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Displaying record number 898

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MAb ID	M25
HXB2 Location	Env	Env Epitope Map
Author Location	gp41
Epitope
Ab Type
Neutralizing
Species (Isotype)	mouse(IgGκ)
Patient
Immunogen	vaccine
Keywords	antibody sequence

Vaccine Details

Vaccine type	purified HIV-1
Vaccine strain	B clade IIIB

Notes

Showing 2 of 2 notes.

M25: This study derived 4 hybridomas against HTLV-III. These 4 Abs (AI73, B69, M16, and M23) reacted with different titers against p24. While the study by Watkins1996 cites Veronese1993 as the source of M25, it is not mentioned in either Veronese1985 or Veronese1993. Veronese1985
M25: heavy and light chains cloned and sequenced -- binding requires heavy and light chain in combination, in contrast to M77. Watkins1996 (antibody sequence)

References

Showing 2 of 2 references.

Veronese1985 F. di Marzo Veronese, M. G. Sarngadharan, R. Rahman, P. D. Markham, M. Popovic, A. J. Bodner, and R. C. Gallo. Monoclonal Antibodies Specific for p24, the Major Core Protein of Human T-Cell Leukemia Virus Type III. Proc. Natl. Acad. Sci. U.S.A., 82:5199-5202, 1985. PubMed ID: 2991911. Show all entries for this paper.

Watkins1996 B. A. Watkins, A. E. Davis, S. Fiorentini, F. di Marzo Veronese, and M. S. Reitz, Jr. Evidence for Distinct Contributions of Heavy and Light Chains to Restriction of Antibody Recognition of the HIV-1 Principal Neutralization Determinant. J. Immunol., 156:1676-1683, 1996. PubMed ID: 8568275. Show all entries for this paper.