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Displaying record number 671

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MAb ID	8F102
HXB2 Location	Env	Env Epitope Map
Author Location	gp120
Epitope
Ab Type	gp120-CD4 complex
Neutralizing
Species (Isotype)	mouse(IgG)
Patient
Immunogen	vaccine
Keywords

Vaccine Details

Vaccine type	sCD4-gp120 complex
Vaccine strain	B clade HXB2
Vaccine component	gp120

Notes

Showing 1 of 1 note.

8F102: MAbs specifically reactive to crosslinked gp120 and CD4 were derived (8F101, 8F102) -- conformation dependent -- competition studies indicate the epitope is immunogenic in infected humans. Devico1995

References

Showing 1 of 1 reference.

Devico1995 A. L. DeVico, R. Rahman, J. Welch, R. Crowley, P. Lusso, M. G. Sarngadharan, and R. Pal. Monoclonal Antibodies Raised against Covalently Crosslinked Complexes of Human Immunodeficiency Virus Type 1 gp120 and CD4 Receptor Identify a Novel Complex-Dependent Epitope on gp120. Virology, 211:583-588, 1995. To explore the immunogenicity of regions of gp120 that are exposed due to conformational changes in gp120 upon CD4 binding, CD4 was covalently linked to gp120 and this complex was used as an immunogen for BALB/c mice. Two MAbs were produced, both of which bind preferentially to the gp120-CD4 complex, and are conformational. Competition assays indicate these MAbs bind to epitopes that are recognized by sera from HIV-1 infected humans. PubMed ID: 7544051. Show all entries for this paper.