Search Antibody Database

Found 1 matching record:

Displaying record number 956

Download this epitope record as JSON.

MAb ID	1202-D (1202-30-D)
HXB2 Location	Env	Env Epitope Map
Author Location	Env
Research Contact	Susan Zolla-Pazner (Zollas01@mcrcr6.med.nyu) (NYU Med. Center)
Epitope
Ab Type	gp120 CD4BS
Neutralizing
Species (Isotype)	human(IgG1κ)
Patient
Immunogen
Keywords	review, subtype comparisons

Notes

Showing 4 of 4 notes.

1202-D: This review summarizes MAbs directed to HIV-1 Env. There are 51 CD4BS MAbs and Fabs in the database; most, like this MAb, neutralize TCLA strains only. Gorny2003 (review)
1202-D: 26 HIV-1 group M isolates (clades A to H) were tested for binding to 47 MAbs, including 6 CD4BS MAbs -- CD4BS MAbs bound consistently to most isolates of clade D, but poorly to isolates of other clades with the exception of broadly reactive MAb IgG1b12. Nyambi2000 (subtype comparisons)
1202-D: Called 1202-30D -- Ab responses, because of their capacity to alter antigen uptake and processing, can influence helper T cell responses -- anti-CD4 binding site MAbs or serum Ig from HIV+ individuals inhibited proliferative responses of gp120 specific T cells -- CD4BS MAbs 654-D, 559/64-D, 588-D, 830-D, 1027-30-D, and 1202-30D strongly diminished proliferation. Hioe2000
1202-D: Using a whole virion-ELISA method, 18 human MAbs were tested for their ability to bind to a panel of 9 viruses from clades A, B, D, F, G, and H -- CD4-BS Abs tended to bind weakly without clade specificity to virions, but bound well to soluble gp120 -- 1202-D did not bind to any B clade viruses, and weakly bound A, C, and G clade isolates -- 559/64-D, 558-D and 1202-D had similar reactivities. Nyambi1998 (subtype comparisons)

References

Showing 4 of 4 references.

Nyambi1998 P. N. Nyambi, M. K. Gorny, L. Bastiani, G. van der Groen, C. Williams, and S. Zolla-Pazner. Mapping of Epitopes Exposed on Intact Human Immunodeficiency Virus Type 1 (HIV-1) Virions: A New Strategy for Studying the Immunologic Relatedness of HIV-1. J. Virol., 72:9384-9391, 1998. 18 human MAbs binding to gp120 and gp41 were tested using a novel assay to test binding to intact HIV-1 virions. The new method involves using MAbs to the host proteins incorporated into virions to bind them to ELIZA plates. Antigenic conservation in epitopes of HIV-1 in clades A, B, D, F, G, and H was studied. MAbs were selected that were directed against V2, V3, CD4bd, C5 or gp41 regions. Antibodies against V2, the CD4BS, and sp41 showed weak and sporadic reactivities, while binding strongly to gp120, suggesting these epitopes are hidden when gp120 is in its native, quaternary structure. PubMed ID: 9765494. Show all entries for this paper.

Hioe2000 C. E. Hioe, G. J. Jones, A. D. Rees, S. Ratto-Kim, D. Birx, C. Munz, M. K. Gorny, M. Tuen, and S. Zolla-Pazner. Anti-CD4-Binding Domain Antibodies Complexed with HIV Type 1 Glycoprotein 120 Inhibit CD4+ T Cell-Proliferative Responses to Glycoprotein 120. AIDS Res. Hum. Retroviruses, 16:893-905, 2000. PubMed ID: 10875615. Show all entries for this paper.

Nyambi2000 P. N. Nyambi, H. A. Mbah, S. Burda, C. Williams, M. K. Gorny, A. Nadas, and S. Zolla-Pazner. Conserved and Exposed Epitopes on Intact, Native, Primary Human Immunodeficiency Virus Type 1 Virions of Group M. J. Virol., 74:7096-7107, 2000. PubMed ID: 10888650. Show all entries for this paper.

Gorny2003 Miroslaw K. Gorny and Susan Zolla-Pazner. Human Monoclonal Antibodies that Neutralize HIV-1. In Bette T. M. Korber and et. al., editors, HIV Immunology and HIV/SIV Vaccine Databases 2003. pages 37--51. Los Alamos National Laboratory, Theoretical Biology \& Biophysics, Los Alamos, N.M., 2004. URL: http://www.hiv.lanl.gov/content/immunology/pdf/2003/zolla-pazner_article.pdf. LA-UR 04-8162. Show all entries for this paper.