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Displaying record number 709

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MAb ID	L81
HXB2 Location	Env	Env Epitope Map
Author Location	gp120
Epitope
Ab Type	gp120 C1-C5
Neutralizing
Species (Isotype)	human(IgG1)
Patient
Immunogen	HIV-1 infection
Keywords

Notes

Showing 2 of 2 notes.

L81: Does not neutralize TCLA strains or primary isolates. Parren1997
L81: gp120 immobilized on solid phase by capture with anti-CD4 BS MAb L72 was used for selection of Fabs -- L81 binding is abolished by C1 substitution 45 W/S, C5 substitution 491 I/F, and C3 substitution L/A. Ditzel1997

References

Showing 2 of 2 references.

Ditzel1997 H. J. Ditzel, P. W. Parren, J. M. Binley, J. Sodroski, J. P. Moore, C. F. Barbas, III, and D. R. Burton. Mapping the Protein Surface of Human Immunodeficiency Virus Type 1 gp120 Using Human Monoclonal Antibodies from Phage Display Libraries. J. Mol. Biol., 267:684-695, 1997. (Genbank: U82767 U82768 U82769 U82770 U82771 U82772 U82942 U82943 U82944 U82945 U82946 U82947 U82948 U82949 U82950 U82951 U82952 U82961 U82962) Recombinant monoclonal antibodies from phage display libraries provide a method for Env surface epitope mapping. Diverse epitopes are accessed by presenting gp120 to the library in different forms, such as sequential masking of epitopes with existing MAbs or sCD4 prior to selection or by selection on peptides. Fabs identified by these methods have specificities associated with epitopes presented poorly on native multimeric envelope. PubMed ID: 9126846. Show all entries for this paper.

Parren1997 P. W. Parren, M. C. Gauduin, R. A. Koup, P. Poignard, Q. J. Sattentau, P. Fisicaro, and D. R. Burton. Erratum to Relevance of the Antibody Response against Human Immunodeficiency Virus Type 1 Envelope to Vaccine Design. Immunol. Lett., 58:125-132, 1997. corrected and republished article originally printed in Immunol. Lett. 1997 Jun;57(1-3):105-112. PubMed ID: 9271324. Show all entries for this paper.