HIV molecular immunology database

 

Search Antibody Database

Found 12 matching records:

Displaying record number 218

Download this epitope record as JSON.

MAb ID 17 (mAb17)
HXB2 Location Pol(740-750)
DNA(4302..4334)
Pol Epitope Map
Author Location Integrase(25-35)
Epitope DFNLPPVVAKE Epitope Alignment
DFNLPPVVAKE epitope logo
Ab Type  
Neutralizing  
Species (Isotype) mouse(IgG1)
Patient  
Immunogen vaccine
Keywords review

Vaccine Details

Vaccine type protein
Vaccine component Int

Notes

Showing 4 of 4 notes.

References

Showing 4 of 4 references.

Bizub-Bender1994 D. Bizub-Bender, J. Kulkosky, and A. M. Skalka. Monoclonal Antibodies against HIV Type 1 Integrase: Clues to Molecular Structure. AIDS Res. Hum. Retroviruses, 10:1105-1115, 1994. PubMed ID: 7530024. Show all entries for this paper.

Levy-Mintz1996 P. Levy-Mintz, L. Duan, H. Zhang, B. Hu, G. Dornadula, M. Zhu, J. Kulkosky, D. Bizub-Bender, A. M. Skalka, and R. J. Pomerantz. Intracellular Expression of Single-Chain Variable Fragments to Inhibit Early Stages of the Viral Life Cycle by Targeting Human Immunodeficiency Virus Type 1 Integrase. J. Virol., 70:8821-8832, 1996. Comments in J Virol 1998 Apr;72(4):3505-6. PubMed ID: 8971011. Show all entries for this paper.

Yi2000b J izu Yi, Jonathan W. Arthur, Roland L. Dunbrack, Jr., and Anna Marie Skalka. An Inhibitory Monoclonal Antibody Binds at the Turn of the Helix-Turn-Helix Motif in the N-Terminal Domain of HIV-1 Integrase. J. Biol. Chem., 275(49):38739-38748, 8 Dec 2000. PubMed ID: 10969077. Show all entries for this paper.

Marchand2009 Christophe Marchand, Kasthuraiah Maddali, Mathieu Metifiot, and Yves Pommier. HIV-1 IN Inhibitors: 2010 Update and Perspectives. Curr. Top. Med. Chem., 9(11):1016-1037, 2009. PubMed ID: 19747122. Show all entries for this paper.


Displaying record number 221

Download this epitope record as JSON.

MAb ID 19 (2-19, scAb2-19)
HXB2 Location Pol(943-951)
DNA(4911..4937)
Pol Epitope Map
Author Location Integrase(228-236 LAI)
Epitope RDSRNPLWK Epitope Alignment
RDSRNPLWK epitope logo
Subtype B
Ab Type  
Neutralizing  
Species (Isotype) mouse(IgG1)
Patient  
Immunogen vaccine
Keywords  

Vaccine Details

Vaccine type protein
Vaccine component Int

Notes

Showing 3 of 3 notes.

References

Showing 4 of 4 references.

Bizub-Bender1994 D. Bizub-Bender, J. Kulkosky, and A. M. Skalka. Monoclonal Antibodies against HIV Type 1 Integrase: Clues to Molecular Structure. AIDS Res. Hum. Retroviruses, 10:1105-1115, 1994. PubMed ID: 7530024. Show all entries for this paper.

Levy-Mintz1996 P. Levy-Mintz, L. Duan, H. Zhang, B. Hu, G. Dornadula, M. Zhu, J. Kulkosky, D. Bizub-Bender, A. M. Skalka, and R. J. Pomerantz. Intracellular Expression of Single-Chain Variable Fragments to Inhibit Early Stages of the Viral Life Cycle by Targeting Human Immunodeficiency Virus Type 1 Integrase. J. Virol., 70:8821-8832, 1996. Comments in J Virol 1998 Apr;72(4):3505-6. PubMed ID: 8971011. Show all entries for this paper.

Kitamura1999 Y. Kitamura, T. Ishikawa, N. Okui, N. Kobayashi, T. Kanda, T. Shimada, K. Miyake, and K. Yoshiike. Inhibition of Replication of HIV-1 at Both Early and Late Stages of the Viral Life Cycle by Single-Chain Antibody against Viral Integrase. J. Acquir. Immune Defic. Syndr. Hum. Retrovirol., 20:105-114, 1999. PubMed ID: 10048896. Show all entries for this paper.

Kanduc2008 Darja Kanduc, Rosario Serpico, Alberta Lucchese, and Yehuda Shoenfeld. Correlating Low-Similarity Peptide Sequences and HIV B-Cell Epitopes. Autoimmun. Rev., 7(4):291-296, Feb 2008. PubMed ID: 18295732. Show all entries for this paper.


Displaying record number 216

Download this epitope record as JSON.

MAb ID 13
HXB2 Location Pol Pol Epitope Map
Author Location Integrase(1-58)
Epitope
Ab Type  
Neutralizing  
Species (Isotype) mouse(IgG1)
Patient  
Immunogen vaccine
Keywords  

Vaccine Details

Vaccine type protein
Vaccine component Int

Notes

Showing 1 of 1 note.

References

Showing 1 of 1 reference.

Bizub-Bender1994 D. Bizub-Bender, J. Kulkosky, and A. M. Skalka. Monoclonal Antibodies against HIV Type 1 Integrase: Clues to Molecular Structure. AIDS Res. Hum. Retroviruses, 10:1105-1115, 1994. PubMed ID: 7530024. Show all entries for this paper.


Displaying record number 217

Download this epitope record as JSON.

MAb ID 14
HXB2 Location Pol Pol Epitope Map
Author Location Integrase(1-58)
Epitope
Ab Type  
Neutralizing  
Species (Isotype) mouse(IgG1)
Patient  
Immunogen vaccine
Keywords  

Vaccine Details

Vaccine type protein
Vaccine component Int

Notes

Showing 1 of 1 note.

References

Showing 1 of 1 reference.

Bizub-Bender1994 D. Bizub-Bender, J. Kulkosky, and A. M. Skalka. Monoclonal Antibodies against HIV Type 1 Integrase: Clues to Molecular Structure. AIDS Res. Hum. Retroviruses, 10:1105-1115, 1994. PubMed ID: 7530024. Show all entries for this paper.


Displaying record number 219

Download this epitope record as JSON.

MAb ID 21
HXB2 Location Pol Pol Epitope Map
Author Location Integrase(58-141)
Epitope
Ab Type  
Neutralizing  
Species (Isotype) mouse(IgG2b)
Patient  
Immunogen vaccine
Keywords  

Vaccine Details

Vaccine type protein
Vaccine component Int

Notes

Showing 2 of 2 notes.

References

Showing 2 of 2 references.

Bizub-Bender1994 D. Bizub-Bender, J. Kulkosky, and A. M. Skalka. Monoclonal Antibodies against HIV Type 1 Integrase: Clues to Molecular Structure. AIDS Res. Hum. Retroviruses, 10:1105-1115, 1994. PubMed ID: 7530024. Show all entries for this paper.

Levy-Mintz1996 P. Levy-Mintz, L. Duan, H. Zhang, B. Hu, G. Dornadula, M. Zhu, J. Kulkosky, D. Bizub-Bender, A. M. Skalka, and R. J. Pomerantz. Intracellular Expression of Single-Chain Variable Fragments to Inhibit Early Stages of the Viral Life Cycle by Targeting Human Immunodeficiency Virus Type 1 Integrase. J. Virol., 70:8821-8832, 1996. Comments in J Virol 1998 Apr;72(4):3505-6. PubMed ID: 8971011. Show all entries for this paper.


Displaying record number 220

Download this epitope record as JSON.

MAb ID 4
HXB2 Location Pol Pol Epitope Map
Author Location Integrase(141-172)
Epitope
Ab Type  
Neutralizing  
Species (Isotype) mouse(IgG2b)
Patient  
Immunogen vaccine
Keywords review

Vaccine Details

Vaccine type protein
Vaccine component Int

Notes

Showing 4 of 4 notes.

References

Showing 3 of 3 references.

Bizub-Bender1994 D. Bizub-Bender, J. Kulkosky, and A. M. Skalka. Monoclonal Antibodies against HIV Type 1 Integrase: Clues to Molecular Structure. AIDS Res. Hum. Retroviruses, 10:1105-1115, 1994. PubMed ID: 7530024. Show all entries for this paper.

Levy-Mintz1996 P. Levy-Mintz, L. Duan, H. Zhang, B. Hu, G. Dornadula, M. Zhu, J. Kulkosky, D. Bizub-Bender, A. M. Skalka, and R. J. Pomerantz. Intracellular Expression of Single-Chain Variable Fragments to Inhibit Early Stages of the Viral Life Cycle by Targeting Human Immunodeficiency Virus Type 1 Integrase. J. Virol., 70:8821-8832, 1996. Comments in J Virol 1998 Apr;72(4):3505-6. PubMed ID: 8971011. Show all entries for this paper.

Marchand2009 Christophe Marchand, Kasthuraiah Maddali, Mathieu Metifiot, and Yves Pommier. HIV-1 IN Inhibitors: 2010 Update and Perspectives. Curr. Top. Med. Chem., 9(11):1016-1037, 2009. PubMed ID: 19747122. Show all entries for this paper.


Displaying record number 222

Download this epitope record as JSON.

MAb ID 16
HXB2 Location Pol Pol Epitope Map
Author Location Integrase
Epitope
Ab Type  
Neutralizing  
Species (Isotype) mouse(IgG2a)
Patient  
Immunogen vaccine
Keywords  

Vaccine Details

Vaccine type protein
Vaccine component Int

Notes

Showing 1 of 1 note.

References

Showing 1 of 1 reference.

Bizub-Bender1994 D. Bizub-Bender, J. Kulkosky, and A. M. Skalka. Monoclonal Antibodies against HIV Type 1 Integrase: Clues to Molecular Structure. AIDS Res. Hum. Retroviruses, 10:1105-1115, 1994. PubMed ID: 7530024. Show all entries for this paper.


Displaying record number 223

Download this epitope record as JSON.

MAb ID 32 (mAb32, Fab32)
HXB2 Location Pol Pol Epitope Map
Author Location Integrase(223-266)
Epitope
Ab Type  
Neutralizing  
Species (Isotype) mouse(IgG2b)
Patient  
Immunogen vaccine
Keywords review

Vaccine Details

Vaccine type protein
Vaccine component Int

Notes

Showing 4 of 4 notes.

References

Showing 4 of 4 references.

Bizub-Bender1994 D. Bizub-Bender, J. Kulkosky, and A. M. Skalka. Monoclonal Antibodies against HIV Type 1 Integrase: Clues to Molecular Structure. AIDS Res. Hum. Retroviruses, 10:1105-1115, 1994. PubMed ID: 7530024. Show all entries for this paper.

Yi2000a Jizu Yi and Anna Marie Skalka. Mapping Epitopes of Monoclonal Antibodies Against HIV-1 Integrase with Limited Proteolysis and Matrix-Assisted Laser Desorption Ionization Time-of-Flight Mass Spectrometry. Biopolymers, 55(4):308-318, 2000. PubMed ID: 11169922. Show all entries for this paper.

Yi2002 Jizu Yi, Hong Cheng, Mark D. Andrake, Roland L. Dunbrack, Jr., Heinrich Roder, and Anna Marie Skalka. Mapping the Epitope of an Inhibitory Monoclonal Antibody to the C-Terminal DNA-Binding Domain of HIV-1 Integrase. J. Biol. Chem., 277(14):12164-12174, 5 Apr 2002. PubMed ID: 11805085. Show all entries for this paper.

Marchand2009 Christophe Marchand, Kasthuraiah Maddali, Mathieu Metifiot, and Yves Pommier. HIV-1 IN Inhibitors: 2010 Update and Perspectives. Curr. Top. Med. Chem., 9(11):1016-1037, 2009. PubMed ID: 19747122. Show all entries for this paper.


Displaying record number 224

Download this epitope record as JSON.

MAb ID 33 (mAb33, Fab33, 33D5, mab 33)
HXB2 Location Pol Pol Epitope Map
Author Location Integrase(223-268 HXB2)
Epitope (Discontinuous epitope)
Subtype B
Ab Type C-term
Neutralizing  
Species (Isotype) mouse(IgG2b)
Patient  
Immunogen vaccine
Keywords antibody binding site, computational epitope prediction, mimotopes, review, structure

Vaccine Details

Vaccine type protein
Vaccine component Int

Notes

Showing 6 of 6 notes.

References

Showing 6 of 6 references.

Bizub-Bender1994 D. Bizub-Bender, J. Kulkosky, and A. M. Skalka. Monoclonal Antibodies against HIV Type 1 Integrase: Clues to Molecular Structure. AIDS Res. Hum. Retroviruses, 10:1105-1115, 1994. PubMed ID: 7530024. Show all entries for this paper.

Levy-Mintz1996 P. Levy-Mintz, L. Duan, H. Zhang, B. Hu, G. Dornadula, M. Zhu, J. Kulkosky, D. Bizub-Bender, A. M. Skalka, and R. J. Pomerantz. Intracellular Expression of Single-Chain Variable Fragments to Inhibit Early Stages of the Viral Life Cycle by Targeting Human Immunodeficiency Virus Type 1 Integrase. J. Virol., 70:8821-8832, 1996. Comments in J Virol 1998 Apr;72(4):3505-6. PubMed ID: 8971011. Show all entries for this paper.

Yi2000a Jizu Yi and Anna Marie Skalka. Mapping Epitopes of Monoclonal Antibodies Against HIV-1 Integrase with Limited Proteolysis and Matrix-Assisted Laser Desorption Ionization Time-of-Flight Mass Spectrometry. Biopolymers, 55(4):308-318, 2000. PubMed ID: 11169922. Show all entries for this paper.

Yi2002 Jizu Yi, Hong Cheng, Mark D. Andrake, Roland L. Dunbrack, Jr., Heinrich Roder, and Anna Marie Skalka. Mapping the Epitope of an Inhibitory Monoclonal Antibody to the C-Terminal DNA-Binding Domain of HIV-1 Integrase. J. Biol. Chem., 277(14):12164-12174, 5 Apr 2002. PubMed ID: 11805085. Show all entries for this paper.

Schreiber2005 Andreas Schreiber, Michael Humbert, Alexander Benz, and Ursula Dietrich. 3D-Epitope-Explorer (3DEX): Localization of Conformational Epitopes within Three-Dimensional Structures of Proteins. J. Comput. Chem., 26(9):879-887, 15 Jul 2005. PubMed ID: 15834923. Show all entries for this paper.

Marchand2009 Christophe Marchand, Kasthuraiah Maddali, Mathieu Metifiot, and Yves Pommier. HIV-1 IN Inhibitors: 2010 Update and Perspectives. Curr. Top. Med. Chem., 9(11):1016-1037, 2009. PubMed ID: 19747122. Show all entries for this paper.


Displaying record number 214

Download this epitope record as JSON.

MAb ID 12
HXB2 Location Pol Pol Epitope Map
Author Location Integrase(1-58)
Epitope
Ab Type  
Neutralizing  
Species (Isotype) mouse(IgG2a)
Patient  
Immunogen vaccine
Keywords  

Vaccine Details

Vaccine type protein
Vaccine component Int

Notes

Showing 2 of 2 notes.

References

Showing 2 of 2 references.

Bizub-Bender1994 D. Bizub-Bender, J. Kulkosky, and A. M. Skalka. Monoclonal Antibodies against HIV Type 1 Integrase: Clues to Molecular Structure. AIDS Res. Hum. Retroviruses, 10:1105-1115, 1994. PubMed ID: 7530024. Show all entries for this paper.

Levy-Mintz1996 P. Levy-Mintz, L. Duan, H. Zhang, B. Hu, G. Dornadula, M. Zhu, J. Kulkosky, D. Bizub-Bender, A. M. Skalka, and R. J. Pomerantz. Intracellular Expression of Single-Chain Variable Fragments to Inhibit Early Stages of the Viral Life Cycle by Targeting Human Immunodeficiency Virus Type 1 Integrase. J. Virol., 70:8821-8832, 1996. Comments in J Virol 1998 Apr;72(4):3505-6. PubMed ID: 8971011. Show all entries for this paper.


Displaying record number 215

Download this epitope record as JSON.

MAb ID 35
HXB2 Location Pol Pol Epitope Map
Author Location Integrase(1-58)
Epitope
Ab Type  
Neutralizing  
Species (Isotype) mouse(IgG2b)
Patient  
Immunogen vaccine
Keywords  

Vaccine Details

Vaccine type protein
Vaccine component Int

Notes

Showing 2 of 2 notes.

References

Showing 1 of 1 references.

Bizub-Bender1994 D. Bizub-Bender, J. Kulkosky, and A. M. Skalka. Monoclonal Antibodies against HIV Type 1 Integrase: Clues to Molecular Structure. AIDS Res. Hum. Retroviruses, 10:1105-1115, 1994. PubMed ID: 7530024. Show all entries for this paper.


Displaying record number 752

Download this epitope record as JSON.

MAb ID 4
HXB2 Location gp160(598-604)
DNA(8016..8036)
gp160 Epitope Map
Author Location gp41(598-609)
Epitope CSGKLIC Epitope Alignment
CSGKLIC epitope logo
Ab Type  
Neutralizing  
Species (Isotype) mouse(IgG2b)
Patient  
Immunogen vaccine
Keywords  

Vaccine Details

Vaccine type peptide
Vaccine component gp41

Notes

Showing 2 of 2 notes.

References

Showing 2 of 2 references.

Isolation Paper
Oldstone1991 M. B. A. Oldstone, A. Tishon, H. Lewicki, H. J. Dyson, V. A. Feher, N. Assa-Munt, and P. E. Wright. Mapping the anatomy of the immunodominant domain of the human immunodeficiency virus gp41 transmembrane protein: peptide conformation analysis using monoclonal antibodies and proton nuclear magnetic resonance spectroscopy. J. Virol., 65:1727-1734, 1991. Disulfide bond between cysteines and type I reverse turn about the residues SGKL are structural features of the immunodominant domain of gp41: CSGKLIC. PubMed ID: 2002540. Show all entries for this paper.

Bizub-Bender1994 D. Bizub-Bender, J. Kulkosky, and A. M. Skalka. Monoclonal Antibodies against HIV Type 1 Integrase: Clues to Molecular Structure. AIDS Res. Hum. Retroviruses, 10:1105-1115, 1994. PubMed ID: 7530024. Show all entries for this paper.


Questions or comments? Contact us at immuno@lanl.gov
 
Managed by Triad National Security, LLC for the U.S. Department of Energy’s National Nuclear Security Administration
Copyright © 2022 Triad National Security, LLC | Disclaimer/Privacy

Dept of Health & Human Services Los Alamos National Institutes of Health