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Displaying record number 671

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MAb ID 8F102
HXB2 Location Env Env Epitope Map
Author Location gp120
Epitope
Ab Type gp120-CD4 complex
Neutralizing  
Species (Isotype) mouse(IgG)
Patient  
Immunogen vaccine
Keywords  

Vaccine Details

Vaccine type sCD4-gp120 complex
Vaccine strain B clade HXB2
Vaccine component gp120

Notes

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References

Showing 1 of 1 reference.

Devico1995 A. L. DeVico, R. Rahman, J. Welch, R. Crowley, P. Lusso, M. G. Sarngadharan, and R. Pal. Monoclonal Antibodies Raised against Covalently Crosslinked Complexes of Human Immunodeficiency Virus Type 1 gp120 and CD4 Receptor Identify a Novel Complex-Dependent Epitope on gp120. Virology, 211:583-588, 1995. To explore the immunogenicity of regions of gp120 that are exposed due to conformational changes in gp120 upon CD4 binding, CD4 was covalently linked to gp120 and this complex was used as an immunogen for BALB/c mice. Two MAbs were produced, both of which bind preferentially to the gp120-CD4 complex, and are conformational. Competition assays indicate these MAbs bind to epitopes that are recognized by sera from HIV-1 infected humans. PubMed ID: 7544051. Show all entries for this paper.


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