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Displaying record number 781

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MAb ID T32
HXB2 Location Env(592-608)
DNA(7998..8048)
Env Epitope Map
Author Location gp41(597-613)
Research Contact Patricia Earl and Christopher Broder, NIH
Epitope LLGIWGCSGKLICTTAV Epitope Alignment
LLGIWGCSGKLICTTAV epitope logo
Ab Type gp41 cluster I
Neutralizing  
Species (Isotype) mouse
Patient  
Immunogen vaccine
Keywords antibody generation, antibody interactions, binding affinity, mutation acquisition, viral fitness and/or reversion

Vaccine Details

Vaccine type tetrameric Env
Vaccine component Env

Notes

Showing 4 of 4 notes.

References

Showing 4 of 4 references.

Isolation Paper
Earl1994 P. L. Earl, C. C. Broder, D. Long, S. A. Lee, J. Peterson, S. Chakrabarti, R. W. Doms, and B. Moss. Native oligomeric human immunodeficiency virus type 1 Envelope glycoprotein elicits diverse monoclonal antibody reactivities. J. Virol., 68:3015-3026, 1994. In a study of the repertoire of response to oligomeric versus monomeric Env protein, 138 murine MAbs were generated in response to an immunogen that was a gp120/bp41 oligomeric molecule that was not cleaved due to a mutation in the cleavage site. The oligomeric molecule was found to elicit a response that was very different than the monomer. Most MAbs were conformational, many were to gp41 or if in gp120, to the CD4 BS. Few MAbs to linear V3 epitopes were produced in response to oligomeric protein, though this was a common specificity in response to immunization with gp120 monomeric protein. PubMed ID: 7512157. Show all entries for this paper.

Earl1997 P. L. Earl, C. C. Broder, R. W. Doms, and B. Moss. Epitope map of human immunodeficiency virus type 1 gp41 derived from 47 monoclonal antibodies produced by immunization with oligomeric envelope protein. J. Virol., 71:2674-84, 1997. PubMed ID: 9060620. Show all entries for this paper.

Vincent2012 Nadine Vincent and Etienne Malvoisin. Ability of Antibodies Specific to the HIV-1 Envelope Glycoprotein to Block the Fusion Inhibitor T20 in a Cell-Cell Fusion Assay. Immunobiology, 217(10):943-950, Oct 2012. PubMed ID: 22387075. Show all entries for this paper.

Joshi2020 Vinita R. Joshi, Ruchi M. Newman, Melissa L. Pack, Karen A. Power, James B. Munro, Ken Okawa, Navid Madani, Joseph G. Sodroski, Aaron G. Schmidt, and Todd M. Allen. Gp41-Targeted Antibodies Restore Infectivity of a Fusion-Deficient HIV-1 Envelope Glycoprotein. PLoS Pathog, 16(5):e1008577, May 2020. PubMed ID: 32392227. Show all entries for this paper.


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