Search Antibody Database

Found 1 matching record:

Displaying record number 855

Download this epitope record as JSON.

MAb ID	polyclonal
HXB2 Location	Env	Env Epitope Map
Author Location	gp120( SF162DeltaV2)
Epitope
Ab Type
Neutralizing
Species (Isotype)	macaque
Patient
Immunogen	vaccine
Keywords

Vaccine Details

Vaccine type	DNA prime with protein boost
Vaccine strain	B clade SF162
Vaccine component	gp140
Adjuvant	MF59

Notes

Showing 2 of 2 notes.

HIV-1 SF162ΔV2 gp140 envelope was used in a DNA-prime plus protein-boost vaccination methodology in Rhesus macaques, the animals were depleted of their CD8+ T lymphocytes, and challenged with pathogenic SHIV(SF162P4)---the vaccinated macaques had lower peak viremia, rapidly cleared virus from the periphery, and developed delayed seroconversion to SIV core antigens relative to non-vaccinated controls. Cherpelis2001b
Two animals were immunized both intradermally and intramuscularly at weeks 0, 4, and 8 with a codon optimized DNA vector expressing the SF162V2 gp140 envelope with an intact gp120-gp41 cleavage site, and both developed lymphoproliferative responses and potent neutralizing Abs -- CD8+ T lymphocytes were depleted in the animals and they were challenged with SHIV162P4 -- at peak viremia, plasma viral levels in the vaccinated animals were 1 to 4 logs lower than those in the unvaccinated animals. Cherpelis2001a

References

Showing 2 of 2 references.

Cherpelis2001a S. Cherpelis, I. Shrivastava, A. Gettie, X. Jin, D. D. Ho, S. W. Barnett, and L. Stamatatos. DNA vaccination with the human immunodeficiency virus type 1 SF162DeltaV2 envelope elicits immune responses that offer partial protection from simian/human immunodeficiency virus infection to CD8(+) T-cell-depleted rhesus macaques. J. Virol., 75(3):1547--50, Feb 2001. URL: http://jvi.asm.org/cgi/content/full/75/3/1547. PubMed ID: 11152527. Show all entries for this paper.

Cherpelis2001b S. Cherpelis, X. Jin, A. Gettie, D. D. Ho, S. W. Barnett, I. Shrivastava, and L. Stamatatos. DNA-Immunization with a V2 Deleted HIV-1 Envelope Elicits Protective Antibodies in Macaques. Immunol. Lett., 79(1-2):47-55, 1 Nov 2001. PubMed ID: 11595289. Show all entries for this paper.