/PGT145: biNAbs (bispecific anti-Env neutralizing antibodies) with potent activity were constructed using an engineered IgG3 hinge domain to increase Fab flexibility necessary for hetero-bivalent binding to HIV-1 Env trimer since biNAbs with IgG1 hinges exhibited reduced neutralization potency compared to their parental bNAbs. While neutralization was generally improved, some combinations of bNAbs were synergistic in potency. Analysis of the neutralization activity of anti-fusion peptide/anti-V2glycan apex combination, PGT151/PGT145, showed it had strongly synergistic neutralization activity compared to its respective parental counterparts. Bournazos2016 (neutralization, bispecific/trispecific)

References

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Displaying record number 3711

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MAb ID	PGT151/PG16
HXB2 Location	Env	Env Epitope Map
Author Location	gp120
Epitope
Ab Type	gp120 V2 // V2 glycan(V2g) // V2 apex, fusion peptide // near gp41-gp120 interface
Neutralizing
Species (Isotype)	human(IgG1)
Patient
Immunogen	virus
Keywords	bispecific/trispecific, neutralization

Notes

Showing 1 of 1 note.

PGT151/PG16: biNAbs (bispecific anti-Env neutralizing antibodies) with potent activity were constructed using an engineered IgG3 hinge domain to increase Fab flexibility necessary for hetero-bivalent binding to HIV-1 Env trimer since biNAbs with IgG1 hinges exhibited reduced neutralization potency compared to their parental bNAbs. While neutralization was generally improved, some combinations of bNAbs were synergistic in potency. Analysis of the neutralization activity of anti-fusion peptide/anti-V2glycan apex combination, PGT151/PG16, showed it had synergistic neutralization activity compared to its respective parental counterparts. Bournazos2016 (neutralization, bispecific/trispecific)

References

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Displaying record number 3712

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MAb ID	3BC176/PG16
HXB2 Location	Env	Env Epitope Map
Author Location	gp120
Epitope
Ab Type	gp120 V2 // V2 glycan(V2g) // V2 apex, gp41-gp41 interface
Neutralizing
Species (Isotype)	human(IgG1)
Patient
Immunogen	virus
Keywords	bispecific/trispecific, neutralization

Notes

Showing 1 of 1 note.

3BC176/PG16: biNAbs (bispecific anti-Env neutralizing antibodies) with potent activity were constructed using an engineered IgG3 hinge domain to increase Fab flexibility necessary for hetero-bivalent binding to HIV-1 Env trimer since biNAbs with IgG1 hinges exhibited reduced neutralization potency compared to their parental bNAbs. While neutralization was generally improved, some combinations of bNAbs were synergistic in potency. Analysis of the neutralization activity of anti-gp120/gp41/anti-V1/V2 combination, 3BC176/PG16, showed it had about equal neutralization activity compared to its respective parental counterparts. Bournazos2016 (neutralization, bispecific/trispecific)

References

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Displaying record number 3713

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MAb ID	3BC176/PGT145
HXB2 Location	Env	Env Epitope Map
Author Location	gp120
Epitope
Ab Type	gp120 V2 // V2 glycan(V2g) // V2 apex, gp41-gp41 interface
Neutralizing
Species (Isotype)	human(IgG1)
Patient
Immunogen	virus
Keywords	bispecific/trispecific, neutralization

Notes

Showing 1 of 1 note.

3BC176/PGT145: biNAbs (bispecific anti-Env neutralizing antibodies) with potent activity were constructed using an engineered IgG3 hinge domain to increase Fab flexibility necessary for hetero-bivalent binding to HIV-1 Env trimer since biNAbs with IgG1 hinges exhibited reduced neutralization potency compared to their parental bNAbs. While neutralization was generally improved, some combinations of bNAbs were synergistic in potency. Analysis of the neutralization activity of anti-gp120/gp41/anti-V1/V2 combination, 3BC176/PGT145, showed it had about equal neutralization activity compared to its respective parental counterparts. Bournazos2016 (neutralization, bispecific/trispecific)

References

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Displaying record number 3714

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MAb ID	3BC176/PGDM1400
HXB2 Location	Env	Env Epitope Map
Author Location	gp120
Epitope
Ab Type	gp41 MPER (membrane proximal external region), gp41-gp41 interface
Neutralizing
Species (Isotype)	human(IgG1)
Patient
Immunogen	virus
Keywords	bispecific/trispecific, neutralization

Notes

Showing 1 of 1 note.

3BC176/PGDM1400: biNAbs (bispecific anti-Env neutralizing antibodies) with potent activity were constructed using an engineered IgG3 hinge domain to increase Fab flexibility necessary for hetero-bivalent binding to HIV-1 Env trimer since biNAbs with IgG1 hinges exhibited reduced neutralization potency compared to their parental bNAbs. While neutralization was generally improved, some combinations of bNAbs were synergistic in potency. Analysis of the neutralization activity of anti-gp120/gp41/anti-V1/V2 combination, 3BC176/PGDM1400, showed it had about equal neutralization activity compared to its respective parental counterparts. Bournazos2016 (neutralization, bispecific/trispecific)

References

Showing 1 of 1 reference.

Displaying record number 3715

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MAb ID	10E8/PGDM1400
HXB2 Location	Env	Env Epitope Map
Author Location	gp120
Epitope
Ab Type	gp120 V2 // V2 glycan(V2g) // V2 apex, gp41 MPER (membrane proximal external region)
Neutralizing
Species (Isotype)	human(IgG1)
Patient
Immunogen	virus
Keywords	bispecific/trispecific, neutralization

Notes

Showing 1 of 1 note.

10E8/PGDM1400: biNAbs (bispecific anti-Env neutralizing antibodies) with potent activity were constructed using an engineered IgG3 hinge domain to increase Fab flexibility necessary for hetero-bivalent binding to HIV-1 Env trimer since biNAbs with IgG1 hinges exhibited reduced neutralization potency compared to their parental bNAbs. While neutralization was generally improved, some combinations of bNAbs were synergistic in potency. Analysis of the neutralization activity of anti-MPER/anti-V1/V2 combination, 10E8/PGDM1400, showed it had synergistic neutralization activity compared to its respective parental counterparts. Bournazos2016 (neutralization, bispecific/trispecific)

References

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Displaying record number 3716

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MAb ID	10E8/PGT145
HXB2 Location	Env	Env Epitope Map
Author Location	gp120
Epitope
Ab Type	gp120 V2 // V2 glycan(V2g) // V2 apex, gp41 MPER (membrane proximal external region)
Neutralizing
Species (Isotype)	human(IgG1)
Patient
Immunogen	virus
Keywords	bispecific/trispecific, neutralization

Notes

Showing 1 of 1 note.

10E8/PGT145: biNAbs (bispecific anti-Env neutralizing antibodies) with potent activity were constructed using an engineered IgG3 hinge domain to increase Fab flexibility necessary for hetero-bivalent binding to HIV-1 Env trimer since biNAbs with IgG1 hinges exhibited reduced neutralization potency compared to their parental bNAbs. While neutralization was generally improved, some combinations of bNAbs were synergistic in potency. Analysis of the neutralization activity of anti-MPER/anti-V1/V2 combination, 10E8/PGT145, showed it had synergistic neutralization activity compared to its respective parental counterparts. Bournazos2016 (neutralization, bispecific/trispecific)

References

Showing 1 of 1 reference.

Displaying record number 3717

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MAb ID	10E8/PG16
HXB2 Location	Env	Env Epitope Map
Author Location	gp120
Epitope
Ab Type	gp120 V2 // V2 glycan(V2g) // V2 apex, gp41 MPER (membrane proximal external region)
Neutralizing
Species (Isotype)	human(IgG1)
Patient
Immunogen	virus
Keywords	bispecific/trispecific, neutralization

Notes

Showing 1 of 1 note.

10E8/PG16: biNAbs (bispecific anti-Env neutralizing antibodies) with potent activity were constructed using an engineered IgG3 hinge domain to increase Fab flexibility necessary for hetero-bivalent binding to HIV-1 Env trimer since biNAbs with IgG1 hinges exhibited reduced neutralization potency compared to their parental bNAbs. While neutralization was generally improved, some combinations of bNAbs were synergistic in potency. Analysis of the neutralization activity of anti-MPER/anti-V1/V2 combination, 10E8/PG16, showed it had synergistic neutralization activity compared to its respective parental counterparts. Bournazos2016 (neutralization, bispecific/trispecific)

References

Showing 1 of 1 reference.

Displaying record number 3718

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MAb ID	10E8/3BC176
HXB2 Location	Env	Env Epitope Map
Author Location	gp120
Epitope
Ab Type	gp41 MPER (membrane proximal external region), gp41-gp41 interface
Neutralizing
Species (Isotype)	human(IgG1)
Patient
Immunogen	virus
Keywords	bispecific/trispecific, neutralization

Notes

Showing 1 of 1 note.

10E8/3BC176: biNAbs (bispecific anti-Env neutralizing antibodies) with potent activity were constructed using an engineered IgG3 hinge domain to increase Fab flexibility necessary for hetero-bivalent binding to HIV-1 Env trimer since biNAbs with IgG1 hinges exhibited reduced neutralization potency compared to their parental bNAbs. While neutralization was generally improved, some combinations of bNAbs were synergistic in potency. Analysis of the neutralization activity of anti-MPER/anti-gp120/gp41 combination, 10E8/3BC176, showed it had inhibitory effect on neutralization activity compared to its respective parental counterparts. Bournazos2016 (neutralization, bispecific/trispecific)

References

Showing 1 of 1 reference.