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Displaying record number 927

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MAb ID E9
HXB2 Location Nef(158-181)
DNA(9268..9339)
Nef Epitope Map
Author Location Nef(158-206 IIIB)
Epitope KGENTSLLHPVSLHGMDDPEREVL Epitope Alignment
Ab Type  
Neutralizing  
Species (Isotype) mouse(IgM)
Patient  
Immunogen  
Keywords  

Notes

Showing 4 of 4 notes.

References

Showing 5 of 5 references.

Fujii1993 Y. Fujii, Y. Nishino, T. Nakaya, K. Tokunaga, and K. Ikuta. Expression of Human Immunodeficiency Virus Type 1 Nef Antigen on the Surface of Acutely and Persistently Infected Human T-cells. Vaccine, 11:1240, 1993. PubMed ID: 8256505. Show all entries for this paper.

Otake1994 K. Otake, Y. Fujii, Y. Nishino, Q. Zhong, K. Fujinaga, M. Kameoka, K. Ohki, and K. Ikuta. The Carboxyl-Terminal Region of HIV-1 Nef Protein Is a Cell Surface Domain That Can Interact with CD4+ T Cells. J. Immunol., 153:5826-5837, 1994. This study shows that the C-terminal end of Nef is accessible to Abs. This domain could bind in a soluble form to CD4+, uninfected cells, and this interaction is inhibited in the presence of the C-terminal specific antibodies. Syncytium formation was reduced by these Abs or peptides. Abs could stain IIIB/M10, but not MN/M10, infected cells, in a membrane immunofluorescence assay. PubMed ID: 7989778. Show all entries for this paper.

Fujii1996 Y. Fujii, K. Otake, M. Tashiro, and A. Adachi. In Vitro Cytocidal Effects of Human Immunodeficiency Virus Type 1 Nef on Unprimed Human CD4+ T Cells without MHC Restriction. J. Gen. Virol., 77:2943-2951, 1996. PubMed ID: 9000084. Show all entries for this paper.

Fujii1996b Y. Fujii, K. Otake, M. Tashiro, and A. Adachi. Human Immunodeficiency Type 1 Nef Protein on the Cell Surface Is Cytocidal for Human CD4+ T cells. FEBS Lett., 393:105-108, 1996. PubMed ID: 8804435. Show all entries for this paper.

Maksiutov2002 A. Z. Maksiutov, A. G. Bachinskii, and S. I. Bazhan. [Searching for Local Similarities Between HIV-1 and Human Proteins. Application to Vaccines]. Mol Biol (Mosk), 36(3):447-459, May-Jun 2002. Article in Russian. PubMed ID: 12068630. Show all entries for this paper.


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