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Notes

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• K14: In a study of NSI and SI virus neutralization, K14 did not influence viral entry. Schutten1997
• K14: Reduced affinity for both SI and NSI viruses relative to MAb MN215, failed to neutralize SI strain. Schutten1995a
• K14: Did not bind to peptides spanning gp41, but it does not react with Env deletion mutant 643-692 -- does not react with HIV-2 -- competition experiments showed this was an immunodominant conserved epitope in HIV-1 positive sera from Europe and Africa. Teeuwsen1990

References

Showing 5 of 5 references.

Teeuwsen1990 V. J. Teeuwsen, K. H. Siebelink, S. Crush-Stanton, B. Swerdlow, J. J. Schalken, J. Goudsmit, R. van de Akker, M. J. Stukart, F. G. Uytdehaag, and A. D. Osterhaus. Production and Characterization of a Human Monoclonal Antibody, Reactive with a Conserved Epitope on gp41 of Human Immunodeficiency Virus Type I. AIDS Res. Hum. Retroviruses, 6:381-392, 1990. PubMed ID: 1692724. Show all entries for this paper.

Schutten1995 M. Schutten, A. C. Andeweg, M. L. Bosch, and A. D. Osterhaus. Enhancement of Infectivity of a Non-Syncytium Inducing HIV-1 by sCD4 and by Human Antibodies that Neutralize Syncytium Inducing HIV-1. Scand. J. Immunol., 41:18-22, 1995. PubMed ID: 7824885. Show all entries for this paper.

Schutten1995a M. Schutten, J. P. Langedijk, A. C. Andeweg, R. C. Huisman, R. H. Meloen, and A. D. Osterhaus. Characterization of a V3 Domain-Specific Neutralizing Human Monoclonal Antibody That Preferentially Recognizes Non-Syncytium-Inducing Human Immunodeficiency Virus Type 1 Strains. J. Gen. Virol., 76:1665-1673, 1995. Characterization of HuMAb MN215. PubMed ID: 9049372. Show all entries for this paper.

Schutten1996 M. Schutten, K. Tenner-Racz, P. Racz, D. W. van Bekkum, and A. D. Osterhaus. Human antibodies that neutralize primary human immunodeficiency virus type 1 in vitro do not provide protection in an in vivo model. J. Gen. Virol., 77:1667-75, Aug 1996. PubMed ID: 8760413. Show all entries for this paper.

Schutten1997 M. Schutten, A. C. Andeweg, G. F. Rimmelzwaan, and A. D. Osterhaus. Modulation of primary human immunodeficiency virus type 1 envelope glycoprotein-mediated entry by human antibodies. J. Gen. Virol., 78:999-1006, 1997. A series of HIV-1 envelope glycoproteins from related primary virus isolates of different SI phenotypes, together with chimeras of these proteins, were tested in an envelope trans-complementation assay for their sensitivity to either antibody mediated inhibition or enhancement of HIV-1 entry. In contrast to the inhibition of HIV-1 entry, antibody mediated enhancement was not temperature dependent and could not be mediated by F(ab) fragments, implicating cross-linking as an important step. Enhancement or inhibition seemed to be determined by virus isolate rather than by the specificity of the antiserum used. 2F5 was the only MAb that inhibited the entry of all viruses. PubMed ID: 9152416. Show all entries for this paper.