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Displaying record number 2867

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• AbCH83: 3 acutely infected subjects, CH40, CH77, CH58, with known transmitter/founder virus were studied immediately post infection by single genome sequencing, deep sequencing, site-directed mutagenesis, Ab absorbtions and virus-entry assays. NAb responses selecting for virus escape were found as early as 2 weeks post-seroconversion. In each subject, Nabs targeted different regions of Env. Autologous clonally related AbCH83 and AbCH84 MAbs from subject CH40 were generated from day 132 and were strictly strain-speific and nearly recapitulated the polyclonal Nab reactivity in 111 day plasma. Env mutations E146K, E146G, N139T/E146T/M147L, R327K/E332K, N300H conferred resistance to both MAbs and the plasma Nabs. Bar2012 (antibody generation, escape, polyclonal antibodies)

References

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Isolation Paper
Bar2012 Katharine J. Bar, Chun-yen Tsao, Shilpa S. Iyer, Julie M. Decker, Yongping Yang, Mattia Bonsignori, Xi Chen, Kwan-Ki Hwang, David C. Montefiori, Hua-Xin Liao, Peter Hraber, William Fischer, Hui Li, Shuyi Wang, Sarah Sterrett, Brandon F. Keele, Vitaly V. Ganusov, Alan S. Perelson, Bette T. Korber, Ivelin Georgiev, Jason S. McLellan, Jeffrey W. Pavlicek, Feng Gao, Barton F. Haynes, Beatrice H. Hahn, Peter D. Kwong, and George M. Shaw. Early Low-Titer Neutralizing Antibodies Impede HIV-1 Replication and Select for Virus Escape. PLoS Pathog., 8(5):e1002721, 2012. PubMed ID: 22693447. Show all entries for this paper.

Displaying record number 2868

Download this epitope record as JSON.

Notes

Showing 1 of 1 note.

• AbCH83: 3 acutely infected subjects, CH40, CH77, CH58, with known transmitter/founder virus were studied immediately post infection by single genome sequencing, deep sequencing, site-directed mutagenesis, Ab absorbtions and virus-entry assays. NAb responses selecting for virus escape were found as early as 2 weeks post-seroconversion. In each subject, Nabs targeted different regions of Env. Autologous clonally related AbCH83 and AbCH84 MAbs from subject CH40 were generated from day 132 and were strictly strain-speific and nearly recapitulated the polyclonal Nab reactivity in 111 day plasma. Env mutations E146K, E146G, N139T/E146T/M147L, R327K/E332K, N300H conferred resistance to both MAbs and the plasma Nabs. Bar2012 (antibody generation, escape, polyclonal antibodies)

References

Showing 1 of 1 reference.

Isolation Paper
Bar2012 Katharine J. Bar, Chun-yen Tsao, Shilpa S. Iyer, Julie M. Decker, Yongping Yang, Mattia Bonsignori, Xi Chen, Kwan-Ki Hwang, David C. Montefiori, Hua-Xin Liao, Peter Hraber, William Fischer, Hui Li, Shuyi Wang, Sarah Sterrett, Brandon F. Keele, Vitaly V. Ganusov, Alan S. Perelson, Bette T. Korber, Ivelin Georgiev, Jason S. McLellan, Jeffrey W. Pavlicek, Feng Gao, Barton F. Haynes, Beatrice H. Hahn, Peter D. Kwong, and George M. Shaw. Early Low-Titer Neutralizing Antibodies Impede HIV-1 Replication and Select for Virus Escape. PLoS Pathog., 8(5):e1002721, 2012. PubMed ID: 22693447. Show all entries for this paper.