Search Antibody Database

Found 1 matching record:

Displaying record number 890

Download this epitope record as JSON.

MAb ID	Fab L9
HXB2 Location	Env	Env Epitope Map
Author Location	gp41( LAI)
Epitope
Subtype	B
Ab Type
Neutralizing
Species (Isotype)	human(IgG1κ)
Patient	L
Immunogen	HIV-1 infection
Keywords

Notes

Showing 1 of 1 note.

Fab L9: Uncharacterized epitope -- variable regions sequenced. Binley1996

References

Showing 1 of 1 reference.

Isolation Paper
Binley1996 J. M. Binley, H. J. Ditzel, C. F. Barbas III, N. Sullivan, J. Sodroski, P. W. H. I. Parren, and D. R. Burton. Human Antibody Responses to HIV Type 1 Glycoprotein 41 Cloned in Phage Display Libraries Suggest Three Major Epitopes Are Recognized and Give Evidence for Conserved Antibody Motifs in Antigen Binding. AIDS Res. Hum. Retroviruses, 12:911-924, 1996. A panel of anti-gp41 human Fab fragments were generated by panning phage display antibody libraries prepared from HIV-1 positive donors with rgp41. Fabs tended to be directed against three epitopes, designated clusters I-III. None were neutralizing. A common CDR3 motif was found in several of the heavy chain sequences. PubMed ID: 8798976. Show all entries for this paper.