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Displaying record number 775

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MAb ID	98-43
HXB2 Location	gp160(579-604) DNA(7959..8036)	gp160 Epitope Map
Author Location	gp41(579-604 HXB2)
Epitope	`RILAVERYLKDQQLLGIWGCSGKLIC`	Epitope Alignment
Subtype	B
Ab Type	gp41 cluster I
Neutralizing
Species (Isotype)	human(IgG2κ)
Patient
Immunogen	HIV-1 infection
Keywords	ADCC, antibody generation, review

Notes

Showing 6 of 6 notes.

98-43: The complexity of the epitopes recognized by ADCC responses in HIV-1 infected individuals and candidate vaccine recipients is discussed in this review. 98-43 is discussed as the Cluster I region-targeting, non-neutralizing anti-gp41 mAb with a linear epitope, exhibiting the least potent ADCC activity and mapped to AA 579-604(Table-1). Pollara2013 (ADCC, review)
98-43: Antibody generation paper. Antibodies were derived from 58 HIV+ patients. Synthesized by immortalization of peripheral blood cells with Epstein-Barr virus. Gorny1989 (antibody generation)
98-43: NIH AIDS Research and Reference Reagent Program: 1241.
98-43: 579-604 binds in the immunodominant region. Xu1991
98-43: Poor ADCC (in contrast to MAb 120-16, gp41(644-663)). Tyler1990 (ADCC)
98-43: Reacts equally well with oligomer and monomer. Pinter1989

References

Showing 5 of 5 references.

Isolation Paper
Gorny1989 M. K. Gorny, V. Gianakakos, S. Sharpe, and S. Zolla-Pazner. Generation of human monoclonal antibodies to human immunodeficiency virus. Proc. Natl. Acad. Sci. U.S.A., 86:1624-1628, 1989. This paper described immortalization of B-cells from HIV-1 positive individuals with Epstein-Barr virus, to produce seven stable antibody producing cell lines. PubMed ID: 2922401. Show all entries for this paper.

Pinter1989 A. Pinter, W. J. Honnen, S. A. Tilley, C. Bona, H. Zaghouani, M. K. Gorny, and S. Zolla-Pazner. Oligomeric Structure of gp41, the Transmembrane Protein of Human Immunodeficiency Virus Type 1. J. Virol., 63:2674-2679, 1989. PubMed ID: 2786089. Show all entries for this paper.

Pollara2013 Justin Pollara, Mattia Bonsignori, M. Anthony Moody, Marzena Pazgier, Barton F. Haynes, and Guido Ferrari. Epitope Specificity of Human Immunodeficiency Virus-1 Antibody Dependent Cellular Cytotoxicity (ADCC) Responses. Curr. HIV Res., 11(5):378-387, Jul 2013. PubMed ID: 24191939. Show all entries for this paper.

Tyler1990 D. S. Tyler, S. D. Stanley, S. Zolla-Pazner, M. K. Gorny, P. P. Shadduck, A. J. Langlois, T. J. Matthews, D. P. Bolognesi, T. J. Palker, and K. J. Weinhold. Identification of sites within gp41 that serve as targets for antibody-dependent cellular cytotoxicity by using human monoclonal antibodies. J. Immunol., 145:3276-3282, 1990. PubMed ID: 1700004. Show all entries for this paper.

Xu1991 J.-Y. Xu, M. K. Gorny, T. Palker, S. Karwowska, and S. Zolla-Pazner. Epitope mapping of two immunodominant domains of gp41, the transmembrane protein of human immunodeficiency virus type 1, using ten human monoclonal antibodies. J. Virol., 65:4832-4838, 1991. The immunodominance of linear epitope in the region 590-600 of gp41 (cluster I) was established, and a second conformational epitope was mapped that reacted with a region between amino acids 644 and 663 (cluster II). Titration experiments showed that there was 100-fold more antibody to cluster I than cluster II in patient sera. PubMed ID: 1714520. Show all entries for this paper.