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Displaying record number 740

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MAb ID	24G3
HXB2 Location	gp160(525-543) DNA(7797..7853)	gp160 Epitope Map
Author Location	gp41(526-543 BH10)
Research Contact	H. Katinger, Inst. Appl. Microbiol., Vienna, Austria
Epitope	`AAGSTMGAASMTLTVQARQ`	Epitope Alignment
Subtype	B
Ab Type
Neutralizing
Species (Isotype)	human(IgG1κ)
Patient
Immunogen	HIV-1 infection
Keywords

Notes

Showing 2 of 2 notes.

24G3: This epitope is similar to a fragment of the HLA class II histocompatibility antigen, GGSCMAALTVTLTV. Maksiutov2002
24G3: Human MAb generated by electrofusion of PBL from HIV-1+ volunteers with CB-F7 cells. Buchacher1992,Buchacher1994

References

Showing 3 of 3 references.

Isolation Paper
Buchacher1994 A. Buchacher, R. Predl, K. Strutzenberger, W. Steinfellner, A. Trkola, M. Purtscher, G. Gruber, C. Tauer, F. Steindl, A. Jungbauer, and H. Katinger. Generation of Human Monoclonal Antibodies against HIV-1 Proteins; Electrofusion and Epstein-Barr Virus Transformation for Peripheral Blood Lymphocyte Immortalization. AIDS Res. Hum. Retroviruses, 10:359-369, 1994. A panel of 33 human monoclonal antibodies were produced. Linear epitopes for some of this set of MAbs were mapped using peptide ELISA. Linear epitopes were mapped in gp41, and a single epitope was mapped in p24. While multiple gp120 specific MAbs were generated, all seemed to be conformational or carbohydrate dependent, or both. PubMed ID: 7520721. Show all entries for this paper.

Buchacher1992 Andrea Buchacher, Renate Predl, Christa Tauer, Martin Purtscher, Gerhard Gruber, Renate Heider, Fraz Steindl, Alexandra Trkola, Alois Jungbauer, and Herman Katinger. Human Monoclonal Antibodies against gp41 and gp120 as Potential Agent for Passive Immunization. Vaccines, 92:191-195, 1992. Show all entries for this paper.

Maksiutov2002 A. Z. Maksiutov, A. G. Bachinskii, and S. I. Bazhan. [Searching for Local Similarities Between HIV-1 and Human Proteins. Application to Vaccines]. Mol Biol (Mosk), 36(3):447-459, May-Jun 2002. Article in Russian. PubMed ID: 12068630. Show all entries for this paper.