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MAb ID Md-1 (MD-1, Md1)
HXB2 Location Env Env Epitope Map
Author Location gp41
Research Contact R. A. Myers State of Maryland Dept. of Health
Epitope
Ab Type gp41 cluster II
Neutralizing  
Species (Isotype) human(IgG1λ)
Patient  
Immunogen  
Keywords antibody binding site, binding affinity, review

Notes

Showing 7 of 7 notes.

References

Showing 6 of 6 references.

Myers1993 R. Myers, T. Meiller, W. Falkler, Jr., J. Patel, and J. Joseph. A Human Monoclonal Antibody to a Cryptic gp41 Epitope on HIV-1 Infected Cells. Abstr. Gen. Meet. Am. Soc. Microbiol., 93:444, 1993. Aidsline: 93291838 Abstract T70. Show all entries for this paper.

Chen1995 C. H. Chen, T. J. Matthews, C. B. McDanal, D. P. Bolognesi, and M. L. Greenberg. A Molecular Clasp in the Human Immunodeficiency Virus (HIV) Type 1 TM Protein Determines the Anti-HIV Activity of gp41 Derivatives: Implication for Viral Fusion. J. Virol., 69:3771-3777, 1995. PubMed ID: 7538176. Show all entries for this paper.

Binley1996 J. M. Binley, H. J. Ditzel, C. F. Barbas III, N. Sullivan, J. Sodroski, P. W. H. I. Parren, and D. R. Burton. Human Antibody Responses to HIV Type 1 Glycoprotein 41 Cloned in Phage Display Libraries Suggest Three Major Epitopes Are Recognized and Give Evidence for Conserved Antibody Motifs in Antigen Binding. AIDS Res. Hum. Retroviruses, 12:911-924, 1996. A panel of anti-gp41 human Fab fragments were generated by panning phage display antibody libraries prepared from HIV-1 positive donors with rgp41. Fabs tended to be directed against three epitopes, designated clusters I-III. None were neutralizing. A common CDR3 motif was found in several of the heavy chain sequences. PubMed ID: 8798976. Show all entries for this paper.

Gorny2003 Miroslaw K. Gorny and Susan Zolla-Pazner. Human Monoclonal Antibodies that Neutralize HIV-1. In Bette T. M. Korber and et. al., editors, HIV Immunology and HIV/SIV Vaccine Databases 2003. pages 37--51. Los Alamos National Laboratory, Theoretical Biology \& Biophysics, Los Alamos, N.M., 2004. URL: http://www.hiv.lanl.gov/content/immunology/pdf/2003/zolla-pazner_article.pdf. LA-UR 04-8162. Show all entries for this paper.

Kalia2005 Vandana Kalia, Surojit Sarkar, Phalguni Gupta, and Ronald C. Montelaro. Antibody Neutralization Escape Mediated by Point Mutations in the Intracytoplasmic Tail of Human Immunodeficiency Virus Type 1 gp41. J. Virol., 79(4):2097-2107, Feb 2005. PubMed ID: 15681412. Show all entries for this paper.

Vincent2008 Nadine Vincent, Amadou Kone, Blandine Chanut, Frédéric Lucht, Christian Genin, and Etienne Malvoisin. Antibodies Purified from Sera of HIV-1-Infected Patients by Affinity on the Heptad Repeat Region 1/Heptad Repeat Region 2 Complex of gp41 Neutralize HIV-1 Primary Isolates. AIDS, 22(16):2075-2085, 18 Oct 2008. PubMed ID: 18832871. Show all entries for this paper.


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