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MAb ID	113/072
HXB2 Location	Gag(213-222) DNA(1426..1455)	Gag Epitope Map
Author Location	p24(213-222 IIIB)
Epitope	DRVHPVHAGP	Epitope Alignment
Ab Type
Neutralizing
Species (Isotype)	mouse(IgG1)
Patient
Immunogen	vaccine
Keywords

Vaccine Details

Notes

Showing 2 of 2 notes.

• 113/072: Similarity level of the 113/072 binding site pentapeptide HPVHA to the host proteome was low, with the low-similarity 5-mer occurring in the host proteome 2 times, indicating that this peptide can be used to elicit Abs for active/passive immunotherapy with low risk of cross-reaction with the host proteome. Kanduc2008
• 113/072: Weak cross-reaction with HIV-2 on WB, otherwise not cross-reactive with HIV-2 or SIV MAC. Niedrig1991

References

Showing 2 of 2 references.

Niedrig1991 M. Niedrig, J. Hinkula, H.-P. Harthus, M. Broker, L. Hopp, G. Pauli, and B. Wahren. Characterization of murine monoclonal antibodies directed against the core proteins of human immunodeficiency virus types 1 and 2. J. Virol., 65:4529-4533, 1991. Multiple anti-HIV p24 MAbs were generated using HIV-1 IIIB p24 or HIV-2 ROD p26 as immunogens. The epitopes for these MAbs were mapped, and the cross-reactivity between HIV-1 IIIB, HIV-2 ROD and SIV MAC antigens were compared using multiple antibody binding assays. While some of the antibodies raised were cross-reactive by some or all of the assays, (ELISA, WB, immunofluorescence, immunoprecipitation and alkaline phosphatase anti-alkaline phosphatase assay), the different assays often gave different results. Only the antibodies raised to HIV-1 IIIB p24 are included in this database. PubMed ID: 1712863. Show all entries for this paper.

Kanduc2008 Darja Kanduc, Rosario Serpico, Alberta Lucchese, and Yehuda Shoenfeld. Correlating Low-Similarity Peptide Sequences and HIV B-Cell Epitopes. Autoimmun. Rev., 7(4):291-296, Feb 2008. PubMed ID: 18295732. Show all entries for this paper.