Search Antibody Database

Found 1 matching record:

Displaying record number 716

Download this epitope record as JSON.

MAb ID	polyclonal
HXB2 Location	Env	Env Epitope Map
Author Location	gp120
Epitope
Ab Type
Neutralizing
Species (Isotype)	macaque
Patient
Immunogen	vaccine
Keywords

Vaccine Details

Vaccine type	peptide, protein
Vaccine strain	B clade SF2, B clade SF33
Vaccine component	gp120
Adjuvant	Immune stimulating complexes (ISCOM), MF59

Notes

Showing 1 of 1 note.

Attempts were made to broaden immune responses induced in Rhesus monkeys by immunization of animals previously immunized that had resisted homologous challenge, with a second immunization with ISCOM-peptides or a boost with gp120 from SF33 -- animals didn't survive a second challenge heterologous challenge virus SHIV(SF33) raising concerns about early antigenic sin. Verschoor1999

References

Showing 1 of 1 reference.

Verschoor1999 E. J. Verschoor, P. Mooij, H. Oostermeijer, M. van der Kolk, P. ten Haaft, B. Verstrepen, Y. Sun, B. Morein, L. Akerblom, D. H. Fuller, S. W. Barnett, and J. L. Heeney. Comparison of Immunity Generated by Nucleic Acid-, MF59-, and ISCOM-Formulated Human Immunodeficiency Virus Type 1 Vaccines in Rhesus Macaques: Evidence for Viral Clearance. J. Virol., 73:3292-3300, 1999. PubMed ID: 10074183. Show all entries for this paper.