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Displaying record number 754

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MAb ID	68.1
HXB2 Location	gp160(598-604) DNA(8016..8036)	gp160 Epitope Map
Author Location	gp41(598-609)
Epitope	CSGKLIC	Epitope Alignment
Ab Type
Neutralizing
Species (Isotype)	mouse(IgM)
Patient
Immunogen	vaccine
Keywords

Vaccine Details

Notes

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• 68.1: Stimulated by immunization with the peptide: LGLIWGCSGKLIC (aa 598-609) -- cross-reactive with HIV-2 peptide CAFRQVC -- more reactive with longer HIV-1 peptide LGLIWGCSGKLIC and HIV-2 peptide NSWGCAFRQVC. Oldstone1991

References

Showing 1 of 1 reference.

Isolation Paper
Oldstone1991 M. B. A. Oldstone, A. Tishon, H. Lewicki, H. J. Dyson, V. A. Feher, N. Assa-Munt, and P. E. Wright. Mapping the anatomy of the immunodominant domain of the human immunodeficiency virus gp41 transmembrane protein: peptide conformation analysis using monoclonal antibodies and proton nuclear magnetic resonance spectroscopy. J. Virol., 65:1727-1734, 1991. Disulfide bond between cysteines and type I reverse turn about the residues SGKL are structural features of the immunodominant domain of gp41: CSGKLIC. PubMed ID: 2002540. Show all entries for this paper.