Search Antibody Database

Found 1 matching record:

Displaying record number 817

Download this epitope record as JSON.

MAb ID	IVI-4G6 (4G6)
HXB2 Location	Env	Env Epitope Map
Author Location	gp41
Research Contact	K. Miyakoshi (Feji-Rebio Co, Tokyo, Japan)
Epitope
Ab Type
Neutralizing
Species (Isotype)	mouse(IgG2b)
Patient
Immunogen	vaccine
Keywords	antibody interactions

Notes

Showing 2 of 2 notes.

4G6: Hybridoma cell lines from trans-chromosome knock-out mice immunized with HIV-1 infected cells produced two human mAbs, 9F11 and 2G9, that reacted with HIV-1 infected cells. 2G9 induced apoptosis of HIV-1 infected cells and 9F11 was able to induce complement-mediated cytolysis. None of the mAbs are thought to bind directly to HIV-1. Unlike 2G9, 4G6 did not react with OM10.1 cells maintained in a latently infected state in the presence of AZT, but it did react when the virus replication was activated in the absence of AZT and in the presence of TNF-α. Okada2005 (antibody interactions)
IVI-4G6: A bi-specific Ab (BFA) was made by combining Fab fragments of gp41-specific MAb IVI-4G6 and CD3-specific MAb UCHT1 -- the BFA suppressed HIV-1 propagation culture and eliminated latently infected cells. Yin2001

References

Showing 2 of 2 references.

Yin2001 S. Yin, N. Okada, and H. Okada. Elimination of latently HIV-1-infected cells by lymphoblasts armed with bifunctional antibody. Microbiol. Immunol., 45(1):101--8, 2001. PubMed ID: 11270601. Show all entries for this paper.

Okada2005 Noriko Okada, Shuping Yin, Suzuka Asai, Noriaki Kimbara, Natsuki Dohi, Masato Hosokawa, Xiaoshan Wu, and Hidechika Okada. Human IgM Monoclonal Antibodies Reactive with HIV-1-Infected Cells Generated Using a Trans-Chromosome Mouse. Microbiol. Immunol., 49(5):447-459, 2005. PubMed ID: 15905607. Show all entries for this paper.