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Displaying record number 810

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MAb ID	ND-15G1 (ND-15GI)
HXB2 Location	gp160(644-663) DNA(8154..8213)	gp160 Epitope Map
Author Location	gp41(644-663 HXB2)
Epitope	SLIEESQNQQEKNEQELLEL	Epitope Alignment
Subtype	B
Ab Type	gp41 cluster II
Neutralizing
Species (Isotype)	human(IgG1κ)
Patient
Immunogen	HIV-1 infection
Keywords	antibody binding site, review

Notes

Showing 2 of 2 notes.

• ND-15G1: One of 19 MAbs and Fabs in this database that bind to the highly immunogenic gp41 cluster II region (aa 644-663); none have neutralizing activity. Gorny2003 (review)
• ND-15G1: Mapped to the conformational epitope within aa 644-663, and reacts with astrocytes, as do 98-6 and 167-7. Eddleston1993 (antibody binding site)

References

Showing 2 of 2 references.

Eddleston1993 M. Eddleston, J. C. de la Torre, J.-Y. Xu, N. Dorfman, A. Notkins, S. Zolla-Pazner, and M. B. A. Oldstone. Molecular Mimicry Accompanying HIV-1 Infection: Human Monoclonal Antibodies That Bind to gp41 and to Astrocytes. AIDS Res. Hum. Retroviruses, 10:939-944, 1993. In this paper, three anti-HIV-1 gp41 specific MAbs were found to react with astrocytes: 98-6, 167-7 and 15G1. Reactive astrocytes in the hippocampus were most prominently involved, and the antibodies stained no other cell type in the brain, kidney or liver. All three mapped to a conformationally dependent epitope between aa 644-663. PubMed ID: 7506553. Show all entries for this paper.

Gorny2003 Miroslaw K. Gorny and Susan Zolla-Pazner. Human Monoclonal Antibodies that Neutralize HIV-1. In Bette T. M. Korber and et. al., editors, HIV Immunology and HIV/SIV Vaccine Databases 2003. pages 37--51. Los Alamos National Laboratory, Theoretical Biology \& Biophysics, Los Alamos, N.M., 2004. URL: http://www.hiv.lanl.gov/content/immunology/pdf/2003/zolla-pazner_article.pdf. LA-UR 04-8162. Show all entries for this paper.