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MAb ID	13.10 (No. 13)
HXB2 Location	Env	Env Epitope Map
Author Location	gp120
Research Contact	Evan Hersh and Yoh-Ichi Matsumoto
Epitope
Ab Type
Neutralizing
Species (Isotype)	human(IgG1λ)
Patient
Immunogen	HIV-1 infection
Keywords

Notes

Showing 4 of 4 notes.

13.10: NIH AIDS Research and Reference Reagent Program: 377.
13.10: 13.10 is V H1 -- V-region heavy chain usage was examined and a bias of enhanced V H1 and V H4, and reduced V H3, was noted among HIV infected individuals. Wisnewski1996
13.10: Heavy (V HI) and light (V lambdaII) chain sequenced -- no enhancing or neutralizing activity -- called No. 13. Moran1993
13.10: First HIV-1 specific human-mouse hybridoma that produces a MAb that binds to gp120 and gp160. Lake1989

References

Showing 3 of 3 references.

Lake1989 D. Lake, T. Sugano, Y. Matsumoto, Y. Masuho, E. A. Petersen, P. Feorino, and E. M. Hersh. A Hybridoma Producing Human Monoclonal Antibody Specific for Glycoprotein 120kDa of Human Immunodeficiency Virus (HIV-1). Life Sciences, 45:iii-x, 1989. PubMed ID: 2554084. Show all entries for this paper.

Moran1993 M. J. Moran, J. S. Andris, Y.-I. Matsumato, J. D. Capra, and E. M. Hersh. Variable Region Genes of Anti-HIV Human Monoclonal Antibodies: Non-Restricted Use of the V Gene Repertoire and Extensive Somatic Mutation. Mol. Immunol., 30:1543-1551, 1993. Sequenced variable regions from four human anti-HIV-1 MAbs: anti-gp120 13, S1-1 and HBW4; and anti-gp41 No.86. Extensive somatic mutation was observed and under-representation of V$_H$ III usage. PubMed ID: 8232339. Show all entries for this paper.

Wisnewski1996 A. Wisnewski, L. Cavacini, and M. Posner. Human antibody variable region gene usage in HIV-1 infection. J. Acquir. Immune Defic. Syndr. Hum. Retrovirol., 11:31-38, 1996. PubMed ID: 8528730. Show all entries for this paper.