Search Antibody Database

Found 1 matching record:

Displaying record number 1287

Download this epitope record as JSON.

MAb ID	polyclonal
HXB2 Location	Env	Env Epitope Map
Author Location	gp120( IIIB)
Epitope
Ab Type
Neutralizing
Species (Isotype)	human
Patient
Immunogen	HIV-1 infection
Keywords	acute/early infection, autologous responses

Notes

Showing 1 of 1 note.

Neutralizing Ab responses to autologous virus envelopes were studied in four acutely HIV-1 infected, treatment-naive, homosexual men (MM1, MM2, MM4 and MM8). Detection of gp120 antibodies was rapid using ELISPOT, within a few weeks, but detection of neutralizing antibodies took between 3 and 16 months, precluding involvement of detectable NAbs with resolution of viremia. Heterologous NAb responses arose even later, by 3 months or more, suggesting gradual broadening of the immune response. Aasa-Chapman2004 (autologous responses, acute/early infection)

References

Showing 1 of 1 reference.

Aasa-Chapman2004 Marlén M. I. Aasa-Chapman, Anna Hayman, Philippa Newton, David Cornforth, Ian Williams, Persephone Borrow, Peter Balfe, and Áine McKnight. Development of the Antibody Response in Acute HIV-1 Infection. AIDS, 18(3):371-381, 20 Feb 2004. PubMed ID: 15090788. Show all entries for this paper.