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Displaying record number 696

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MAb ID	66a
HXB2 Location	Env	Env Epitope Map
Author Location	gp120
Epitope
Ab Type	gp120 V2 // V2 glycan(V2g) // V2 apex
Neutralizing	L (HXB2)
Species (Isotype)	mouse(IgG1)
Patient
Immunogen	vaccine
Keywords

Vaccine Details

Vaccine type	protein
Vaccine strain	B clade BH10
Vaccine component	gp120

Notes

Showing 2 of 2 notes.

66a: UK Medical Research Council AIDS reagent: ARP3074.
66a: Substitutions 176-177 FY/AT, 179-180 LD/DL, 183-184 PI/SG, and 191-193 YSL/GSS abrogate binding -- same competition group as CRA4. Shotton1995

References

Showing 1 of 1 references.

Shotton1995 C. Shotton, C. Arnold, Q. Sattentau, J. Sodroski, and J. A. McKeating. Identification and characterization of monoclonal antibodies specific for polymorphic antigenic determinants within the V2 region of the human immunodeficiency virus type 1 envelope glycoprotein. J. Virol., 69:222-230, 1995. Anti-V2 linear and conformation dependent MAbs were studied. All V2 Abs studied could bind IIIB, but failed to neutralize non-clonal stocks. Epitope exposure is different in rgp120 compared to native gp120. HXB2 V2-MAb neutralization escape mutants were sequenced. PubMed ID: 7527084. Show all entries for this paper.