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Displaying record number 959

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MAb ID	1595
HXB2 Location	Env	Env Epitope Map
Author Location	Env( PR12, BH10)
Epitope
Ab Type	gp120 CD4BS
Neutralizing
Species (Isotype)	human
Patient
Immunogen	HIV-1 infection
Keywords	antibody binding site, antibody generation, review, subtype comparisons, variant cross-reactivity

Notes

Showing 2 of 2 notes.

1595: This review summarizes MAbs directed to HIV-1 Env. There are 51 CD4BS MAbs and Fabs in the database; most, like this MAb, neutralize TCLA strains only. Gorny2003 (review)
1595: BH10 was mutated to form the PR12 protein with the first 74 C-terminal amino acids and the V1, V2 and V3 hypervariable loops deleted and a very well exposed CD4 binding domain (CD4bd) -- this proteins was used to select three new human CD4BS MAbs 1570, 1595 and 1599 -- 1595 was able to bind gp120 from the A, B, and D clades from a panel of recombinant proteins from the A, B, C, D, and E subtypes. Jeffs2001 (antibody binding site, antibody generation, variant cross-reactivity, subtype comparisons)

References

Showing 2 of 2 references.

Isolation Paper
Jeffs2001 S. A. Jeffs, M. K. Gorny, C. Williams, K. Revesz, B. Volsky, S. Burda, X. H. Wang, J. Bandres, S. Zolla-Pazner, and H. Holmes. Characterization of human monoclonal antibodies selected with a hypervariable loop-deleted recombinant HIV-1(IIIB) gp120. Immunol. Lett., 79(3):209--13, 3 Dec 2001. PubMed ID: 11600200. Show all entries for this paper.

Gorny2003 Miroslaw K. Gorny and Susan Zolla-Pazner. Human Monoclonal Antibodies that Neutralize HIV-1. In Bette T. M. Korber and et. al., editors, HIV Immunology and HIV/SIV Vaccine Databases 2003. pages 37--51. Los Alamos National Laboratory, Theoretical Biology \& Biophysics, Los Alamos, N.M., 2004. URL: http://www.hiv.lanl.gov/content/immunology/pdf/2003/zolla-pazner_article.pdf. LA-UR 04-8162. Show all entries for this paper.