HIV molecular immunology database
Found 1 matching record:
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|HXB2 Location||Env||Env Epitope Map|
|Ab Type||gp120-CD4 complex|
|Vaccine type||sCD4-gp120 complex|
|Vaccine strain||B clade HXB2|
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Showing 1 of 1 reference.
Devico1995 A. L. DeVico, R. Rahman, J. Welch, R. Crowley, P. Lusso, M. G. Sarngadharan, and R. Pal. Monoclonal Antibodies Raised against Covalently Crosslinked Complexes of Human Immunodeficiency Virus Type 1 gp120 and CD4 Receptor Identify a Novel Complex-Dependent Epitope on gp120. Virology, 211:583-588, 1995. To explore the immunogenicity of regions of gp120 that are exposed due to conformational changes in gp120 upon CD4 binding, CD4 was covalently linked to gp120 and this complex was used as an immunogen for BALB/c mice. Two MAbs were produced, both of which bind preferentially to the gp120-CD4 complex, and are conformational. Competition assays indicate these MAbs bind to epitopes that are recognized by sera from HIV-1 infected humans. PubMed ID: 7544051. Show all entries for this paper.