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Displaying record number 773

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MAb ID	41-7
HXB2 Location	gp160(598-604) DNA(8016..8036)	gp160 Epitope Map
Author Location	gp41(605-611)
Epitope	CSGKLIC	Epitope Alignment
Ab Type
Neutralizing
Species (Isotype)	human(IgG1κ)
Patient
Immunogen	HIV-1 infection
Keywords

Notes

Showing 2 of 2 notes.

• 41-7: Monoclonal antibodies to this epitope have distinct phenotypes---41-7 and 1B8.env were found to be not neutralizing, 2F11 possibly enhancing, and clone 3 beneficial. Database note: First author "EnshellSeijffers" is also found as "Enshell-Seijffers" on annotated papers in this database. EnshellSeijffers2001
• 41-7: Sera from 6/6 HIV-1 positive, but no HIV-2 positive individuals, interfered with 41-7 binding -- Ab does not neutralize. Bugge1990

References

Showing 2 of 2 references.

Bugge1990 T. H. Bugge, B. O. Lindhardt, L. L. Hansen, P. Kusk, E. Hulgaard, K. Holmback, P. J. Klasse, J. Zeuthen, and K. Ulrich. Analysis of a Highly Immunodominant Epitope in the Human Immunodeficiency Virus Type 1 Transmembrane Glycoprotein, gp41, Defined by a Human Monoclonal Antibody. J. Virol., 64:4123-4129, 1990. PubMed ID: 1696634. Show all entries for this paper.

EnshellSeijffers2001 David Enshell-Seijffers, Larisa Smelyanski, Nurith Vardinon, Israel Yust, and Jonathan M. Gershoni. Dissection of the Humoral Immune Response Toward an Immunodominant Epitope of HIV: A Model for the Analysis of Antibody Diversity in HIV+ Individuals. FASEB J., 15(12):2112-1220, Oct 2001. PubMed ID: 11641237. Show all entries for this paper.